Lay Hong Chuah

Lay Hong Chuah
Monash University (Malaysia) · School of Pharmacy

MPharm (Strathclyde), PhD (Nottingham)

About

51
Publications
20,812
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1,252
Citations
Additional affiliations
April 2013 - present
Monash University (Malaysia)
Position
  • Lecturer

Publications

Publications (51)
Article
The significant growth in type 2 diabetes mellitus (T2DM) prevalence strikes a common threat to the healthcare and economic systems globally. Despite the availability of several anti-hyperglycaemic agents in the market, none can offer T2DM remission. These agents include the prominent incretin-based therapy such as glucagon-like peptide-1 receptor...
Article
Full-text available
Sunlight is an important factor in regulating the central circadian rhythm, including the modulation of our sleep/wake cycles. Sunlight had also been discovered to have a prominent influence on our skin’s circadian rhythm. Overexposure or prolonged exposure to the sun can cause skin photodamage, such as the formation of irregular pigmentation, coll...
Article
Full-text available
The purpose of this work was to study the biodistribution of niosomes in tumor-implanted BALB/c mice using gamma scintigraphy. Niosomes were first formulated and characterized, then radiolabeled with Technetium-99 m ( 99m Tc). The biodistribution of 99mTc-labeled niosomes was evaluated in tumor-bearing mice through intravenous injection and imaged...
Article
Full-text available
Background: With the increased availability of safe antiretroviral therapy (ART) in recent years, achieving optimal adherence and patient retention is becoming the biggest challenge for people living with HIV (PLWH). Care retention is influenced by several socioeconomic, socio-cultural, and government policies during the COVID-19 pandemic. Therefor...
Article
Full-text available
There are many extrinsic factors that can contribute to the premature aging of the skin. In recent years, the demand for natural cosmetic from the general population has noticeable grow. Therefore, this research aimed to investigate the bioproperties of sky fruit (Swietenia macrophylla) seed extract that could help to inhibit premature skin aging....
Article
The use of sunscreens in our daily lives to reduce UV exposure on our skin is a good measure against photoaging. However, the current active ingredients in the market are not able to cover the entire spectrum range of UVA and UVB. Therefore, broader spectrum compounds are constantly being searched by cosmetic companies to replace the commercially a...
Article
Full-text available
In this day and age, the expectation of cosmetic products to effectively slow down skin photoaging is constantly increasing. However, the detrimental effects of UVB on the skin are not easy to tackle as UVB dysregulates a wide range of molecular changes on the cellular level. In our research, irradiated keratinocyte cells not only experienced a com...
Article
G protein-coupled receptors (GPCRs) belong to the largest family of protein targets comprising over 800 members in which at least 500 members are the therapeutic targets. Among the GPCRs, G protein-coupled estrogen receptor-1 (GPER-1) has shown to have the ability in estrogen signaling. As GPER-1 plays a critical role in several physiological respo...
Article
Cancer ranks in second place among the cause of death worldwide. Cancer progress in multiple stages of carcinogenesis and metastasis programs through complex pathways. Sex hormones and their receptors are the major factors in promoting cancer progression. Among them, G protein-coupled estrogen receptor-1 (GPER) has shown to mediate cellular signali...
Article
Full-text available
Retinal pigment epithelial (RPE) cells are an essential part of the human eye because they not only mediate and control the transfer of fluids and solutes but also protect the retina against photooxidative damage and renew photoreceptor cells through phagocytosis. However, their function necessitates cumulative exposure to the sun resulting in UV d...
Article
Full-text available
A library of 126 compounds with a 6,N²-diaryl-1,3,5-triazine-2,4-diamine scaffold was prepared using a one-pot, microwave-assisted method from readily available cyanoguanidine, aromatic aldehydes and arylamines. The three-component condensation of these reagents in the presence of hydrochloric acid was followed by the treatment with a base, which p...
Article
Full-text available
Molecular docking is one of the most frequently used technique in structure-based drug design. Molecular docking can predict the binding-conformation and interactions of small molecule to the appropriate binding site within the target protein. This tutorial aimed to design a step by step protocol to get the basic insight into the molecular docking...
Article
Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. Resistance to apoptosis is a hallmark of virtually all malignancies. Despite being a cause of pathological conditions, apoptosis could be a promising target in cancer treatment. Tumor necrosis factor (TNF)-related apoptosis-inducing l...
Chapter
