Li Jun

• Nanjing University

Background Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, and its pathogenesis and potentially relevant biomarkers require further study. Imbalance in copper (Cu²⁺) metabolism is related to a series of diseases, but its role in COPD has not been specified. Methods A dataset relevant to COPD was downloaded from...

Currently, there are no effective prevention or therapeutic methods for breast cancer bone metastasis (BC-BM), which leading to severe skeletal complications and increased mortality. Understanding the mechanisms underlying BC-BM could provide potential strategies for its prevention and treatment. In this study, we identified a new microprotein enco...

Background Non-small cell lung cancer (NSCLC) is highly heterogeneous, leading to varied treatment responses and immune-related adverse reactions (irAEs) among patients. Habitat radiomics allows non-invasive quantitative assessment of intratumor heterogeneity (ITH). Therefore, our objective is to employ habitat radiomics techniques to develop a rob...

CO2 injection significantly impacts the saline aquifer’s pressure system, with overpressure in the caprock and fluctuations in inter-layer pressure differentials threatening the integrity of the caprock and wellbore, thereby affecting sequestration effectiveness and environmental safety. To address this, a numerical model for CO2 saline aquifer seq...

Acute-on-chronic liver failure (ACLF) is a complicated syndrome associated with high short-term mortality and reversibility. Whether the prior decompensation should be included in the definition of ACLF is controversial. A total of 532 patients with decompensation (prior or first) of chronic liver disease were retrospectively enrolled and analyzed...

Introduction Anemia is prevalent after kidney transplantation (KTx) and is associated with reduced graft survival. The associations between temporal changes in hemoglobin (Hb) level in the early posttransplant period with left ventricular (LV) and atrial (LA) function and strain are unknown. Methods The study cohort included 71 successful pediatri...

Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) remains a major challenge in the treatment of lung cancer. Cancer associated fibroblasts (CAFs) play a key role in promoting resistance to anti-cancer therapies. This study identified a subpopulation of CAFs characterized by the overexpression of collagen...

Background Colorectal cancer (CRC) is known for its high heterogeneity, with liver metastases significantly impairing survival outcomes. Understanding the tumor microenvironment (TME) and genomic alterations in metastatic sites is crucial for developing personalized therapies that overcome drug resistance and improve prognosis. Methods We profiled...

Both managed pressure drilling (MPD) and kill procedures depend on the rapid and precise control of the choke under varying conditions. To enhance drilling safety and automate MPD and well kill operations, we employed the African vulture optimization algorithm, a proportional integral derivative controller, and an automated choke control panel for...

It has been reported that tumor-associated macrophages (TAMs) play a complicated role in cancer occurrence and development, immune escape, and immune checkpoint blockade (ICB) resistance. However, the role of granulin precursor (GRN) highly expressed macrophages (hereafter refer to GRN ⁺ macrophages) in hepatocellular carcinoma (HCC) remains poorly...

Background Resistance to paclitaxel‐based chemotherapy is the major obstacle in triple‐negative breast cancer (TNBC) treatment. However, overcoming paclitaxel resistance remains an unsolved problem. The present study aimed to determine whether paclitaxel treatment impairs Aly/REF export factor (ALYREF) cytoplasmic–nuclear shuttling, its mechanism,...

Background Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease. Given its rapid disease progression and high mortality rate, early warning is crucial in improving the outcomes, However, to date, relevant comprehensive predictors or an effective prediction model are still poorly explored. Methods A plasma prote...

Repeated cycles of internal pressure are a primary cause of cement sheath sealing failure during multi-stage fracturing. However, the influence of temperature on cement sheath performance, as well as the damage char acteristics across different well sections, has not been adequately investigated. In this study, uniaxial compres sion experiments we...

Background Dual kidney transplantation (DKT) from small pediatric donors, either en-bloc or split dual kidney transplantation, contributes to mitigating organ scarcity. This study investigates the prognosis of DKT from pediatric deceased donors, and influencing factors. Method A retrospective study included recipients who underwent DKT from pediat...

Background: This study aimed to assess the diagnostic accuracy of combining donor-derived cell-free DNA (dd-cfDNA) fraction and absolute quantification in detecting kidney allograft rejection. Methods: A prospective study was conducted from December 2019 to April 2021 at the First Affiliated Hospital of Sun Yat-sen University. Kidney transplant rec...

A new megastigmane glycoside, conspurcoside A (1), two new phenol glycosides, conspurcosides B (2) and C (3), along with twelve known compounds (4 - 15) were isolated from the bark of Mallotus conspurcatus Croizat. The structures of these compounds were identified through analysis of spectroscopic data, including 1D and 2D NMR, HRESIMS, and ECD met...

