Li-Chern Richard Pan

Taipei Medical University | TMU · General Education

In this paper, we propose a microfluidic device capable of generating a retarding flow field for the sorting and separation of human motile sperm in a high-throughput manner. The proposed sorting/separation process begins with a rapid flow field in a straight-flow zone to carry sperm into a sorting zone to maintain the sperm's mobility. The sorting...

The invention relates to a kit and method for the capture of tumor cells in a body fluid sample. The kit and method of the invention can capture living tumor cells but not non-living tumor cells or cell fragments so that the tumor species can be further identified by further culture of the captured tumor cells. Also, the kit and method of the inven...

The present invention provides a mobile and web-based 12-lead ECG management information system for processing clinical 12-lead ECG, comprising: (a) a clinical device for automatically extracting a SCP-ECG or XML-ECG file and processing signals; (b) an ECG database for saving data exported from the clinical device with web-based user interface, and...

In this study, we propose a microfluidic device with a diffuser type chamber to differentiate the sperm velocity by gradually lowering down the flow speed in diffuser by gradually increasing the width of the channel. When the sperms' moving speed match the flow speed, the sperms tend to have the ability to flow against the stream, thus separating t...

In this study, we propose a microfluidic device with a diffuser type chamber to differentiate the sperm velocity by gradually lowering down the flow speed in diffuser by gradually increasing the width of the channel. When the sperms' moving speed match the flow speed, the sperms tend to have the ability to flow against the stream, thus separating t...

Since male abnormality has now been reported to account at least thirty percent of couples with fertility problem. Therefore, distinguishing and classification of sperm has become more and more important, especially when Assisted Reproductive Technology (ART) like in vitro fertilization (IVF) is involved. However, traditional sperm sorting methods...

In this paper the signal-to-noise ratio and impendence matching problems can be improved by integrating the micro array bio-sensing probes and a thin-film-transistor (TFT) amplifier for signal processing together, both of them are produced respectively on the flexible substrate, and thus the product can be designed and disposed relying on the profi...

The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-alpha concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were c...

To describe and evaluate a fully automated method for characterizing abdominal adipose tissue from magnetic resonance (MR) transverse body scans. Four MR pulse sequences were applied: SE, FLAIR, STIR, and FRFSE. On 39 subjects, each abdomen was traversed by 15 contiguous transaxial images. The total abdominal adipose tissue (TAAT) was calculated fr...

This paper introduces a capacitive-type elastomeric tactile sensor for the application of orthodontia. Different from many capacitive-type tactile sensors employing gap-distance or electrode-overlap changing for pressure or shear signal measurement, this sensor applies electrostriction effect (dielectric constant change due to dielectric particles...

Radiographic examination and palpation have been two of most common the methods often used in clinical assessment for implant stability for years. However, radiographs are two-dimensional and difficult to standardize in dental clinical diagnosis. In current study, an in vitro model for dental implant during osseointegration was designed and tested....

The current study reports a novel bioelectrode design based on a series of micro needle arrays for the measurement of surface biopotential. Without the pain sensation, the goal of these micro needles is to penetrate skin and minimize the variations in skin impedance, as well as body motion. Needle electrodes with high depth definition were fabricat...

Post-curing treatments have been known to improve the mechanical stability of visible light-cured composites. After individual post-curing treatment, the flexural strength (FS) of four commercial direct/indirect placement composite materials which differ greatly in composition [oligocarbonate dimethacrylate (OCDMA)-based Conquest C & B (CQT), Bisph...

Modal analysis is carried out to test the natural frequencies of certain human teeth, including central incisors (CIs), canines (CAs), first premolars (FPs) and first molars (FMs). A total number of 1007 teeth are tested, taking into account tooth type, oral location, age and gender, to analyse the effects of the above-mentioned factors on the natu...

For years, radiographic examination has been the main clinical method for the assessment of the dental implant in vivo condition. However, the use of such method is limited for many applications due to its low sensitivity. As a result, it is thus difficult to diagnose in the early stages of bone losses. Therefore, there is a strong clinical demand...

The present study used the acoustic emission (AE) technique to evaluate interactions among soldering temperature, flux treatment, and the resultant ultimate tensile strength (UTS). Scanning electron microscopy (SEM) was used to examine fracture surfaces of the solder joints. Specimens were cast from removable partial denture alloy and then placed i...

A number of techniques have been proposed for detecting the stability of dental implants. However, the clinical applicability of those methods is still limited. The purpose of this study was to evaluate a new innovative, noninvasive, minimum-contact method for the stability assessment of dental implants. Natural frequency is a physical property of...

A laser thermoacoustic technique was innovated to evaluate laser-induced acoustic emissions (AEs) in experimental dental composites aged with 75% ethanol solution. Experimental composite systems of 75/25 BisGMA/TEGDMA resin filled with 0, 12.6, 30.0, and 56.5 vol% of 8-microm silanized and unsilanized BaSiO6 were analyzed. The sample size was 4.65...

The mechanism of brain contusion has been investigated using a series of three-dimensional (3D) finite element analyses. A head injury model was used to simulate forward and backward rotation around the upper cervical vertebra. Intracranial pressure and shear stress responses were calculated and compared. The results obtained with this model suppor...

Acoustic emission (AE) technique was used for the assessment of dental soldering Specimens were cast from removable partial denture alloy and then placed in a jig with a gap distance of 1.0 mm. A high-frequency soldering machine equipped with an optical pyrometer was used for the control of the soldering temperature at 1200°C. The flux was pure flu...

This study tested predictions derived from D.C. Glass's (1977) uncontrollability model regarding the link between control-related personality attributes and the dissociation of affective and autonomic responses to stress. Pressured drive, measured by the Jenkins Activity Survey (D. S. Krantz, D. C. Glass, & M. L. Snyder, 1974), and emotional defens...

Distinguishing and classification of sperm has become more and more important, especially when Assisted Reproductive Technology like in vitro fertilization is involved. However, traditional sperm sorting methods limited by sperm quantitative assessment and concentration calibrations. Therefore, the staining results, also confirmed that the most mot...

This paper introduces a laminar-stream-based microfluidic system that can separate sperms based on their motility. In this Laminar Stream Sperm Separator (LSSS), the flows were arranged injected from multiple reservoirs to form multiple parallel laminar streams. Sperms with higher motility would cross more streams to approach to the outer chambers...