Lia Rimondini

Lia Rimondini
Amedeo Avogadro University of Eastern Piedmont | UNIPMN · Dipartimento di Scienze della Salute

Professor

About

247
Publications
60,985
Reads
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6,505
Citations
Additional affiliations
March 2005 - present
Amedeo Avogadro University of Eastern Piedmont
Position
  • Professor (Full)
January 1998 - December 2006
Istituto Ortopedico Rizzoli
Position
  • Visiting Researcher
Education
October 1981 - October 1986
University of Bologna
Field of study
  • Dentistry

Publications

Publications (247)
Poster
Full-text available
This poster was presented at the Scandinavian Society for Biomaterials (ScSB) 15th Annual Meeting from 13th to 15th June 2022.
Article
Full-text available
Tissue regeneration is a hot topic in health sciences, particularly because effective therapies promoting the healing of several cell types are lacking, specifically those of the musculoskeletal system. Mesenchymal Stem/Stromal Cells (MSCs) have been identified as crucial players in bone homeostasis, and are considered a promising therapy for disea...
Article
Full-text available
Functional ability is the basis of healthy aging. Articular cartilage degeneration is amongst the most prevalent degenerative conditions that cause adverse impacts on the quality of life; moreover, it represents a key predisposing factor to osteoarthritis (OA). Both the poor capacity of articular cartilage for self-repair and the unsatisfactory out...
Article
Full-text available
Zirconium-Copper-based metallic glass thin films represent promising coatings in the biomedical sector for their combination of antibacterial property and wear resistance. However, finding a Zr-Cu metallic glass composition with desirable cytocompatibility and antibacterial property is extremely challenging. In this work, we have created a cytocomp...
Article
Full-text available
In vitro and in vivo studies are fundamental steps in the characterization of new implantable materials to preliminarily assess their biological response. The present study reports the in vitro and in vivo characterizations of a novel experimental silicate bioactive glass (BG) (47.5 B, 47.5 SiO2-10 Na2O-10 K2O-10 MgO-20 CaO-2.5 P2O5 mol.%). Cytocom...
Article
In this work, copper and zinc co-doped coatings were successfully produced on commercially pure titanium samples by plasma electrolytic oxidation (PEO) using a sodium borate-based electrolyte. The effect of different duty cycles and frequencies on the treatment process was assessed, showing a significant influence of these parameters on the morphol...
Article
Background and aim of the work: Magnesium (Mg) is a metal physiologically present in bone tissue and essential for bone health. Mg-based-alloys exhibit mechanical properties, namely density and strength, similar to human cortical bone. These features have been exploited for the development of osteosynthesis devices in biodegradable Mg-based-alloys...
Article
Full-text available
Cytocompatible bioactive surface treatments conferring antibacterial properties to osseointegrated dental implants are highly requested to prevent bacteria-related peri-implantitis. Here we focus on a newly designed family of mesoporous coatings based on zirconia (ZrO2) microstructure doped with gallium (Ga), exploiting its antibacterial and pro-os...
Article
Full-text available
Stainless steel implants are suitable candidates for bone replacement due to their cytocompatibility and mechanical resistance, but they suffer from lack of bioactivity and are prone to bacterial infections. Accordingly, to overcome those limitations, in this study we developed by electrophoretic deposition (EPD), an innovative surface coating made...
Article
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Bioactive glasses are the materials of choice in the field of bone regeneration. Antioxidant properties of interest to limit inflammation and foreign body reactions have been conferred to bioactive glasses by the addition of appropriate ions (such as Ce or Sr). On the other hand, the antioxidant activity of bioactive glasses without specific ion/mo...
Article
In this research work composite coatings made of alginate and 45S5 bioactive glass particles doped with B, Zn and Sr were synthesized by means of electrophoretic deposition and characterized from morphological, compositional, thermogravimetric, mechanical and electrochemical point of view. The developed coatings were also subjected to in vitro test...
Article
Bioactive glasses have been widely investigated for their ability to release ions with therapeutic effect. In this paper, a silica-based-bioactive glass was doped with a low-amount of tellurium dioxide (1 and 5 mol%) to confer antibacterial and antioxidant properties. The obtained glasses were characterized in terms of morphology, composition, stru...
