Lavinia Grasso

Lavinia Grasso
University of Milan | UNIMI · Department of Bioscience

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4
Publications
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39
Citations

Publications

Publications (4)
Article
Full-text available
Ethanol is a ubiquitous environmental stressor that is toxic to all lifeforms. Here, we use the model eukaryote Saccharomyces cerevisiae to show that exposure to sublethal ethanol concentrations causes DNA replication stress and an increased mutation rate. Specifically, we find that ethanol slows down replication and affects localization of Mrc1, a...
Article
Full-text available
In the last decade, it has become evident that RNA is frequently found in DNA. It is now well established that single embedded ribonucleoside monophosphates (rNMPs) are primarily introduced by DNA polymerases and that longer stretches of RNA can anneal to DNA, generating RNA:DNA hybrids. Among them, the most studied are R-loops, peculiar three-stra...
Article
Full-text available
RNA:DNA hybrids are transient physiological inter-mediates that arise during several cellular processes such as DNA replication. In pathological situations, they may stably accumulate and pose a threat to genome integrity. Cellular RNase H activities process these structures to restore the correct DNA:DNA sequence. Yeast cells lacking RNase H are n...

Questions

Question (1)
Question
Hello everyone, I would like to understand how the FiberStudio analysis program provided by the Genomic Vision facility works. I tried to find a demo version of the program or a video tutorial, but I didn't find anything. I hope that someone knows the tool and could give me some feedbacks. In particular I would like to understand if it is worth to be used instead of programs like MetaMorph or ImageJ. Thank you very much for your help!

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