Levente Kovács

Levente Kovács
Óbudai Egyetem · John von Neumann Faculty of Informatics

Professor

About

519
Publications
47,806
Reads
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2,803
Citations
Citations since 2016
202 Research Items
1894 Citations
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20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
Introduction
Levente Kovács is professor and rector of Obuda University.. Levente does research in Control Systems Engineering, Computer Engineering and Biomedical Engineering. Their current project is 'ERC StG grant "Tamed Cancer"'.
Additional affiliations
July 2019 - present
Óbudai Egyetem
Position
  • CEO
May 2018 - July 2019
Óbudai Egyetem
Position
  • Professor
September 2016 - present
Óbudai Egyetem
Position
  • Professor (Full)
Education
June 2013 - June 2013
Óbudai Egyetem
Field of study
September 2008 - June 2010
Budapest University of Technology and Economics
Field of study
  • Biomedical Engineering
September 2002 - June 2008
Budapest University of Technology and Economics
Field of study
  • PhD in Electrical Engineering

Publications

Publications (519)
Article
Full-text available
Non-coordinated physical activity may lead to hypoglycemia, which is a dangerous condition for diabetic people. Decision support systems related to type 1 diabetes mellitus (T1DM) still lack the capability of automated therapy modification by recognizing and categorizing the physical activity. Further, this desired adaptive therapy should be achiev...
Article
Modern technologies, as well as the technologies that will emerge in the near future, pose a great challenge to researchers and educators in education and educational methodology. Teaching the intuitive use of mathematical tools, developing the ability to abstract, using appropriate theoretical and practical models and demonstration tools are all r...
Chapter
In this study, we developed a Nonlinear Model Predictive Control algorithm for tumour growth regulation. It is unique from the perspective that the subjects of the optimization were the feedback gains in the state feedback kind closed control loop. During the controller design, we utilized the results of our previous qualitative analysis of the mod...
Chapter
Modeling physiological phenomena in tumor growth under the effect of chemotherapeutic agents promises to have a significant impact on cancer research. A reliable mathematical model enables the application of the numerous optimization techniques used in several engineering fields in order to optimize the therapeutic protocol. Modern mathematical too...
Chapter
This paper is a contribution to concepts and methodologies of context definition in Engineering Model System (EMS). Change for contextual modeling was important paradigm shift in engineering at beginning of this new century. By now, EMS is a very complex model because it is required to serve all engineering activities during lifecycle of an enginee...
Article
Full-text available
Background: The Versus Arthritis Musculoskeletal Health Questionnaire (MSK-HQ) measures symptom severity and health-related quality of life (HRQoL) of people with musculoskeletal (MSK) conditions. We aimed to test the psychometric properties of the MSK-HQ among the general adult population and identify the determinants of MSK-HQ states. In additio...
Article
Full-text available
In this article, we review recently proposed, advanced methods, for the control of blood glucose levels, in patients with type 1 diabetes. The proposed methods are based on various techniques, such as predictive control, filters, and machine learning. Results have shown that the artificial pancreas may control blood glucose levels better than conse...
Conference Paper
Full-text available
The most important driving force in today’s industry is fast and efficient data processing and evaluation. To this end, it is important for the industry to pay attention and resources to real-time analysis of the large amount of data collected, so that valuable information can be used to detect outliers in a timely manner, false data, or prediction...
Article
Full-text available
Cancer therapy optimization is an issue that can be solved using the control engineering approach. An optimal therapy generation algorithm is presented and tested using a tractable mouse model of breast cancer. The optimized therapeutic protocol is calculated in a closed-loop manner at fixed time instants, twice in a week. The controller consists o...
Article
Full-text available
Accurate simulation of tumor growth during chemotherapy has significant potential to alleviate the risk of unknown side effects and optimize clinical trials. In this study, a 3D simulation model encompassing angio-genesis and tumor growth was developed to identify the vascular endothelial growth factor (VEGF) concentration and visualize the formati...
Article
Full-text available
Background: Healthy life expectancy (HLE) is becoming an important indicator of population health. While actuarial estimates of HLE are frequently studied, there is scarcity of research on the subjective expectations of people about their HLE. The objective of this study is to compare actuarial and subjective HLE (sHLE) estimates in the ≥50-year-o...
Article
Full-text available
Background Patient activation comprises the skills, knowledge and motivation necessary for patients’ effective contribution to their care. We adapted and validated the 13-item Patient Activation Measure (PAM-13) in the ≥ 40 years old Hungarian general population. Methods A cross-sectional web survey was conducted among 900 respondents selected fro...
