Laurie Chassin

• Phd
• Arizona State University

Objective: The theory of aversive transmission posits that children of parents who have an alcohol use disorder (AUD) may abstain or limit their own alcohol use because they believe themselves to be at risk of developing problems with alcohol. The present study examined relationships among parental AUD, perceived parental AUD, perceived risk for AU...

As part of the special issue of Development and Psychopathology honoring the remarkable contributions of Dr Dante Cicchetti, the current paper attempts to describe the recent contributions that a developmental psychopathology perspective has made in understanding the development of alcohol use and alcohol-related problems over the lifespan. The pap...

Research suggests that parental substance use disorder is associated with adolescent drinking indirectly through negative urgency, a form of impulsivity that is particularly associated with high-risk drinking. Moreover, childhood mechanisms of risk may play a role in this developmental chain such that childhood temperament and parenting may be mech...

The genetic architectures underlying symptoms of conduct problems and depression have largely been examined separately and without incorporating temperament, despite evidence for their genetic overlap. We examined how symptoms and temperament dimensions were transmitted together in families to identify highly heritable composite phenotypes, and how...

Involvement of grandparents in grandchildren’s lives is important for grandchild well-being. Studies suggest that the quality of relationships between grandparents and their adult children may “spill over” to the quality of their relationships with their grandchildren. However, no research has tested whether grandparent alcohol use disorder (AUD) d...

Background The Acquired Preparedness Model (APM) posits that highly impulsive individuals develop stronger positive alcohol expectancies, which in turn predicts heavier drinking. However, most acquired preparedness studies have focused solely on between‐person relations, despite the theory suggesting that there are potential developmental‐specific...

There is evidence for intergenerational transmission of substance use and disorder. However, it is unclear whether separation from a parent with substance use disorder (SUD) moderates intergenerational transmission, and no studies have tested this question across three generations. In a three-generation study of families oversampled for familial SU...

Previous theories have emphasized genetic effects “inside the skin” via endophenotypes within the broader developmental psychopathology theory. Expanding on the mechanisms of gene-environment correlation, we propose a new integrative framework emphasizing how genetic effects “outside the skin” (Reiss & Leve, 2007) accumulate due to individual varia...

Objective Reductions in substance involvement into adulthood are thought to represent a normative maturing out of substance use. However, patterns and predictors of maturing out of alcohol and cannabis co‐use remain largely unstudied. Therefore, the current study tested developmental trajectories of alcohol and cannabis use from late adolescence in...

Theory suggests that behavioral undercontrol mediates the effect of parental substance disorder on offspring substance use, but no studies have tested multidimensional impulsive personality traits as mechanisms of risk. Adolescents (N = 392; 48% female) from a multigenerational study of familial alcohol disorder self-reported impulsive personality...

Substantial effort has gone into neuroimaging studies of neural mechanisms underlying addiction. Human studies of smoking typically either give monetary reward during an fMRI task or else allow subjects to smoke outside the scanner, after the session. This raises a fundamental issue of construct validity, as it is unclear whether the same neural me...

Objective: Several studies find between-person reciprocal relations between adolescent/college drinking and positive expectancies. However, drinking and expectancies from college into adulthood are largely unstudied, as are within-person associations. During these age periods, negative alcohol consequences may represent “teachable moments” via expe...

A large body of literature suggests that parent-child separation predicts child maladjustment. However, further advancement in methodology is needed to account for heterogeneity in types of separation. Additionally, given a lack of research examining different types of separation as predictors of offspring substance use, further research into this...

Objective Alcohol and cannabis co-users experience more negative alcohol consequences, but distal and mediating mechanisms of this association remain largely unstudied. Considering research suggests that individuals high in impulsivity and sensation seeking are more likely to be co-users, it is possible that co-users have more positive expectancies...

