Lei Pan

Lei Pan
Binzhou Medical University Hospital · Department of Respiratory and Critical Care Medicine

MD, PhD

About

41
Publications
4,908
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2,716
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Introduction
My research interest focuses on COPD, pulmonary rehabilitation, and evidence-based medicine.

Publications

Publications (41)
Article
Full-text available
At present, it has been noticed that some patients recovered from COVID-19 present a recurrent positive RNA test of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) after being discharged from hospitals. The purpose of the current study was to characterize the clinical features of re-hospitalized patients with recurrent SARS-CoV-2 posit...
Article
Full-text available
S Omega-3 polyunsaturated fatty acids (PUFAs) possess anti-inflammatory properties. There is a lack of consensus regarding the effects of omega-3 PUFAs on C-reactive protein (CRP), a marker of systemic inflammation, in cancer patients. Herein, a meta-analysis of randomized controlled trials was conducted to evaluate the effects of omega-3 PUFAs on...
Article
Full-text available
Lung ultrasound (LUS) has recently been used to identify interstitial lung disease (ILD). However, data on the role of LUS in the detection of ILD remain limited. The aim of this study was to investigate the diagnostic value of LUS compared with high-resolution computed tomography (HRCT) in patients with ILD.The retrospective study was carried out...
Article
Full-text available
Background: The aim of this meta-analysis was to evaluate the diagnostic value of lung ultrasound (LUS) in comparison to chest radiography (CXR) in children with pneumonia. Methods: Computer-based retrieval was performed on PubMed and EMBASE. Quality was evaluated according to the quality assessment of diagnostic accuracy studies-2, and Meta-Dis...
Preprint
Full-text available
Background Optimal fluid management in patients with COVID-19 has not been reported. This retrospective, multicenter study investigated the impact of intravenous infusion volume in the early stage of COVID-19 on clinical outcomes. Methods 127 patients from two tertiary hospitals were separated into the “conservative” and “liberal” groups based on...
Article
Full-text available
Objective: Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, various digestive symptoms have been frequently reported in patients infected with the virus. In this study, we aimed to further investigate the prevalence and outcomes of COVID-19 patients with digestive symptoms. Methods: In this descriptive, cross-sectional...
Article
Full-text available
Background: METTL3 is an RNA methyltransferase that mediates m6A modification and is implicated in mRNA biogenesis, decay, and translation. However, the biomechanism through which METTL3 regulates MALAT1-miR-1914-3p-YAP axis activity to induce NSCLC drug resistance and metastasis is not very clear. Methods: The expression of mRNA was analyzed by...
Preprint
Background Interstitial lung disease (ILD) is a serious threat to human health due to its difficult diagnosis and lack of effective treatment. Lung ultrasound (LUS) has recently been applied to the detection of ILD, and butthe data on its role in the diagnosis of ILD remain limited. The aim of this study was to explore the value of LUS in the diagn...
Article
Full-text available
Background: Granulomatosis with polyangiitis (GPA) is characterised by the main violation of the upper and lower respiratory tract and kidney. GPA is considered a systemic vasculitis of medium-sized and small blood vessels where aortic involvement is extremely rare. Case presentation: A 28-year-old male was admitted to the hospital due to 4 h of...
Data
Table S1| Additional information reported in all the randomized controlled trials.
Data
Figure S1| Risk‐of‐bias analysis. (a) Risk‐of‐bias graph: the authors’ judgments about each risk‐of‐bias item presented as percentages across all included studies. (b) Risk‐of‐bias summary: the authors’ judgments about each risk‐of‐bias item for the each included studies.
Article
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Sphingomonas paucimobilis strain LCT-SP1 is a glucose-nonfermenting Gram-negative, chemoheterotrophic, strictly aerobic bacterium. The major feature of strain LCT-SP1, isolated from the Chinese spacecraft Shenzhou X, together with the genome draft and annotation are described in this paper. The total size of strain LCT-SP1 is 4,302,226 bp with 3,86...
Article
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Streptococcus pneumoniae is one of the most frequent opportunistic pathogens worldwide. DNA processing protein A (DprA) is an important factor involved in bacterial uptake and DNA integration into bacterial genome, but its role in S. pneumoniae virulence remains unclear. The aim of this study was to characterize the effects of the pneumococcal dprA...
Article
Full-text available
Currently, whether endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is superior to conventional TBNA (cTBNA) in the diagnosis of mediastinal lymphadenopathy remains controversial. We undertook a meta-analysis of randomized controlled trials (RCTs) to evaluate the diagnostic yield of EBUS-TBNA versus cTBNA in the diagnosi...
Article
Full-text available
Aims/introduction: A meta-analysis was performed to evaluate the efficacy of yoga in adult patients with T2DM. Materials and methods: The PubMed, EMBASE, and Cochrane databases were searched to obtain eligible randomized controlled trials (RCTs). The primary outcome was fasting blood glucose (FBG), and the secondary outcomes included glycosylate...
Article
Full-text available
Purpose A meta-analysis of prospective cohort studies was conducted to clarify the association between obstructive sleep apnoea (OSA) and future risk of all-cause mortality. Methods Eligible studies were identified by searching the PubMed and EMBASE databases up to July 2015. Pooled hazard ratios (HRs) and their corresponding 95 % confidence interv...
Data
The result of cumulative meta-analysis based on sample size.
Data
The result of cumulative meta-analysis based on sample size.
Article
This study aims to identify the effects of OM-85 BV in patients with chronic obstructive pulmonary disease (COPD). PubMed, Embase, CINAHL, and ClinicalTrials.gov were searched for eligible randomized controlled trials (RCTs). The major endpoint was exacerbation rate, and the minor endpoints included duration of hospitalization, severity of acute ex...
