Laurence Cooper

Background: T cells expressing antigen-specific chimeric antigen receptors (CARs) improve outcomes for CD19-expressing B cell malignancies. We evaluated a human application of T cells that were genetically modified using the Sleeping Beauty (SB) transposon/transposase system to express a CD19-specific CAR. Methods: T cells were genetically modif...

Significance We describe an approach based on cytokine therapeutics to enhance the persistence and effectiveness of T-cell–based immunotherapies using chimeric antigen receptors (CARs). This strategy is effective without the use of high-dose exogenous cytokines that are typically associated with toxicities. Moreover, we report that the persistence...

Key Points Allogeneic-donor–derived cells can be genetically modified to eliminate expression of HLA-A. HLA-A disruption from donor cells is a step toward generating allogeneic cells as an off-the-shelf therapeutic.

Clinical-grade T cells are genetically modified ex vivo to express a chimeric antigen receptor (CAR) to redirect specificity to a tumor associated antigen (TAA) thereby conferring antitumor activity in vivo. T cells expressing a CD19-specific CAR recognize B-cell malignancies in multiple recipients independent of major histocompatibility complex (M...

Significance Patients with compromised T-cell function are at risk for opportunistic fungal infections. We have developed a novel approach to restore immunity by using a fungal pattern-recognition receptor Dectin-1 to redirect T-cell specificity to carbohydrate antigen in the fungal cell wall. We did so by genetically modifying T cells using the no...

Adoptive cell therapy using engineered natural killer (NK) cells has emerged as a promising new treatment, with gene editing offering opportunities to further increase antitumor potency. However, strategies to address both intrinsic and extrinsic therapeutic barriers remain largely unexplored. To address this, we developed a pooled CRISPR discovery...

Increasing evidence suggests that the gut microbiome may influence the responses and toxicities associated with chimeric antigen receptor (CAR) therapy. We conducted whole-genome shotgun sequencing on stool samples (n=117) collected at various times from multiple myeloma patients (n=33) undergoing idecabtagene vicleucel (ide-cel) anti-B cell matura...

Outcomes of patients with CD30-positive (CD30⁺) lymphomas have improved with the advent of brentuximab vedotin (BV) and, in Hodgkin lymphoma, anti-PD1 checkpoint inhibitors (CPI). However, there is a need for new therapies for patients with tumors refractory to both BV and CPI, who face dismal outcomes. AFM13—a CD30/CD16A bispecific antibody—activa...

There are scarce data in the literature focusing on newly diagnosed multiple myeloma (NDMM) patients who undergo autologous haematopoietic cell transplantation (autoHCT) after achieving suboptimal response to induction. To address this, we performed a retrospective, single‐centre analysis of patients with NDMM who underwent upfront autoHCT between...

176 Background: Colorectal cancer (CRC) is the second most common type of cancer. Even following successful curative treatment, patients often relapse, likely because of undetected micro-metastatic foci. Tumor-informed ctDNA testing has helped to identify those patients before they developed radiographic evidence of disease, introducing the concept...

Background Efficacious cellular immunotherapy requires donor cells that robustly proliferate in vitro and in vivo despite manipulation during engineering, in vitro culture, prior exposure to pharmacologic treatment or antigens, and cryopreservation. A barrier to rapid patient and donor selection for autologous and allogeneic cell therapy is predict...

Background Natural killer (NK) cells are crucial for eliminating tumor and virally-infected cells by integrating signals from activating and inhibitory receptors. While NK-cell therapy has shown success in treating leukemias and lymphomas, its effectiveness against solid tumors remains limited due to tumor-mediated suppression. Oncolytic viruses, w...

Background Immunotherapies, such as bi-specific antibodies, chimeric antigen receptor (CAR) T cells, NK, and CAR NK cells have revolutionized the treatment of patients with certain malignancies. For this reason, these technologies are under development to treat a wide range of cancers. While many of these therapies are moving through preclinical de...

Background There is a critical need to test novel strategies with improved anti-tumor response and safety profile for patients with relapsed and/or refractory metastatic melanoma (RRFM). Notably, adoptive cell therapy (ACT) has been recognized as a promising avenue for addressing the unmet need for more potent anti-tumor approaches. Allogeneic cord...

Background: Deletion of the short arm of chromosome 1 (del1p) has been speculated to be associated with worse outcomes in patients diagnosed with multiple myeloma (MM). There are scarce data on the outcomes of MM patients with del1p following autologous hematopoietic stem cell transplantation (autoHCT). Methods: We conducted a single-center, retros...

