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6
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Introduction
Leonel Vargas currently works at the Centre for Genomic Sciences, Universidad Nacional Autónoma de México. Leonel does research in Molecular Biology and Biotechnology. Their most recent publication is 'Recombinant expression of Intrepicalcin from the scorpion Vaejovis intrepidus and its effect on skeletal ryanodine receptors'.
Current institution
Publications
Publications (6)
Scorpionism in México is a public health problem caused by stings from the Centruroides scorpion family. The Ct1a and Ct17 toxins from the venom of the Centruroides tecomanus scorpion are the most abundant and toxic for mammals. This study describes the heterologous expression of recombinant proteins from genes encoding these toxins merged with thi...
Malaria is a parasitic disease, caused by protozoa of the genus Plasmodium, and is transmitted to humans through the bites of infected Anopheles mosquitoes. More than 200 million cases of malaria are reported annually and about 400,000 deaths worldwide. Currently, the use of antimalarial drugs has been efficient in most cases, however, resistance t...
Background:
Scorpion venoms contain toxins that modulate ionic channels, among which are the calcins, a small group of short, basic peptides with an Inhibitor Cystine Knot (ICK) motif that target calcium release channels/ryanodine receptors (RyRs) with high affinity and selectivity. Here we describe the heterologous expression of Intrepicalcin, id...
