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Laust Hvas Mortensen

Laust Hvas Mortensen
Statistics Denmark · Methods and Analysis

PhD

About

189
Publications
14,338
Reads
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3,402
Citations
Additional affiliations
November 2015 - present
Statistics Denmark
Position
  • Chief Advisor
June 2014 - December 2014
Stanford University
Position
  • Visiting Associate Professor
December 2012 - present
University of Copenhagen
Position
  • Professor

Publications

Publications (189)
Article
STUDY QUESTION Does the incidence of spontaneous abortion correlate positively over conception cohorts with the incidence of non-clinically indicated induced abortion as predicted by shared risk aversion?
Article
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with substantial morbidity and mortality. Its prevalence is currently rising partly due to population ageing. However, reported trends in incidence rates are conflicting, and the comparability of existing reports is limited due to methodological inconsistenc...
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Background Ambient air pollution is likely a risk factor for asthma, and recent evidence suggests the possible relevance of road traffic noise. Objectives We examined the associations of long-term exposure to air pollution and road traffic noise with adult-asthma incidence. Methods We followed 28,731 female nurses (age > 44 years) from the Danish...
Preprint
Cellular senescence is a critical component of aging and many age-related diseases, but understanding its role in human health is challenging in part due to the lack of exclusive or universal markers. Using neural networks, we achieve high accuracy in predicting senescence state and type from the nuclear morphology of DAPI-stained human fibroblasts...
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Danish municipalities monitor older persons who are at high risk of declining health and would later need home care services. However, there is no established strategy yet on how to accurately identify those who are at high risk. Therefore, there is great potential to optimise the municipalities’ prevention strategies. Denmark’s comprehensive set o...
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Introduction Colorectal cancer (CRC) does not affect different sociodemographic groups uniformly. CRC screening programmes could seek to reduce this inequality; however, the screening programmes themselves might be subject to differential participation across sociodemographic groups. This study investigates the sociodemographic inequality at all st...
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Background The high level of medical spending at the end of life is well-documented, but whether there is any real potential for cost reductions there is still in question, and studies have tended to overlook the costs of care. Aim To identify the most common health care spending trajectories over the last five years of life among older Danes, as...
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Background Knowledge of the role of melatonin, xenograft experiments, and epidemiological studies suggests that exposure to light at night (LAN) may disturb circadian rhythms, possibly increasing the risk of developing breast cancer. Objectives We examined the association between residential outdoor LAN and the incidence of breast cancer: overall...
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Background Updated population-based estimates on incidence and prevalence of chronic pancreatitis are scarce. Methods We used nationwide healthcare registries to identify all Danish patients diagnosed with chronic pancreatitis and computed crude and standardised incidence rates and prevalence estimates in 1994–2018. Incidence and prevalence were e...
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Background Stroke incidence rates declined in Norway during 2001 to 2014. Atrial fibrillation (AF) incidence rates were stable in the same period. Purpose We aimed to study time trends in incidence (first time) of acute stroke hospitalizations and stroke deaths associated with AF in Norway in the period 2001–2014. Methods Nationwide hospital disc...
Article
Colorectal cancer (CRC) contributes extensively to the overall cancer burden, with substantial and increasing social inequality in both incidence and survival. In several countries, this social inequality in incidence and survival has been increasing over time, and the increase is expected to continue. To overcome this, it is advised to implement n...
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Background The association between air pollution and mortality is well established, yet some uncertainties remain: there are few studies that account for road traffic noise exposure or that consider in detail the shape of the exposure–response function for cause-specific mortality outcomes, especially at low-levels of exposure. Objectives We exami...
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Background: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts. Methods: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderl...
Article
Introduction Social and family conditions are likely of great importance to dental health; however, limited evidence of familial aggregation of caries among adolescent siblings exists. Moreover, social and family-level factors have never been evaluated as isolated caries predictors at the individual level. Objectives The objectives were to evaluat...
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Ambient air pollution has been linked to stroke, but few studies have examined in detail stroke subtypes and confounding by road traffic noise, which was recently associated with stroke. Here we examined the association between long-term exposure to air pollution and incidence of stroke (overall, ischemic, hemorrhagic), adjusting for road traffic n...
Preprint
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In this paper, we study linear regression models built on categorical predictor variables that have a hierarchical structure. For such variables, the categories are arranged as a directed tree, where the categories in the leaf nodes give the highest granularity in the representation of the variable. Instead of taking the fully detailed model, the u...
Article
Introduction: Prior studies have shown associations between a first-born boy and increased risks of pregnancy loss, stillbirth, decreased birth weight, and preterm birth in subsequent pregnancies, but with limited precision. Material and methods: We examined associations between sex of the first-born and obstetric complications in second births....
Article
