Lauriane Segaux

Lauriane Segaux
Hôpital Henri Mondor (Hôpitaux Universitaires Henri Mondor) · Service de Santé Publique

About

22
Publications
567
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137
Citations
Citations since 2017
20 Research Items
137 Citations
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20172018201920202021202220230102030405060
20172018201920202021202220230102030405060

Publications

Publications (22)
Article
Full-text available
Background Inter-individual variations of non-GFR determinants of serum creatinine, such as muscle mass, account for the imperfect performance of eGFR equations. We aimed to develop an equation based on creatinine and total lumbar muscle cross-sectional area (MCSA) measured by unenhanced CT-scan at the third lumbar vertebra. Methods The muscle mas...
Article
Data regarding renal involvement in patients with hereditary transthyretin (ATTRv) amyloidosis are scarce and the natural course of chronic kidney disease (CKD) in this population remains unclear. This observational study, including adult patients diagnosed with ATTRv amyloidosis at the French Reference Centre for Cardiac Amyloidosis, investigated...
Article
Full-text available
Background: A prognostic assessment is crucial for making cancer treatment decisions in older patients. We assessed the prognostic performance (relative to one-year mortality) of eight comorbidity indices in a cohort of older patients with cancer. Methods: We studied patients with cancer aged ≥70 included in the Elderly Cancer Patient (ELCAPA) c...
Article
Objectives: Understated executive dysfunction (UED) is predictive of cognitive decline and death. We aimed to assess the prevalence of UED, assessed with the clock-drawing test (CDT) and the Frontal Assessment Battery (FAB) in middle-aged adults and to investigate associated characteristics. Methods: Cross-sectional analysis of data on 516 commu...
Article
Introduction The periods of lockdown during 2020 led to changes in daily occupations. As participation relies on dynamic interactions between the person, his/her occupations and his/her environment, we wondered whether people from different generations shared the same perception of occupational disruptions during the lockdown. Methods We performed...
Article
Full-text available
ATTRwt-CA occurs in elderly patients and leads to severe heart failure. The disease mechanism involves cardiac and extracardiac infiltration by amyloid fibrils. The objectives of this study are to describe the frailty phenotype in patients with ATTRwt-CA and to assess the associations between frailty parameters, the severity of cardiac involvement,...
Article
Introduction Avec le vieillissement de la population, le déclin cognitif et les troubles neurocognitifs majeurs sont de plus en plus fréquents. Par ailleurs, les données de la littérature suggèrent qu’un trouble cognitif non repéré (TCNR, défini comme l’altération d’un test cognitif chez des individus sans plainte cognitive subjective (PCS)) est pr...
Article
Full-text available
Although frailty can arise in middle age, very few studies have investigated frailty before 65 years. Our objectives were to assess the prevalence of frailty parameters in middle-aged individuals and probe the association with future adverse events. We performed cross-sectional and longitudinal analyses of community-dwelling individuals aged 50 to...
Article
Background Senile transthyretin amyloidosis (ATTRwt) occurs in elderly patients and leads to severe heart failure (HF). The mechanism of the disease involved cardiac and extra cardiac amyloid fibril infiltrations. Consequence of extracardiac infiltration on frailty has been poorly studied. Purpose Ours aims were to describe the frailty phenotype i...
Article
: We performed an observational prospective monocentric study in patients living with HIV (PLWH) diagnosed with COVID-19. Fity four PLWH developed COVID-19 with respectively 14 severe (25.9%) and 5 critical cases (9.3%). By multivariate analysis, age, male gender, ethnic origin from Sub Saharan Africa, and metabolic disorder, were associated with s...
Article
Objectives To estimate the prevalence of understated cognitive impairment by administering the Clock-Drawing Test (CDT) to community-dwelling individuals aged ≥50 years and to investigate the associated clinical phenotype. Design A cross-sectional analysis of baseline data on community-dwelling individuals assessed at an outpatient clinic in the P...
Article
Background Because of comorbidities and polypharmacy, older patients with cancer have a greater risk of iatrogenic events. We aimed to characterize potential drug-drug interactions (PDIs) and the risk of unplanned hospitalization in older patients with cancer treated with antineoplastic agents (ANAs). Methods We analyzed all older patients (≥70 y...
Article
Introduction Le test de l’horloge (TdH) est couramment utilisé pour dépister les troubles cognitifs chez les sujets âgés. Il permet l’évaluation des fonctions visuo-constructives et des fonctions exécutives peu, ou pas évaluées par les tests classiques comme le MMS. Une altération des performances au TdH serait un marqueur précoce de risque d’évène...
Article
Introduction Le repérage de la fragilité chez les 75 ans et plus est crucial pour prévenir/retarder la dépendance. Cependant des études en population ont montré que des paramètres de fragilité étaient présents chez de jeunes seniors qui ne bénéficient habituellement pas d’évaluation gérontologique multi-domaine. Considérant la fragilité comme un ét...
Article
Objectives: We sought to identify frailty profiles in individuals aged 50-75 by considering frailty as an unobservable latent variable in a latent class analysis (LCA). Study design: 589 prospectively enrolled community-dwelling individuals aged 50-75 (median: 61.7 years) had undergone a standardized, multidomain assessment in 2010-2015. Adverse...
Article
Background The expression of depressive symptoms in older people with cancer is heterogeneous because of specific features of age or cancer comorbidity. We aimed to identify depressive symptom profiles in this population and describe the associated features including survival. Materials and Methods Patients ≥70 years who were referred to geriatric...
Article
Objectifs L’objectif principal était l’identification de profils distincts de symptomatologie dépressive chez les patients âgés atteints de cancer. Les objectifs secondaires étaient l’identification des facteurs associés à ces profils et de leur impact pronostique. Méthode L’étude portait sur les 1086 patients inclus dans la cohorte ELCAPA de 2007...
Article
Objectives: To evaluate the efficacy of an intervention on the practice of venous thromboembolism prevention. Design: A multicenter, prospective, controlled, cluster-randomized, multifaceted intervention trial consisting of educational lectures, posters, and pocket cards reminding physicians of the guidelines for thromboprophylaxis use. Setting...
Article
Introduction: Ruptured descending thoracic aneurysm (rDAA) is a rare but devastating condition. Open aortic surgery which uses cardiopulmonary bypass is associated with a high mortality. Thoracic Endovascular Aortic Repair (TEVAR) is a less invasive approach for which it remains unclear whether outcomes are superior or equivalent to open aortic su...

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