Lavanya Yaidikar

Seven Hills College of Pharmacy · Pharmacology

One possible approach to developing prolonged release devices is to optimize liquisolid technology in such a way that the drug dissolves at a slower rate. In this experiment, metoprolol succinate was dispersed in polyethylene glycol 400, a liquid medium. Subsequently, the medication was continuously combined in a mortar with a binary mixture of car...

One obstacle to using topical insulin effectively is finding a reliable and efficient carrier to transport the hormone to the area of the wound where it needs to be applied. There is more time for insulin absorption in the new formulation, and experiments done efore formulation show that it is stable. The ideal application features of insulin hydro...

2024) Investigation of Moringa oliefera leaf hydroalcoholic extract's pharmacognostic, phytochemical, and antioxidant effects. Frontiers in Health Informatics, 13 (4), 436-443 ABSTRACT: Background and Objectives: Moringa oleifera, which is in the Moringaceae family, is thought to be one of the most useful plants for medicine. M. oleifera has pods,...

One possible approach to developing prolonged release devices is to optimize liquisolid technology in such a way that the drug dissolves at a slower rate. In this experiment, metoprolol succinate was dispersed in polyethylene glycol 400, a liquid medium. Subsequently, the medication was continuously combined in a mortar with a binary mixture of car...

Polyphenols are a class of secondary metabolic products found in plants that have been extensively studied for how well they regulate biological processes, such as the proliferation of cells, autophagy, and apoptosis. The mitogen-activated protein kinase (MAPK)-mediated signaling cascade is currently identified as a crucial pro-inflammatory pathway...

Chrysin (5,7-dihydroxyflavone) is a flavonoid with a vast number of pharmacological properties because of its antioxidant potential. Chronic stress is one of the predominant etiological factors which evoke molecular alterations in the brain leading to the development of depressive disorder. In the present study, we investigated the effect of Chrysi...

Diabetes is the most prevailing health disorder with high mortality rate and showing increased health costs across the globe. World Health Organization has claimed that lifestyle changes are one of the major causes of diabetes in this modern living. Gliclazide is an oral antidiabetic drug that is taken by majority of patients suffering with type-2...

World Health Organization has mentioned that one of the most prevailing health complications across the globe is diabetes and it is the major reason for deaths due to comorbidities. Once the person is affected by diabetes, it is said to be a lifelong treatment and hence patients look after supportive therapy in general. Nutraceuticals are one such...

AMP activated protein kinase (AMPK) regulates various signalling pathways which are concerned with upholding energy equilibrium. In many catabolic and anabolic pathways, AMPK acts as a switch control. The present study is to find out the effect of edible oil on AMPK pathway in rabbit lipid Metabolism. The study is conducted as per CPCSEA guidelines...

Objective: To investigate the protective effect of Hippophae salicifolia D.Don (H. salicifolia) berries extract against cerebral reperfusion injury induced neurobehavioral and neurochemical changes in a rat model of middle cerebral artery occlusion (MCAO). Methods: Rats were pretreated with alcoholic extract of H. salicifolia (250 and 500 mg/kg) fo...

Background: Arjunolic acid (AA), a pentacyclic triterpenoidal saponin of Terminalia arjuna is well recognized for its antioxidant properties. We proposed to evaluate its antioxidant potential against focal cerebral ischemia reperfusion (I/R) injury in rats subjected to middle cerebral artery occlusion (MCAO). Methods: In the present study, rats...

Icariin (ICA), a flavonol glycoside derived from several species of plants belonging to genus Epimedium, family berberidaeceae. It is well known for its antioxidant properties. Its antioxidant potential against cisplatin induced nephrotoxicity is not yet reported. The present study is hypothesized and proposed to evaluate the antioxidant potential...

Punicalagin (PG) is a hydrolysable tannin compound found in Punica granatum L. The purpose of the present work is to explore the neuroprotective mechanism of PG against ischemia–reperfusion (I/R) injury in rat model of middle cerebral artery occlusion (MCAO). Rats were randomly divided into sham, MCAO, and PG-treated groups. PG (15 and 30 mg/kg), t...

Background: Punicalagin (PG) is a hydrolyzable polyphenol in Punica granatum. It has been previously reported that it has a protective effect against hypoxia-induced ischemia brain injury. It is a potent antioxidant. The present study is aimed to evaluate the antioxidant potential of PG against focal cerebral ischemia-reperfusion injury in rats su...

Argyreia nervosa (AN) is traditionally used in rheumatic disorders, cerebral disorders, syphilis, leucohohhrea and as wound healing agent. We aimed to validate the anti-arthritic effect of AN in Freund Complete Adjuvant (FCA) induced arthritis rats. The effects of hydroalcoholic extract of Argyreia nervosa leaves on the changes in rheumatoid factor...

The present study was aimed at investigating the ameliorative effect of Tinospora cordifolia in sciatic nerve root Ligation -induced sciatica pain in rats. Adult male albino rats weighing 130-150gm were used for the study, and were divided into seven groups and ligation was performed on left sciatic nerve in group II to group VII. Tail cold-hyperal...