Laurence Mabile

Université Toulouse III - Paul Sabatier | UPS Toulouse · Laboratoire d'Epidémiologie et Analyses en Santé Publique - UMRS 1027 - LEASP

Environmental challenges are rarely confined to national, disciplinary, or linguistic domains. Convergent solutions require international collaboration and equitable access to new technologies and practices. The ability of international, multidisciplinary and multilingual research teams to work effectively can be challenging. A major impediment to...

Social inequality impacts health, is aggravated by the consequences of climate change, and may be influenced by inappropriate policy responses. These interdependent effects create a self-perpetuating loop exacerbating the impact of climate dysregulation on health in an uncontrolled and poorly understood way. Holistic approaches to public health suc...

Social inequality impacts health, is aggravated by the consequences of climate change, and may be influenced by inappropriate policy responses. These interdependent effects create a self-perpetuating loop exacerbating the impact of climate dysregulation on health in an uncontrolled and poorly understood way. Holistic approaches to public health suc...

There are global movements aiming to promote reform of the traditional research evaluation and reward systems. However, a comprehensive picture of the existing best practices and efforts across various institutions to integrate Open Science into these frameworks remains underdeveloped and not fully known. The aim of this study was to identify perce...

Data Management Plans (DMP) are now a routine part of research proposals but are generally not referred to after funding is granted. The Belmont Forum requires an extensive document, a ‘Data and Digital Object Management Plan’ (D(DO)MP) for its awarded projects that is expected to be kept current over the life of the project. The D(DO)MP is intende...

This presentation was given at the Terrestrial Ecosystem Research Network's 2023 Science Symposium, accessible through the web https://www.tern.org.au/science-symposium-2023/ on Day 2, session 5. The UNESCO Recommendation on Open Science (2021) states that increased openness leads to increased transparency and trust in scientific information. The...

Improve your team’s open practices. Codify these practices in your team’s Code of Open Science Practice. How to encourage open behaviors with your research team such as collaboration, transparency, and working openly. Which responsibilities and tasks to assign for open science. How to establish consistent communication that facilitates common...

Streamline your team’s research needs with resources that ensure they are as efficient, collaborative and open as possible. How to establish common team resources and digital object registry. How to manage and track your team’s digital objects. How to ensure equitable team contributions to research outputs and provide appropriate credit.

Document, select, and preserve your team’s research. How to ensure your project files have an effective backup plan in place. Determine what digital objects to preserve and the supporting documentation. Determine how open and FAIR to make your digital objects. ________________________

This presentation was given at a session organised by the ESIP/RDA Earth, Space, Environmental Sciences Interest Group for the RDA Plenary 20 in Gothenburg, Sweden on the 23th March 2023 entitled 'Continuing the Circle of Life of Earth and Environmental Science Data Infrastructure Projects: Maturing PARSEC and ENVRI-FAIR, Beginning New Adventures…'...

Plan, manage and share your data. When and how to manage your data during your research project. How to share your data as openly as possible: determining which data, which repository, which license. How to cite data and help others cite your data.

Plan, manage and share your software. When and how to manage your software during your research project. How to preserve and share the version of your software used for your research. How to cite software and help others cite your software.

Background: Exposome research aims to describe and understand the extent to which all the exposures in human environments may affect our health over the lifetime. However, the way in which humans interact with their environment is socially patterned. Failing to account for social factors in research exploring the exposome may underestimate the mag...

Background Exposome research aims to describe and understand the extent to which all the exposures in human environments may affect our health over the lifetime. However, the way in which humans interact with their environment is socially patterned. Therefore, including social factors in research exploring the exposome is fundamental and may contri...

For many decades, the immunogenetics community has been among the frontrunners in sharing data and samples, ensuring a great scientific progress in this domain. International histocompatibility workshops and scientific meetings in immunogenetics societies as EFI and ASHI have largely contributed to this progress In many other fields it has now bee...

