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Background: Most women with primary breast cancers that express estrogen receptor alpha (ER or ESR1) are treated with endocrine therapies including the anti-estrogen tamoxifen, but resistance to these anti-endocrine therapies often develops. This study characterizes the expression of hormone receptors, and the mRNA and DNA methylation levels of do...
Chemical modification of silk materials is a powerful method of tailoring the desired physical properties for possible application in various fields. In this work, we modified silk fibroin with poly(2,6-dimethyl-1,5-phenylene ether) (PPE) in order to imbue the silks with hydrophobicity so as to resist the absorption of humidity. This modification w...
In the present study, an artificial spider silk gene, 6mer, derived from the consensus sequence of Nephila clavipes dragline silk gene, was fused with different silica-binding peptides (SiBPs) A1, A3 and R5 to study the impact of the fusion protein sequence chemistry on silica formation and the ability to generate composite silk-silica in two diffe...