Allogeneic stem cell transplantation (ASCT) is a curative immunotherapy for patients with hematologic malignancies and performed more than 7000 per year in the US. Here, patients receive the conditioning chemo-radiation to eradicate the residual blood cancer, followed by donor stem cells to reconstitute the donor immunity. However, only 30-40% pati...

Background: Leukemia recurrence remains a continuing cause of treatment failure post-allogeneic hematopoietic cell transplantation (allo-HSCT) in FLT3-mutated AML patients (pts). Maintenance therapy with FLT3 inhibitors is a promising strategy to reduce the risk of relapse risk. Currently, no FLT3 inhibitors have been approved. Crenolanib is a high...

Background: Approximately 60% of patients with relapsed/refractory (r/r) large B-cell lymphoma (LBCL) experience progression after chimeric antigen receptor (CAR) T-cell therapy, which confers dismal outcomes and there is unmet need to improve clinical trial participation. However, former studies have shown that only less than 20% of patients are t...

Several studies estimate that primary induction failure (PIF), meaning persistent leukemia following intensive induction chemotherapy (1,2) occurs in approximately 10-40% of patients with acute myeloid leukemia (AML). The lack of response to treatment is considered a major predictor for poor outcomes. Curative treatment is unlikely to be achieved w...

Background: Chimeric antigen receptor T-cell (CAR-T) therapy targeting CD19 offers curative potential for relapsed or refractory large B-cell lymphoma (LBCL), but recurrence occurs in >50% of patients. CAR-T is also associated with serious toxicities including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrom...

In patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL), CAR-T cells have shown very high complete remission (CR) rates with two therapies approved in this setting, tisagenlecleucel and brexucabtagene autoleucel with overall response rates of 81% and 71%, respectively (1,2). Despite being a highly efficacious therapy, relapse...

Introduction Upfront high-dose therapy and autologous hematopoietic stem cell transplantation (autoHCT) is considered a standard of care for eligible patients with newly diagnosed MM (NDMM). Historically, Hispanic or African-American patients with multiple myeloma (MM) have been reported to have worse outcomes. In this study, we examined the impact...

Background: Previous research by the US Lymphoma Chimeric Antigen Receptor T-cell (CAR-T) consortium identified several factors to be associated with outcomes and complications from standard-of-care CAR-T for large B-cell lymphoma (LBCL) (Nastoupil et al. Journal of Clinical Oncology, 2020). Among these factors, elevated total bilirubin (> 1.5 g/dL...

Introduction: Outcomes of patients (pts) with acute myeloid leukemia (AML) are improving, but certain high-risk subsets continue to fare poorly. Outcomes of pts with AML secondary (s-AML) from a prior myeloid neoplasm are usually adverse and often influenced by their underlying genomics. Pts who has had therapy for their prior myeloid neoplasms who...

Background Disease progression, graft-versus-host disease (GvHD) and non-relapse mortality are the main causes of failure after allogeneic hematopoietic cell transplantation (HCT). There have been many studies focusing on the biological models of HLA-DPB1 mismatching, namely permissiveness according to T-cell epitope (TCE) groups to determine their...

Post-transplant cyclophosphamide (PTCy) graft-versus-host disease (GvHD) prophylaxis has shifted the epidemiology of GvHD by reducing the rate of grade III-IV acute (aGvHD) and chronic GvHD (cGVHD). Use of PTCy has recently expanded beyond the haploidentical (haplo) transplant (SCT) setting, which necessitates reassessment of the conventional risk...

Introduction: A reliable and sustainable supply of platelets remains a critical challenge in managing thrombocytopenic patients, with over 2 million platelet units transfused annually in the United States alone. This demand is common in patients undergoing treatments such as chemotherapy or bone marrow transplantation, who frequently require platel...

Chimeric antigen receptor (CAR) T-cell therapies induce durable responses in many patients with hematological malignancies. However, these therapies are associated with unique and significant toxicities, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), with grade 3-4 ICANS occurring in up...

Background Acute myeloid leukemia, myelodysplastic syndrome, and TKI resistant CML continue to be the most aggressive forms of blood cancer. Allogeneic hematopoietic stem cell transplantation (alloSCT) remains one of the most effective treatments available due to the immune-mediated graft-versus-leukemia effect to prevent relapse. Nevertheless, dis...