This presentation is a contribution from the PARSEC team. PARSEC is a project sponsored by the Belmont Forum as part of its Collaborative Research Action (CRA) on Science-Driven e-Infrastructures Innovation (SEI), with funding from FAPESP, the ANR, JST and the NSF, with collaborators from Australia, and support from the synthesis centre CESAB of th...

Socioeconomic indicators are essential to help design and monitor the impact of public policies on society. Such indicators are usually obtained through census data collected at 10-year intervals, which are not only temporally coarse but expensive. Over recent years other ways of collecting data and producing these indicators have been explored, in...

Abstract: Steady progress is being made across the Earth and space science disciplines to move towards more common sharing of the data and software that supports our research. As each discipline determines what is best for them, the experience gained by synthesis center communities is valuable to support the collaboration needed for cross-disciplin...

Notre société est aujourd'hui confrontée à de profonds changements (biodiversité, climat, pandémie, etc.). Les impacts humains et leur atténuation dépendent de notre capacité à mobiliser la recherche au niveau mondial. Le développement durable de la société dépendra en grande partie du développement sur le long terme d’une science globale et d’outi...

Estamos agora enfrentando mudanças profundas (biodiversidade, clima, pandemia, etc.). Os impactos humanos e sua mitigação dependerão de nossa capacidade de mobilizar pesquisas em nível global. O desenvolvimento sustentável da sociedade dependerá em grande parte do desenvolvimento sustentável da ciência global e das ferramentas de pesquisa científic...

We are now facing profound changes (biodiversity, climate, pandemic, etc.). Human impacts and their mitigation will depend on our ability to mobilize research at the global level. The sustainable development of the society will largely depend on the sustainable development of global science and scientific research tools, outputs, and research ecosy...

Reducing the risk of misuse of data is particularly crucial in the context of research on highly pathogenic agents. But as demonstrated during the COVID19 crisis, sharing data of high quality is a sine qua non condition to compare research results at a large scale. Our actual challenge is to ensure compliance with the FAIR principles while taking i...

In the PARSEC project, our team of data science experts are partnering with our multi-country synthesis science research team to build relevant tools and processes for better data and software management that integrate into the research lifecycle and are to be shared with the wider research community. This poster articulates the technology challeng...

présentation du RDA SHARC interet group (Sharing Rewards and Credit) Co-chairs: R. David, L. Mabile, A. Cambon-Thomsen https://www.rd-alliance.org/groups/sharing-rewards-and-credit-sharc-ig Observation: Malgré de nombreuses annonces / promotion active, le partage de données selon les principes FAIR n'est toujours pas effectif dans la plupart des c...

The SHARC Interest Group of the Research Data Alliance was established to improve research crediting and rewarding mechanisms for scientists who wish to organise their data (and material resources) for community sharing. This requires that data are findable and accessible on the Web, and comply with shared standards making them interoperable and re...

In addition to the iPoster prepared for the session, this presentation provides an overview of the Data and Digital Output Management Plan and Workbook developed for the PARSEC project. The Workbook and the supporting checklist are outputs designed to be shared broadly in the community with supporting materials for use by Earth, space, and environm...

PARSEC Data and Digital Output Management Plan and Workbook for the Belmont Forum Collaborative Research Action (CRA) Science-driven e-Infrastructure Innovation (SEI) for the Enhancement of Transnational, Interdisciplinary and Transdisciplinary Data Use in Environmental Change Project Building New Tools for Data Sharing and Reuse through a Trans...

Despite the fact that the implementation of the FAIR principles (Findable, Accessible, Reusable, Interoperable) has become necessary in new research projects to meet the requirements of funding organisations and respond to some funders calls, many institutions do not consider data sharing through implementation of the FAIR principles as a research...

a mixed informative and interactive session with speakers and audience. Objectives of the joint meeting; Goals of the group’s project; current standing; A. Cambon-Thomsen, 5 min; Towards SHARC recommendations / guidance? L. Mabile 5 min FAIR criteria assessment survey results, Romain David 5 min How can the FAIR criteria best be employed in gu...