Purpose Comprehension of the anatomical characteristics of pediatric kidney tumors is crucial for making surgical decisions. Previous kidney tumor nephrometry systems failed to incorporate two significant factors: tumor thrombus and multifocality. We develop a refined nephrometry system based on a comprehensive understanding of the characteristics...

Six new triterpenoids, heritieras C–H (1–6), along with thirteen known triterpenoids (7–19), were isolated from the leaves of Heritiera littoralis. Their structures were identified by spectroscopic analysis, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison w...

Bacterial-infected skin wounds caused by trauma remain a significant challenge in modern medicine. Clinically, there is a growing demand for wound dressings with exceptional antibacterial activity and robust regenerative properties. To address the need, this study proposes a novel multifunctional dressing designed to combine efficient gas exchange,...

Severe fever with thrombocytopenia syndrome (SFTS) is a severe emerging infectious disease caused by Dabie bandavirus (DBV). Tectorigenin has been demonstrated to exert anti‐inflammatory effect. Here, we aimed to investigate the effects of tectorigenin on DBV‐induced cytokine storm. Effects of tectorigenin on cytokines in DBV‐infected THP‐1 cells a...

The marine shallow gas hydrate reservoirs consist mainly of non-diagenetic hydrates, characterized by shallow burial, weak cementation, loose mineral deposition, and fragility. By non-diagenetic, we mean hydrates that have not undergone significant post-depositional chemical or physical alteration processes, unlike diagenetic hydrates, which form t...

Ammonia (NH3) plays an important role in the development and evolution of Earth's life system. The extremely high bond energy (941 kJ mol⁻¹) of N2 hinder the conversion of N2 to NH3 under mild conditions. Meanwhile, clearly identifying the distribution of intermediates for NH3 synthesis remains a huge challenge in the experiment. Herein, we anchore...

Eleven polyketide derivatives, including two new compounds, xanthoradone D (1) and arisochromophilone (2), were isolated from Arcopilus aureus HJ-7, a Chinese medicinal plant Ardisia mamillata Hance-associated fungus. Their structures were elucidated on the basis of spectroscopic analysis and ECD (Electronic Circular Dichroism) calculations. The an...

Photocatalytic CO2 reduction serves as an important technology for value‐added solar fuel production, however, it is generally limited by interfacial charge transport. To address this limitation, a two‐dimensional/two‐dimensional (2D/2D) p‐n heterojunction CuS‐Bi2WO6 (CS‐BWO) with highly connected and matched interfacial lattices was designed in th...

In the context of CO2 geological storage, the wellbore is a critical location for potential CO2 leakage, with the cement bond surface being the primary pathway. The mechanical bond strength (MBS) of cement is crucial for wellbore seal integrity. To clarify the potential impact of long-term CO2 sequestration environments on MBS and uncover its evolu...

Kupffer cells (KCs), as residents and sentinels of the liver, are involved in the formation of hepatic fibrosis (HF). However, the biological functions of circular RNAs (circRNAs) in KCs to HF have not been determined. In this study, the expression levels of circRNAs, microRNAs, and messenger RNAs (mRNAs) in KCs from a mouse model of HF mice were i...

Photocatalytic CO2 reduction serves as an important technology for value‐added solar fuel production; however, it is generally limited by interfacial charge transport. To address this limitation, a two‐dimensional/two‐dimensional (2D/2D) p‐n heterojunction CuS‐Bi2WO6 (CS‐BWO) with highly connected and matched interfacial lattices was designed via a...

Six new highly oxidized seco-terpenoids, including three 3-nor-labdane type diterpenes, talaroterpenoids A–C (1–3), and three meroterpenoids containing an orthoester group, talaroterpenoids D–F (6–8), together with five known compounds (4–5 and 9–11), were isolated from the marine-derived fungus Talaromyces aurantiacus. Their chemical structures we...

As oil production increasingly transitions from shallow to deep formation, the need for efficient PDC cutters to drill through deep hard rock becomes paramount. Currently, there is a lack of effective methods for optimizing cutter shapes and their cutting parameters. This study addresses this gap by developing a rock-breaking mechanism model for PD...

The proliferation, metastasis, and drug resistance of cancer cells pose significant challenges to the treatment of lung squamous cell carcinoma (LUSC). However, there is a lack of optimal predictive models that can accurately forecast patient prognosis and guide the selection of targeted therapies. The extensive multi‐omic data obtained from multi‐...

Acute myeloid leukemia (AML), which has distinct genetic abnormalities, has unique clinical and biological features. In this study, the incidence, clinical characteristics, induction treatment response, and outcomes of a large cohort of Chinese AML pediatric patients treated according to the BCH-AML 2005 protocol were analyzed. RUNX1-RUNX1T1 was th...