Substantial effort has gone into neuroimaging studies of neural mechanisms underlying addiction. Human studies of smoking typically either give monetary reward during an fMRI task or else allow subjects to smoke outside the scanner, after the session. This raises a fundamental issue of construct validity, as it is unclear whether the same neural me...

Negative urgency, rash action during negative mood states, is a strong predictor of risky behavior. However, its developmental antecedents remain largely unstudied. The current study tested whether childhood temperament served as a developmental antecedent to adolescent negative urgency. Participants (N=239) were from a longitudinal study oversampl...

This chapter reviews the research evidence concerning relations between parent substance use and substance use disorder and child physical and mental health outcomes. We discuss methodological issues in the literature and review major theoretical biopsychosocial mechanisms thought to explain these effects. These mechanisms include fetal exposure, t...

Although alcohol expectancies and subjective response are independent predictors of drinking, social–cognitive theory suggests that expectancies may distort one’s subjective response, creating discrepancies between expected and actual alcohol effects. A recent cross-sectional study found that unmet expectancies (using difference scores) were associ...

Objective: Research suggests associations between adolescent alcohol use and early reproduction, but other findings show that alcohol use disorder (AUD) may actually predict delayed reproduction. However, most studies generally do not consider the effects of parental AUD, which is correlated with AUD and may influence reproductive timing. The prese...

Parenting during early adolescence is key in protecting adolescents against substance use initiation and patterned use. Parental alcohol use disorder is a robust risk factor for maladaptive parenting and adolescent alcohol use. However, it is unclear what effect parent prescription opioid misuse has on parenting and adolescent alcohol use. Associat...

Executive cognitive functioning (ECF) and trait impulsivity have long been implicated in risky drinking and alcohol-related problems. However, research on these constructs has developed independently. The present study tested whether two subdomains of adolescent ECF (updating and response inhibition) and adolescent trait impulsivity, considered sep...

Background Parental drinking and parent alcohol use disorder (AUD) are known predictors of adolescent positive alcohol expectancies, but their link to negative expectancies is unclear. Research suggests that parent drinking may indirectly predict adolescent expectancies through exposure to parental drinking events. However, exposure to parent negat...

Adolescent cannabis use is common, has been associated with several deleterious outcomes, and is often associated with previous parent cannabis use. Therefore, identifying protective factors that prevent this intergenerational transmission of cannabis use is increasingly important given shifting contemporary policies around cannabis use. The presen...

Adolescents' effortful control is subject to numerous maternal influences. Specifically, a mother's own effortful control is associated with her child's effortful control. However, maternal substance use, psychopathology, and stress within the parenting role may also lead to poor effortful control for their child. Poor effortful control during adol...

Objective: Parental cannabis use disorder (CUD) is a known risk factor in the development of adolescent cannabis use. One potential mechanism is parenting behaviors. This study considered cannabis-specific parenting strategies as a mechanism of the relation between parental CUD and adolescent cannabis use. Method: Pathways were examined using mu...

Background Adolescent and young adult alcohol use is a major public health concern; alcohol is the most widely used substance by teenagers. It is imperative to better understand alcohol use during adolescence and early adulthood given the important changes that occur. Although numerous measures aim to capture alcohol use during this time, no existi...

Cigarette smoking is a well-established cause of excess morbidity and mortality in the United States and globally. The current study builds on the existing literature by examining how smoking trajectories might be a mechanism through which adolescent tolerance for deviance predicts premature all-cause and tobacco-specific mortality. Participants we...

Adolescent alcohol use is related to disinhibition traits and family environments. However, research is scarce on whether these factors predict alcohol use trajectories distally, from early adolescence into early adulthood. We examined whether sensation seeking and parenting environments in early adolescence predicted adolescents’ alcohol use traje...

The structure of adolescents’ families, and thus parental forms, in the United States, have become more heterogeneous and fluid over the past several decades. These changes are due to increases in never‐married, single parents, divorce, cohabitation, same‐sex parenting, multipartnered fertility, and co‐residence with grandparents. We document curre...