Introduction Chimeric antigen receptor T-cell therapy (CAR-T) has improved outcomes for relapsed/refractory (r/r) large B-cell lymphoma (LBCL) but is associated with a unique toxicity profile. Pre-existing mental health disorders (MHD) negatively impact prognosis in various hematological malignancies, including de-novo LBCL. However, the effect of...

Introduction: With the clinical benefits of chimeric antigen receptor (CAR)- T-cell therapy are increasingly recognized, both acute and late-onset severe symptomatic toxicities, CRS and ICANS, that require initial hospitalization followed by careful monitoring while patients discharged. A more relevant and effective monitoring and managing the toxi...

Introduction: Secondary myeloid neoplasms (MN) are a recognized risk following chimeric antigen receptor (CAR) T-cell therapy. Prior studies are limited to low-resolution adverse event reporting or small case series. We provide a comprehensive account of MN characteristics and outcomes following CAR T. Methods: We reviewed our institutional experie...

Background and Significance: Although patient social/ financial barriers impact transplant and cellular therapy (TCT) outcomes (e.g. Fingrut et al., Blood Adv. 2023), prospectively collected, comprehensive, granular data concerning the social determinants of health (SDOH) are not routinely collected across the TCT field. Study design and Methods: W...

Background: For patients with newly-diagnosed multiple myeloma (MM), induction therapy with bortezomib, lenalidomide, and dexamethasone (VRD) followed by autologous hematopoietic stem cell transplantation (autoHCT) and single-agent lenalidomide (Len) maintenance is one of the most commonly-used standard of care therapy sequences for transplant-elig...

Background and Significance: Outcomes for most patients with AML remain poor. Efforts to improve both the remission rate and the durability of remission in patients of all ages are paramount. IDH1 mutations occur in 7-14% of patients with AML, often enriched in older patients, and both hypomethylating agents in combination with venetoclax, and IDH1...

Background: For patients with multiple myeloma (MM) undergoing autologous hematopoietic stem cell transplantation (autoHCT), high dose melphalan has been the standard conditioning for many years. A prospective randomized clinical trial at our institution compared the outcomes of patients who received busulfan + melphalan (BuMel) to melphalan 200mg/...

Introduction: Consolidation with high-dose chemotherapy and autologous stem cell transplantation (ASCT) for patients with light chain amyloidosis (AL) is associated with deeper responses and improved outcomes. Several factors are known to be associated with worse outcomes. Older patients with AL frequently present with more advanced disease and hav...

Background: Among donor-related factors, younger age is consistently associated with improved outcomes in patients undergoing hematopoietic cell transplantation (HCT). While a female donor for a male recipient (F-to-M) may pose an increased risk of graft-versus-host disease (GVHD), it may offer a potential benefit through mismatched minor histocomp...

Background: Inotuzumab ozogamicin (INO) is a humanized antibody-drug conjugate that targets CD22+ B-cells. We recently demonstrated that INO can be added safely to a non-myeloablative conditioning of bendamustine, fludarabine, and rituximab in patients with indolent lymphoid malignancies who required an allogeneic hematopoietic transplantation (HCT...

Background: Allogeneic stem cell transplantation (SCT) is recommended for younger or fit patients with acute myeloid leukemia (AML) in first complete remission (CR1) who possess a relapse risk exceeding 35-40% (Dohner et al., 2022). The ideal number of post-remission intensive consolidation chemotherapy (IC) cycles prior to allogeneic SCT is curren...

Background: The prognosis for patients with AML and MDS who relapse after allogeneic stem cell transplant (allo-SCT) is dismal. AML is susceptible to immunotherapy, as evidenced by the success of allo-SCT. Enhancing graft-versus-leukemia effect of allo-SCT is a major area of focus. We investigated combination immune checkpoint inhibition (ICI) usin...

Background: An increasing number of older patients are undergoing hematopoietic stem cell transplantation (HCT). Optimal donor selection is critical for driving positive outcomes post-HCT. Older patients are more likely to have older siblings as potential donors and recent reports have associated older donor age with worse outcomes. In the absence...

Autologous transplantation remains the standard of care for eligible multiple myeloma (MM) patients, yet optimal CD34⁺ cell dose remains unclear. We conducted a retrospective study on MM patients undergoing upfront transplant between 2005 and 2021 and divided them into low (≤2.5 × 10⁶ cells/kg) and high (>2.5 × 10⁶ cells/kg) CD34⁺ dose groups. We i...

