Leila Zare Fekri

Leila Zare Fekri
Payame Noor University | PNU · Department of Chemistry

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115
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Publications

Publications (115)
Article
A three-component reaction under ultrasound irradiation and with a catalytic amount of citric acid was presented for the synthesis of a series of 2-aryl-quinazolin-4(1H)-ones with excellent efficiency and short reaction time. This one-pot reaction with 2-aminobenzonitrile, ammonium hydroxide or glycine and benzaldehydes is a clean and safe route fo...
Article
Tannic acid‐functionalized silica‐coated Fe3O4 nanocomposites (Fe3O4@SP@TA) were synthesized and characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FE-SEM), X-ray powder diffraction (XRD), X-ray spectroscopy (EDX), vibrating sample magnetometry (VSM) and Fourier transform infrared spectroscopy (FT-...
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Coumarins (2H-1-benzopyran-2-ones) are an important group of biological heterocyclic compounds present in various parts of many plant species, encompassing an array of biological and pharmaceutical activities. In view of the importance of coumarins in heterocyclic chemistry and biological sciences and recent advances in the design of magnetic nanoc...
Article
Background Dihydropyrimidinones are essential component of heterocycles due to their useful attributes such as calcium channel blockers, anti-inflammatory agents, anti-neoplastic agents, anti-bacterial agents, anti-hypertensives, , and, anti-virals. Objective Synthesis of Fe3O4@SiPr@vanillin@TGA MNPs and their structure and morphology determinatio...
Article
Fe3O4@Silicapropyl@Vanillin/Thiamin nanoparticles were synthesized by a simple immobilization method using cheap and natural materials. The nanocatalyst was analyzed by XRD, FT-IR, FE-SEM, TEM, VSM and TGA techniques and was applied as a new, effective and magnetically recoverable solid acid for the synthesis of azo-linked benzo[d]imidazoles or bis...
Article
Objective Vanillin/Vitamin B1 (Thiamine) supported Fe3O4@SiO2 nanoparticles (Fe3O4 @SP@VT) were synthesized and thoroughly analyzed, and was used for the green and efficient synthesis of chromenes using the multicomponent reaction of aldehyde, malononitrile and 4-hydroxy coumarin, as well as the multicomponent reaction of aldehyde, α-naphthol or β–...
Article
Chitosan‐functionalized silica‐double magnetite parts that contains magnetite in the core and outer layer of synthetic nanoparticles (Fe3O4@SP@chitosan@Fe3O4) were prepared and approved by field emission scanning electron microscope (FE-SEM), fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), X-ray powder diffraction...
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Tannic acid‐functionalized silica‐coated Fe3O4 nanoparticles (Fe3O4@SP@TA) were synthesized and characterized by X-ray spectroscopy (EDX), X-ray powder diffraction (XRD), field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), vibrating sample magnetometry (VSM) and Fourier transform infrared spectroscopy (FT-I...
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Bis(thioglycolic acid)-vanillin (2,2′-(((4-hydroxy-3-methoxyphenyl)methylene)bis(sulfanediyl))diacetic acid)‐functionalized silica‐coated Fe3O4 magnetic nanocomposite (Fe3O4@SiPr@vanillin@TGA nanocomposite) were synthesized and characterized by field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), vibrating s...
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Bis(thioglycolic acid)-vanillin (2,2'-(((4-hydroxy-3-methoxyphenyl)methylene)bis(sulfanediyl))diacetic acid)-functionalized silica-coated Fe3O4 magnetic nanoparticles (Fe3O4@SiO2@vanillin@thioglycolic acid MNPs) were synthesized and characterized by transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), thermo...
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1,3-Thiazolidines have attracted a lot of interest due to their biological and pharmaceutical properties. For this reason, their synthesis is very important. Nanotechnology, nowadays, plays an important role in organic chemistry. Nano compounds, todays, act as support and catalyst in organic transformations. This review focuses on the recent advanc...
