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Léa Duchesne

Léa Duchesne
Sorbonne Université | UPMC · Ecole Doctorale de Santé Publique : Epidémiologie et Sciences de l'Information Biomédicale (ED 393)

Doctor of Public Health

About

9
Publications
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92
Citations
Introduction
Skills and Expertise

Publications

Publications (9)
Article
Background: Implementing opt-out hepatitis C virus (HCV) screening across Canadian provincial prisons is crucial to achieving micro-elimination. Given short incarceration lengths, the most cost-effective screening strategy remains unknown. We compared the cost-effectiveness of current standard of care (venipuncture-based HCV-antibody+HCV RNA) and...
Article
Full-text available
Background Whereas 72% of hepatitis C virus (HCV)-infected people worldwide live in low- and middle-income countries (LMICs), only 6% of them have been diagnosed. Innovative technologies for HCV diagnosis provide opportunities for developing testing strategies more adapted to resource-constrained settings. However, studies about their economic feas...
Thesis
L’arrivée sur le marché en 2011 de nouveaux traitements de l’hépatite C – les antiviraux à action directe (AAD) – bien plus efficaces et mieux tolérés que leurs prédécesseurs ont rendu l’élimination de cette dernière envisageable. Le prix élevé des AAD ainsi que le faible taux de diagnostic de l’hépatite C dans le monde ont cependant limité le nomb...
Article
Full-text available
Background: Scaling-up the access to hepatitis C virus (HCV) diagnostics for people who use injecting drugs (PWID) is essential to reduce the HCV incidence in low and middle-income countries. Methods: A decision tree model was developed to compare the cost-effectiveness of 12 strategies for diagnosing HCV in Senegal with a health sector perspect...
Article
Introduction Les migrants sont très exposés à la multirésistance aux antibiotiques et aux infections en raison d’une prévalence élevée dans les pays d’origine et conditions de vie précaires pendant et après la migration. Il existe peu de données sur la colonisation par des Bactéries MultiRésistantes (BMR) et Hautement Résistantes émergentes (BHRe)...
Article
Full-text available
Introduction The World Health Organization has aimed for global elimination of both hepatitis B virus (HBV) and hepatitis C virus (HCV) by 2030. Treatments available to cure HCV and control HBV, as well as vaccination to prevent HBV infection, have certainly allowed for such bold goals, yet the final steps to usher in elimination require further ev...
Article
Sub-Saharan Africa and hepatitis C: challenges and insights regarding the implementation of innovative diagnostics With the advent of novel treatments with a cure rate higher than 90%, the elimination of chronic hepatitis C has become achievable. In developing countries, the chronic lack of diagnostic facilities represents a barrier to their spread...
Article
Full-text available
According to the Global Burden of Diseases, chronic viral hepatitis B and C are one of the most challenging global health conditions that rank among the first causes of morbidity and mortality worldwide. Low and middle income countries are particularly affected by the health burden associated with HBV or HCV infection. One major gap in efficiently...
Article
Full-text available
Introduction: The diagnostic procedure for chronic hepatitis C infection (CHC) usually combines anti-HCV antibody (HCV-Ab) and HCV-RNA measurement. Quantifying HCV core antigen (cAg) as a one-step procedure could shorten the diagnostic process. We aimed to assess the performance of cAg quantification in diagnosing CHC and how it is influenced by c...

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