Poor family cohesion and elevated adolescent aggression are associated with greater alcohol use in adolescence and early adulthood. In addition, evocative gene–environment correlations ( r GEs) can underlie the interplay between offspring characteristics and negative family functioning, contributing to substance use. Gene–environment interplay has...

Background Parent alcohol use disorder (AUD) is a well-established risk factor for the development of offspring AUD and is associated with poor parenting. However, few studies have examined heterogeneity in trajectories of parental AUD and its influence on adolescent offspring drinking, and no studies to date have considered the differential risk t...

In this chapter, findings from a long-term, cohort-sequential, multigenerational study of cigarette smoking are used to illustrate the importance of a developmental approach for (1) understanding trajectories of smoking behavior (in relation to other forms of tobacco use) and the conditions and challenges of the developmental periods that show tran...

Hypotheses about change over time are central to informing our understanding of development. Developmental neuroscience is at critical juncture: although the majority of longitudinal imaging studies have observations with two time points, researchers are increasingly obtaining three or more observations of the same individuals. The goals of the pro...

Parental cannabis use disorder (CUD) and low positive parenting (monitoring, support, and consistency) are risk factors for adolescent cannabis use. However, it is unclear whether parental cannabis use without CUD is sufficient to increase risk for low positive parenting and adolescent cannabis use. Additionally, parents may not treat each of their...

Emerging evidence suggests that family conflict shows continuity across generations and that intergenerational family conflict can be more intense and deleterious than conflict experienced in a single generation. However, few investigations have identified etiological mechanisms by which family conflict is perpetuated across generations. Addressing...

Serotonin (5-HT) functioning is associated with alcohol problems. However, the mechanisms underlying this association remain unclear. In the current study the authors tested whether five separate dimensions of impulsivity (UPPS-P) mediated the relation between a polygenic score indexing 5-HT functioning and alcohol problems and whether any of these...

Adolescent substance use carries a considerable public health burden, and early initiation into use is especially problematic. Research has shown that trait sensation seeking increases risk for substance use initiation, but less is known about contextual factors that can potentially unmask this risk. This study utilized a diverse longitudinal subsa...

Parental monitoring can buffer the effect of deviant peers on adolescents' substance use by reducing affiliation with substance-using peers. However, children's genetic predispositions may evoke poorer monitoring, contributing to negative child outcomes. We examined evocative genotype-environment correlations underlying children's genetic predispos...

The current study used data from two longitudinal samples to test whether self-regulation, depressive symptoms, and aggression/antisociality were mediators in the relation between a polygenic score indexing serotonin (5-HT) functioning and alcohol use in adolescence. The results from an independent genome-wide association study of 5-hydroxyindoleac...

Alcohol use disorders and internalizing disorders are highly comorbid, but how this comorbidity unfolds over development is not well understood. The present study investigated effects of internalizing symptoms in late childhood on speed of transition between three alcohol involvement milestones: first drink, first binge, and onset of first alcohol...

The present study investigated the associations between multigenerational continuity in family conflict and current psychopathology symptoms and social impairment experienced by parents and adolescents. We sampled 246 families from a multigenerational, high-risk, longitudinal study of parents (G1s) and their children (G2s), followed from adolescenc...

Previous research suggests that mothers’ and fathers’ parenting may be differentially influenced by marital and child factors within the family. Some research indicates that marital stress is more influential in fathers’ than mothers’ parenting, whereas other research shows that children's difficult behavior preferentially affects mothers’ parentin...

Using participants from an 1-and-1⁄2-year longitudinal study of smoking socialization (N = 709), we examined peer smoking, and implicit and explicit attitudes on smoking initiation among initial nonsmoking adolescents. We also tested whether implicit and explicit attitudes mediated the effect of peer smoking on smoking initiation, and whether impli...

