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Publications (35)
Although intentional poisonings with 2-Methyl-4-chlorophenoxyacetic acid (MCPA) are relatively rare and in most cases cause moderate toxicity, deaths have been described, mainly due to cardiorespiratory arrest. Treatment is generally supportive, with opposing effects from the application of urinary alkalization and other methods for secondary elimi...
Diabetes mellitus has been reaching pandemic proportions as 537 million adults are living with diabetes worldwide. At the same time, we have witnessed the infectious pandemic of COVID-19 with over 557 million cases as of 15-Jul-2022. Diabetes has been one of the major risk factors for COVID-19 morbidity and mortality; on the other hand, COVID-19 ha...
Introduction : Rhabdomyolysis is characterized by a muscle injury that leads to the release of intracellular muscle contents/constituents into the systemic circulation.
Aim : We examined the association between the severity of the clinical presentation and creatinine phosphokinase values in patients with rhabdomyolysis acutely intoxicated with psyc...
Posttransplantation disturbances in glucose metabolism and increased insulin resistance are major factors affecting overall cardiovascular morbidity, reduced graft function, and survival after renal transplantation. We analyzed the prevalence of increased insulin resistance simultaneously with the prevalence of pre-diabetes in kidney transplant pat...
It is very important for patients with spontaneous bacterial peritonitis (SBP) to assess the length of survival and the risk of death, primarily because of the wide range of potential complications that can lead to multisystem organ failure and fatal outcome. The aim of this study was to determine the predictive potential of MELD and Child-Turcotte...
Aluminum phosphide (AlP) has been known for more than 80 years as an effective pesticide for grain protection, but also as a suicidal agent used for human self-poisoning. Phosphine gas released in contact with stomach acid after oral ingestion of AlP is responsible for its toxicity. The poison affects all systems, so the mortality rate is quite hig...
Background: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate pathway and mutation of the enzyme methylentetrahydrofolate reductase MTHFR C677T gene. But whether it has influence on the level of total homocysteine is still under debate. Several polymorphisms have been reported in MTHFR gene, but C677T polymorphism is the most st...
Spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis is a newly developed, spontaneous bacterial infection of sterile ascites fluid, in the absence of intraabdominal sources of infection or malignancy. The most sensitive indicator of diagnosis is when the polymorphonuclear cell count (PMNC) is ≥250 in 1 ml ascites fluid (manua...
Background and aims: Our country is estimated to have the second
highest diabetes age-adjusted (20-79 years) comparative prevalence
in Europe (10.1%), and is categorized as a very high risk country for
cardiovascular disease (CVD) mortality (CVD mortality >450/100,000
for men, and >350/100,000 for women). Aim of the study was, for
the first ti...
Background: The aim was to evaluate the Nt-proBNP discriminatory role between symptomatic and asymptomatic patients with severe aortic stenosis.
Methods: 187 patients with severe valvular aortic stenosis, with normal EF > 50%, were included, 61 asymptomatic and 126 symptomatic. We used clinical, laboratory (Nt-proBNP) and echocardiographic paramete...
BACKGROUND: Elderly population (≥ 65) are more prone to develop acute kidney injury (AKI) compared to younger, also elderly with AKI have an increased requirement for dialysis treatment and an elevated risk of short-term and long-term mortality.
AIM: The objectives of this study were to examine the effect of treatment of short-term outcomes and mo...
Introduction. Post-transplant diabetes (PTDM), impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are common complications of immunosuppressive therapy (IT) and are associated with increased cardiovascular morbidity and impaired graft function (GF).
Methods. Fifty-nine living donor kidney transplant recipients (KTR) were included i...
Introduction:
The aim of this study is to show the importance of hemodialysis as an active method in treatment of acute acetic acid poisonings. Its main role is to support the renal function during the state of the intoxication when patients develop acute renal failure.
Methods:
We analyzed data from a 10-year period, a total of 71 patients who...
BACKGROUND: Use and abuse of cocaine are associated with numerous adverse effects, independent of the route of administration. More severe conditions of poisoning, however, are observed after cocaine intravenous administration.
AIM: We present a case of severe poisoning after violent intravenous injection of cocaine, but with a good outcome.
CASE...
A 64-year-old man ingested about 60 ml 2% of topical minoxidil solution in order tomake his hair grow faster. Twelve hours after ingestion he was brought to the University Clinic of Toxicology with severe hypotension, tachycardia, chest pain and subendocardial ischemia. ECG showed diffuse T-wave inversion and depressed ST segments. He was also olig...
Background:
Collecting and consuming wild mushrooms is a historical tradition in many European countries, including The Republic of Macedonia. This activity is predominantly performed in the period between June and October, when the weather is warm and humidity in the air and soil is at higher levels.The Amanita genus consists of 500 different spe...
Dyslipidemia in heroin addicts is considered to be a precondition for developing metabolic syndrome.
The aim was to evaluate the frequency in serum lipid disturbances of hepatitis C virus (HCV) seronegative heroin addicts; the capacity of high-density lipoprotein (HDL)-C and apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) for predicting hypertr...
Post-transplant diabetes mellitus and impaired glucose tolerance are confirmed complications after solid organ transplantation associated with the use of glucocorticoids and calcinuerin inhibitors in maintenance immunosuppression. Insulin resistance (IR) is also an independent factor for cardiovascular morbidity and mortality among renal allograft...
Long-term heroin abuse is related to pathological changes in many organs mediated by oxidative stress (OS).
Estimation of systemic OS and antioxidant capacity in heroin addiction and detoxification provides information about prooxidant/antioxidant homeostasis in heroin misuse and need for antioxidant supplementation.
OS was evaluated by the measure...
