About
144
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Introduction
Le Li received Ph.D degree in the Department of Health Technology and Informatics, The Hong Kong Polytechnic University in 2007. He completed his postdoctoral training in the same University at 2010. From 2014-2016, Dr. Li worked as a visiting scientist at TIRR Memorial Hermann Research Center and Department of Physical Medicine and Rehabilitation, UTHealth at Houston, USA. He is currently a professor in Institute of Medical Research, Northwestern Polytechnical University, China
Additional affiliations
Education
June 2003 - December 2007
September 2000 - June 2003
September 1996 - July 2000
Publications
Publications (144)
The study aimed to investigate changes in corticomuscular coupling during elbow flexion and extension in stroke survivors using functional near-infrared spectroscopy (fNIRS) and surface electromyography (sEMG), and to evaluate the relationship between coupling characteristics and clinical assessment scales. This study recruited 12 stroke survivors...
Jiecheng Guo Sixuan He Li Yan- [...]
Le Li
Although previous studies have demonstrated that transcranial focused ultrasound stimulation protects the ischemic brain, clear criteria for the stimulation time window and intensity are lacking. Electrical impedance tomography enables real-time monitoring of changes in cerebral blood perfusion within the ischemic brain, but investigating the feasi...
Deciphering coordinated movements is integral to understanding the daily activities and interactions between the nervous system and muscles, especially in robot-assisted rehabilitation. This study proposes a novel temporal-guided adaptive graph learning (TAGL) network to recognize coordinated movements from functional near-infrared spectroscopy (fN...
Background
Investigating the spatial distribution of muscle activity would facilitate understanding the underlying mechanism of spasticity. The purpose of this study is to investigate the characteristics of spastic muscles during passive stretch and active contraction by high-density surface electromyography (HD-sEMG).
Methods
Fourteen spastic hem...
Li Yan Kang Fu Le Li- [...]
Xiaodong Zhou
Brain tumors have a poor prognosis. Early, accurate diagnosis and treatment are crucial. Although brain surgical biopsy can provide an accurate diagnosis, it is highly invasive and risky and is not suitable for follow-up examination. Blood-based liquid biopsies have a low detection rate of tumor biomarkers and limited evaluation ability due to the...
Objective
The cause of increased knee pain related to quadriceps weakness in knee osteoarthritis remains unclear. This study aimed to assess the impact of alterations in the effusion-synovitis, a special kind of nociceptive structure, on changes in knee pain associated with quadriceps weakness.
Methods
Based on the Osteoarthritis Initiative cohort...
Myoelectric pattern recognition (MPR) has evolved into a sophisticated technology widely employed in controlling myoelectric interface (MI) devices like prosthetic and orthotic robots. Current MIs not only enable multi-degree-of-freedom control of prosthetic limbs but also demonstrate substantial potential in consumer electronics. However, the non-...
Ultrasound neuromodulation technology is a promising neuromodulation approach, with the advantages of noninvasiveness, high-resolution, deep penetration and good targeting, which aid in circumventing the side effects of drugs and invasive therapeutic interventions. Ultrasound can cause mechanical effects, activate mechanosensitive ion channels and...
Le Li Xiang Wang Bo Yao- [...]
Ping Zhou
This study aimed to evaluate the utility of sample entropy (SampEn) of surface electromyographic signals (sEMG) in quantifying neuromuscular changes after spinal cord injury (SCI). Using a linear electrode array, sEMG signals were obtained from the biceps brachii muscles of 13 healthy control subjects and 13 SCI subjects during isometric elbow flex...
Objective: A growing body of research shows the promise and efficacy of EMG-based robot interventions in improving the motor function in stroke survivors. However, it is still controversial whether the effect of EMG-based robot is more effective than conventional therapies. This study focused on the effects of EMG-based robot on upper limb motor co...
Carotid artery intima-media thickness (CIMT) is an essential factor in signaling the risk of cardiovascular diseases, which is commonly evaluated using ultrasound imaging. However, automatic intima-media segmentation and thickness measurement are still challenging due to the boundary ambiguity of intima-media and inherent speckle noises in ultrasou...
Objective: The relationship between muscle activation during motor tasks and cerebral cortical activity remains poorly understood. The aim of this study was to investigate the correlation between brain network connectivity and the non-linear characteristics of muscle activation changes during different levels of isometric contractions.
