Liangrui Pan

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Verified

Liangrui verified their affiliation via an institutional email.

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• Doctor of Engineering
• Student at Hunan University

Relying solely on a single medical data for cancer diagnosis may increase the risk of misdiagnosis and missed diagnosis. Multi-modal data provides comprehensive information on disease characteristics and can effectively promote the development of precision oncology. This paper first introduces the genomic, pathological, radiological and clinical in...

Spread through air spaces (STAS) is a distinct invasion pattern in lung cancer, crucial for prognosis assessment and guiding surgical decisions. Histopathology is the gold standard for STAS detection, yet traditional methods are subjective, time-consuming, and prone to misdiagnosis, limiting large-scale applications. We present VERN, an image analy...

Background and Objective: Given the high heterogeneity and clinical diversity of cancer, substantial variations exist in multi-omics data and clinical features across different cancer subtypes. Methods: We propose a model, named DEDUCE, based on a symmetric multi-head attention encoders (SMAE), for unsupervised contrastive learning to analyze mult...

Protein-nucleic acid interactions play a fundamental and critical role in a wide range of life activities. Accurate identification of nucleic acid-binding residues helps to understand the intrinsic mechanisms of the interactions. However, the accuracy and interpretability of existing computational methods for recognizing nucleic acid-binding residu...

Spread through air spaces (STAS) represents a newly identified aggressive pattern in lung cancer, which is known to be associated with adverse prognostic factors and complex pathological features. Pathologists currently rely on time consuming manual assessments, which are highly subjective and prone to variation. This highlights the urgent need for...

In this paper, a monitoring and classification system for human activities on stairs is presented. The contribution of this work is that, first, we develop the real-time wireless sensor monitoring system for measuring human motion data using 2.4 GHz IEEE 802.15.4 XBee3 micro modules as the low-power wireless modules, where the GY-521 accelerometer...

Protein-nucleic acid interactions play a fundamental and critical role in a wide range of life activities. Accurate identification of nucleic acid-binding residues helps to understand the intrinsic mechanisms of the interactions. However, the accuracy and interpretability of existing computational methods for recognizing nucleic acid-binding residu...

Spread through air spaces (STAS) is a distinct invasion pattern in lung cancer, crucial for prognosis assessment and guiding surgical decisions. Histopathology is the gold standard for STAS detection, yet traditional methods are subjective, time-consuming, and prone to misdiagnosis, limiting large-scale applications. We present VERN, an image analy...

Hematoxylin and Eosin (H&E) staining of whole slide images (WSIs) is considered the gold standard for pathologists and medical practitioners for tumor diagnosis, surgical planning, and post-operative assessment. With the rapid advancement of deep learning technologies, the development of numerous models based on convolutional neural networks and tr...

DNA-protein interactions exert the fundamental structure of many pivotal biological processes, such as DNA replication, transcription, and gene regulation. However, accurate and efficient computational methods for identifying these interactions are still lacking. In this study, we propose a method ESM-DBP through refining the DNA-binding protein se...

DNA-protein interactions exert the fundamental structure of many pivotal biological processes, such as DNA replication, transcription, and gene regulation. However, accurate and efficient computational methods for identifying these interactions are still lacking. In this study, we propose a novel method ESM-DBP through refining the DNA-binding prot...

Accurate segmentation of medical images is vital for disease detection and treatment. Convolutional Neural Networks (CNN) and Transformer models are widely used in medical image segmentation due to their exceptional capabilities in image recognition and segmentation. However, CNNs often lack an understanding of the global context and may lose spati...

Accurately predicting the survival rate of cancer patients is crucial for aiding clinicians in planning appropriate treatment, reducing cancer-related medical expenses, and significantly enhancing patients’ quality of life. Multimodal prediction of cancer patient survival offers a more comprehensive and precise approach. However, existing methods s...

Histopathology image segmentation is the gold standard for diagnosing cancer, and can indicate cancer prognosis. However, histopathology image segmentation requires high-quality masks, so many studies now use image�level labels to achieve pixel-level segmentation to reduce the need for fine-grained annotation. To solve this problem, we propose...

—Due to the high heterogeneity and clinical characteristics of cancer, there are significant differences in multi-omic data and clinical characteristics among different cancer subtypes. Therefore, accurate classification of cancer subtypes can help doctors choose the most appropriate treatment options, improve treatment outcomes, and provide...

Histopathological images are the gold standard for diagnosing liver cancer. However, the accuracy of fully digital diagnosis in computational pathology needs to be improved. In this paper, in order to solve the problem of multi�label and low classification accuracy of histopathology images, we propose a locally deep convolutional Swim framework...

In the semi-Lagrangian interpolation scheme of Yin-he Global Spectral model (YHGSM), communication needs to be performed before interpolation, resulting in significant communication overhead. To solve this problem, we propose an optimized scheme that overlaps computation with communication based on grouping levels. The scheme divides the vertical l...

Histopathological images are the gold standard for diagnosing liver cancer. However, the accuracy of fully digital diagnosis in computational pathology needs to be improved. In this paper, in order to solve the problem of multi-label and low classification accuracy of histopathology images, we propose a locally deep convolutional Swim framework (LD...

Histopathology image segmentation is the gold standard for diagnosing cancer, and can indicate cancer prognosis. However, histopathology image segmentation requires high-quality masks, so many studies now use imagelevel labels to achieve pixel-level segmentation to reduce the need for fine-grained annotation. To solve this problem, we propose an at...

