Lefteris Koumakis

Lefteris Koumakis
Foundation for Research and Technology - Hellas | forth · Institute of Computer Science

Ph.D.

About

111
Publications
22,468
Reads
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1,222
Citations
Citations since 2016
66 Research Items
1050 Citations
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
Additional affiliations
October 2014 - present
Education
March 2011 - September 2014
Technical University of Crete
Field of study
  • Production Engineering and Management School

Publications

Publications (111)
Article
Full-text available
Background: Major chronic diseases such as cardiovascular disease (CVD), diabetes, and cancer impose a significant burden on people and health care systems around the globe. Recently, deep learning (DL) has shown great potential for the development of intelligent mobile health (mHealth) interventions for chronic diseases that could revolutionize th...
Article
Full-text available
Augmented reality (AR) provides excellent learning potential, especially in a school environment. Multiple students can share the virtual scene and interact with it using the mobile interface as a hand-held display in AR children’s books. Students’ participation is an essential element of learning, and one of AR’s greatest strengths is its ability...
Article
Full-text available
Patient-reported outcomes (PROs) are an emerging paradigm in clinical research and healthcare, aiming to capture the patient's self-assessed health status in order to gauge efficacy of treatment from their perspective. As these patient-generated health data provide insights into the effects of healthcare processes in real-life settings beyond the c...
Preprint
BACKGROUND Diabetes is a chronic condition that necessitates regular monitoring and self-management of the patient's blood glucose levels. People with type 1 diabetes (T1D) can live a productive life if they receive proper diabetes care. Nonetheless, a loose glycemic control might increase the risk of developing hypoglycemia. This incident can occu...
Article
Background: Diabetes is a chronic condition that necessitates regular monitoring and self-management of the patient's blood glucose levels. People with type 1 diabetes (T1D) can live a productive life if they receive proper diabetes care. Nonetheless, a loose glycemic control might increase the risk of developing hypoglycemia. This incident can occ...
Article
Full-text available
Today, there are excellent resources for the semantic annotation of biomedical text. These resources span from ontologies, tools for NLP, annotators, and web services. Most of these are available either in the form of open source components (i.e., MetaMap) or as web services that offer free access (i.e., Whatizit). In order to use these resources i...
Preprint
BACKGROUND Major chronic diseases such as cardiovascular disease, diabetes, and cancer impose a significant burden on people and the healthcare systems around the globe. Recently, Deep Learning (DL) has shown great potential towards the development of intelligent mobile health (mHealth) interventions for chronic diseases which could revolutionize t...
Article
Background: Major chronic diseases such as cardiovascular disease (CVD), diabetes, and cancer impose a significant burden on people and health care systems around the globe. Recently, deep learning (DL) has shown great potential for the development of intelligent mobile health (mHealth) interventions for chronic diseases that could revolutionize t...
Poster
Full-text available
Randomization is an inherent part of Randomized Clinical Trials (RCTs), typically requiring the split of participants in intervention and control groups. We present a web service supporting randomized patient distribution, developed in the context of the MyPal project RCT. The randomization process is based on a block permutation approach to mitiga...
Article
Full-text available
PURPOSE Capitalizing on the promise of patient-reported outcomes (PROs), electronic implementations of PROs (ePROs) are expected to play an important role in the development of novel digital health interventions targeting palliative cancer care. We performed a systematic and mapping review of the scientific literature on the current ePRO-based appr...
Preprint
High-throughput technologies, such as chromatin immunoprecipitation (ChIP) with massively parallel sequencing (ChIP-seq) have enabled cost and time efficient generation of immense amount of genome data. The advent of advanced sequencing techniques allowed biologists and bioinformaticians to investigate biological aspects of cell function and unders...
Article
Full-text available
With the evolution of biotechnology and the introduction of the high throughput sequencing, researchers have the ability to produce and analyze vast amounts of genomics data. Since genomics produce big data most of the bioinformatics algorithms are based on machine learning methodologies, and lately deep learning, to identify patterns, make predict...
Article
Full-text available
The new era of artificial intelligence (AI) has introduced revolutionary data-driven analysis paradigms that have led to significant advancements in information processing techniques in the context of clinical decision-support systems. These advances have created unprecedented momentum in computational medical imaging applications and have given ri...
Chapter
Full-text available