The mechanisms underlying stimuli-induced dynamic structural remodeling of RNAs for the maintenance of cellular physiological function and survival remain unclear. Here, we showed that in MGMT promoter–methylated glioblastoma (GBM), the RNA helicase DEAD-box helicase 46 (DDX46) is phosphorylated by temozolomide (TMZ)–activated checkpoint kinase 1 (...

Suitable geological sites for CO2 sequestration often contain numerous existing wellbores, which have been identified as high-risk locations for CO2 leakage. To investigate whether the pressure disturbances caused by CO2 injection have the potential to drive the propagation of micro-annulus in nearby wells, this paper develops and validates a numer...

All-aqueous thermally regenerative batteries (ATRBs) have shown great potential in harvesting low-grade waste heat. In this study, a hydrophilic porous graphene aerogel (GA) electrode developed by an ice template was developed for ATRBs to enhance electricity generation. The physicochemical property of GA was analyzed by traditional characterizatio...

Objectives Effectiveness of nirmatrelvir/ritonavir (NR) in kidney transplant recipients (KTRs) infected COVID-19 for more than 5 days has not been evaluated. Methods In this multicenter retrospective study, 85 KTRs with COVID-19 were enrolled, including 50 moderate, 21 severe, and 14 critical patients. Results The median time from onset to starti...

Background Non-small cell lung cancer (NSCLC) is highly heterogeneous, leading to varied treatment responses and immune-related adverse reactions (irAEs) among patients. Habitat radiomics allows non-invasive quantitative assessment of intratumor heterogeneity (ITH). Therefore, our objective is to employ habitat radiomics techniques to develop a rob...

Heterogeneous advanced oxidation processes (AOPs) based on non-radical reactive species are considered as a powerful technology for wastewater purification due to their long half-lives and high adaptation in a wide pH range. Herein, we fabricate surface Co defect-rich spinel ZnCo2O4 porous nanosheets, which can generate ≡CoIV=O and ¹O2 over a wide...

Implementing novel technologies, including the “well factory” model and zipper fracturing techniques, has become prevalent in shale gas development. During completion operations such as lowering casing and multistage fracturing, the casing is subjected to many complex loads, reducing its strength and increasing the risk of casing deformation. By es...

Rationale: Patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) have a high short-term mortality rate. Semaphorin-6B (SEMA6B) plays a crucial role in the pathogenesis of HBV-ACLF, but its molecular basis remains unclear. This study aimed to elucidate the mechanisms of SEMA6B in HBV-ACLF progression. Methods: A total of...

Background Epstein-Barr virus (EBV) can be reactivated and proliferated with fatal outcome in immuno-compromised people, but the clinical consequences of EBV infection in patients with severe fever with thrombocytopenia syndrome (SFTS) remain uncertain. In this study, we investigated the infection rate, the influence and the early predictors of EBV...

The high‐voltage pulse discharge technology, which is based on the electrohydraulic effect, can generate powerful, controllable, and repetitive electrohydraulic shock waves (EHSWs) in underground confined space, so it has been applied in the petroleum industry to improve the permeable of the reservoir. In this paper, a numerical model based on LS‐D...

Macrophage polarization is vital to mounting a host defense or repairing tissue in various liver diseases. Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is related to the orchestration of inflammation and alcohol-associated liver disease (ALD) pathology. Rab GTPases play critical roles in regulating vesicular...

The aim of the present study was to predict the response of non-small cell lung cancer (NSCLC) patients to immune checkpoint inhibitors (ICIs) by leveraging computed tomography (CT) images using deep learning techniques. Retrospectively, 624 sequential CT images were gathered from 156 patients at Jiangsu Province Hospital, along with their clinical...

The current extension limit prediction model for offshore extended-reach well (ERW) in mudstone does not consider the formation collapse, which poses a huge risk to offshore drilling construction. To address this problem, this paper presents new open-hole extension limit prediction model for ERW. By considering formation collapse, rate of penetrati...

Ternary halo‐sulfur bismuth compound Bi19X3S27 (X = Cl, Br, I) with distinct electronic structure and full‐spectrum light‐harvesting properties show great application potential in the CO2 photoreduction field. However, the relationship between photocatalytic CO2 reduction performance and the function of halogens in Bi19X3S27 is still poorly underst...

Lung adenocarcinoma (LUAD) is a tumour characterized by high tumour heterogeneity. Although there are numerous prognostic and immunotherapeutic options available for LUAD, there is a dearth of precise, individualized treatment plans. We integrated mRNA, lncRNA, microRNA, methylation and mutation data from the TCGA database for LUAD. Utilizing ten c...