Article
Full-text available
Injectable bioactive glass-based pastes represent promising biomaterials to fill small bone defects thus improving and speed up the self-healing process. Accordingly, injectable nanocomposite pastes based on bioactive glass-gelatin-3-glycidyloxypropyl trimethoxysilane (GPTMS) were here synthesized via two different glasses 64SiO2. 27CaO. 4MgO. 5P2O...
Article
Full-text available
Bioactive glass (BG) represents a promising biomaterial for bone healing; here injectable BG pastes biological properties were improved by the addition of gelatin or chitosan, as well as mechanical resistance was enhanced by adding 10 or 20 wt% 3-Glycidyloxypropyl trimethoxysilane (GPTMS) cross-linker. Composite pastes exhibited bioactivity as apat...
Article
Full-text available
Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine b...
Preprint
Full-text available
Bioactive glass (BG) represents a promising biomaterial for bone healing; here injectable BG pastes biological properties were improved by 25 wt% gelatin or chitosan, as well as mechanical resistance was enhanced by adding 10 or 20 wt% 3-Glycidyloxypropyl trimethoxysilane (GPTMS) cross-linker. Composites exhibited bioactivity as apatite formation w...
Article
Full-text available
Background and aim of the work: Tibial plateau fractures include a wide spectrum of lesions with potentially disabling sequelae. Arthroscopically-assisted Reduction and Internal Fixation (ARIF) is an alternative to traditional ORIF. The aim of this retrospective single centre study is to evaluate medium-term clinical and radiographic outcomes achi...
Article
Full-text available
Cartilage repair still represents a challenge for clinicians and only few effective therapies are nowadays available. In fact, surgery is limited by the tissue poor self-healing capacity while the autologous transplantation is often forsaken due to the poor in vitro expansion capacity of chondrocytes. Biomaterials science offers a unique alternativ...
Article
Full-text available
: Biomolecules and extracts from natural products are gaining increasing interest due to their beneficial properties for human health, low toxicity, environmental compatibility and sustainability. In this work, keratin, chitosan and peppermint essential oil have been used for the preparation of coatings on titanium substrates for biomedical implant...
Article
Carbohydrate-based porous scaffolds are promising biomaterials to support cartilage regeneration. In this respect, their composition could be designed to face clinical challenges, i.e., articular load bearing, infections and oxidative stress. Herein, an innovative scaffold has been developed, combining raw materials belonging to different kingdoms...
Article
Full-text available
Soft tissue adhesion and infection prevention are currently challenging for dental transmucosal or percutaneous orthopedic implants. It has previously been shown that aligned micro-grooves obtained by Electron Beam (EB) can drive fibroblast alignment for improved soft tissue adhesion. In this work, evidence is presented that the same technique can...
Article
Full-text available
Nowadays, there is a large amount of research aimed at improving the multifunctional behavior of the biomaterials for bone contact, including the concomitant ability to induce apatite formation (bioactivity), fast and effective osteoblasts colonization, and antibacterial activity. The aim of this study is to develop antibacterial and bioactive surf...
Article
Full-text available
This work contains original data supporting our research paper "Advances in cartilage repair: the influence of inorganic clays to improve mechanical and healing properties of antibacterial Gellan gum-Manuka honey hydrogels", by Maria A. Bonifacio, Andrea Cochis, Stefania Cometa, Annachiara Scalzone, Piergiorgio Gentile, Giuseppe Procino, Serena Mil...
Article
Full-text available
The study explores antibacterial, antiinflammatory and cytoprotective capacity of Pelargonium sidoides DC root extract (PSRE) and proanthocyanidin fraction from PSRE (PACN) under conditions characteristic for periodontal disease. Following previous finding that PACN exerts stronger suppression of Porphyromonas gingivalis compared to the effect on c...
Article
Effective treatment of cartilage defects represents a challenging problem, mainly due to the tissue's limited intrinsic self-repair capacity; the use of polymeric scaffolds as tissue substitute is rapidly increasing, but it is still limited by poor mechanical properties. Moreover, the onset of an infection can irreversibly affect the healing proces...