Significant improvements in cancer research have led to more cancer patients being cured, and many more enabled to live with their cancer. As the disease is now managed as a chronic illness, it requires long-term surveillance and maintenance treatment. This requires a transformation in the nature of healthcare from reactive to preventive, personali...
Chapter
Chronic pain is one of the most common health problems affecting daily activity, employment, relationships and emotional functioning. Unfortunately, the lack of specialized health care personnel, and the high heterogeneity in terms of clinical manifestation and treatment results contribute in failure to manage efficiently and effectively pain. Info...
Article
This paper analyzes the clinical and technological characteristics of cancer mobile apps that enable patients to securely record, manage, and share their information. It proposes an integrated approach towards developing quality mobile health apps for cancer and discusses issues relevant to the enhancement of patient experience and acceptance, adhe...
Chapter
Full-text available
In the current study, a model-based system for predicting resilience in silico, as part of personalizing precision medicine, to better understand the needs for improved therapeutic protocols of each patient is proposed. The computational environment, which is currently under implementation within the BOUNCE EU project (“Predicting Effective Adaptat...
Conference Paper
Full-text available
Processing and managing sensitive health data requires a high standard of security and privacy measures to ensure that all ethical and legal requirements are respected. Data anonymization is one of the key technologies to this purpose. However, the plethora and the complexity of the available anonymization techniques make it difficult for a non-exp...
Article
In this review we focus on the various integrated care models that have been applied for the management of dementia patients. We explore the different types of assistive technologies (mobile, wearable and home-based systems) for dementia care, with a special emphasis on technologies that involve or target to the informal caregiver as end user. In a...
Article
Full-text available
Chronic pain is one of the most common health problems affecting daily activity, employment, relationships and emotional functioning. Unfortunately, the lack of specialized health care personnel, and the high heterogeneity in terms of clinical manifestation and treatment results contribute in failure to manage efficiently and effectively pain. Info...
Article
Anxiety and stress are very common symptoms of patients facing a forthcoming surgery. However, limited time and resources within healthcare systems make the provision of stress relief interventions difficult to provide. Research has shown that provision of preoperative stress relief and educational resources can improve health outcomes and speed re...
Chapter
The ever-growing demand for acquiring, managing, and exploiting patient health-related information has led to the development of several mobile health apps to support cancer patients. This chapter analyzes the clinical and technological characteristics of mobile apps enabling cancer patients to securely record, manage, and share their information o...
Technical Report
Full-text available
Because of the increasing ageing population, the frequency of chronic diseases has been growing in Europe over the past decades. In addition, the ever-growing demand for acquiring, managing and exploiting patient health related information has led to the development of many electronic health (eHealth) systems and applications. However, despite the...
Article
Full-text available
Clinical decision support systems can play a crucial role in healthcare delivery as they promise to improve health outcomes and patient safety, reduce medical errors and costs and contribute to patient satisfaction. Used in an optimal way, they increase the quality of healthcare by proposing the right information and intervention to the right perso...
Article
Full-text available
In the last decade, clinicians have started to shift from an individualistic perspective of the patient towards family-centred models of care, due to the increasing evidence from research and clinical practice of the crucial role of significant others in determining the patient's adjustment to cancer disease and management. eHealth tools can be con...
Article
Full-text available
Nowadays, patients have a wealth of information available on the Internet. Despite the potential benefits of Internet health information seeking, several concerns have been raised about the quality of information and about the patient’s capability to evaluate medical information and to relate it to their own disease and treatment. As such, novel to...
Article
Full-text available
Developments in information and communication technology have changed the way healthcare processes are experienced by both patients and healthcare professionals: more and more services are now available through computers and mobile devices. Smartphones are becoming useful tools for managing one’s health, and today, there are many available apps mea...
Conference Paper
Full-text available
It is well documented that the diagnosis of cancer affects the wellbeing of the whole family adding overwhelming stresses and uncertainties. As such, family education and enhancement of resilience is an important factor that should be promoted and facilitated in a holistic manner for addressing a severe and chronic condition such as cancer. In this...