FAIRisation: includes all the necessary processes to implement FAIR principles from the moment a political decision has been validated in this direction. It includes pre-Fairification steps, FAIRification steps and evaluation steps for each aspect of FAIRification. Pre-FAIRification: Processes necessary in a community to permit the FAIR principles...

The immunogenetics community is characterised by a widespread international collaboration between laboratories with exchange of biological samples and data. However, the researchers who are involved in building and curating bioresources do not always get the credit they deserve and this is an obstacle for sharing practices. Several international in...

The SHARC (SHAring Reward & Credit) interest group (IG) is an interdisciplinary group set up in the framework of RDA (Research Data Alliance) to improve crediting and rewarding mechanisms in the sharing process throughout the data life cycle. Notably, one of the objectives is to promote data sharing activities in research assessment schemes at nati...

Short introduction describing the scope of the group and if any previous activities Data sharing statements and promotion face a challenging reality, as many obstacles remain on several fronts. Among them is the lack of relevant and recognized rewarding mechanisms for the very specific efforts required to share organized datasets and physical res...

What for? to foster data sharing by improving recognition of the work required How? by providing a set of recommendations to guide researchers and other relevant stakeholders (research institutions administrators, funders, policy makers and publishers/editors) in moving through the necessary steps towards crediting and rewarding in the data/resourc...

SHARC (SHAring Reward & Credit) est un groupe d'intérêt scientifique interdisciplinaire créé dans le cadre de RDA (Research Data Alliance) dans le but de faciliter le partage des données de recherche (et des ressources) par la valorisation de l'ensemble des activités pré-requises à ce partage, tout au long du cycle de vie des données. Dans ce cadre...

The RDA-SHARC (SHAring Reward & Credit) interest group is an interdisciplinary volunteer member-based group set up as part of RDA (Research Data Alliance) to unpack and improve crediting and rewarding mechanisms in the sharing process throughout the data life cycle. Background and objectives of this group are reported here. Notably, one of the obje...

Collections intended for purely academic purposes are run on a nonprofit basis, whereas commercially managed collections are intended to make a profit for their owners by placing on the market samples private researchers can buy when they do not have their own source of research materials. In recent years, researchers using collections for multicen...

Background: Governments across Europe have attempted to address the obesogenic environment through a variety of policy measures over the last two decades. A growing literature advocates for complex population interventions in public health. Such approaches embrace the need for interventions that can operate within the complexity of real-life situat...

Background: Governments across Europe have attempted to address the obesogenic environment through a variety of policy measures over the last two decades. A growing literature advocates for complex population interventions in public health. Such approaches embrace the need for interventions that can operate within the complexity of real-life situat...

Currently, a great deal of biomedical research in fields such as epidemiology, clinical trials and genetics is reliant on vast amounts of biological and phenotypic information collected and assembled in biobanks. While many resources are being invested to ensure that comprehensive and well-organised biobanks are able to provide increased access to,...

Data sharing institutional incentives exist but no practical tools to implement such policy are in place. The BRIF (Bioresource Research Impact Factor) initiative was conceived as a possible way to fill this gap. It is an ongoing initiative that encompasses considerations and actions from various stakeholders (researchers, funders, industrials, edi...

Interdisciplinary research and teaching often present similar challenges to investigators and teachers in higher education settings. Capturing and harnessing disciplinary knowledge from different fields to strengthen the process is desirable. However, in practice, this may be difficult to achieve. In this paper we set out a methodology developed in...

Even though an increasing portion of biomedical research today relies on the use of bioresources, at present biobankers are not able to trace this use in scientific literature and measure its impact with a variety of citation metrics. The “BRIF (Bioresource Research Impact Factor) and journal editors” subgroup was created precisely with the aim to...