Refractory aggressive lymphomas can be treated with allo-SCT, pursuing a graft-vs-lymphoma effect. While reduced intensity conditioning is safe, tumors often progress rapidly, indicating the need for more active conditioning regimens. The preclinical synergy we saw between gemcitabine (Gem), clofarabine (Clo) and busulfan (Bu) against lymphoma cell...

HLA-matched sibling donors (MSDs) are preferred for hematopoietic cell transplantation (HCT). However, the use of alternative donors, especially haploidentical, is increasing, as is our understanding of the impact of HLA factors such as B-leader and DRB1-matching on its outcomes. Yet, data comparing these donor types, particularly considering these...

Bronchiolitis obliterans syndrome (BOS) after hematopoietic cell transplantation (HCT) is associated with substantial morbidity and mortality. Quantitative CT (qCT) can help diagnose advanced BOS meeting National Institutes of Health (NIH) criteria (NIH-BOS) but has not been used to diagnose early, often asymptomatic BOS (early BOS), limiting the p...

Immunization programs against SARS-CoV-2 with commercial intramuscular vaccines prevent disease but are less efficient in preventing infections. Mucosal vaccines can provide improved protection against transmission, ideally for different variants of concern (VOCs) and related sarbecoviruses. Here, we report a multi-antigen, intranasal vaccine, Nano...

Respiratory viral infections cause morbidity and mortality worldwide. Despite the success of vaccines, vaccination efficacy is weakened by the rapid emergence of viral variants with immunoevasive properties. The development of an off-the-shelf, effective, and safe therapy against respiratory viral infections is thus desirable. Here, we develop Nano...

PURPOSE Access to allogeneic hematopoietic cell transplantation (HCT) remains limited among persons of non-European ancestry if human leukocyte antigen (HLA) matching is required. We evaluated whether post-transplant cyclophosphamide (PTCy)–based graft-versus-host disease (GVHD) prophylaxis improved HCT outcomes with HLA-matched unrelated donor (MU...

TPS5626 Background: Novel treatments are needed for patients with ovarian, pancreatic, and mesonephric-like adenocarcinoma (MLA) that has recurred or progressed after initial treatment, as current standard of care therapies in these settings result in low response rates. Chimeric antigen receptor-transduced natural killer (CAR-NK) cells have emerge...

Chimeric antigen receptor (CAR) T cells used for the treatment of B cell malignancies can identify T cell subsets with superior clinical activity. Here, using infusion products of individuals with large B cell lymphoma, we integrated functional profiling using timelapse imaging microscopy in nanowell grids with subcellular profiling and single-cell...

The introduction of posttransplant cyclophosphamide (PTCy)-based graft-versus-host disease (GVHD) prophylaxis lead to significant improvements in haploidentical stem cell transplantation (haplo-SCT) outcomes over the past decade. We retrospectively assessed long-term outcomes of patients who had their first haplo-SCT between February 2009 and March...

Veno-occlusive disease (VOD) is a rare but potentially life-threatening complication following allogeneic hematopoietic stem cell transplantation (allo-SCT). While increasing awareness and modern transplant techniques have mitigated risk, the interaction of historic risk factors in the current era with post-transplant cyclophosphamide (PTCy) is unk...

There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord blood-derived natural killer (NK) cells expressing anti-CD19 chimeric antigen receptor and interleukin-15 (CAR19/IL-15) in 37 patients with CD19⁺ B cell malignancies. The prima...

The prognostic impact of additional copies of chromosome 1q (1q + ) on outcomes of newly-diagnosed multiple myeloma (NDMM) patients undergoing autologous transplantation (autoSCT) is unclear. We conducted a retrospective single-center analysis of NDMM patients with 1q21 gain/amplification (3 or ≥4 copies of 1q, respectively) that received autoSCT b...

Background The prognostic significance of minimal residual disease (MRD) status before autologous hematopoietic stem cell transplantation (autoHCT) in patients with multiple myeloma (MM) has not been clearly elucidated. Methods Retrospective single‐center study of adult MM patients who achieved ≥very good partial response (VGPR) after induction th...

Complications occurring after lymphodepleting chemotherapy (LDC) may delay chimeric antigen receptor (CAR) T-cell infusion. The effect of these delays on clinical outcomes is unclear. We performed a retrospective analysis of 240 patients with relapsed/refractory large B-cell lymphoma treated with standard-of-care axicabtagene ciloleucel (axi-cel) a...