Due to the high heterogeneity and clinical characteristics of cancer, there are significant differences in multi-omic data and clinical characteristics among different cancer subtypes. Therefore, accurate classification of cancer subtypes can help doctors choose the most appropriate treatment options, improve treatment outcomes, and provide more ac...

Hematoxylin and eosin stained whole slide images (WSIs) are the gold standard for pathologists and medical professionals for tumor diagnosis, surgery planning, and postoperative examinations. In recent years, due to the rapidly emerging field of deep learning, there have been many convolutional neural networks (CNNs) and Transformer based models ap...

Due to the high heterogeneity and clinical characteristics of cancer, there are significant differences in multi-omics data and clinical features among subtypes of different cancers. Therefore, the identification and discovery of cancer subtypes are crucial for the diagnosis, treatment, and prognosis of cancer. In this study, we proposed a generali...

Colorectal cancer (CRC) is among the top three malignant tumor types in terms of morbidity and mortality. Histopathological images are the gold standard for diagnosing colon cancer. Cellular nuclei instance segmentation and classification, and nuclear component regression tasks can aid in the analysis of the tumor microenvironment in colon tissue....

Colorectal cancer (CRC) is among the top three malignant tumor types in terms of morbidity and mortality. Histopathological images are the gold standard for diagnosing colon cancer. Cellular nuclei instance segmentation and classification, and nuclear component regression tasks can aid in the analysis of the tumor microenvironment in colon tissue....

The degree of malignancy of osteosarcoma and its tendency to metastasize/spread mainly depend on the pathological grade (determined by observing the morphology of the tumor under a microscope). The purpose of this study is to use artificial intelligence to classify osteosarcoma histological images and to assess tumor survival and necrosis, which wi...

Hybrid beamforming can provide rapid data transmission rates while reducing the complexity and cost of massive multiple-input multiple-output (MIMO) systems. However, channel state information (CSI) is imperfect in realistic downlink channels, introducing challenges to hybrid beamforming (HBF) design. This paper proposes an unsupervised deep learni...

Computational pathology is part of precision oncology medicine. The integration of high-throughput data including genomics, transcriptomics, proteomics, metabolomics, pathomics, and radiomics into clinical practice improves cancer treatment plans, treatment cycles, and cure rates, and helps doctors open up innovative approaches to patient prognosis...

The degree of malignancy of osteosarcoma and its tendency to metastasize/spread mainly depend on the pathological grade (determined by observing the morphology of the tumor under a microscope). The purpose of this study is to use artificial intelligence to classify osteosarcoma histological images and to assess tumor survival and necrosis, which wi...

The use of chest X-ray images (CXI) to detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) caused by Coronavirus Disease 2019 (COVID19) is life-saving important for both patients and doctors. This research proposes a multi-channel feature deep neural network (MFDNN) algorithm to screen people infected with COVID19. The algorithm int...

Abstract——Diabetic retinopathy(DR) is the main cause of blindness in diabetic patients. However, DR can easily delay the occurrence of blindness through the diagnosis of the fundus. In view of the reality, it is difficult to collect a large amount of diabetic retina data in clinical practice. This paper proposes a few-shot learning model of a deep...

Diabetic retinopathy(DR) is the main cause of blindness in diabetic patients. However, DR can easily delay the occurrence of blindness through the diagnosis of the fundus. In view of the reality, it is difficult to collect a large amount of diabetic retina data in clinical practice. This paper proposes a few-shot learning model of a deep residual n...

In general, most of the substances in nature exist in mixtures, and the noninvasive identification of mixture composition with high speed and accuracy remains a difficult task. However, the development of Raman spectroscopy, machine learning, and deep learning techniques has paved the way for achieving efficient analytical tools capable of identify...

The use of chest X-ray images (CXI) to detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) caused by Coronavirus Disease 2019 (COVID-19) is life-saving important for both patients and doctors. This research proposed a multi-channel feature deep neural network algorithm to screen people infected with COVID-19. The algorithm integrate...

In general, most of the substances in nature exist in mixtures, and the noninvasive identification of mixture composition with high speed and accuracy remains a difficult task. However, the development of Raman spectroscopy, machine learning, and deep learning techniques have paved the way for achieving efficient analytical tools capable of identif...

With a noisy environment caused by fluorescence and additive white noise as well as complicated spectra fingerprints, the identification of complex mixture materials remains a significant challenge in Raman spectroscopy application. This paper proposes a new scheme based on a constant wavelet transform (CWT) and a deep network for classifying compl...

Because it is relatively difficult in practice to classify the Raman spectrum under baseline noise and additive white Gaussian noise environments, this paper proposes a new framework based on a wavelet transform and deep neural network for identification of noisy Raman spectra. The framework consists of two main engines. Wavelet transform is propos...

With noisy environment caused by fluoresence and additive white noise as well as complicated spectrum fingerprints, the identification of complex mixture materials remains a major challenge in Raman spectroscopy application. In this paper, we propose a new scheme based on a constant wavelet transform (CWT) and a deep network for classifying complex...

In a normal indoor environment, Raman spectrum encounters noise often conceal spectrum peak, leading to difficulty in spectrum interpretation. This paper proposes deep learning (DL) based noise reduction technique for Raman spectroscopy. The proposed DL network is developed with several training and test sets of noisy Raman spectrum. The proposed t...

This paper proposes a new framework based on a wavelet transform and deep neural network for identifying noisy Raman spectrum since, in practice, it is relatively difficult to classify the spectrum under baseline noise and additive white Gaussian noise environments. The framework consists of two main engines. Wavelet transform is proposed as the fr...