Article
Bacterial contamination and bone tissue overgrowth are currently the main issues for temporary fixation devices. The aim of this research is the development of innovative inorganic coatings able to reduce bacterial adhesion and bone tissue overgrowth without hampering cytocompatibility. 316L stainless-steel, Titanium grade4 and Titanium grade5 were...
Article
Essential oils are effective as alternative biocide molecules, but they are currently not used against bacterial contamination of surfaces for biomedical, industrial or everyday life applications. In this work, the grafting of peppermint oil to a chemically-treated titanium alloy is explored as a coating or through functionalization (soaking in an...
Preprint
Full-text available
The study explores antibacterial, antiinflammatory and cytoprotective capacity of Pelargonium sidoides DC root extract (PSRE) and proanthocyanidin fraction from PSRE (PACN) under conditions characteristic for periodontal disease. Following previous finding that PACN exerts stronger suppression of Porphyromonas gingivalis compared to the effect on c...
Article
Aims: To evaluate OPN, MCM7, Ki-67, p53, Bcl-2 and 53BP1 presence, together with the abnormal adaptive CD4 and CD8 T-cell response markers expression in a series of oral lichen planus (OLP) affected patients and assess their combined contribution for a more objective disease classification. Methods and results: In this ex-vivo retrospective anal...
Article
X-ray photons attenuation characteristics for the two tellarite based glasses Bi2O3– B2O3– TeO2– TiO2 and PbO–ZnO–TeO2–B2O3 have been investigated at dental diagnostic energies (between 30-80 keV) using Geant4 code and WinXcom software. The correlation coefficient (R²) is utilized to evaluate the extent to which Geant4 results are related to the Wi...
Chapter
Full-text available
The Red Sea is largely undiscovered, strange wellspring of bioactive materials that its waters have not received sufficient and broad inspection till date. It expands for approximately 2000 kms and its semi segregation jointly with a rising saltiness at high water temperatures have offered new research trends for biological communities and developm...
Article
Full-text available
Bioactive glasses (BGs) are attractive materials for bone replacement due to their tailorable chemical composition that is able to promote bone healing and repair. Accordingly, many attempts have been introduced to further improve BGs' biological behavior and to protect them from bacterial infection, which is nowadays the primary reason for implant...
Article
Full-text available
Background: Periodontitis is a disease that leads to serious functional and esthetic dysfunctions. Periodontitis exists in different forms, and its etiology is related to multiple component causes. Two key processes involved in the evolution of this pathology are angiogenesis and inflammatory infiltrate. The aim of this study was to understand if...
Article
Full-text available
It is widely recognized that surface nanotextures applied on a biomaterial can affect wettability, protein absorption and cellular and/or bacterial adhesion; accordingly, they are nowadays of great interest to promote fast osseointegration and to maintain physiological healing around biomedical implants. In order to be suitable for clinical applica...
Article
Full-text available
Orthopedic metallic devices are often related with devasting complications due to acute prosthetic joint infections. Gallium (Ga) antibacterial activity has been demonstrated by the evidence that Ga in solution ionize in a Ga³⁺ trivalent form that replace Fe³⁺ thus arresting metabolism. However, it is not clear whether such effect is restricted onl...
Article
Teeth and the periodontal tissues represent a highly specialized functional system. When periodontal disease occurs, the periodontal complex, composed by alveolar bone, root cementum, periodontal ligament, and gingiva, can be lost. Periodontal regenerative medicine aims at recovering damaged periodontal tissues and their functions by different mean...
Article
Full-text available
The human body is naturally colonized by a huge number of different commensal microbial species, in a relatively stable equilibrium. When this microbial community undergoes dysbiosis at any part of the body, it interacts with the innate immune system and results in a poor health status, locally or systemically. Research studies show that bacteria a...
Article
Full-text available
Objective The aim of this work is to evaluate the diagnostic accuracy of 0.3T sectoral MR imaging, compared with arthroscopy, for meniscal, cruciate ligaments and chondral knee lesions. Materials and Methods We conducted a retrospective study analyzing all the consecutive knees subjected to arthroscopy at our institution between January 2014 and Ju...
Article
Even if soft tissue adhesion on titanium surfaces is an issue of great interest for transmucosal dental implants and percutaneous devices, few specific surface modification strategies have been approached so far to face it. Topographical surface modification is an interesting strategy because quality of soft tissues can be effectively improved by c...