Introduction:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, clinically aggressive hematologic malignancy that commonly involves four major compartments: cutaneous, bone marrow/blood, lymph nodes, and central nervous system (CNS). Tagraxofusp (TAG) is a first-in-class therapy directed to CD123, a target expressed in BPDCN, and is th...

Background. Increasing data have demonstrated that acquired genetic aberrations, including TP53 mutations in the tumor cells and clonal hematopoiesis, can impact the efficacy and/or toxicity of anti-CD19 autologous CAR T-cell therapy (CART) in patients with large B-cell lymphoma (LBCL). Recent data have suggested that germline genetic aberrations,...

Background: We previously showed that PTCy/Tac ± MMF is associated with a significant reduction in the rate of chronic graft-versus-host disease (cGvHD) as compared to Tac/MTX after HLA-matched sibling (MSD) but not after HLA-matched unrelated (MUD) donor stem cell transplant (SCT). Notably, ATG was used with Tac/MTX in MUD but not in MSD. [ Transp...

Background: Veno-occlusive disease (VOD) is a rare but potentially life-threatening complication following allogeneic stem cell transplantation (allo-SCT). Improved transplant techniques and increased awareness of modifiable risk factors have reduced VOD incidence. However, the interaction of historic risk factors in the current era, particularly w...

Relapsed/refractory T-cell malignancies have a particularly poor prognosis and novel therapies are direly needed. CD5 is a great candidate for adoptive cellular therapy to target T-cell malignancies since it is ubiquitously expressed on T cells with restricted expression on other hematopoietic cells. NK cells are an attractive platform for CAR engi...

Chronic lymphocytic leukemia (CLL) is a heterogeneous disease, presenting with a highly variable clinical course, outcome and response to therapy. This variability has been linked to a complex tumor microenvironment and genetic/epigenetic modifications that lead to immunosuppression. Indeed, the clinical hallmark of this disease is the susceptibili...

Introduction: Richter transformation (RT) describes the emergence of an aggressive lymphoma in the setting of chronic lymphocytic leukemia (CLL). The prognosis is poor, with a median overall survival (OS) of 10 months. Treatment of RT is still challenging despite the availability of novel agents, and stem cell transplant (SCT) is commonly used as a...

The ability to re-direct the intrinsic power of the immune system against cancer has resulted in unprecedented outcomes in certain patients with otherwise incurable diseases. Natural killer (NK) cells, similar to T cells, are powerful immune effectors that possess intrinsic anti-tumor properties and are capable of generating a strong cytotoxic resp...

Background: Ph-like ALL is a high-risk subset of B-lineage ALL that responds poorly to standard chemotherapy regimens. While allogeneic hematopoietic cell transplantation (HCT) is routinely recommended for patients with Ph-like ALL, large multicenter data addressing its role is limited. Here, we conducted a multicenter study to evaluate the role of...

Background: Inotuzumab ozogamicin (InO) is a humanized antibody-drug conjugate that targets CD22+ B-cells. InO demonstrated antitumor activity and manageable toxicity in phase 1/2 trials for the treatment of B-cell non-Hodgkin lymphoma (NHL) as a single agent and in combination with rituximab. In order to improve outcomes in patients with relapsed...

Background: There is contradictory data regarding the prognostic impact of additional copy numbers of chromosome 1q (1q+) on the outcomes of newly diagnosed multiple myeloma (NDMM) patients, and there is scarce data in the context of autologous stem cell transplantation (autoSCT). In this report, we studied outcomes of NDMM patients with 1q+ who re...

Background: Minimal residual disease (MRD) has emerged as one of the most important prognostic markers in patients with multiple myeloma (MM). However, the prognostic significance of MRD status prior to autologous hematopoietic stem cell transplantation (autoHCT) has not been clearly elucidated. Methods: In this retrospective single-center study we...

Background: The second revision of the International Staging System (R2-ISS) is a new and simple tool to risk stratify newly diagnosed multiple myeloma (NDMM) patients. Our aim in this study was to evaluate the utility of R2-ISS in NDMM patients who received upfront autologous hematopoietic stem cell transplantation (auto-HCT). Methods: We conducte...