Methods: Twe...
Aging is a non-modifiable risk factor for stroke and the global burden of stroke is continuing to increase due to the aging society. Muscle dysfunction, common sequela of stroke, has long been of research interests. Therefore, how to accurately assess muscle function is particularly important. Electrical impedance myography (EIM) has proven to be f...
Considerable studies have focused on the neural basis of visually guided tracking movement in the frontoparallel plane, whereas the neural process in real-world circumstances regarding the influence of binocular disparity and motion-in-depth (MID) perception is less understood. Although the role of stereoscopic versus monoscopic MID information has...
Le Li Huijing Hu Bo Yao- [...]
Ping Zhou
A surface electromyography (EMG) analysis was performed in this study to examine central neural and peripheral muscle changes after a spinal cord injury (SCI). A linear electrode array was used to record surface EMG signals from the biceps brachii (BB) in 15 SCI subjects and 14 matched healthy control subjects as they performed elbow flexor isometr...
Objective
The aim of this study was to explore the association between quadriceps strength and synovitis in the knee osteoarthritis (KOA).
Methods
This study was derived from the Osteoarthritis Initiative (OAI) cohort which recruited adults with or at risk of KOA. Knees with complete records of isometric quadriceps strength, effusion-synovitis and...
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: Although existing assist-as-needed (AAN) controllers have been designed to adapt the robotic assistance to patients' movement performance, they ignore patient's active participation. This study proposed a voluntary AAN (VAAN) controller con...
Background
Studies have demonstrated that elderly people with low back pain (LBP) may have poor postural control compared to healthy older adults. Poor postural control is associated with poor balance performance and a high risk of serious falls. A variety of training strategies are proposed for LBP therapy, particularly core stabilization training...
Li Yan Huijing Hu Yu Zheng- [...]
Le Li
In recent years, China has actively promoted the construction of first-class universities and disciplines of the world (‘Double First-Class’), and built a new model of university development to solve Chinese problems and support high-quality economic and social development. In the context of China’s efforts to promote the construction of new engine...
Objective
The correlation between the performance of coordination movement and brain activity is still not fully understood. The current study aimed to identify activated brain regions and brain network connectivity changes for several coordinated finger movements with different difficulty levels and to correlate the brain hemodynamics and connecti...
Ischemic stroke is a serious medical condition that is caused by cerebral vascular occlusion and leads to neurological dysfunction. After stroke, patients suffer from long-term sensory, motor and cognitive impairment. Non-invasive neuromodulation technology has been widely studied in the field of stroke rehabilitation. Transcranial ultrasound stimu...
Objective
The transversus abdominis (TrA) and multifidus (MF) muscles are essential in preventing chronic low back pain (CLBP) recurrence by maintaining segmental stabilization and stiffness. Sling exercise is a high-level core stability training to effectively improve the activities of the TrA and MF muscles. However, the neural mechanism for slin...
Background
Stroke is among the leading causes of long-term disability worldwide. Motor impairments after stroke not only impact the individuals quality of life but also lay substantial burdens on the society. Motor planning is a key component of cognitive function that impacts motor control. Hand movements such as grasping or reaching to grasp requ...
Xiaohan Wang Le Ge Huijing Hu- [...]
Le Li
In recent years, the potential of non-invasive brain stimulation (NIBS) for the therapeutic effect of post-stroke spasticity has been explored. There are various NIBS methods depending on the stimulation modality, site and parameters. The purpose of this study is to evaluate the efficacy of NIBS on spasticity in patients after stroke. This systemat...
Objective
Increased muscle co-contraction of the agonist and antagonist muscles during voluntary movement is commonly observed in the upper limbs of stroke survivors. Much remain to be understood about the underlying mechanism. The aim of the study is to investigate the correlation between increased muscle co-contraction and the function of the cor...
Background
Electrical impedance myography (EIM) has been applied to assess muscle health conditions in neuromuscular disorders. This study aimed to detect immediate muscle electrical impedance property alterations in lower extremity of chronic stroke survivors immediately after functional electrical stimulation (FES)-assisted cycling training.
Met...
Scoliosis is a disease caused by deformation of the spine, and precise imaging of human spine tissues is crucial and instructive for the subsequent treatment. Currently, radiographs are clinically used to monitor disease progress. However, radiation exposure is a safety concern and is undesirable for regular monitoring during rehabilitation interve...