Article
Previous meta-analyses have shown that ultrasound guidance is an effective technique for radial artery catheterization. However, these reports neglected to include several non-English language studies. Therefore, an updated meta-analysis including more eligible studies was performed to assess the effectiveness of ultrasound-guided radial artery cat...
Article
Full-text available
Introduction: Currently, several studies have assessed the effect of yoga training on the management of chronic obstructive pulmonary disease (COPD), but these studies involved a wide variation of sample and convey inconclusive results. Hence, the present study was performed a systematic review and meta-analysis to investigate the efficacy of yoga...
Article
Full-text available
Background: It is controversial whether Tai Chi (TC) benefits breast cancer survivors (BCS) on quality of life (QoL). We therefore undertook a meta-analysis to assess this question. Materials and methods: A computerized search through electronic databases was performed to identify relevant randomized controlled trials (RCTs). The primary outcome...
Article
Full-text available
Anabolic steroids are known to improve body composition and muscle strength in healthy people. However, whether anabolic steroids improve the physical condition and function in patients with chronic obstructive pulmonary disease (COPD) remains undetermined. A meta-analysis was conducted to review the current evidence regarding the effects of anabol...
Article
Randomized controlled trials (RCT) were carried out to investigate the role of neuromuscular electrical stimulation (NMES) in patients with chronic obstructive pulmonary disease (COPD). However, these studies have small sample size and different measures for evaluating outcomes, and convey inconclusive results. We carried out a meta-analysis to ass...
Article
Full-text available
Our meta-analysis was performed to estimate the effect of continuous positive airway pressure (CPAP) therapy on systemic inflammation in patients with obstructive sleep apnea (OSA). A comprehensive literature search of PubMed and EMBASE was performed for literature published up to January 2013. Standardized mean difference (SMD) was calculated to e...
Article
Full-text available
Although several large studies showed roflumilast (Rof) has demonstrated efficacy in patients with chronic obstructive pulmonary disease (COPD), the efficacy of Rof in dyspnea remains unclear. We therefore undertook a meta-analysis to assess the efficacy of Rof in dyspnea for COPD patients. A computerized search through electronic databases was per...
Article
Full-text available
Background: Currently, several large studies showed that roflumilast has been demonstrated efficacy during treatment chronic obstructive pulmonary disease (COPD) patients, but also caused some side effects. Aim: To assess the efficacy and safety of roflumilast in COPD patients. Methods: A computerized search through electronic databases includ...
Article
Full-text available
Currently, several studies assessed the role of Tai Chi (TC) in management of chronic obstructive pulmonary disease, but these studies have wide variation of sample and convey inconclusive results. We therefore undertook a meta-analysis to assess the effects of TC. A computerized search through electronic databases was performed to obtain sample st...
Article
Full-text available
Whether Tai Chi benefits patients with osteoarthritis remains controversial. We performed a meta-analysis to assess the effectiveness of Tai Chi exercise for pain, stiffness, and physical function in patients with osteoarthritis. A computerized search of PubMed and Embase (up to Sept 2012) was performed to identify relevant studies. The outcome mea...
Data
PRISMA Checklist. (DOC)
Article
Full-text available
Aims: Whether Tai Chi (TC) benefits patients with type 2 diabetes mellitus (T2DM) remains controversial. Thus, we performed a meta-analysis to assess the efficacy of TC in T2DM patients. Methods: A computerised search through PubMed and Embase was performed to identify relevant studies. The primary outcomes were fasting blood glucose (FBG), haemog...
Article
Full-text available
Background: Associations between elevated C-reactive protein (CRP) and cancer risk have been reported for many years, but the results from prospective cohort studies remains controversial. A meta-analysis of prospective cohort studies was therefore conducted to address this issue. Methods: Eligible studies were identified by searching the PubMed...
Article
Full-text available
Aim: Whether Tai Chi (TC) is effective in the cardiac rehabilitation of patients with chronic heart failure (CHF) remains controversial. We performed a meta-analysis to examine the effects of TC on exercise capacity and quality of life (QoL) in CHF patients. Methods and results: PubMed and EMBASE databases were searched (up to May 2012) for rele...
Article
Full-text available
Introduction Ventilator-associated pneumonia (VAP) remains a common hazardous complication in mechanically ventilated patients and is associated with increased morbidity and mortality. We undertook a systematic review and meta-analysis of randomized controlled trials to assess the effect of toothbrushing as a component of oral care on the preventio...
Article
Although unsupported upper extremity exercise (UUEE) is recommended in the guidelines for pulmonary rehabilitation (PR), it is controversial whether UUEE improves dyspnea in patients with COPD. The present study conducted a meta-analysis of randomized controlled trials to clarify whether UUEE could improve dyspnea in COPD patients. A computerized s...
Article
Full-text available
Purpose: C-reactive protein (CRP) is associated with the development of obstructive sleep apnea (OSA) and cardiovascular diseases. Continuous positive airway pressure (CPAP) is an effective treatment for OSA, but the impact of CPAP therapy on CRP levels in patients with OSA remains unclear. To obtain this information, we performed a meta-analysis...

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Projects

Project (1)
Project
To explorer the effects of neuromuscular electrical stimulation of the lower extremities in acute exacerbated patients with chronic obstructive pulmonary disease