Leonar Antonio Arroyo

• PhD
• Professor at Universidad del Sinú

Introduction Weight-related stigma (WS) has been associated with adverse psychosocial and physical health effects. Despite the relationship between WS and allostatic load, there are no integrative reviews of this association. This scoping review aims to provide a comprehensive overview of the relationship between allostatic load biomarkers associat...

Background: Tuberculosis (TB) remains one of the most deadly infectious diseases. One-third to one-fourth of the human population is estimated to be infected with Mycobacterium tuberculosis (Mtb) without showing clinical symptoms, a condition called latent TB infection (LTBI). Diagnosis of Mtb infection is based on the immune response to a mixture...

Tuberculosis (TB) occurs in only 3–10% of Mycobacterium tuberculosis (Mtb) infected individuals, suggesting that natural immunity can contain Mtb infection, although this remains poorly understood. Next to T-cells, a potentially protective role for B-cells and antibodies has emerged recently. However, the Mtb antigens involved remain ill-defined. H...

Multifunctional T cells have been shown to be protective in chronic viral infections. However, in mycobacterial infections evidence for a protective role of multifunctional T cells remains inconclusive. Short-term cultures of peripheral blood mononuclear cells stimulated with the early-infection phase induced Mycobacterium tuberculosis ( Mtb ) RD-1...

Immune response to DosR and Rpf antigens from Mycobacterium tuberculosis (Mtb) seems to be important for latency maintenance. Little is known about the dynamics of the immune response to these antigens in an endemic community. Thus, the IFNγ response and cytokine production in response to PPD, Esat6-Cfp10 (E6-C10), DosR and Rpf antigens in healthy...

Tuberculosis (TB) remains as a major health problem worldwide with around 9 millions of new cases and 1.4 million of deaths per year. Surveys with tuberculin skin test (TST) estimate that one-third of the world’s population is latently infected with Mycobacterium tuberculosis (Mtb), the etiological agent of human TB. The study of the immune respons...

Mycobacterium tuberculosis (Mtb) infects different populations of macrophages. Alveolar macrophages (AMs) are initially infected, and their response may contribute to controlling Mtb infection and dissemination. However, Mtb infection may disseminate to other tissues, infecting a wide variety of macrophages. Given the difficulty in obtaining AMs, m...

Introduction. Previously, we found a predominance of T CD4+ response with a TCM phenotype to selected DosR and Rpf antigens of M. tuberculosis (Mtb) in LTBI subjects (> 3 years), suggesting that this response may be important to maintain latent infection. To better understand the development of this response, we followed-up for one year the T CD4 a...