Article
An efficient, solvent-free, and environmentally benign route via mechanochemical means is described for the synthesis of azo-linked 2-amino-4H-chromene derivatives. The four-component reaction of azo-linked salicylaldehydes, malononitrile, ethyl acetoacetate, and hydrazine hydrochloride has exploited recyclable magnetic nano-catalyst, Fe3O4@SiO2@KI...
Article
Fe3O4@[email protected] isoniazid-copper(I) nanocomposite was synthesized as a novel heterogeneous catalyst and was characterized by FT-IR, EDX, XRD, FESEM, TEM, zeta potential, VSM and TGA-DTG. The strategy relies on the covalently bonding of vaniline to Fe3O4@silicapropyl followed by the condensation reaction of aldehyde moiety of vaniline in the...
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Nanomagnetic dapsone-Cu supported on the silica-coated Fe 3 O 4 (Fe 3 O 4 @SiO 2 -pr@dapsone-Cu) nanocomposite was synthesized and characterized by Fourier transform infrared (FT-IR), energy-dispersive X-ray (EDX), X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), transmission electron microscopy (TEM), zeta potential,...
Article
In this study, the synthesis of novel azo-linked acridines via the reaction of dimedone and synthesized diazoaryl-(2-amino-5-(phenyl)methanone using GO-ZnO nanocomposite is reported. The synthesized catalyst was characterized by FT-IR, XRD, UV-Visible, TEM and SEM. According to the results, Graphene Oxid-ZnO (GO-ZnO) nanocomposite revealed high act...
Article
Introduction In this study, the synthesis of azo-linked acridine by the reaction of dimedone and synthesized diazoaryl-(2-amino-5-(phenyl)methanone using Ag2S/RHA-MCM-41nanocomposite is reported. Materials and Methods The synthesized catalyst was characterized by FT-IR, XRD, and SEM. According to the obtained results, Ag2S/RHA-MCM-41 nanocomposite...
Article
Copper/dapsone cuvalented Fe3O4@SiO2-propyl nanocomposite (Fe3O4@SiO2-propyl@dapsone/Cu) was prepared using cheap compounds in simple immobilization methodology. This nanocompound was identified by X-ray diffraction, FT-IR, VSM, TEM, FE-SEM, and TGA analyses and was found to be effective and green nanocomposite for the multicomponent reaction of al...
Article
Background Thiazolidinone-4-ones belong to an important heterocyclic compounds because of their broad spectrum of biological activities. Several methods for the synthesis of 4-thiazolidinones were reported in the literature. The main synthetic routes to synthesize 1,3-thiazolidin-4-ones is the three component reaction between amine, a carbonyl comp...
Article
Background: Dihydroquinazolinone derivatives are an important family of fused heterocyclic shows a wide range of biological, medicinal and pharmacological properties such as anti-tumor, anti-biotic, diuretic, analgesic, antihypertonic, anti-pyretic, anti-depressant, anti-histamine and vasodilation activities. Introduction: So far some acid catal...
Article
A novel, efficient, and grind stone procedure for the synthesis of pyrazolo[4,3-e]pyridine compounds at room temperature was reported. This methodology offers several advantages such as mild conditions, excellent yields, simple procedure, and reduced environmental consequences. The structures of synthesized 4-Aryl-4,10-dihydroindeno[1,2-b]pyrazolo[...
Article
DABCO‐diacetate (1,4‐diazabicyclo[2.2.2]octaniumdiacetate) was synthesized and applied as a green media for the synthesis of new derivatives of benzo[d]imidazole with azo‐linked core and bis benzo[d]imidazoles via condensation reaction of aldehydes and 1,2‐diaminobenzene under solvent‐free conditions. This procedure has benefits such as: good produ...
Article
Amino glucose‐functionalized silica‐coated NiFe2O4 nanoparticles (NiFe2O4@SP@GA) were synthesized and characterized by X-ray powder diffraction, X-ray spectroscopy, transmission electron microscope, field emission scanning electron microscope, vibrating sample magnetometry, and Fourier transform infrared spectroscopy (FT-IR). NiFe2O4@SP@GA supply a...