Background It is unclear how recurrent pregnancy loss ( RPL ) impacts disease risk and whether there is a difference in risk between women with or without a live birth before RPL (primary versus secondary RPL ). We investigated the disease risk following RPL , and whether there was a difference between primary and secondary RPL . Methods and Resul...
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Aim To explore whether increasing parental education has a causal effect on risk of cerebral palsy (CP) in the child, or whether unobserved confounding is a more likely explanation. Method We used data from Norwegian registries on approximately 1.5 million children born between 1967 and 2011. We compared results from a traditional cohort design wi...
Preprint
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The epidemiological transition from young to old deaths in high-income countries reduced mortality at all ages, but a major role was played by a decline of infant and child mortality from infectious diseases1,2 that greatly increased life expectancy at birth2,3. Over time, declines in infectious disease continue but chronic and degenerative causes...
Article
The present register-based study investigated the influence of familial factors on the association of IQ with educational and occupational achievement among young men in Denmark. The study population comprised all men with at least one full brother where both the individual and his brothers were born from 1950 and appeared before a draft board in 1...
Preprint
Background: Pregnancy loss is one of the most frequent pregnancy complications. It is unclear how recurrent pregnancy loss (RPL) impacts disease risk later in life and if later disease risk is different in women with or without a live birth prior to RPL (primary vs. secondary RPL). We sought to investigate if women have an increased risk of disease...
Article
Background: On 13 November 2015, coordinated terrorist attacks swept through Paris. This large stressor, like earlier terrorist attacks in the USA, may have perturbed the health of pregnant women. We test whether the attacks preceded an increase in the risk of preterm parturition among live-born males as well as excess male loss in utero. We focus...
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Objectives Socioeconomic disparities in pregnancy outcomes have been found across times and places, but there is a lack of studies investigating the underlying causes. The present study investigated the influence of child protective services in the pregnant woman’s family of origin as a proxy of childhood social disadvantage. Methods The study popu...
Article
The Danish healthcare system offers free and equal access to healthcare, including free preventive maternity care and birth assistance. Nevertheless, in Denmark, women of low socioeconomic status, especially women with a low level of education, have an increased risk of obstetric complications including low birth weight, preterm birth, stillbirth a...
Article
Objectives We know little about whether an elevated stillbirth sex ratio (ratio of male to female stillbirths) gauges stronger selection in utero against frail male gestations and therefore predicts greater male infant survival. An alternative scenario could involve a “low endowment” case in which pregnancy cohorts show both excess male stillbirths...
Article
Background Socio‐economic disparities in preterm delivery have often been attributed to socially patterned smoking habits. However, most existing studies have used methods that potentially give biased estimates of the mediating effect of smoking. We used a contemporary mediation approach to study to which extent smoking during pregnancy mediates ed...
Article
Aims: Educational inequality in cardiovascular disease and in modifiable risk factors changes over time and between birth cohorts. We aimed to assess how cardiovascular disease risk factors mediate educational differences in premature cardiovascular disease mortality and how this varies over birth cohorts and sex. Methods: We followed 360,008 40...
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It has been reported that foetal death follows a seasonal pattern. Influenza virus infection has been postulated as one possible contributor to this seasonal variation. This ecological study explored the temporal association between the influenza activity and the frequency of foetal death. Time series analysis was conducted using weekly influenza-l...
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Objective To investigate socioeconomic differences in six perinatal health outcomes in Denmark in the first decade of the 21st century. Design A population-based cohort study. Setting Danish national registries. Participants A total of 646 829 live born children and 3076 stillborn children (≥22+0 weeks of gestation) born in Denmark from 2000 to...
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Purpose Synthetic oxytocin for labor augmentation during birth has been linked to negative neurodevelopment effects in children. We examined whether maternal labor augmentation was associated with lower cognitive ability in young adulthoods. Patients and methods We identified 330,107 individuals (96.6% were men), with noninduced labor and with a c...
Article
While existing research on regions with high prevalence of centenarians has focused on selected candidate geographical regions, we explore the existence of hotspots in the whole of Denmark.We performed a Kulldorff spatial scan, searching for regions of birth, and of residence at age 71, where an increased percentage of the cohort born 1906-1915 bec...
Article
Background: International comparisons of stillbirth allow assessment of variations in clinical practice to reduce mortality. Currently, such comparisons include only stillbirths from 28 or more completed weeks of gestational age, which underestimates the true burden of stillbirth. With increased registration of early stillbirths in high-income cou...
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Objectives To investigate the associations of interpregnancy interval (IPI) with miscarriage, stillbirth, preterm delivery and small for gestational age delivery. Methods The study population comprised all women who had a live birth and at least one subsequent pregnancy in Denmark during the period from 1994 to 2010 (N = 328,577). Linear regression...
Article
Introduction Sibling designs in assessing familial aggregation and risk prediction of dental caries have been largely unutilized. This large-scale investigation evaluated the robustness of parental socioeconomic position (SEP) as a cardinal determinant of caries experience by appraising it at the family level. Moreover, sibling-specific aggregation...
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Background Cystic fibrosis (CF) is a chronic, life-shortening disease with a significant treatment burden. To support young adults with CF in their everyday life, we previously conducted a life coaching feasibility trial (published elsewhere). The aim of the current study was to explore how life coaching was experienced by study participants within...