The poster presents to the community of librarians and information specialists the CoBRA Guideline. This guideline for Citation of BioResources in journal Articles was published in February 2015 in BMC Medicine. It is now included in the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network, and shared by international associa...

Introduction La réduction des inégalités sociales de santé (ISS) est devenue un objectif explicite de santé publique. Tant pour le développement de la recherche interventionnelle, qui associe acteurs et chercheurs, que pour l’aide à la décision, la mise à disposition d’expertise est nécessaire. C’est l’objectif de la plateforme AAPRISS (apprendre e...

Many biomedical publications refer to data obtained from collections of biosamples. Sharing such bioresources (biological samples, data, and databases) is paramount for the present governance of research. Recognition of the effort involved in generating, maintaining, and sharing high quality bioresources is poorly organized, which does not encourag...

Recently many international initiatives have been developed to improve access to scientific information and to promote open data sharing. In the complex field of bioresources, the BRIF (Bioresource Research Impact Factor) project aims to create suitable methods to recognise and measure the use and impact of biological resources in scientific/academ...

The number of biobanks, in particular hospital-integrated tumor biobanks (HITB), is increasing all around the world. This is the consequence of an increase in the need for human biological resources for scientific projects and more specifically, for translational and clinical research. The robustness and reproducibility of the results obtained depe...

HIV-infected patients starting antiretroviral treatment (ART) experience deep and early disorders in fat and bone metabolism, leading to concomitant changes in fat mass and bone mineral density. We conducted a prospective study in treatment-naive HIV-infected patients randomized to receive two nucleoside reverse transcriptase inhibitors in combinat...

An increasing portion of biomedical research relies on the use of biobanks and databases. Sharing of such resources is essential for optimizing knowledge production. A major obstacle for sharing bioresources is the lack of recognition for the efforts involved in establishing, maintaining and sharing them, due to, in particular, the absence of adequ...

Citability of data, including also results from studies utilizing biological samples, prominent issue in scientific publishing. Data deriving from bìoresources are important for the advancement of biomedicai research. This paper aims at promoting the relevance of a good standardized citation in journal articles which w ill help in the creation of a...

Objectives To explore current evidence of the physiological embedding of stress to discuss whether adverse childhood experiences (ACE) causing chronic or acute stress responses may alter fundamental biological functions. Methods A non-systematic review of the literature was carried out using keyword searches in Pubmed and the web of science from Ma...

The central aim of the BRIF (Bioresource Research Impact Factor) initiative is to construct a quantitative parameter to evaluate bioresources, modeled to some degree on the Journal Impact Factor (JIF), and to provide guidance and methodology for optimizing recognition of bioresources, their use and their sharing at international level. To implement...

The central aim of the BRIF (Bioresource Research Impact Factor) initiative is to construct a quantitative parameter to evaluate bioresources, modeled to some degree on the Journal Impact Factor (JIF), and to provide guidance and methodology for optimizing recognition of bioresources, their use and their sharing at international level. To implement...

This editorial talks about Bioresources (for example, biobanks, databases and bioinformatics tools) and why these need to be easily accessible to facilitate advancement of research. The authors comment on the proposition of a Bioresource Research Impact Factor (BRIF), which would promotethe sharing of bioresources by creating a link between their i...

This document is a detailed summary of the presentations and discussions from the BRIF (Bioresource Impact Factor) workshop, held in Toulouse on 17-18 january 2011.

Number of attendees, geographical origin of the group, skills and areas represented, tools developed to help the BRIF progress.

The impact of shift work on cardiovascular disease (CVD) risk factors and metabolic syndrome are not yet completely understood. The objectives of this study were to evaluate the impact of shift work on metabolic syndrome according to two different definitions in a population of strictly rotating shift workers (3x8 h) compared to paired counterparts...

Cell proliferation of vascular cells is a key feature in vascular biology, wound healing, and pathophysiological processes such as atherosclerosis and restenosis. In atherosclerotic intima, cell proliferation colocalizes with oxidized LDL that indicate a local oxidative stress. This study aims to investigate whether cell proliferation is causally r...