Article
Aims Synthesis of pyrano[c-2,3]chromens with Ionic Liquid catalyst with simple method. Background Synthesis of pyrano[c]coumarins has a special place in the structure due to two bioactive compounds in its structure and attracts a great deal of attention in this research work, it has been attempted to attach chromatically valuable skeletons to them...
Article
Background Thiazolidinoneones are important pharmaceutical compounds because of their biological activities. Several methods for the synthesis of 4-thiazolidinones arewidely reported in the literature. The main synthetic routes to synthesize 1,3-thiazolidin-4-ones involve three components reaction between amine, a carbonyl compound and thioglycolic...
Article
A practical and scalable synthetic method for the synthesis of new amides and pyridazinones was established starting from the readily accessible materials as arenes, cyclic anhydrides, and 2-aminobenzimidazole or phenylhydrazine. This synthetic method includes a scalable reaction using L-proline functionalized propyl modified nanomagnetic in aqueou...
Article
Background: Imidazo[1,2-a]pyrimidinone, quinazolinone and amide derivatives have attracted a lot of interest because of their broad scope of biological and pharmacological activities. There are a lot of methods reported in literature for the synthesis of them. Therefore, we became interested in developing a convenient synthetic method for the prep...
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Full-text available
A copper/Schiff‐base complex supported on amine‐functionalized silica mesoporous magnetic nanoparticles was prepared as novel magnetically interphase nanoparticles and its morphology and structure were evaluated using Fourier transform infrared spectroscopy, X‐ray diffraction, field emission scanning electron microscopy, transmission electron micro...
Article
Copper/Schiff-base complex immobilized on KIT-6-NH2 magnetic nanoparticles as a novel heterogeneous catalyst was synthesized and the structure and morphology of nanomagnetic catalyst was characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDX), Xray diffraction patterns (XRD), scanning electron mi...
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Full-text available
Urazolium diacetate catalyzed synthesis of new derivatives of 1,3-thiazolidine-4-ones (azo dispersive dyes family) via multicomponent reaction of various aldehydes, thioglycolic acid and 4-aminoazobenzene under solvent-free reaction was reported.
Article
The potassium 2-oxoimidazolidine-1,3-diide (POImD) have been used as an efficient and reusable catalyst for the mild and green multicomponent synthesis of chromenes by the reaction between various derivatives of aldehydes, 1-naphthol or 2-naphthol and malononitrile in excellent yields. The recovery and reuse of the catalyst was demonstrated 10× wit...
Article
An efficient procedure for the synthesis of fused pyrano[4,3-b]chromene derivatives via three-component condensation reaction of aromatic aldehydes, 2-naphthol and 4-hydroxycoumarin, using CuO@RHA/MCM-41 nanocomposite at room temperature, is described. This nanocomposite consists of CuO nanoparticles and MCM-41 matrix obtained from rice husk ash (R...
Article
A convenient and high yielding procedure for the synthesis of triazolo[1,2-a]indazole-triones by the condensation reaction between 1,2,4-triazolidine-3,5-dione (urazole), 5,5-dimethylcyclohexane-1,3-dione (dimedone) and aryl aldehydes in the presence of acidic dicationic ionic liquid 1,4-diazabicyclo[2.2.2] octanium diacetate as a highly stable and...
Article
L-proline-functionalized silica-coated Fe 3 O 4 nanoparticle was synthesized and characterized using Fourier Transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA), Zet...
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Full-text available
A novel, efficient, one-pot, catalyst-free grinding procedure for synthesis of 6-amino-3-methyl-4-aryl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile is reported. The condensation of substituted benzaldehydes, 3-amino-5-methylpyrazole, and malononitrile according to a three-component reaction was investigated using density functional theory (DFT) at B3L...