Article
Full-text available
The known challenge of underutilization of data and biological material from biorepositories as potential resources for medical research has been the focus of discussion for over a decade. Recently developed guidelines for improved data availability and reusability-entitled FAIR Principles (Findability, Accessibility, Interoperability, and Reusabil...
Chapter
Full-text available
The vision of personalized medicine has led to an unprecedented demand for acquiring, managing and exploiting health related information, which in turn has led to the development of many e-Health systems and applications. However, despite this increasing trend only a limited set of information is currently being exploited for analysis and this has...
Article
Full-text available
Chronic pain is one of the most common health problems affecting daily activity, employment, relationships and emotional functioning. Unfortunately, limited access to pain experts, the high heterogeneity in terms of clinical manifestation and treatment results, contribute in failure to manage efficiently and effectively pain. Information and Commun...
Article
Full-text available
This paper reports on the development of a self-sustaining and community-responsive platform that streamlines the wealth of available open Bioinformatics resources to accelerate multi-disciplinary collaboration and boost innovation in post-genomics biomedical research. Our approach adopts the principles of reproducible, reusable and remixable compu...
Poster
Full-text available
The ever-growing demand for acquiring, managing and exploiting patient health related information has led to the development of several eHealth applications. However, despite the number of Information Technology (IT) systems already developed and the apparent need for such systems, end users can only collect online and exploit, only a limited set o...
Article
Full-text available
The ever-growing demand for acquiring, managing and exploiting patient health related in-formation has led to the development of many e-Health systems and applications. However, despite the number of systems already developed and the apparent need for such systems, end users can only collect online and exploit, only a limited set of information for...
Article
Full-text available
The ever-growing demand for acquiring, managing and exploiting patient health related information has led to the development of many e-Health systems and applications. However, despite the number of systems already developed and the apparent need for such systems, end users can only collect online and exploit, only a limited set of information for...
Article
Full-text available
Minepath: ( www.minepath.org ) is a web-based platform that elaborates on, and radically extends the identification of differentially expressed sub-paths in molecular pathways. Besides the network topology, the underlying MinePath algorithmic processes exploit exact gene-gene molecular relationships (e.g. activation, inhibition) and are able to id...
Chapter
Next-generation sequencing (NGS) and microarrays have vastly increased the ability to detect sequence variation and gene expression. These technologies require specific bioinformatics tools to extract information from the raw data. For analyzing human data, NGS pipelines work on three basic tiers: sequence generation, alignment to a reference genom...
Article
Full-text available
Author Summary It is generally recognized that using different sources of information and knowledge is better than just using a single source. This is most profound in the post-genomics era. On one hand, the advent of genomic high-throughput technologies realized by DNA microarray and next generation RNAseq technologies enabled a ‘systems level an...
Article
Full-text available
Purpose: Biomedical research is being catalyzed by the vast amount of data rapidly collected through the application of information technologies (IT). Despite IT advances, the methods for involving patients and citizens in biomedical research remain static, paper-based and organized around national boundaries and anachronistic legal frameworks. Th...
Article
Full-text available
Background: As cancer survival increases, a new partnership model that empowers patients and caregivers and promotes self‐management of the disease is needed. The H2020 iManageCancer project aims to respond to the aforementioned needs with a cancer specific personalized platform. This abstract describes the development of two tools to: 1) monitor t...
Article
Full-text available
Background: The adoption in oncology of Clinical Decision Support (CDS) may help clinical users to efficiently deal with the high complexity of the domain, lead to improved patient outcomes, and reduce the current knowledge gap between clinical research and practice. While significant effort has been invested in the implementation of CDS, the upta...
Article
Full-text available
Anti-VEGF antibody bevacizumab has prolonged progression-free survival in several cancer types, however acquired resistance is common. Adaption has been observed pre-clinically, but no human study has shown timing and genes involved, enabling formulation of new clinical paradigms. In a window-of-opportunity study in 35 ductal breast cancer patients...