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12
Publications
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139
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Introduction
Additional affiliations
November 2015 - November 2018
Publications
Publications (12)
Aim
We aimed to assess the role of FGF21 in metabolic dysfunction‐associated steatotic liver disease (MASLD) at a multi‐scale level.
Methods
We used human MASLD pathology samples for FGF21 gene expression analyses (qPCR and RNAseq), serum to measure circulating FGF21 levels and DNA for genotyping the FGF21 rs838133 variant in both estimation and v...
The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry and gene expression analyses. Three-hundred-and-eighty-two biopsy-proven NAFLD patients were genotyped for rs1047891, a function...
Dietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic fatty liver disease (NAFLD), which is associated with insulin resistance (IR). Fatty acid composition is critical for IR and subsequent NAFLD development. Extra-virgin olive oil (EVOO) is the main source of monounsaturated fatty acids (MUFA) in Mediterranean die...
Background: Healthy diet could promote control of the progression of nonalcoholic fatty liver disease (NAFLD). Weight loss, metabolic control, and hepatic protection could be three main ways to avoid disease progression. Methods: Systematic Review of manuscripts published addressing diet and NAFLD. Results: Macronutrients such as saturated fatty ac...
A healthy diet and weight loss might be sufficient to control the progression of non-alcoholic fatty liver disease (NAFLD). However, the importance of the diet’s extent and composition is less known. Thus, it is necessary to establish nutritional guidelines targeting disease mechanisms, improving disease evolution. On the one hand, considering nutr...
Dietary composition plays an important role in the pathophysiology of type 2 diabetes. Monounsaturated fatty acid consumption has been positively associated with improved insulin sensitivity and β-cell function. We examined whether an extra virgin olive oil (EVOO) high fat diet (HFD) can improve glucose homeostasis. C57BL/6J mice were fed a standar...
Introduction:
non-alcoholic fatty liver disease is one of the most prevalent liver disorders in the developed world. Currently, there is no approved pharmacological therapy except for lifestyle intervention. Therefore, there is a need to increase the knowledge of preclinical models in order to boost novel discoveries that could lead to a better th...
Scope
We evaluated the effect of olive oils with different phenolic content in high‐fat diets (HFDs) on hypertrophy and inflammation in adipose tissue and associated atherosclerosis, in the context of obesity.
Methods and results
We used Ldlr‐/‐.Leiden mice fed three different HFDs for 32 weeks and compared them with mice fed the standard low‐fat...
Introduction: It has been found that the olfactorygustatory function is altered in patients with eating disorders, with an impairment affecting the perception of olfactory and gustatory stimuli. Objective: The aim was to explore the subjective reactivity after the exposure and tasting of foods with different gradient of sweetness and different fats...