As an inflammatory cell, the macrophage produces various oxidizing agents, such as free radical species. These can modify LDL as a secondary effect and doing so may favor atherogenic processes. Any molecule able to counteract these reactions would be of much benefit, especially if secreted by the macrophage itself at the lesion site. Such is the ca...

High triglycerides and low HDL cholesterol are frequently associated with insulin resistance. Statins are potent hypocholesterolemic drugs, while fibrates are better at reducing triglycerides and enhancing HDL. However, little is known of their effects on other parameters potentially associated with insulin resistance, such as γ-glutamyl transferas...

Hepatic lipase (HL) is a lipolytic enzyme, synthesized by hepatocytes and found localized at the surface of liver sinusoid capillaries. In humans, the enzyme is mostly bound onto heparan-sulfate proteoglycans at the surface of hepatocytes and also of sinusoid endothelial cells. HL shares a number of functional domains with lipoprotein lipase and wi...

The important triacylglycerol-lowering capacity of n-3 fatty acids is counterbalanced by their inherent sensitivity to oxidation. Inconsistent results about the latter have been reported in hypertriglyceridemic individuals. After incorporation into cell membranes, n-3 fatty acids may alter membrane-related functions. In view of the distinct composi...

This brief review and update considers a few aspects of the mechanisms of action of statins, especially those related to some of the pleiotropic effects that have clinical relevance. The beneficial effect on endothelial dysfunction is a class effect that is related not only to the lowering of plasma LDL-cholesterol but also to a direct effect on ni...

Previous studies have shown that oral administration of 300 mg α-tocopherol/day to healthy volunteers decreases platelet function and enhances their sensitivity to the platelet inhibitor, prostaglandin E1, when full dose-response curves to a range of agonist concentrations are made. In this study, the effects of oral doses of natural α-tocopherol (...

Major advances have been made in our understanding of the role of apolipoprotein E (apoE) in the onset and development of atherosclerosis. Increasing evidence from both animal and human studies suggests that apoE is able to protect against atherosclerosis by: a) promoting efficient uptake of triglyceride-rich lipoproteins from the circulation; b) m...

Human endothelial cells (ECs) grown under standard conditions are able to generate a basal level of oxygen free radicals and induce progressive oxidation of LDLs. Inhibition of cell-mediated LDL oxidation by superoxide dismutase, EDTA, or desferrioxamine implicates a role for superoxide anion and/or transition metals in this process. The potential...

Oxidized chylomicrons may be a metabolic factor involved in the injury of the arterial wall and may constitute a potential link between postprandial lipemia and atherogenesis. It was of interest to study the influence of dietary fatty acid composition on the oxidizability and subsequent cytotoxicity of chylomicrons on cultured cells. Human chylomic...

Low-density lipoproteins (LDLs), treated by UV-C radiations under conditions permitting mildly oxidized LDL (6 +/- 2 nmol TBARS/mg apoB, without major structural or functional alteration of apoB), have been used for studying their cytotoxicity to cultured bovine aortic endothelial cells and the cytoprotective effect of various analogs of alpha-toco...

Low-density lipoproteins (LDL) mildly oxidized by copper ions or UV radiations exhibit a cytotoxic effect to cultured endothelial cells. Rutin, a polyphenolic flavonoid, ascorbic acid, and alpha-tocopherol were able to inhibit the peroxidation of LDL and their subsequent cytotoxicity. The mixture of the three compounds (rutin/ascorbic acid/alpha-to...

The ability of 17 beta-estradiol, progesterone, testosterone and cholesterol in preventing the cytotoxicity of oxidized LDL to cultured aortic bovine endothelial cells (BAEC) was tested and compared. The lipid peroxidation of LDL, promoted either by UV-C radiation, copper ions or cultured human lymphoblastoid cells, was inhibited in a dose-dependen...