Leyte L Winfield

Leyte L Winfield
Spelman College · Department of Chemistry & Biochemistry

B.S., Ph.D.

About

65
Publications
3,565
Reads
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254
Citations
Citations since 2017
14 Research Items
151 Citations
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201720182019202020212022202301020304050
201720182019202020212022202301020304050
Additional affiliations
June 2014 - July 2014
New York University
Position
  • Scholar in Residence
August 2013 - May 2014
New York University
Position
  • Visiting Scientist
June 2013 - July 2013
New York University
Position
  • Scholar in Residence
Education
May 2013 - May 2014
Chicago School of Professional Psychology
Field of study
  • Academic Leadership
August 1997 - August 2003
University of New Orleans
Field of study
  • Medicinal/Organic Chemistry
August 1993 - May 1997
Dillard University
Field of study
  • Chemistry

Publications

Publications (65)
Article
Full-text available
Chemistry scholars and educators are intentionally creating inclusive curriculum and equitable learning opportunities in response to the inequities in society exposed by the challenges of discrimination and the pandemic over the past few years. This special issue shines a light on discipline-based education research (DBER) in chemistry that address...
Article
Full-text available
As undergraduate students cultivate their scientific knowledge and abilities, several high-impact educational practices such as undergraduate research and global experiences have proven exponentially beneficial for their development and success. Current literature on underrepresented racial and ethnic minorities has focused primarily on the impact...
Article
Full-text available
The Journal of Chemical Education announces a call for papers for an upcoming special issue on diversity, equity, inclusion, and respect in chemistry education research and practice.
Article
Full-text available
Uncovering systemic racism and ensuring the equitable inclusion and respect of all individuals are at the core of the current public outcries. This editorial is a call to action for the chemistry community to adopt practices and research scholarship that respond to the needs of diversity, equity, inclusion, and respect.
Article
Background Ovarian cancer and ovarian related diseases affect reproductive health. Therapeutic molecules are needed to improve treatment outcomes and overcome drug resistance. The benzimidazole-based sulphonamide LLW-3-6 has both anti-apoptotic and anti-proliferative effects when used to treat prostate, breast, and brain cancer cells. Objective Th...
Article
This account reports building a community of practice for organic chemistry instructors. With support from Chemistry Collaborations, Workshops, and Communities of Scholars (cCWCS), a group of organic chemistry faculty facilitated multiple workshops to introduce active learning techniques to their colleagues across the country. A Web site, organicer...
Article
Strategies employed in the organic chemistry course must have the shared benefit of promoting concept mastery and visual literacy. With this in mind, an iSpartan-enabled visualization and computational activity was developed to complement learning in the first-semester, introductory organic chemistry course. The activity provides students an opport...
Chapter
Our forefathers came here as slaves and were able to create rhythm and they kept rhythm no matter what. Now, we came here as slaves, but we going out as royalty.
Article
Full-text available
The learning environment in higher education has morphed from a lecture-driven paradigm to an amalgam of experiences that utilizes collaborative and interactive engagement pedagogies enhanced by technology. Such learning strategies are believed to result in deeper learning, with students taking control of their educational experiences, and improvin...
Conference Paper
Full-text available
A community-based element was merged with an interactive engagement learning environment in the organic chemistry course. The learning community was established by requiring chemistry and biochemistry majors to enroll in the same section of general chemistry and subsequently organic chemistry (courses designated as majors only). This allowed freshm...
Conference Paper
The Spelman College Strategic Plan calls for an “internationalized” curriculum and a learning environment that extends to locations abroad, “Spelman Going Global.” The campaign endeavors to provide opportunities for both faculty and students. To sustain the effort, the College has established the Gordon-Zeto Center for Global Education and provides...
Conference Paper
The learning environment in higher education has morphed from a lecture-driven paradigm to an amalgam of experiences that utilizes collaborative and active learning pedagogies enhanced by technology. In line with this, the current projects focuses on community-based, active learning strategies in the first- and second-year chemistry lecture courses...
Article
Full-text available
Gliomas are among the most commonly diagnosed central nervous system tumors. Celecoxib has been utilized with success in the treatment of several types of cancer, including gliomas. The present study examined the antiproliferative effects of celecoxib and its benzimidazolebased analog, LLW-3-6, when used as co-treatment with sulfasalazine against h...
Conference Paper
In an effort to improve student retention and success in the Organic Chemistry course, a blend learning format has been implemented. A number of pedagogical strategies are utilized synergistically to promote learning and knowledge retention in the course. While students read course material and review online lectures outside of class, the in class...