Background: Post-transplant cyclophosphamide (PTCy) has become a standard of care for graft-versus-host disease (GvHD) prophylaxis in recipients of human leukocyte antigen (HLA)-matched and mismatched unrelated donor (MMUD) allografts, generating new opportunities for successful hematopoietic cell transplantation (HCT) regardless of patient ancestr...

Introduction Wilms Tumor 1 ( WT1) is integral to cell proliferation and survival and is mutated in up to 10-15% of patients (pts) with acute myeloid leukemia (AML). WT1 mutated ( WT1 m) AML frequently co-occurs with fms-like tyrosine kinase 3 ( FLT3) and nucleophosmin 1 ( NPM1) mutations, and is generally thought to impart poorer outcomes, however...

Background: Autologous CAR-T therapy targeting CD19 is an effective treatment for relapsed or refractory large B-cell lymphoma (LBCL). However, morbidity and mortality related to CAR-T toxicity remain significant concerns. This study aims to evaluate the patterns, risk factors, and implications of cytokine release syndrome (CRS) and immune effector...

Background: Despite the introduction of newer drugs and combination therapies, outcomes of patients with AML and TP53mutation (mut) and/or loss continue to remain poor, with a median survival of 6-12 months. The phase 2 study of venetoclax (Ven) added to Clad+ LDAC alternating with azacitidine (Aza) in pts with newly diagnosed (ND) AML demonstrated...

Introduction Remarkable advances have been made in the treatment of multiple myeloma (MM) with the advent of novel therapies and the use of post-transplant maintenance. We report trends in outcomes of MM patients who received upfront autologous hematopoietic stem cell transplantation (autoHCT) at our institution over more than three decades. Method...

Background: Eligible patients with multiple myeloma (MM) are offered autologous hematopoietic cell transplantation (auto-HCT) in their first remission. The usual conditioning regimen consists of melphalan (Alkeran) 200 mg/m 2 infused over ~ 30 minutes due to its limited stability. Evomela is a newer formulation of melphalan, which is stable at room...

Despite the high response rates of chimeric antigen receptor (CAR) - T cells targeting the B-cell maturation antigen (BCMA) for multiple myeloma (MM), patients eventually still relapse. At this time there is no clear subsequent therapy. Furthermore, CAR T-cell therapy is associated with significant toxicities such as cytokine release syndrome and i...

Background: Adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) are treated with various chemotherapy regimens. Some patients undergo allogeneic hematopoietic stem cell transplantation (HCT) due to high-risk genetic characteristics, chemo-resistant disease (failure to achieve timely measurable residual disease (MRD) negative...

Background: Calcineurin-inhibitor (CNI) with mycophenolate mofetil (MMF) or methotrexate (MTX) is commonly used as graft-versus-host disease (GVHD) prophylaxis for HLA-matched hematopoietic cell transplantation (HCT) but MMF, which targets both T- and B-lymphocytes, is associated with higher risk for cytomegalovirus (CMV) reactivation [ Blood Adv.2...

CONCLUSIONS Pts with refractory Hodgkin (HL) and other CD30+ lymphomas have few effective therapies available and targeted NK cell immunotherapy is an active area of research. Transfer of non-targeted NK cells has shown limited clinical benefit as target recognition of cancer cells by NK cells constitutes a barrier. The innate cell engager AFM13 is...

Background: CAR-T cell therapies have revolutionized cancer therapeutics with durable responses in hematologic malignancies. However, toxicities such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) are well-established off-target effects of CAR-T therapy. Immune effector cell (IEC) therapy can result in...

Introduction: In patients undergoing allogeneic hematopoietic cell transplantation (HCT), venous thromboembolism (VTE) is associated with increased morbidity and worse survival. Central venous catheters (CVC) are placed for administration of both stem cell products and other supportive measures. CVC are a common etiology of VTE during HCT. This stu...

Background and Significance. Approximately 30% of patients with large B-cell lymphoma (LBCL) treated with autologous anti-CD19 CAR T-cell therapy (CART) achieve a partial response (PR) on day 30 (D30) assessment. Of those, up to 30% may spontaneously convert to a complete response (CR) during subsequent re-staging. While up to 70% of patients with...

T-cell lymphomas (TCL) are a heterogenous group of non-Hodgkin lymphoma characterized by resistance to conventional therapies posing an urgent need for safe and effective therapies. CAR-NK cells have emerged as a promising “off-the-shelf” cancer immunotherapy and are especially attractive for the treatment of T-cell malignancies. This is especially...