Article
Aim and Objective Potassium 2-oxoimidazolidine-1,3-diide (POImD) as a novel and reusable catalyst was used for the synthesis of pyrazolyl-bis coumarinyl methanes by a nucleophilic addition reaction of synthetized pyrazolecarbaldehyde and two equivalents of 4-hydroxycoumarin under grinding. The catalyst can be reused and recovered several times with...
Article
A convenient and efficient route for synthesis of various derivatives of 3‐benzoyl‐4‐phenyl‐2‐(trifluoromethyl)pyrano[3,2‐c]chromen‐5(4H)‐one has been used via tandem Knoevenagel condensation–Michael addition and intramolecular cyclization sequence. These products have been synthesized in the presence of catalytic amount of metal–organic framework...
Article
A novel, efficient and one-pot multi-component procedure for the synthesis of xanthene-ones via reaction of aldehydes, dimedone and β-naphthol or aldehydes and dimedone promoted by amino glucose-functionalized silica-coated NiFe2O4 nanoparticles under solvent-free condition without using any other harmful organic reagents was reported. The catalyst...
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Full-text available
A novel, clean, mild and eco-friendly benign route to pyrano[4,3 -b ]chromenes through cyclocondensation reaction of β -naphthol, aldehydes and 4-hydroxycoumarin, using POImD as a novel and reusable organometallic catalyst, is described. The present methodology offers several advantages such as simple work-up procedure, short reaction time, high yi...
Article
2-Oxoimidazolidine-1,3-disulfonic acid is a recoverable catalyst for the synthesis of novel triflouromethyl-1H-benzo[f]chromene by the condensation of 2-naphthol, 4,4,4-trifluoro-1-phenyl-1,3-butanedione and different substituted benzaldehyde at room temperature in a one-pot procedure without additional organic solvents. Moreover, the catalyst coul...
Article
A series of azo-linked 4H-benzo[d][1,3]oxazine-2,4-diones were synthesized in excellent yields and short reaction time by one-pot reaction between various synthetized azo-linked carboxylic acids and carbon dioxide in the presence of [email protected]/MCM-41 nanocomposite as a novel catalyst at room temperature. This nanocomposite consists of CuO na...
Article
Amino glucose-functionalized silica-coated NiFe2O4 nanoparticles (NiFe2O4@SiO2@amino glucose) were chemically synthesized and characterized by transmission electron microscope (TEM), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), energy dispersive X-ray analysis (EDX), vibrating sample magnetometer (VSM), Zetasizer and Fourier transfo...
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Full-text available
A novel, efficient and one-pot multi-component procedure for the synthesis of simple pyrano[3,2-c]chromen-5(4H)-ones or pyrazolyl pyrano[3,2-c]chromen-5(4H)-ones via reaction of aryl aldehydes, acetophenones and 4-hydroxycoumarin promoted by amino glucose-functionalized silica-coated NiFe2O4 nanoparticles under solvent-free conditions without using...
Article
Magnetic multiwalled carbon nanotube nanocomposite as a recoverable catalyst for the synthesis of novel 1,3‐thiazolidine‐4‐ones at room temperature in a one‐pot procedure without additional organic solvents. IR, 1HNMR, and 13CNMR spectroscopies and elemental analysis were used for the identification of these compounds. Moreover, the catalyst could...
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Full-text available
P(O)–X (X = S, N, O, P) bond-containing compounds have extensive application in medicinal chemistry, agrochemistry, and material chemistry. These useful organophosphorus compounds also have many applications in organic synthesis. In light of the importance of titled compounds, there is continuing interest in the development of synthetic methods for...
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This review surveys the construction of sulfur–nitrogen bonds through cross-dehydrogenative coupling reactions between thiols and N–H compounds.
Article
In recent years, N-functionalized sulfoximines have attracted the significant attention of medicinal chemists due to their wide spectrum of biological activities. This class of organosulfur compounds has also found a number of applications in agricultural chemistry. In addition to these benefits, sulfoximines are one of the most important and versa...