Deviance proneness models propose a multilevel interplay in which transactions among genetic, individual, and family risk factors place children at increased risk for substance use. We examined bidirectional transactions between impulsivity and family conflict from middle childhood to adolescence and their contributions to substance use in adolesce...

The current study demonstrates the application of an analytic approach for incorporating multiple time trends in order to examine the impact of cohort effects on individual trajectories of eight drugs of abuse. Parallel analysis of two independent, longitudinal studies of high-risk youth that span ages 10 to 40 across 23 birth cohorts between 1968...

This study used two waves of data to investigate pathways through which adolescents' response inhibition related to later externalizing problems. A polygenic risk score indexed genetic risk for poor response inhibition. Adolescents' performance on a response inhibition task mediated the relation between adolescents' polygenic risk scores and mother...

We evaluated the effects of marital dissatisfaction on adolescent-perceived conflict in 435 families with and without a parental history of alcoholism. On average, family conflict decreased linearly as adolescents aged. Families with an alcoholic parent demonstrated higher adolescent-reported family conflict and this effect was partially mediated b...

Substance use and substance use disorders are of great public health significance because of their high prevalence and associated mortality, morbidity, and economic cost. Moreover, substance use and substance use disorders must be studied within a developmental context, given the etiological importance of age-related neurobiological maturation of r...

Background: Delay discounting is a potential etiological factor in adolescents' alcohol use, making it important to understand its antecedents. Family disorganization might contribute to delay discounting, but few studies have tested this relation. Moreover, because delay discounting is heritable, the effects of family disorganization on delay dis...

The present study utilizes longitudinal data from a high-risk community sample to examine the unique effects of genetic risk, parental knowledge about the daily activities of adolescents, and peer substance use on emerging adult substance use disorders (SUDs). These effects are examined over and above a polygenic risk score. In addition, this polyg...

Testing mediation models is critical for identifying potential variables that need to be targeted to effectively change one or more outcome variables. In addition, it is now common practice for clinicians to use multiple informant (MI) data in studies of statistical mediation. By coupling the use of MI data with statistical mediation analysis, clin...

Objective: Test the effect of exposure to the U.S. Food and Drug Administration's proposed graphic images with text warning statements for cigarette packages on implicit and explicit attitudes toward smoking. Design and methods: A two-session web-based study was conducted with 2192 young adults 18-25 years old. During session one, demographics,...

Self-regulation plays an important role in understanding adolescent substance use. From a trait perspective, adolescent substance use is related to high levels of reward seeking, low levels of harm avoidance, and deficits in inhibitory control. Moreover, these characteristics influence adolescents’ motivations to use substances as a means to achiev...

Effortful control is associated with fewer aggressive-antisocial behaviors (AAB) and depressive symptoms (DEP), but impulsivity may moderate these relations. However, few researchers have considered the effects of AAB-DEP co-occurrence. A multi-informant, multimethod approach assessed 5- to 10-year-olds' effortful control and impulsivity and, 5-6 y...

Although research has documented robust prospective relationships between externalizing symptomatology and subsequent adolescent alcohol use, the extent to which internalizing symptoms such as anxiety may increase risk for alcohol consumption remains controversial. Recent evidence suggests that one possible reason for mixed findings is that separat...

Justice-involved youth have high rates of alcohol and marijuana use. However, little is known about what may drive these rates over time. Using a large-scale (N = 1,056; 41.4% African American, 33.5% Hispanic) longitudinal study with strong retention (M retention = 90% over Years 1-7), we utilized random-effects regression to determine the comparat...

In the current study, we examined continuity in conflict across generations and explored potential mediators and moderators that could explain this continuity. We followed 246 targets from adolescence to adulthood and examined family conflict as reported by multiple reporters in targets' family of origin and current families. Results showed that co...

Using a high-risk community sample (N = 567), the current study examined risk for externalizing and internalizing problems in the children of parents with recovered and current substance use disorders (SUDs). This study also tested whether parenting mediated the relations between these variables. Results suggest that children of parents with curren...