Background
Lumbar paraspinal muscle (LPM) is important in spinal stabilization in patients with chronic low back pain (CLBP). However, the electrical properties of LPM in patients with CLBP remain unclear. Electrical impedance myography (EIM) is a novel and non-invasive technique that provides a simple quantitative evaluation of electrical properti...
Electrical impedance myography (EIM) is a sensitive assessment for neuromuscular diseases to detect muscle inherent properties, whereas surface electromyography (sEMG) is a common technique for monitoring muscle activation. However, the application of EIM in detecting training effects on stroke survivors is relatively few. This study aimed to evalu...
The objective of this study was to evaluate the interrater and intrarater reliability of electrical impedance myography (EIM) using handheld sensors of different sizes. Electrical impedance myography of the biceps brachii muscle of twenty healthy individuals was performed by two raters using both large and small sensors. The procedures were also re...
BACKGROUND
Stroke is among the leading causes of long-term disability worldwide. Motor impairments after stroke not only impact the individuals quality of life but also lay substantial burdens on the society. Motor planning is a key component of cognitive function that impacts motor control. Hand movements such as grasping or reaching to grasp requ...
Background: Survivors with spinal cord injury (SCI) have neuromuscular deficits such as muscle atrophy that lead to functional impairments. This study utilized myotonometry and electrical impedance myography (EIM) to quantitatively evaluate the changes in muscle mechanical properties and compositions after SCI.
Methods: This study adopted a cross-s...
Background
Non-specific chronic low back pain (NSCLBP) is a multifactor disorder with high prevalence rate of people all around the world. Lumbar paraspinal muscle (LPM) plays an important role of spine stabilization. However, the electrical properties of LPM in the patients were unclear. Aim to explore the electrical properties of bilateral LPM be...
Objectives. This study is aimed at exploring the effects of virtual reality (VR) training on postural control, measured by anticipatory and compensatory postural adjustments (APAs and CPAs, respectively), in patients with chronic nonspecific low back pain (CNLBP) and the potential neuromuscular mechanism of VR training. Methods. Thirty-four patient...
This study aimed to examine the redistribution of neuromuscular junctions or innervation zones (IZs) after spinal cord injuries (SCI). Fifteen able-bodied subjects and 15 subjects with SCI (American Spinal Injury Association Impairment Scale A to D), participated in the study. Surface electromyography (EMG) signals were collected from the biceps br...
Background
Virtual reality (VR) technology is increasingly used in stroke rehabilitation. This study aimed to investigate the effectiveness of using the glasses-free VR training to improve motor function of upper limb in patients with stroke.
Methods
Twelve patients with stroke were recruited to participate in the intervention of 3 weeks. At the b...
This study aimed to identify characteristics of the triceps surae muscles and aponeuroses stiffness in vivo, during graded isometric submaximal plantarflexion efforts. A total of twelve healthy male subjects (age: 27 ± 4 years) participated and were required to stay at rest (0% MVC) and perform isometric submaximal plantar flexion contractions (20%...
Xin Li Hao Liu Le Ge- [...]
Chuhuai Wang
Introduction:
The transversus abdominis (TVA) and multifidus (MF) muscles are the main segmental spinal stabilizers that are controlled by the primary motor cortex of the brain. However, relocations of the muscle representation in the motor cortex may occur after chronic lower back pain (cLBP); it still needs more evidence to be proven. The curren...
Background: This study combined neuromechanical modeling analysis, muscle tone measurement from mechanical indentation and electrical impedance myography to assess the neural and peripheral contribution to spasticity post stroke at wrist joint. It also investigated the training effects and explored the underlying mechanism of radial extracorporeal...
The functional connectivity (FC) between multiple brain regions during tasks is currently gradually being explored with functional near‐infrared spectroscopy (fNIRS). However, the FC present during grip force tracking tasks performed under visual feedback remains unclear. In the present study, we used fNIRS to measure brain activity during resting...
Background:
Empirical evidence that demonstrates the relationship between pelvic asymmetry and non-specific chronic low back pain (NCLBP) is currently lacking.
Objective:
To establish the reliability of the Global Postural System (GPS) in assessing pelvic asymmetry and identify the association between pelvic asymmetry parameters and the occurren...
