Lazhar Bechki

• Professor
• University of Ouargla

A convenient FeCl3-catalyzed synthesis of N-sulfonylimines via the condensation of aldehydes with N-sulfonylamides in mild and neutral conditions (in ethanol at room temperature) is reported. This procedure constitutes the first iron-catalyzed synthesis of N-sulfonylimines and is adapted to the condensation of both aromatic and aliphatic aldehydes.

Carbenes containing ferrocenyl substituents are interesting target compounds due to the stereoelectronic influence of the ferrocenyl group in terms of steric protection, electron-donation, and reversible redox chemistry. In this paper synthetic approaches to novel ferrocenyl-N-heterocyclic carbenes (NHC’s) are summarized and their 1H RMN spectrosco...

Medicinal plants possess the potential to yield bioactive compounds that offer significant health benefits; positioning them as valuable and promising sources for the development of innovative pharmaceutical products. This study aims to comprehensively assess the in vitro and in vivo pharmacological effects of the aqueous extract of the plant Atrac...

This study investigates the binding of ferrocenylmethyl nucleobase derivatives to DNA through electrostatic interactions, employing a combination of experimental and theoretical approaches to elucidate binding mechanisms and explore their potential for DNA targeting. UV–Vis spectroscopy and cyclic voltammetry (CV) were used to evaluate binding affi...

The present study has investigated the binding interactions of four N‐ferrocenylmethyl‐nucleobase derivatives: N1‐ferrocenylmethyladenine (FcMeAd), N1‐ferrocenylmethyl‐cytosine (FcMeCy), N1‐ferrocenylmethylthymine (FcMeTh), and N6,9‐bis(ferrocenyl‐methyl)adenine ((FcMe)2Ad), with human hemoglobin (HHb) and bovine serum albumin (BSA). A combination...

This study presents the synthesis and characterization of a novel series of ferrocenylmethylnucleobase compounds, namely, FcMeAd, FcMeCy, FcMeTh, and (FcMe)₂Ad with promising antioxidant and antidiabetic properties. Spectroscopic techniques confirmed their sandwich‐like geometry, with the nucleobase moiety coordinated to the ferrocene unit. Density...

Nickel tetraphenyl‐porphyrin (NiTPPH₂) and zinc tetra(4‐methophenyl)‐porphyrin (ZnTPPH₂(p‐methyl)) were successfully synthesized and characterized using ¹ H NMR spectroscopy. Their antioxidant activities and interactions with the superoxide anion radical () were evaluated using cyclic voltammetry. Remarkably, NiTPPH₂ displayed superior antioxidant...

The investigation employed cyclic voltammetry (CV) assays to assess the scavenging efficacy of two recently developed compounds, namely meso-tetramethophenyl-porphyrin TPPH2(o-methyl) and mesotetrabiphenyl- porphyrin (TbiPPH2), against the superoxide anion radical ( �� ._). The IC50 values derived from the CV assays indicated significant scavenging...

Ethnopharmacological relevance Atractylis aristata batt., as an endemic plant from the Asteraceae family, holds a significant position in the Ahaggar region of southern Algeria's traditional medicine. The aerial parts of Atractylis aristata was used to cure inflammation, fever, and stomach disorders. Aim of the study The objective of the present i...

Atractylis aristata batt. is an endemic plant from Asteraceae family occupying an important place in traditional medicine in the Hoggar region in Algeria. The different extracts of the plant were obtained after maceration then liquid-liquid extraction using solvents of increasing polarity. The obtained extracts were tested for their content in tota...

This is the first study aimed to investigate the anti-cholinesterase (anti-Alzheimer), anti-lipase, antioxidant and photoprotective effects of various organic extracts prepared from the aerial parts of Fagonia bruguieri DC species endemic to southern Algeria. The research was also aimed to determine the total phenolics and flavonoid contents and ev...

Introduction: Natural products from medicinal plants, as pure compounds or as extracts, provide unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity. Recently, there has been a renewed interest in natural product research due to the failure of alternative drug discovery methods to deliver many compo...

Artemisia campestris L. is commonly used in folk medicine due to its antioxidant, antidiabetic, nutritional, and culinary properties. Our study assessed the total phenolics contents, antioxidant, and pharmacological activities of various organic extracts prepared from the aerial parts of Artemisia campestris, and its mineral elements and chemical p...

The inhibition effect of meso-tetraphenyl-porphyrin (TPPH2), meso-tetra4-methophenyl-porphyrin TPPH2(p-Me), and meso-tetra4-actophenyl-porphyrin (TAcPPH2) on the corrosion of XC52 mild steel in aerated 0.5 M aqueous sulfuric acid solution was studied by potentiodynamic polarization experiments and quantum chemical calculations. Results from potenti...

Phytochemical compounds are known to be components of many plants and herbs; they have received great interest from the public and scientists due to their health benefits as antioxidants. The aim of the present study was to reveal the bioactive compounds and evaluation of antioxidant activity of the dichloromethane, ethyl acetate, n-butanol and res...