Article
Full-text available
The proliferation in human prostate carcinomas, PC3 and MDA-PCa-2b, was analyzed for cells treated with LLW-3-6 and celecoxib in the presence and absence of sulfasalazine. LLW-3-6 was more potent than celecoxib at mediating a dose-dependent reduction of viable PC3 cells. Co-treatment with a non-lethal dose of sulfasalazine diminished the potency of...
Article
Full-text available
A computational module has been developed in which students examine the binding interactions between indinavir and HIV-1 protease. The project is a component of the Medicinal Chemistry course offered to upper level chemistry, biochemistry, and biology majors. Students work with modeling and informatics tools utilized in drug development research wh...
Conference Paper
Spelman College has sustained a strong record of educating African American women in STEM disciplines and continues to strengthen its capacity to contribute to the diversity of the science workforce. While Spelman College is exceptional in carrying out its mission to educate talented women from economically disadvantaged backgrounds, the national r...
Conference Paper
Spelman College has sustained a strong record of educating African American women in STEM disciplines and continues to strengthen its capacity to contribute to the diversity of the science workforce. While Spelman College is exceptional in carrying out its mission to educate talented women from economically disadvantaged backgrounds, the national r...
Patent
This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine, imidazopyridine, and imidazopyrizine compounds having selected substitution patterns are disclosed, and the activity of various subject compounds is demonstr...
Article
Full-text available
Celecoxib is a multifaceted drug with promising anticancer properties. A number of studies have been conducted that implicate the compound in modulating the expression of Bcl-2 family members and mitochondria-mediated apoptosis. The growing data surrounding the role of celecoxib in the regulation of the mitochondrial death pathway provides a platfo...
Article
Full-text available
http://www.nyu.edu/frn/publications/emerging.technologies/index.html
Article
Full-text available
Inquiry-based learning is a unique student-centered alternative to traditional instruction. This form of active learning is ideal for the organic chemistry laboratory as it encourages critical thinking and hands on problem solving to complete an experiment. Electrophilic Aromatic Substitution is immediately associated with the undergraduate organic...
Article
With cancer-related fatalities being the second leading cause of death in the USA, understanding the activity of effective chemotherapeutic agents is critical to addressing prostate and other cancers. Celecoxib, an FDA-approved drug for the treatment of colon tumors, has been used successfully as a lead compound in the development of antiproliferat...
Article
PDK1 is pivotal in the development and progression of several cancers. A 3D pharmacophore was developed for pyrazole derivatives displaying anti-proliferative activity and PDK1 inhibition. The pharmacophore was utilized in the design of benzimidazole analogs. Our preliminary results indicate the pharmacophore should be useful in designing PDK1 inhi...
Article
Tetrahydropyridine (THP) moiety is a part of many biologically active systems. The discovery of the neurotoxic properties of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as well as numerous alkaloids, prompted extensive research on the synthesis and pharmacological properties of these compounds. The goal was extending the database for struct...
Article
A series of 2,5-disubstituted 1,3,5-dithiazine derivatives were synthesized as potential analogues of the potent dopamine uptake inhibitor GBR 12909. The lipophilic character of the 1,3,5-dithiazine derivatives were experimentally (log P) and computationally (clog P) determined. The in vitro binding affinities of the 2,5-disubstituted 1,3,5-dithiaz...
Article
A series of 2,5-disubstituted 1,3,5-dithiazine derivatives were synthesized as potential analogues of the potent dopamine uptake inhibitor GBR 12909. The lipophilic character of the 1,3,5-dithiazine derivatives were experimentally (log P) and computationally (clog P) determined. The in vitro binding affinities of the 2,5-disubstituted 1,3,5-dithiaz...
Thesis
Full-text available
A series of novel GBR 12909 analogs have been prepared. Among, them are the 2,6-dioxopiperazine compounds. The synthesis of the piperazine derivatives comprised of three steps. However, the preparation of the 1-(2-hydroxyethyl)-4-alkylaryl-2,6-dioxopiperazines was tedious and difficult to accomplish. Formation of the ether linkage was straightforwa...
Article
A series of eight 2-substituted 3-tolyltropane derivatives were synthesized, and the in vitro and in vivo biological activities as dopamine uptake inhibitors were determined. From the in vitro structure-activity data, it is apparent that a tolyl group in the 2-position, independent of the stereochemical attachment to the tropane ring system, provid...
Article
A series of GBR 12909 analogues containing a 2,6-dioxopiperazine ring system were prepared and evaluated as ligands for the dopamine transporter. These less lipophilic analogues of GBR 12909 exhibited diminished in vitro binding affinities (Ki) at the dopamine transporter relative to GBR 12909.

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