Article
Derivation of the Robust Fixed Point Transformations based method is presented in both continuous and discrete time. Foundations of the method are built on the theory of the Input-Output linearization principle. The robustness of the controller is achieved by using fixed-point iterations on the difference between the inverse model and the true stru...
Article
Full-text available
Objective The ICECAP-A and ICECAP-O were validated as capability wellbeing measures of adults aged 18 + and 65 + years, respectively. We aimed to compare their measurement properties in age group 50–70. Methods Data were derived from a cross-sectional survey among a sample representative for the adult Hungarian population. Respondents aged between...
Article
Full-text available
Objective Characterizing blood glucose curves and providing precise patient level risk assessment of hyperglycemia using extreme value statistics and comparing these assessments with traditional indicators of glycemic variability which are not designed to specifically capture the risk of hyperglycemia. Research Design and Methods One year return l...
Article
Full-text available
The state and disturbance estimations are an indispensable part of the state-of-the-art model-based controllers related to the artificial pancreas, supporting the decision-making and self-tuning of the algorithms. They are not just important when state-feedback kind of controller structure is applied, but also play a crucial role in the estimation...
Article
Full-text available
Összefoglaló. Bevezetés: A HbA1c integrált retrospektív mutatója az elmúlt időszak vércukrának, rendszeres vizsgálata a cukorbetegek anyagcserekontrolljának megítélésében elengedhetetlen. Helyes értékelése azonban nem egyszerű, mert a HbA1c és a vércukor közötti összefüggés nem lineáris. A mérést közvetlenül megelőző hyperglykaemiás epizódok hatása...
Chapter
Engineering software platform supports engineering activities in continuously widening disciplinary area of complex systems operated industrial and commercial products and other engineering achievements. Engineering activities increasingly include research extending the conventional product lifecycle engineering to the whole innovation cycle. Compr...
Article
Full-text available
Objectives The ICEpop CAPability measure for Adults (ICECAP-A) was developed to assess the capability well-being of adults for use in economic evaluations. Currently, ICECAP-A tariffs are available only for the UK population. The objectives of this study were to develop a Hungarian tariff set for the ICECAP-A instrument and to explore intercountry...
Article
During the past decades, the relationship between various psychological parameters had been studied in detail. However, the dependency structure of correlated parameters was rarely investigated. Knowing the dependence structure helps in finding the probability matrix of the interaction between the parameters. In this research, a novel approach was...
Article
Full-text available
Összefoglaló. Bevezetés: A lakosság idősödésével növekvő betegségteher egyéni és társadalmi szinten is fokozódó nyomást jelent. Célkitűzés: Felmérni a hazai általános felnőtt lakosságnak a korlátozottsággal, a gondozási igényekkel és a munkavégzéssel kapcsolatos időskori szubjektív várakozásait. Módszer: Online keresztmetszeti felmérést végeztünk....
Article
Full-text available
Chemotherapy plays an important role in the treatment of cancer. While clinical chemotherapy protocols can lead to remission in some patients, in many cases tumor progression occurs despite continued treatment. In the present study we summarize mathematical approaches to model tumor growth and response to treatment, focusing on anticancer therapy r...
Article
Background The capability approach has received increasing attention in wellbeing measurement in the past years, but it has still remained an underexplored area in musculoskeletal (MSK) health. Objective We aimed to explore the capability wellbeing in relation to MSK health, by measuring the associations between the Health Assessment Questionnaire...
Conference Paper
As material analysis method, the bioimpedance spectroscopy (BIS) is an effective technique to obtain material characteristics in many biological applications. Among the BIS models, the single-dispersion RC model and the Cole-Cole model constitute the fundamental mathematical descriptions for BIS measurements. These models enable both the evaluation...
Conference Paper
Full-text available
In today’s rapidly evolving age of technology, the industry try to keep up with developments and integrate smart devices called the Internet of Things (IoT). However, in integrating them, we need to consider how flexible existing robust industrial systems are when it comes to expanding smart devices, and how much risk these IoT devices pose to syst...
Article
Full-text available
Összefoglaló. Számos adat igazolja, hogy az inzulinrezisztencia gyakori jelenség gyermek- és serdülőkorban, és szoros kapcsolatban áll a cardiovascularis kockázat növekedésével, ami miatt a kérdéskörre az életnek ebben a korai szakaszában is kiemelt figyelmet kell fordítani. Ma már egyre több ismerettel rendelkezünk a kockázati tényezőket illetően,...
Preprint
Full-text available
