Lavanya Yaidikar

Seven Hills College of Pharmacy · Pharmacology

Diabetes is the most prevailing health disorder with high mortality rate and showing increased health costs across the globe. World Health Organization has claimed that lifestyle changes are one of the major causes of diabetes in this modern living. Gliclazide is an oral antidiabetic drug that is taken by majority of patients suffering with type-2...

World Health Organization has mentioned that one of the most prevailing health complications across the globe is diabetes and it is the major reason for deaths due to comorbidities. Once the person is affected by diabetes, it is said to be a lifelong treatment and hence patients look after supportive therapy in general. Nutraceuticals are one such...

AMP activated protein kinase (AMPK) regulates various signalling pathways which are concerned with upholding energy equilibrium. In many catabolic and anabolic pathways, AMPK acts as a switch control. The present study is to find out the effect of edible oil on AMPK pathway in rabbit lipid Metabolism. The study is conducted as per CPCSEA guidelines...

Objective: To investigate the protective effect of Hippophae salicifolia D.Don (H. salicifolia) berries extract against cerebral reperfusion injury induced neurobehavioral and neurochemical changes in a rat model of middle cerebral artery occlusion (MCAO). Methods: Rats were pretreated with alcoholic extract of H. salicifolia (250 and 500 mg/kg) fo...

Background: Arjunolic acid (AA), a pentacyclic triterpenoidal saponin of Terminalia arjuna is well recognized for its antioxidant properties. We proposed to evaluate its antioxidant potential against focal cerebral ischemia reperfusion (I/R) injury in rats subjected to middle cerebral artery occlusion (MCAO). Methods: In the present study, rats...

Icariin (ICA), a flavonol glycoside derived from several species of plants belonging to genus Epimedium, family berberidaeceae. It is well known for its antioxidant properties. Its antioxidant potential against cisplatin induced nephrotoxicity is not yet reported. The present study is hypothesized and proposed to evaluate the antioxidant potential...

Punicalagin (PG) is a hydrolysable tannin compound found in Punica granatum L. The purpose of the present work is to explore the neuroprotective mechanism of PG against ischemia–reperfusion (I/R) injury in rat model of middle cerebral artery occlusion (MCAO). Rats were randomly divided into sham, MCAO, and PG-treated groups. PG (15 and 30 mg/kg), t...

Background: Punicalagin (PG) is a hydrolyzable polyphenol in Punica granatum. It has been previously reported that it has a protective effect against hypoxia-induced ischemia brain injury. It is a potent antioxidant. The present study is aimed to evaluate the antioxidant potential of PG against focal cerebral ischemia-reperfusion injury in rats su...

Argyreia nervosa (AN) is traditionally used in rheumatic disorders, cerebral disorders, syphilis, leucohohhrea and as wound healing agent. We aimed to validate the anti-arthritic effect of AN in Freund Complete Adjuvant (FCA) induced arthritis rats. The effects of hydroalcoholic extract of Argyreia nervosa leaves on the changes in rheumatoid factor...

The present study was aimed at investigating the ameliorative effect of Tinospora cordifolia in sciatic nerve root Ligation -induced sciatica pain in rats. Adult male albino rats weighing 130-150gm were used for the study, and were divided into seven groups and ligation was performed on left sciatic nerve in group II to group VII. Tail cold-hyperal...