Association, Université USTO, Bir El Djir, Oran, 31000, Algeria https://www.aneau.org/ajeau/

https://www.aneau.org/ajeau/ Association, Université USTO, Bir El Djir, Oran, 31000, Algeria

Pour sa (leur) participation au SÉMINAIRE INTERNATIONAL SUR LES SCIENCES DE LA MATIERE (PHYSIQUE ET CHIMIE) en ligne (webinaire), organisé par Algerian Journal of Engineering, Architecture and Urbanism le 17 et 18 Septembre 2021, avec un poster intitulé: Electrochemical, spectroscopic and molecular docking studies of Nferrocenylmethyl-4-nitroanilin...

1er Séminaire International PERTURBATEURS ENDOCRINIENS ENVIRONNEMENT & REPRODUCTION (PEER 2021) tenu du 07 au 08 juillet 2021. Université Saad Dahlab BLIDA 1

SÉMINAIRE INTERNATIONAL SUR LES SCIENCES DE LA MATIÈRE (PHYSIQUE ET CHIMIE) en ligne (webinaire), organisé par Algerian Journal of Engineering, Architecture and Urbanism le 22 Janvier 2021

Zygophyllaceae is commonly used in the indigenous system of medicine for treatment of conditions like diabetes, cancer, fever, asthma, toothache, stomach troubles and kidney disorders. This genus is one of the 27 genera of Zygophyllaceae family, The present work is devoted to the phytochemical and biological and antioxidant activity study of an end...

Artemisia is an Asteraceae species, with a large distribution in the northern hemisphere. Artemisia has many medicinal actions, including: anticancer, antidiabetic, antihypertensive, antivenom, and genital diseases. The phytochemical profile of Artemisia has shown abundance in flavonoids, phenolic acids, coumarins..,The pharmacological activities s...

Many species of the family Zygophyllaceae are used in traditional medicine for their biological properties including: antidiabetic, antirheumatic, antitumor, antithrombotic, diuretic, antipyretic. The presentworkisdevoted to the phytochemical and biological and antioxidantactivitystudy of an endemicspecies of the septentrional Sahara (Zygophyllacea...

The present work is devoted to the phytochemical and biological and antioxidant activity study of an endemic species of the septentrional Sahara Fagonia (Zygophyllaceae). Organic extracts were obtained by extration soxlhet with four solvents:chloroform, acetate ethyl and butanol. The yields were: 0.6% (w/w), and 1.9% ,7% (w/w) respectively. Chemica...

Synthèse et étude de l'activité antioxydante et antimutagène de quelques porphyrines H2TPP(o,p-methoxy) et H2TPP(p-acetyl)

ABSTRACT The present work is devoted to the phytochemical and biological and antioxidant activity study of an endemic species of the septentrional Sahara Fagonia (Zygophyllaceae). Organic extracts were obtained by extration soxlhet with four solvents:chloroform, acetate ethyl and butanol. The yields were: 0.6% (w/w), and 1.9% ,7% (w/w) respectively...

We have studied the binding interaction of N-ferrocenylmethyl-2-nitroaniline (2FMNA), N-ferrocenylmethyl-3-nitroaniline (3FMNA), and N-ferrocenylmethyl-4-nitroaniline (4FMNA) with bovine serum albumin (BSA) by absorption spectroscopy, cyclic voltammetry, and molecular docking techniques. The results indicated that these derivatives could bind to BS...

Three ferrocenylmethylnucleobases (FcMeNb) were synthesized and characterized by cyclic voltammetry, electronic absorption, FT-IR and NMR spectroscopy. The energy of frontier molecular orbitals was determined using DFT/B3LYP method combined with 6-311++G(d,p) basis set in acetonitrile. The lower standard rate constant values of the FcMeNb compounds...

Background An electrochemical method based on cyclic voltametry techniques was used to measure the antioxidant activity of two ferrocene-nucleobases. Objective The present study aims to measure the antioxidant activity of two ferrocene derivatives bearing nucleobases; the technique is based on the reaction of the in-situ electrochemical generated...

The first part of this work is an overlook on ferrocene derivatives-DNA and BSA interactions. The binding free energies of ferrocene derivatives with double-stranded DNA and BSA were determined using cyclic voltammetry and electronic spectroscopy techniques under similar conditions. Binding free energy values obtained from cyclic voltammetry were v...

Background Meso-tetra-4-actophenyl-porphyrin (TAcPPH2) was synthesized by reacting 4- acetyl-benzaldehyde with pyrrole in propionic acid, and used as a ligand for the synthesis of palladium (II) complex (PdTAcPP). The structure of the ligand and the complex were characterized by NMR and electronic spectroscopy. Methods he antioxidant activity and...

In this paper we present the synthesis and the evaluation of the antioxidant activity of meso-tetra-p-tolylporphyrin (TPPH 2 (p-methyl)) using superoxide anion radical. 2 (O)  in DMF as a solvant. The binding parameters of the interaction between the synthesised compound and the radical. 2 O  were also measured using cyclic voltammetry techniques...

This study aims to establish a group of heterogeneous organic compounds of porphyrin and derived compounds. This is useful for many medical fields such as phototherapy or industrial therapy such as dyes and OLED screens. On this basis, we assembled a group of six compounds and a group of their compounds with different metals such as Zn and Co, and...