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Increased mortality has been observed in mothers and fathers with male offspring but little is known regarding specific diseases. In a register linkage we linked women born 1925–1954 having survived to age 50 (n = 661,031) to offspring and fathers (n = 691,124). Three approaches were used: 1) number of total boy and girl offspring, 2) sex of the fi...
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Objective To estimate the relation of single-layer closure at previous caesarean delivery, and other pre-labour and intra-partum risk factors for complete uterine rupture in trial of vaginal birth after a caesarean (TOLAC) at term. Study design Population-based case-control study. We identified all women (n = 39 742) recorded in the Danish Medical...
Article
Background: The Physical Activity Scale (PAS2) was developed to measure physical activity (PA) during work, transportation and leisure time, in the Danish adult population. The objective of this study was to assess the criterion validity of PAS2 against a combined accelerometer and heart rate monitor in Danish adults and to investigate if the crit...
Article
Aims: Educational inequality in diseases in the circulatory system (here termed cardiovascular disease) is well documented but may be confounded by early life factors. The aim of this observational study was to examine whether the associations between education and all cardiovascular diseases, ischaemic heart disease and stroke, respectively, were...
Article
Background: The Physical Activity Scale (PAS2) was developed to measure physical activity during work, transportation, and leisure time, in the Danish adult population. The objective of this study was to assess the criterion validity of PAS2 against a combined accelerometer and heart rate monitor in Danish adults and to investigate if the criterion...
Article
Background: Few studies have investigated international variations in the gestational age (GA) distribution of births. While preterm births (22-36 weeks GA) and early term births (37-38 weeks) are at greater risk of adverse health outcomes compared to full term births (39-40 weeks), it is not known if countries with high preterm birth rates also h...
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Background Over the last two decades, lifespan has increased significantly for people living with cystic fibrosis (CF). However, several studies have demonstrated that many young adults with CF report mental health problems and poor adherence to their prescribed treatments, challenging their long-term physical health. Treatment guidelines recommend...
Preprint
Full-text available
Background The study of regions with high prevalence of centenarians is motivated by a desire to find determinants of healthy ageing. While existing research has focused on selected candidate geographical regions, we explore the existence of hotspots in the whole the Denmark, which is a small and homogeneous country. Methods We performed a Kulldor...
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Objective To explore the importance of early life factors shared by siblings, such as parental socioeconomic position, parental practices, housing and neighbourhood, for the association between cardiovascular disease (CVD) risk factors and mortality from CVD, ischaemic heart disease (IHD) and cerebrovascular disease. Methods Norwegian health surve...
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Background Elective abortions show a secular decline in high income countries. That general pattern, however, may mask meaningful differences—and a potentially rising trend—among age, income, and other racial/ethnic groups. We explore these differences in Denmark, a high-income, low-fertility country with excellent data on terminations and births....
Article
Background: Scandinavian welfare states, despite having better population oral health than less egalitarian societies, are characterized by ubiquitous social gradients and large relative socioeconomic inequalities in oral health. However, trends in these inequalities among Scandinavian children and adolescents have not been studied in detail. Obj...
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Background Various indicators of childhood socioeconomic position have been related to cardiovascular disease (CVD) risk in adulthood. We investigated the impact of shared family factors on the educational gradient in midlife CVD risk factors by assessing within sibling similarities in the gradient using a discordant sibling design. Methods Norwegi...
Article
Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood cancer in offspring in a large...
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Advanced paternal age has been associated with a variety of rare conditions and diseases of great public health impact. An increased number of de novo point mutations in sperm with increasing age have been suggested as a mechanism, which would likely also affect fetal viability. We examined the association between paternal age and stillbirth rate i...
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Circumstances in the family of origin have short- and long-term consequences for people's health. Family background also influences educational achievements – achievements that are clearly linked to various health outcomes. Utilizing population register data, we compared Swedish siblings with different levels of education (1,732,119 individuals wit...
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Background Socioeconomic inequalities in birth weight and in body mass index (BMI) later in childhood are in opposite directions, which raises questions about when during childhood the change in direction happens. We examined how maternal and paternal education and household income were associated with birthweight z-scores and with BMI z-scores at...
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Background: Cystic fibrosis (CF) is a life shortening disease, however prognosis has improved and the adult population is growing. Most adults with cystic fibrosis live independent lives and balance the demands of work and family life with a significant treatment burden. The aim of this study was to examine the relationships among treatment adhere...
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Full-text available
Objectives Prior work has examined the shape of the income–mortality association, but work has not compared gradients between countries. In this study, we focus on changes over time in the shape of income–mortality gradients for 4 Nordic countries during a period of rising income inequality. Context and time differentials in shape imply that the re...