Curcumin (CUR) is the bio-active agent found in turmeric and has been used for centuries as a flavouring and colouring agent in the Southeast Asian cuisine. It possesses a wide range of biological activities, such as anti-inflammatory, antioxidant, antimicrobial, antirheumatic and anticancer characteristics. CUR is a desirable anticancer agent as i...
Method
Full-text available
UVC is one of the three forms of ultraviolet radiation that is produced by the sun and is harmful to those who are exposed to it. On earth, our ozone layer acts as a filter against UVC (solar UVC) from the sun. However, this is not the case for those exploring space as there would not be any filter for solar UVC once out of Earth's atmosphere. Addi...
Article
Full-text available
UVC is one of the three forms of ultraviolet radiation that is produced by the sun and is harmful to those who are exposed to it. On earth, our ozone layer acts as a filter against UVC (solar UVC) from the sun. However, this is not the case for those exploring space as there would not be any filter for solar UVC once out of Earth’s atmosphere. Addi...
Article
Full-text available
Colorectal cancer (CRC) is the third most prevalent form of cancer, after lung cancer and breast cancer, with the second highest death incidence. Over the years, natural compounds have been explored as an alternative to conventional cancer therapies such as surgery, radiotherapy, and chemotherapy. Curcumin, an active constituent of turmeric has bee...
Article
Piroxicam-CMSC solid dispersions were produced by spray drying from aqueous solvents. Depending on the drug-polymer ratio, loading and entrapment efficiency of CMSC microparticles were 6.8–46.75 and 40.79–60.35% w/w, respectively. Scanning electron microscopy revealed non-spherical geometry and agglomeration of the spray-dried particles. The averag...
Data
Full range FTIR spectra (400–4,000 cm−1) of DTPA anhydride, TPGS, and synthesized TPGS-DTPA. Abbreviations: DTPA, diethylenetriaminepentaacetic acid; FTIR, Fourier-transform infrared spectroscopy; TPGS, d-α-tocopherol polyethylene glycol 1000 succinate.
Data
1H NMR spectrum (0–2.4 ppm) of TPGS. Abbreviations: NMR, nuclear magnetic resonance; TPGS, d-α-tocopherol polyethylene glycol 1000 succinate.
Data
1H NMR spectrum (2–4.4 ppm) of TPGS. Abbreviations: NMR, nuclear magnetic resonance; TPGS, d-α-tocopherol polyethylene glycol 1000 succinate.
Data
13C NMR spectrum (0–180 ppm) of synthesized TPGS-DTPA. Abbreviations: NMR, nuclear magnetic resonance; TPGS-DTPA, d-α-tocopherol polyethylene glycol 1000 succinate-diethylenetriaminepentaacetic acid.
Data
1H NMR spectrum (0–5 ppm) of synthesized TPGS-DTPA. Abbreviations: NMR, nuclear magnetic resonance; TPGS-DTPA, d-α-tocopherol polyethylene glycol 1000 succinate-diethylenetriaminepentaacetic acid.
Data
13C NMR spectrum (0–180 ppm) of TPGS. Abbreviations: NMR, nuclear magnetic resonance; TPGS, d-α-tocopherol polyethylene glycol 1000 succinate.
Chapter
Since its discovery in the 1900s, vitamin E remains an essential micronutrient, playing a pivotal role as an antioxidant and neuroprotection agent. It is a family of compounds categorized into two groups based on chemical structure, i.e. tocopherols and tocotrienols. Although tocopherols are widely recognized due to their abundance in vegetable oil...
Article
Full-text available
Background and purpose Niosomes are nonionic surfactant-based vesicles that exhibit certain unique features which make them favorable nanocarriers for sustained drug delivery in cancer therapy. Biodistribution studies are critical in assessing if a nanocarrier system has preferential accumulation in a tumor by enhanced permeability and retention ef...
Article
Full-text available
Three-dimensional cell culture methods revolutionize the field of anticancer drug discovery, forming an important link-bridge between conventional in vitro and in vivo models and conferring significant clinical and biological relevant data. The current work presents an affordable yet reproducible method of generating homogenous 3D tumor spheroids....
Method
Full-text available
Three-dimensional cell culture methods revolutionize the field of anticancer drug discovery, forming an important link-bridge between conventional in vitro and in vivo models and conferring significant clinical and biological relevant data. The current work presents an affordable yet reproducible method of generating homogenous 3D tumor spheroids....
Article
Full-text available
G protein-coupled estrogen receptor-1 (GPER-1) is a seven transmembrane receptor, responsible for mediating rapid estrogen signaling in many physiological responses in reproductive, nervous, endocrine, immune and cardiovascular systems. Due to unavailability of the crystal structure of GPER-1, we have performed sequential ligand-based virtual scree...
Article
Background and purpose: Niosomes are nonionic surfactant-based vesicles that exhibit certain unique features which make them favorable nanocarriers for sustained drug delivery in cancer therapy. Biodistribution studies are critical in assessing if a nanocarrier system has preferential accumulation in a tumor by enhanced permeability and retention e...
Article
Background Pharmacists as highly qualified professionals face ethical dilemmas and conflicts in their daily practice. These issues manifest themselves in the daily practice of pharmacists, which require pharmacists to have the competencies to manage these dilemmas but there is limited formal training in ethical decision making during undergraduate...
