Lei Wang

• Phd
• Faculty at Drexel University

Background: Restricting certain patients with hypertrophic cardiomyopathy (HCM) from exercise likely has negative cardiovascular effects and may not reduce the risk of sudden cardiac death. Promoting exercise in children with HCM is complex and requires knowledge of the environmental factors that impact exercise capacity in children with HCM. Metho...

There is concern that repetitive head impact exposure (RHIE) may lead to neurophysiological deficits in adolescents. Twelve high school varsity soccer players (5 female) completed the King-Devick (K-D) and complex tandem gait (CTG) assessments pre- and post-season while wearing a functional near-infrared spectroscopy (fNIRS) sensor. The average hea...

Exploring individual brain atrophy patterns is of great value in precision medicine for Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, the current individual brain atrophy detection models are deficient. Here, we proposed a framework called generative adversarial network constrained multiple loss autoencoder (GANCMLAE) for p...

The online health community (OHC) is the primary channel for laypeople to share health information. To analyze the health consumer-generated content (HCGC) from the OHCs, identifying the colloquial medical expressions used by laypeople is a critical challenge. The open-access and collaborative consumer health vocabulary (OAC CHV) is the controlled...

Background In concussion, functional near infrared spectroscopy (fNIRS) has been shown to detect differences in cortical oxygenation during neurocognitive testing, with concussed adults manifesting less task-based cortical activation compared to controls. In addition, fNIRS has identified significantly reduced interhemispheric coherence in adult co...

Hemorrhage is a common consequence of traumatic brain injury and can be detected by near-infrared spectroscopy (NIRS)-based noninvasive sensors over scalp. In this study, our aim was to investigate NIRS measurements comprehensively using both phantoms and simulated head models of different age groups from infant to adult with intracranial hematoma...

Statement of Purpose Concussed adolescents frequently experience neurocognitive deficits even after symptom resolution. Measurement of cognitive deficits can be obtained using functional near-infrared spectroscopy (fNIRS), a portable, non-invasive imaging technology that measures prefrontal cortical (PFC) activity. The goal of this exploratory stud...

Mental workload assessment is a core element of designing complex high-precision human machine interfaces with industrial and medical applications, from aviation to robotic neurosurgery. High accuracy and continuous mental state decoding play an essential role for keeping the operator’s mental workload on a moderate level to prevent cognitive tunne...

Understanding near infrared light propagation in tissue is vital for designing next generation optical brain imaging devices. Monte Carlo (MC) simulations provide a controlled mechanism to characterize and evaluate contributions of diverse near infrared spectroscopy (NIRS) sensor configurations and parameters. In this study, we developed a multi‐la...

A Brain-computer Interface (BCI) is a system that interprets specific patterns in human brain activity, such as the intention to perform motor functions, in order to generate a signal which can be used for communication or control. Functional near infrared spectroscopy (fNIRS) is an emerging optical neuroimaging technique which is a relatively new...

Functional Near Infrared Spectroscopy (fNIRS) is an emerging neuroimaging technique that utilizes near infrared light to detect cortical concentration changes of oxy-hemoglobin and deoxy-hemoglobin non-invasively. Using light sources and detectors over the scalp, multi-wavelength light intensities are recorded as time series and converted to concen...

HISTORY: A 16-year-old female soccer goalie sustained a head injury during a heading drill. The player reported a few awkward headers, including one that hit her in the back of the head. The player developed a headache and nausea, but had a normal evaluation by an athletic trainer on the sidelines. The trainer still removed the athlete from play du...

Visual cortical stroke patients may have hemianopia symptom, which affects a number of visual functions. Most studies on hemianopia stroke have mainly focused on cortical activation during visual stimulation, leaving the pattern of functional connectivity between different brain regions uncovered yet. In the present study, we investigate the restin...