Lawrence E Kurlandsky

• Doctor of Medicine
• SUNY Upstate Medical University

Elevated levels of exhaled carbon monoxide have been reported in patients with active or persistent asthma or allergic rhinitis. With the recent availability of a noninvasive pulse CO-Oximeter that measures carboxyhemoglobin, measurements were made on healthy clinic staff as well as children with controlled or active asthma and asymptomatic or acti...

Carboxyhemoglobin levels may be elevated by the inspiration of environmental carbon monoxide or as a result of its endogenous production by inducible heme oxygenase, which is a stress protein that breaks down heme. Heme breakdown products, including carbon monoxide, have antioxidant, anti-inflammatory, and cytoprotective effects. Increased exhaled...

A North American medical school holds a pediatric clerkship in 6 widely separated locations. To provide uniform exposure to the pediatric curriculum in these sites, a new technique using written cases assigned to students for independent study was developed. Since student experiences varied across campuses and over time, flexibility in case assignm...

Our objective was to determine the in vitro activity of minocycline against isolates of Burkholderia cepacia (BC), Stenotrophomonas maltophilia (SM), and Pseudomonas aeruginosa (PA) cultured from the respiratory tract of patients with cystic fibrosis (CF). Cultures of BC, SM, and PA were isolated in a hospital bacteriology laboratory from the sputu...

Our objective was to determine the in vitro activity of minocycline against isolates of Burkholderia cepacia (BC), Stenotrophomonas maltophilia (SM), and Pseudomonas aeruginosa (PA) cultured from the respiratory tract of patients with cystic fibrosis (CF). Cultures of BC, SM, and PA were isolated in a hospital bacteriology laboratory from the sputu...

Background: The growing recognition of the need for primary care physicians, despite the declining numbers of medical graduates choosing these careers, has led medical schools to evaluate the focus of their instruction. Many have blamed traditional academic medical centers for this problem and called for fundamental reforms designed to encourage pr...

Somatic mosaicism in genetic disease generally results from a de novo deleterious mutation during embryogenesis. We now describe a somatic mosaicism due to the unusual mechanism of in vivo reversion to normal of an inherited mutation. The propositus was an adenosine deaminase-deficient (ADA-) child with progressive clinical improvement and unexpect...

We identified the remarkable event of in vivo reversion to normal of an inherited mutation as the basis for somatic mosaicism of lymphoid cells in an adenosine deaminase (ADA) deficient patient. Somatic mosaicism was associated with mild clinical course, substantial residual ADA activity in lymphoid cells (15% NI), minimally elevated toxic metaboli...

The substitution of omega-3 (n-3) fatty acids for omega-6 (n-6) fatty acids generates eicosanoids with diminished inflammatory effects. As the lungs of patients with cystic fibrosis (CF) are in a state of chronic inflammation in which increased amounts of eicosanoids are found, n-3 supplementation may reduce this level of inflammation and result in...

To determine whether multiple and diverse clinical settings and resources in a pediatric clerkship result in satisfactory performance by medical students and affect their choice of a pediatric residency after graduation. Retrospective study 1985 through 1990. Medical students in a pediatric clerkship in a medical school that is part of a land grant...

We report a child with partial adenosine deaminase (ADA) deficiency who in infancy had clinical features suggestive of the hyperimmunoglobulinemia E syndrome (HIE), including recurrent staphylococcal cutaneous abscesses and pneumonia, atopic dermatitis, and sinusitis associated with lymphopenia, eosinophilia, and an elevated IgE of 16,400 IU/ml. No...

Common pulmonary vein atresia is a rare congenital anomaly that is rapidly fatal unless immediately recognized and corrected by surgical intervention. This article describes three neonates who died with the diagnosis soon after birth. In the constellation of presenting clinical features in each case, the occurrence of early spontaneous pneumothorax...

Respiratory syncytial virus (RSV) is a cause of significant morbidity and mortality in infants and children with an immunocompromised status or a congenital heart disease. The following case describes a 6 8/12-year-old, previously normal child who had a fatal interstitial pneumonitis caused by RSV. Documentation of RSV as the etiologic agent and do...

The ciliated, mucus-secreting urn cell complex (UCC) is found swimming in the coelomic cavity of the marine invertebrate Sipunculus nudus. This cell complex, which can be maintained in suspension cultures, responds to various stimuli by hypersecreting mucus in the form of a cohesive mucus "tail." This tail can be measured and expressed as a multipl...

The activation of the terminal complement components, C3--9, plays an important role in the host's defense against infection. In the present study, the ability of bacteria to activate the third component of complement (C3) in newborn serum was examined. A variety of bacteria were incubated in test sera at 37 degrees C for 30 min and the percent of...

In the article, "Munchausen Syndrome by Proxy: Definition of Factitious Bleeding in An Infant by 51Cr Labeling of Erythrocytes" by Kurlandsky et al (Pediatrics 63: 228-231, February 1979) "vocal chords" (p 229, col 1) should be spelled "vocal cords."

The Munchausen syndrome by proxy is a phenomenon in which symptoms of a disease are fabricated by some person other than the patient. This report describes and 8-week-old infant with repetitive bleeding episodes, presumably originating from the upper respiratory tract. Extensive investigations, including angiography, several endoscopies under gener...

Brodie's abscess is a form of subacute osteomyelitis which is defined by a particular constellation of clinical, radiological and pathological features. Its occurrence in infants is extremely rare. This case documents just such an occurrence. To our knowledge, the pathogen Haemophilus influenzae has not been previously recognized as a cause of Brod...

In vitro assays have demonstrated the presence of a “factor” in the serum of patients with cystic fibrosis (CF) which alters mucus production and ciliary action. A more quantitative assay system is needed. Mucociliated “urn cells”, which are found in the coelamic fluid of the marine invertebrate Sipunculus nudus are being used to approach this prob...