Background Research has shown a developmental process of “maturing out” of problem drinking beginning in young adulthood. Perhaps surprisingly, past studies suggest that young adult drinking reductions may be particularly pronounced among those exhibiting relatively severe forms of problem drinking earlier in emerging adulthood. This may occur beca...

Identifying trajectories of tobacco use is critical for understanding its natural history and targeting interventions, but research on trajectories of smokeless tobacco and dual use of smokeless tobacco and cigarettes is very limited. This study identified tobacco use trajectories from adolescence to midlife and tested correlates of trajectory grou...

Conduct problems, alcohol problems and hyperactive-inattentive symptoms co-occur at a high rate and are heritable in adolescence. The γ-aminobutyric acid A receptor, α2 gene (GABRA2) is associated with a broad spectrum of externalizing problems and disinhibitory-related traits. The current study tested whether two important forms of disinhibition i...

Impulse control and future orientation increase across adolescence, but little is known about how contextual factors shape the development of these capacities. The present study investigates how stress exposure, operationalized as exposure to violence, alters the developmental pattern of impulse control and future orientation across adolescence and...

The objective of this study is to test the mediational adequacy of the Ajzen-Fishbein (1975) model. Triandis has proposed a competing model for the prediction of intentions. Intentions are predicted by the person’s affect (A) toward the behavior, social factors (S), and the value of perceived consequences (C), according to the following equation: $...

Intentions to try a cigarette were predicted significantly better by the Ajzen and Fishbein model when the attitudinal and normative components were operationalized in terms of beliefs specifically related to “trying than when operationalized by beliefs specifically related to “smoking,” and intentions to smoke were predicted significantly better b...

Serious youthful offenders are presented with a number of significant challenges when trying to make a successful transition from adolescence to adulthood. One of the biggest obstacles for these youth to overcome concerns their ability to desist from further antisocial behavior, and although an emerging body of research has documented important ris...

Implicit attitudes have been shown to predict smoking behaviors. Therefore, an important goal is the development of interventions to change these attitudes. This study assessed the effects of a web-based intervention on implicit attitudes toward smoking and receptivity to smoking-related information. Smokers (N = 284) were recruited to a two-sessio...

The present study utilized longitudinal data from a community sample (n = 377; 166 trauma-exposed; 54% males; 73% non-Hispanic Caucasian; 22% Hispanic; 5% other ethnicity) to test whether pretrauma substance use problems increase risk for trauma exposure (high-risk hypothesis) or posttraumatic stress disorder (PTSD) symptoms (susceptibility hypothe...

Integrative data analysis (IDA) is a methodological framework that allows for the fitting of models to data that have been pooled across 2 or more independent sources. IDA offers many potential advantages including increased statistical power, greater subject heterogeneity, higher observed frequencies of low base-rate behaviors, and longer developm...

Objective: This study examined how effort to regulate alcohol use may interact with anxiety and affective disorders to influence long-term remission from alcohol dependence. Method: Using participants (n = 96; 73% male; 66% children of alcoholics; 71% non-Hispanic Caucasian; 26% Hispanic) from a high-risk community study who showed evidence of reco...

Research has shown a developmental process of "maturing out" of alcohol involvement beginning in young adulthood, but the precise nature of changes characterizing maturing out is unclear. We used latent transition analysis to investigate these changes in a high-risk sample from a longitudinal study of familial alcoholism (N = 844; 51% children of a...

The last 25 years have seen significant advances in our conceptualization of alcohol use and alcohol use disorders within a developmental framework, along with advances in our empirical understanding that have been potentiated by advances in quantitative methods. These include advances in understanding the heterogeneity of trajectories of alcohol o...

Psychologists often obtain ratings for target individuals from multiple informants such as parents or peers. In this article we propose a trifactor model for multiple informant data that separates target-level variability from informant-level variability and item-level variability. By leveraging item-level data, the trifactor model allows for exami...