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Full-text available
2,3-Dihydrofuranediones were prepared by an efficient one-pot multicomponent Knoevnagel-like condensation between pyrazolecarbaldehydes or indole-3-carbaldehyde, ethyl pyruvate and bromine, followed by an intramolecular cyclization in aqueous medium.
Article
This study reports a clean and environmentally benign route for the synthesis of a series of pyrazolyl-bis coumarinyl methane derivatives by a nucleophilic addition reaction of synthetized pyrazolecarbaldehyde and two equivalents of 4-hydroxycoumarin, using a catalytic amount of citric acid as a one-pot and green reaction under ultrasound irradiati...
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Full-text available
A simple and efficient method is presented for the synthesis of benzodiazepines through the multicomponent reaction of o-phenylenediamine, various aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in the presence of the acidic bis ionic liquid 1,4-diazabicyclo[2.2.2]octanium diacetate under ultrasound irradiation. The ionic liquid used is...
Article
Aim and objective: Citrus Juice as an efficient, cost-effective and green catalyst employed for one-pot synthesis of various β-substituted enaminones through the reaction of β- dicarbonyl compounds with different primary amines in a solvent-free conditions on silica gel as solid surface using grindstone technique in high yields and short reaction...
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Full-text available
In this study, a novel, clean, convenient, appropriate and environmentally benign route to dihydropyrimidinone and thione derivatives has been developed using the reaction between various benzaldehydes, urea or thiourea, and ethyl acetoacetate in the presence of Fe⁺³-montmorillonite K10 under grind condition. The present methodology has several adv...
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Full-text available
3,3-(Butane-1,4-diyl)bis(1,2-dimethyl-1H-imidazole-3-ium)bromide ([BDBDMIm]Br) is easily used as an efficient and recyclable ionic liquid for the synthesis of bis coumarinyl methanes in the presence of a catalytic amount of ceric ammonium nitrate (CAN) under grinding. All reactions are performed in the absence of solvent in excellent yield during s...
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Full-text available
2-Oxoimidazolidine-1,3-disulfonic acid (OImDSA) is a recoverable catalyst for the synthesis of 1,3-thiazolidine-4-ones at room temperature in a one-pot procedure without using any organic solvents. Moreover, the catalyst can be easily recovered and recycled for five runs without significant loss of catalytic activity. The structures of the synthesi...
Article
Background: A facile, effective, new and green methodology has been developed for the synthesis of 3,3-di(indolyl)indolin-2-one through electrophilic condensation reaction of indole derivatives with various isatins in the presence of 1,4-diazabicyclo[2.2.2]octanium diacetate as an efficient homogeneous media under grinding. This work consistently h...
Article
Aim and objective: Korea advanced institute of science and technology cubic ordered mesoporous silica (KIT-6 mesoporous) silica coated magnetite nanoparticles, is an effective, ecobenign and recyclable catalyst for the electrophilic substitution reactions of indoles with various synthetized aldehydes to afford the corresponding novel diindolylmeth...
Article
Full-text available
A clean and environmentally benign route to 2-amino-4H-chromenes has been developed via three-component condensation reaction of various benzyl alcohols, malononitrile and 1-naphthol, using a catalytical amount of CAN and a reusable ionic liquid 3,3-(Butane-1,4-diyl)bis(1,2-dimethyl-1H-imidazole-3-ium) bromide ([BDBDMIm]Br) as a catalyst at room te...
Article
Background: In recent years, an increasing interest has been focused on the synthesis of 2-substituted 1,3-indandione compounds owing to their significant biological activity. It is well known that indandione and related compounds exhibit a wide range of biological activities such as antitumor, anticancer, sedative, hypotensive and neuromuscular bl...
Article
Background: Coumarin constitutes one of the major classes of naturally occurring compounds. In the well-known family of coumarin derivatives, dimeric coumarins (also called biscoumarins) occupy an interesting position. Although some types of these compounds could be isolated from plants and interest in its chemistry because of its usefulness as bio...