Preprint
Full-text available
Background: Periodontitis is a disease that leads to serious functional and aesthetic dysfunctions resulting in impairment of life quality; it exists in different forms and its etiology is related with multiple component causes. Angiogenesis, together with inflammatory infiltrate, are two key processes in the evolution of inflammatory processes inv...
Article
Full-text available
Objective: In recent years metagenomic analysis has become more accessible for the characterization of biological specimens. There has been an important increase of studies using this technique for subgingival human samples. To date, there are no updated systematic reviews on the relationship between oral microbiota and periodontal disease. The ai...
Article
Objective: This review aims to describe trigeminal neuralgia and the molecular basis contributing to the pathophysiology of this condition by focusing on the state of the art. Patients and methods: An electronic search of PubMed was performed using the following keywords: "trigeminal neuralgia" AND "classification", "pathophysiology," "molecular...
Article
Full-text available
Air-polishing with low abrasiveness powders is fast arising as a valid and mini-invasive instrument for the management of biofilm colonizing dental implants. In general, the reported advantage is the efficient removal of plaque with respect to the titanium integrity. In the present study, we evaluated the in situ plaque removal and the preventive e...
Article
Full-text available
Bacterial resistance to antibiotics and the disruption of beneficial microbiota are key problems in contemporary medicine and make the search for new, more efficient infection treatment strategies among the most important tasks in medicine. Multicomponent plant-derived preparations with mild antibacterial activity created by many simultaneous mecha...
Article
Full-text available
This work contains original data supporting our research paper "Antibacterial effectiveness meets improved mechanical properties: Manuka Honey/Gellan Gum composite hydrogels for cartilage repair", Bonifacio et al., in press [1], in which innovative composite hydrogels, based on Gellan Gum/Manuka honey/Halloysite nanotubes were described as biomater...
Preprint
Full-text available
Air-polishing with low abrasiveness powders is fats arising as a valid and mini-invasive instrument for the management of biofilm colonizing dental implants. The reported advantage is the efficient removal of plaque with respect of the titanium integrity. In the present study, we evaluated the in-situ plaque-removal and continual the post-treatment...
Chapter
One of the most important complications for implanted biomaterials is the attachment of bacteria on their surface and eventual biofilm formation which can result in significant patient discomfort and may require revision surgeries. In this chapter, the sequence, the underlying causes an consequences of bacterial attachment to biomaterial surfaces w...
Article
Full-text available
To promote osteointegration and simultaneously limit bacterial contamination without using antibiotics, we designed innovative composite cements containing copper (Cu)-doped bioactive glass powders. Cu-doped glass powders were produced by a melt and quenching process, followed by an ion-exchange process in a Cu salt aqueous solution. Cu-doped glass...
Article
Biomaterials surface modification represents a very attractive tool to modulate host tissue response. Surface modifications of titanium for bone contact applications have been widely investigated, while only few papers can be found regarding modifications aimed at soft tissue contact. However, soft tissue healing represents a crucial step for percu...
Article
Biomaterials for cartilage repair are still far from clinical requirements, even if several studies recently focused on this topic. In this respect, Nature-derived hydrogels are a promising class of scaffolds for cartilage tissue engineering, mimicking the native cellular microenvironment. However, they frequently lack mechanical features required...
Article
Full-text available
A possible strategy in regenerative medicine is cell-sheet engineering (CSE), i.e., developing smart cell culture surfaces from which to obtain intact cell sheets (CS). The main goal of this study was to develop 3D printing via extrusion-based bioprinting of methylcellulose (MC)-based hydrogels. Hydrogels were prepared by mixing MC powder in saline...
Article
Periodontal regeneration is still a challenge for periodontists and tissue engineers, as it requires the simultaneous restoration of different tissues—namely, cementum, gingiva, bone, and periodontal ligament (PDL). Here, we synthetized a chitosan (CH)–based trilayer porous scaffold to achieve periodontal regeneration driven by multitissue simultan...
Article
Full-text available
Peri-implantitis is a severe condition affecting the success of transmucosal dental implants: tissue healing is severely limited by the inflammatory processes that come about to control homeostasis in the surrounding...