Levin Joe Klages

Levin Joe Klages
Bielefeld University · CeBiTec - Center for Biotechnology

Bachelor of Science

About

4
Publications
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Citations

Publications

Publications (4)
Article
Full-text available
Genomic surveillance of the SARS-CoV-2 pandemic is crucial and mainly achieved by amplicon sequencing protocols. Overlapping tiled-amplicons are generated to establish contiguous SARS-CoV-2 genome sequences, which enable the precise resolution of infection chains and outbreaks. We investigated a SARS-CoV-2 outbreak in a local hospital and used nano...
Poster
Full-text available
Final project poster from team Bielefeld-CeBiTec 2018 (nanoFactory) for the presentation at the iGEM Giant Jamboree 2018 from October 24th to 28th in Boston, Massachusetts, USA.
Poster
Full-text available
Nanoparticles can be used for a wide range of applications. Especially if used in the medical field they need to be free from toxic chemicals, which are used in the conventional way of nanoparticle formation. Therefore, our goal is to use synthetic biology to create a way of generating environmentally friendly nanoparticles. Our Escherichia coli ta...
Poster
Full-text available
Nanoparticles can be used for a wide range of applications. Especially if used in the medical field they need to be free from toxic chemicals, which are used in the conventional way of nanoparticle formation. Therefore, our goal is to use synthetic biology to create a way of generating environmentally friendly nanoparticles. Our Escherichia coli ta...

Questions

Question (1)
Question
Hi guys
we are currently researching the production of iron nanoparticles by ferritin and have come across the magnetic effect of these. However, we have not found a method to prove this low effect. Does anyone have any experience or ideas?
Thank you and best wishes
Levin Joe Klages

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Projects

Project (1)
Project
Copper, silver and gold - metals are essential for our daily life but resources are dwindling. Industrial mining of metals and electronic waste cause pollution of the environment. Therefore, we established new approaches to recover valuable resources through synthetic biology. By enhancing bacterial abilities to scavenge metal ions from the environment we generated nanoparticles. We optimized Escherichia coli to accumulate metal ions as copper and iron by overexpression of dedicated importers and silencing of exporters while reducing the effects of oxidative stress. To gather nanoparticles from various metal ions we engineered the iron storage protein ferritin. Recycled into nanoparticles the metals could be used for various applications as demonstrated by printing electronics. Considering Dual Use aspects we decided to extract metal ions from pit water instead of dissolving electronics directly. Therefore, in close collaboration with leading experts we developed a customized cross-flow bioreactor for the mining industry.