The real-life merit functions have an unimaginable complexity of an M-dimensional topography, where M is the number of the parameters. It is shown that there is an underlying noise-free merit function, called follower merit function which can be constructed from simulated, noise-free data using the solution of a Least Squares minimization. The diff...
Article
Full-text available
From conventional turbines to cutting-edge bladeless turbines, energy harvesting from wind has been well explored by researchers for more than a century. The vortex bladeless wind turbine (VBT) is considered an advanced design that alternatively harvests energy from oscillation. This research investigates enhancing the output electrical power of VB...
Conference Paper
Statistics is defined as the combination of numerous mathematical methods and logic models that are used for appropriate decisions making or judgments that involves uncertainty. However, the expected result could be certain/uncertain. Hence, it can be applied in many areas of life, which includes problem-solving purposes, investigations, and for ma...
Article
Full-text available
The accurate and reliable segmentation of gliomas from magnetic resonance image (MRI) data has an important role in diagnosis, intervention planning, and monitoring the tumor’s evolution during and after therapy. Segmentation has serious anatomical obstacles like the great variety of the tumor’s location, size, shape, and appearance and the modifie...
Conference Paper
Full-text available
In the case of diabetes mellitus physical activity does have a high effect on the glycemic state of the patients. This is especially regarding the patients with Type 1 diabetes mellitus, who need external insulin administration in their daily life. Nevertheless, physical activity - as one source of stress - is underrepresented in the decisions of p...
Article
OBJECTIVES: PAM-13 is a measure of the knowledge, skill, and confidence for managing one’s own health. We developed the Hungarian version of the PAM-13 instrument and tested its psychometric properties. METHODS: In linguistic adaptation and psychometric testing, we followed the WHO and COSMIN guidelines, respectively. From a commercial online panel...
Article
Receding Horizon Control (RHC), also known as Model Predictive Control (MPC) is one of the most intensively researched areas of control algorithms applied in the artificial pancreas concept. Nevertheless, MPC algorithms have not yet been implemented in commercially available insulin pumps, mainly due to their high computational demand, their less r...
Article
Therapeutic optimization is a promising direction of computer aided medicine. Optimization of chemotherapy based on mathematical models can result in lower doses, fewer side effects, a smaller chance of acquired drug resistance and more efficient personification. We explore model-based chemotherapy optimization for high frequency low dose therapies...
Article
A Moving Horizon Estimator (MHE) based Nonlinear Model Predictive Controller (NMPC) was designed for an impulsive minimal tumor growth model. The estimator computes the time-varying model parameters using mean square error with parameter deviation penalization and provides state estimations for the controller. The controller computes optimal doses...
Article
Full-text available
One challenging aspect of therapy optimization and application of control algorithms in the field of tumor growth modeling is the limited number of measurable physiological signals—state variables—and the knowledge of model parameters. A possible solution to provide such information is the application of observer or state estimator. One of the most...
Chapter
The development of brain tumor segmentation techniques based on multi-spectral MR image data has relevant impact on the clinical practice via better diagnosis, radiotherapy planning and follow-up studies. This task is also very challenging due to the great variety of tumor appearances, the presence of several noise effects, and the differences in s...
Conference Paper
Full-text available
In this study, we review recently proposed advanced methods based on various techniques in order to improve blood glucose control while avoiding an increased risk of hypoglycemia or hyperglycemia in patients with type 1 diabetes. We introduce type 1 diabetes and the artificial pancreas and provide an overview of research advances based on predictiv...
Article
Introduction: Health disorders may affect negatively work productivity of individuals, leading to absence from work (absenteeism) and/or decreased functioning in the workplace (presenteeism). Aim: To assess the health-related work productivity of the adult population in Hungary by the Work Productivity and Activity Impairment questionnaire (WPAI...
Article
Full-text available
Accurate and reliable measurement of the electrical impedance spectrum is an essential requirement in order to draw relevant conclusions in many fields and a variety of applications; in particular, for biological processes. Even in the state-of-the-art methods developed for this purpose, the accuracy and efficacy of impedance measurements are reduc...
Article
Full-text available
Background: The incidence of lower limb major amputations is an important healthcare quality indicator, as it reflects all efforts aimed to prevent limb loss. Analysis of within-country regional variations in incidence may reveal the sources of disparities in care. Materials and methods: Based on the data of the Hungarian healthcare beneficiary pop...