Abstract.1The binding free energy of 9N-(ferrocenyl- methyl)adenine (FMA) with double-stranded deoxyribo- nucleic acid (DNA) was measured in solution using cyclic voltammetry and electronic spectroscopy (UV-Vis) techniques under similar conditions. The obtained results were confirmed by computational molecular docking. The docking studies yield goo...

Objective: Ten racemic 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones were separated by liquid chromatography on Chiralcel®OD-H column containing cellulose tris(3, 5-dimethylphenylcarbamate). Method: The enantioseparation was carried out using of Chiralcel®OD-H polysaccharide-type chiral stationary phase to resolve such enan...

This study aims to establish a group of heterogeneous organic compounds of porphyrin and derived compounds. This is useful for many medical fields such as phototherapy or industrial therapy, namely dyes and OLED screens. On this basis, we assembled a group of six compounds and a group of their compounds with different metals (Zn, Co, Cu, Fe and Pd)...

ABSTRACT The objective of this study is the valorization of the agricultural waste (nut shells) by preparing an active carbon from these wastes using the activating agent HCl 37%. The yields of the prepared active carbons were in the range 27.81 and 31.02 %. The influences of calcination temperatures in the range (550°C, 650°C and 750°C) on the ads...

Weak Zn⋅⋅⋅N interactions have been exploited in homogeneous palladium catalysis. The selective binding between pyridine-containing compounds and zinc-containing scaffolds (porphyrin or salphen) prevents undesired catalyst inhibition, thus increasing the activity of the palladium-phosphane catalyst. The picture illustrates how a magician uses the “Z...

Non-covalent interactions between halopyridine substrates and catalytically inert building blocks, namely zinc(II)-porphyrins and zinc(II)-salphens, influence the catalytic outcome of Suzuki-Miyaura and Mizoroki-Heck palladium-catalyzed cross-coupling reactions. The weak Zn…N interactions between halopyridine substrates and zinc(II)-containing porp...

Summary: This work is done in an effort to improve the wastewater at a plant that is certified to reduce the presence of Ozone and phosphorus using a manual sand filter to be used in non-consumptive agriculture and other uses using local materials such as sand, where the percentage of reducing the oils to 65% and the reduction of phosphorus 50%

In this paper, we study the effectiveness of corrosion inhibition of X70 carbon steel in the acidic medium HCl 1M at different concentrations and at ambient temperature using the compound prepared in laboratory in France this compound is: N -mésitylimidazole. This study was conducted at analytical laboratory and the inhibitory. We have used two met...

Imidazole is a heterocyclic compound a five-membered of diunsaturated cyclic the structure composed of atoms three carbon and two atoms nitrogen in non-adjacent positions. The simplest member of the family is imidazole itself, colorless to pale yellow crystalline solid yellow with a faint odor amine like, soluble in water and alcohol, melts at 89°C...

Résumé : Dans Ce travail on à étudier l’efficacité inhibitrice d’inhibiteur Imidazole sur la corrosion d’acier XC70 dans un milieu d’acide sulfurique H2SO4 0.5 M. on a utilisé deux méthodes :La méthode classique (dosage volumétriques) et la méthode électrochimique des courbes de polarisation puis par l’impédance électrochimique. Les résultats obten...

Le 1-hydroxyéthylferrocène, a été synthétisée par la réduction de Fc-CO-CH3 approprié, avec LiAlH réduction de l’acétylferrocène. L'étude électrochimique d’alcool et de métanitrophénylferrocène ont été étudiée par la voltammétrie cyclique dans deux milieux différents (milieu organique aprotique et mixte eau/éthanol : 1/4) avec KClO4 et H2SO4 comme...

Le 1-hydroxyéthylferrocène, a été synthétisée par la réduction de Fc-CO-CH3 approprié, avec LiAlH réduction de l’acétylferrocène. L'étude électrochimique d’alcool et de métanitrophénylferrocène ont été étudiée par la voltammétrie cyclique dans deux milieux différents (milieu organique aprotique et mixte eau/éthanol : 1/4) avec KClO4 et H2SO comme...

La synthèse de dithioliques (nitrones) 1 et (imines) 2, conduit par la condensation de p-nitroso N,N-diméthylaniline sur les 5-méthyl-1,2-dithiole-3-thiones diversement substituées en position 4. Cette réaction conduite, de manière surprenante, à un mélange de nitrones et d'imines. D'une manière générale, les dithiolethiones et les dithiolones étud...

Laboratoire de valorisation et promotion des ressources sahariennes (VPRS) Site de l'université KASDI Merbah-Ouargla : http:/www.ouargla-univ.dz E-mails du secrétariat du JICOC 2012 : jicoc30@yahoo.fr

The first part of the present study concerns the synthesis of new N-heterocyclic ligands motivated by ferrocenyl in order to be used later in catalysis. The carbenes which contain Ferrocenyl sustitutes are target interesting compounds resulting from stereoelectronic influence of the Ferrocenyl group in terms of steric protections and electrodonatio...