Objective: The primary aim of the current study was to examine three dimensions of alcohol-specific parenting (anti-alcohol parenting strategies, parental legitimacy in regulating adolescent drinking, and parental disclosure of negative alcohol experiences) as mechanisms in the prospective relations between parental drinking and alcohol use disord...

The current study examined risk for young adult affective disorder in the children of parents with alcohol use disorders (AUDs), and tested whether negative experiences during the leaving home transition mediated this effect. Using multiple reporter data from a high-risk community sample, the current study included 346 emerging adults (M = 21.97 ye...

Adolescence is often described as a time of experimentation with risky or problem behaviors (Arnett, 2000), and substance use is one such behavior that is initiated during this age period. Substance use and addictive disorders are topics of considerable importance both because of their significance for adolescent development and because of their pu...

Economic declines and their associated stress, shortage of financial resources, and changes in available time can impair health behaviors. This study tested the association between change in working hours, change in employment status, and financial strain and health behaviors measured after the 2008 recession after controlling for pre-recession lev...

Introduction: Recent work demonstrated a direct relation between work-family conflict and likelihood of smoking. This study furthered this area of research by (a) testing the association between work-family conflict and smoking quantity and (b) testing demographic, workplace, and home factors as moderators of this relation. Methods: Participants...

Researchers examined whether ethnicity alters the risk for difficulty in the transition out the home among children of alcoholics (COAs). We tested this question in a community based, longitudinal sample of 705 COAs and matched with non-COA controls as well as their parents. Latino COAs were less likely to leave home than were Euro-American COAs. E...

Purpose: Juvenile offenders are at heightened risk of death in adolescence and young adulthood compared to adolescents in the general population. The current study extends previous research by testing the joint contributions of distal (historical and demographic characteristics) and proximal (closer to the time of the death) predictors of mortalit...

Age-related patterns of substance use and their association with childhood predictors suggest the value of applying a developmental perspective to the study of addiction. This chapter focuses on methodological issues in research on developmental factors in addiction. It focuses on methodological issues in studies of substance use during childhood a...

The present study utilized longitudinal data from a high-risk community sample (N = 377; 166 trauma-exposed; 202 males; 175 females; 73% non-Hispanic Caucasian) to test pretrauma measures of adolescent internalizing and externalizing symptoms as unique prospective predictors of type of trauma exposure and PTSD over and above the influence of correl...

We examined the association of joint trajectories of ethnic identity and criminal offending to psychosocial maturity, gang membership, and Mexican American affiliation among 300 Mexican American male juvenile offenders from ages 14 to 22. There were two low-offending groups: one was the highest in ethnic identity and changing slightly with age and...

The current study examined the distal, proximal, and time-varying effects of parents' alcohol-related consequences on adolescents' substance use. Previous studies show that having a parent with a lifetime diagnosis of alcoholism is a clear risk factor for adolescents' own substance use. Less clear is whether the timing of a parent's alcohol-related...

The present study used longitudinal data from a community study of familial alcoholism to examine the extent to which the long-term influence of posttraumatic stress disorder (PTSD) symptoms on future adult alcohol and drug problems was mediated by increases in early adult internalizing or externalizing symptoms. The subsample of participants inclu...

This study examined the interplay between the influence of peers who promote alcohol use and μ-opioid receptor M1 (OPRM1) genetic variation in the intergenerational transmission of alcohol use disorder (AUD) symptoms while separating the "traitlike" components of AUD symptoms from their age-specific manifestations at three ages from emerging adulth...

Outcome expectancy is a central construct in models of addiction and relapse. Much expectancy research has been conducted in the context of alcohol; however, less is known about the structure of expectancies for marijuana and their associations with marijuana use outcomes. The data are taken from waves 3 and 4 of a longitudinal high-risk study of p...