Article
Ultrasound as green process and an alternative energy source was investigated for the eco-benign synthesis of novel diindolylmethanes from various synthesized aldehydes with indoles in short reaction time and high yield. The present methodology offers several advantages such as excellent yields, simple procedure, mild conditions and reduced environ...
Article
A clean and environmentally benign route to synthesize a series of some benzothiazole derivatives using the reaction between various synthetized aldehydes, thiosemicarbazide and different acetophenones and N-bromosuccinimide as a substrate instead of haloacetophenones reported in the previous reactions in the presence of a catalytic amount of Korea...
Article
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A clean and environmentally benign route for the preparation of substituted thiazoles 4a–k via a three component reaction of an aldehyde, thiosemicarbazide and a bromoacetophenone in the presence of 3,3′-(pentane-1,5-diyl)bis(1,2-dimethyl-1H-imidazol-3-ium) bromide is reported. The present methodology offers several advantages such as solvent-free...
Article
A general synthetic route to benzo[d]imidazoles has been developed using 1,4-diazabicyclo [2.2.2] octanium diacetate as a new bis ionic liquid under thermal and solvent free condition. The union of two fragments including one equivalent of various aldehydes and one equivalent of 1,2-phenylenediamine was accomplished by an efficient and convenient p...
Article
In this study, a new, effective and environmentally benign procedure for the synthesis of dihydropyrimidinone and thione derivatives with various benzaldehydes, urea or thiourea, and ethyl acetoacetate in the presence of 1,4-diazabicyclo[2.2.2]octanium diacetate as a novel acidic ionic liquid, in high yield and short reaction time is reported. This...
Article
KIT-6 mesoporous silica-coated magnetite nanoparticles as highly ordered large-pore nanoparticles supply an environmentally friendly procedure for the synthesis of benzo[d]imidazoles through condensation of 1,2-diaminobenzene with aryl aldehydes. These compounds were obtained in high yields and short reaction times. The catalyst could be easily rec...
Article
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A general synthetic route to dibenzoxanthenes has been developed using 1,4-diazaniumbicyclo[2.2.2]octane diacetate as a new bis ionic liquid under thermal and solvent free condition. This method provides several advantages such as a simple work-up, environmental friendliness and shorter reaction time along with high yields. All of the synthesized c...
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Efficient nucleophilic addition reactions of indole derivatives with various azo-linked aldehydes were carried out using Fe+3-montmorillonite K10 under solvent free condition to afford the corresponding diindolylmethanes in short reaction times and excellent yields.
Article
Background: Xanthenes are an important class of organic compounds and have also received significant attention due to their wide range of pharmacological activities such as antibacterial, antiviral, antiinflammatory activities, antagonists for the paralyzing action of zoxazolamine and efficiency in photodynamic therapy, a well-known method for cont...
Article
A clean and environmentally benign route to 2-amino-4H-chromenes has been developed using the reaction between various benzaldehydes, malononitrile and alpha-naphthol in the presence of 3,3'-(pentane-1,5-diyl) bis(1,2-dimethyl-1H-imidazol-3-ium) bromide. The present methodology offers several advantages such as solvent-free conditions, excellent yi...
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Ultrasound as green process and an alternative energy source was investigated for the environmentally benign synthesis of novel benzoxazoles from different azo-linked salicylic acid derivatives and 2-amino-4-chlorophenol in short reaction time and high yield. These benzoxazole compounds have been characterized by elemental analysis, FT-IR, (1)H NMR...
Article
Bis-ionic liquid 3,3-(butane-1,4-diyl)bis(1,2-dimethyl-1H-imidazole-3-ium)bromide ([BDBDIm]Br) was found to be an effective catalyst for the synthesis of novel benzoxazoles using different salicylic acid derivatives and 2-amino-4-chlorophenol at room temperature. The present methodology offers several advantages such as solvent-free conditions, exc...