Background:
Pressure biofeedback unit (PBU) is a widely used non-invasive device to assist core muscle training by providing pressure feedback. The aim this study was to compare the muscle activities of transverse abdominis (TA) and multifidus (MF) at different target pressures (50, 60 and 70 mmHg) of PBU between individuals with and without cLBP....
This study investigated electroencephalogram (EEG) changes during movement preparation and execution in stroke patients. EEG-based event-related potential (ERP) technology was used to measure brain activity changes. Seventeen stroke patients participated in this study and completed ERP tests that were designed to measure EEG changes during unilater...
Ambrose lo Di Lei Yan Leng- [...]
Le Li
Objective
The mechanism underlying the benefit of nonsurgical spinal decompression (NSSD) on low back pain is unclear. This study was performed to investigate the immediate impact of NSSD on the mechanical properties and morphology of the paraspinal muscles.
Methods
Participants with low back pain were recruited. NSSD therapy was provided on one o...
Control schemes based on electromyography (EMG) have demonstrated their superiority in human-robot cooperation due to the fact that motion intention can be well estimated by EMG signals. However, there are several limitations due to the noisy nature of EMG signals and the inaccuracy of EMG-force/torque estimation, which might deteriorate the stabil...
Functional electric stimulation (FES) is a common intervention to correct foot drop for patients after stroke. Due to the disturbances from internal time-varying muscle characteristics under electrical stimulation and external environmental uncertainties, most of the existing FES system used pre-set stimulation parameters and cannot achieve good ga...
Background: Pressure biofeedback unit (PBU) is a widely used non-invasive device for the monitoring of transverse abdominals (TA) and multifidus (MF) muscles in patients with low back pain (LBP). There is little research that compared trunk muscle activities with pressure feedback during trunk muscle contraction in a seated position. The aim this s...
Wearable electrochemical biosensors, which measure the concentration of small biochemical molecules in biofluids in a non-invasive way, are still highly desired. Herein, a wearable, mediator-free electrochemical biosensor for real-time sweat glucose monitoring is proposed. A flexible and hierarchical meso/macro porous carbon nanotubes (CNT) - ethyl...
Background Empirical evidence that identifies the pelvic asymmetry in which movement plane that contribute to non-specific chronic low back pain (NCLBP) is currently lacking.
Objective To establish the reliability of the Global Postural System (GPS) in assessing pelvic asymmetry and identify the association between pelvic asymmetry parameters and t...
Background: Empirical evidence that demonstrates the relationship between pelvic asymmetry and non-specific chronic low back pain (NCLBP) is currently lacking.
Objective: To establish the reliability of the Global Postural System (GPS) in assessing pelvic asymmetry and identify the association between pelvic asymmetry parameters and the occurrence...
Background: Empirical evidence that demonstrates the relationship between pelvic asymmetry and non-specific chronic low back pain (NCLBP) is currently lacking.
Objective: To establish the reliability of the Global Postural System (GPS) in assessing pelvic asymmetry and identify the association between pelvic asymmetry parameters and the occurrence...
Background: Empirical evidence that demonstrates the relationship between pelvic asymmetry and non-specific chronic low back pain (NCLBP) is currently lacking.
Objective: To establish the reliability of the Global Postural System (GPS) in assessing pelvic asymmetry and identify the association between pelvic asymmetry parameters and the occurrence...
Background: Empirical evidence that demonstrates the relationship between pelvic asymmetry and non-specific chronic low back pain (NCLBP) is currently lacking.
Objective: To establish the reliability of the Global Postural System (GPS) in assessing pelvic asymmetry and identify the association between pelvic asymmetry parameters and the occurrence...
Introduction:
The supine and prone sling exercise may facilitate activation of the local trunk muscles. Does the side-lying sling exercise activate trunk muscles more easily than the supine and prone training with sling settings? Clinical work has shown that the side-lying sling exercise could reduce pain in patients with unilateral low back pain...
Background: Pressure biofeedback unit (PBU) is a non-invasive, low-cost, and widely used device for monitoring, evaluating and training transverse abdominals (TA) and multifidus (MF) muscles of patients with low back pain (LBP). There has been little research on quantifying muscle activity under different pressures. The primary aim of this prelimin...