Article
Despite advances in the treatment regimen, the high incidence rate of breast cancer (BC) deaths is mostly caused by metastasis. Recently, the aberrant epigenetic modifications, which involve DNA methylation, histone modifications and microRNA (miRNA) regulations become attractive targets to treat metastatic breast cancer (MBC). In this review, the...
Article
Red palm oil was encapsulated in carboxymethyl sago cellulose (CMSC) beads by emulsification and ionotropic gelation using aluminium chloride as a gelling agent. The influence of % of CMSC, plasticizer (glycerine or polyethylene glycol) and drying method on the shape, surface, and stability of the beads prepared by vibration technology were evaluat...
Article
Full-text available
Bacterial foodborne pathogens are a significant health burden and the recent emergence of pathogenic resistant strains due to the excessive use of antibiotics makes it more difficult to effectively treat infections as a result of contaminated food. Awareness of this impending health crisis has spurred the search for alternative antimicrobials with...
Article
E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by sequestering β-catenin from its binding to LEF (Lymphoid enhancer factor)/TCF (T cell factor) which serves the function of transcribing genes of the proliferative Wnt sig...
Article
Full-text available
Surfactin, a cyclic lipopeptide biosurfactant produced by various strains of Bacillus genus, has been shown to induce cytotoxicity against many cancer types, such as Ehrlich ascites, breast and colon cancers, leukemia and hepatoma. Surfactin treatment can inhibit cancer progression by growth inhibition, cell cycle arrest, apoptosis, and metastasis...
Article
Full-text available
Vibrio vulnificus is a Gram negative, rod shaped bacterium that belongs to the family Vibrionaceae. It is a deadly, opportunistic human pathogen which is responsible for the majority of seafood-associated deaths worldwide. V. vulnificus infection can be fatal as it may cause severe wound infections potentially requiring amputation or lead to sepsis...
Article
Full-text available
Vitamin E is recognized as an essential vitamin since its discovery in 1922. Most vegetable oils contain a mixture of tocopherols and tocotrienols in the vitamin E composition. Structurally, tocopherols and tocotrienols share a similar chromanol ring and a side chain at the C-2 position. Owing to the three chiral centers in tocopherols, they can ap...
Article
Full-text available
Cancer mortality and morbidity is projected to increase significantly over the next few decades. Current chemotherapeutic strategies have significant limitations, and there is great interest in seeking novel therapies which are capable of specifically targeting cancer cells. Given that fundamental differences exist between the cellular membranes of...
Article
Full-text available
Rice is a staple food source for more than three billion people worldwide. However, rice is vulnerable to diseases, the most destructive among them being rice blast, which is caused by the fungus Magnaporthe oryzae (anamorph Pyricularia oryzae). This fungus attacks rice plants at all stages of development, causing annual losses of approximately 10–...
Poster
Full-text available
As specified by the European Pharmacopoeia, thin layer chromatography (TLC) is the method used for the measurements of radiochemical purity of technetium (99mTc) medronate. For decades and as specified by the pharmacopoeia, Instant Thin Layer Chromatography Silica Gel (ITLC-SG) stationary phase has been used. However, in 2008 the manufacture of thi...
Article
Tumor metastasis involves some of the most complex and dynamic processes in cancer, often leading to poor quality of life and inevitable death. The search for therapeutic compounds and treatment strategies to prevent and/or manage metastasis is the ultimate challenge to fight cancer. In the past two decades, research focus on vitamin E has had a sh...
Poster
Full-text available
Niosomes capable of entrapping and retaining tocotrienol-rich fraction (TRF) were prepared with Span 60, cholesterol and TPGS using two methods: stirring method (SM) and thin film hydration method (FHM). The niosomal formulations were evaluated for particle size and drug loading. HPLC analysis revealed that SM niosomes had encapsulated double the a...
Article
Real-time nanoparticle tracking analysis (NTA) was used to evaluate the propensity of curcumin-containing chitosan nanoparticles (CUR-CS-NP) to muco adhere and release curcumin under simulated colon conditions. This novel procedure is relatively simple and fast and does not require use of animals, but more importantly, it permits the correlation of...
Article
Full-text available
In the present study, we investigate the mucoadhesive characteristics and release of the anticancer agent curcumin, contained in chitosan nanoparticles (CS-NPs). Such a system has potential therapeutic benefits in the treatment of colon cancer through prolonged retention and delivery. The CS-NPs were ionically gelled with tripolyphosphate (TPP) and...

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