Lauren E Sergio

Lauren E Sergio
York University · School of Kinesiology and Health Sciences

PhD

About

91
Publications
11,656
Reads
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3,129
Citations
Citations since 2017
34 Research Items
1169 Citations
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Additional affiliations
January 2000 - present
York University
November 1994 - December 1999
Université de Montréal
September 1988 - December 1994
McGill University
Position
  • PhD Student
Education
September 1988 - February 1995
McGill University
Field of study
  • Psychology
September 1984 - June 1988
McGill University
Field of study
  • Physiology

Publications

Publications (91)
Article
Full-text available
Introduction Visuomotor impairments have been demonstrated in preclinical AD in individuals with a positive family history of dementia and APOE e4 carriers. Previous behavioral findings have also reported sex-differences in performance of visuomotor tasks involving a visual feedback reversal. The current study investigated the relationship between...
Article
Introduction Fifteen percent of individuals who sustain a concussion develop persistent concussion symptoms (PCS). Recent literature has demonstrated atrophy of the frontal, parietal, and cerebellar regions following acute concussive injury. The frontoparietal-cerebellar network is essential for the performance of visuomotor transformation tasks re...
Article
Full-text available
Introduction Non-standard visuomotor integration requires the interaction of large networks in the brain. Previous findings have shown that non-standard visuomotor performance is impaired in individuals with specific dementia risk factors (family history of dementia and presence of the APOE ε4 allele) in advance of any cognitive impairments. These...
Article
University athletes are exposed to numerous impacts to the body and head, though the potential cumulative effects of such hits remain elusive. This study examined resting-state functional connectivity (rsFC) of brain networks in female varsity athletes over the course of a season. Nineteen female university athletes involved in collision (N = 12) a...
Article
Full-text available
Objective: To examine attention, executive control, and performance variability in healthy varsity athletes and identify unique resting-state functional connectivity (rsFC) patterns associated with measures of speed, stability, and attention. Method: A sample of 29 female university varsity athletes completed cognitive testing using the Attention N...
Article
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Background The ability to perform visually-guided motor tasks requires the transformation of visual information into programmed motor outputs. When the guiding visual information does not align spatially with the motor output, the brain processes rules to integrate somatosensory information into an appropriate motor response. Performance on such ru...
Article
Purpose: This paper provides recommendations for neurorehabilitative research informed by insights from critical disability studies (CDS) and a research study that tested an augmented neurorehabilitative technology prototype. Methods: The methodology combines critical reflection, feminist science studies and CDS to analyze how neurorehabilitatio...
Article
Full-text available
Objective clinical tools, including cognitive-motor integration (CMI) tasks, have the potential to improve concussion rehabilitation by helping to determine whether or not a concussion has occurred. In order to be useful, however, an individual must put forth their best effort. In this study, we have proposed a novel method to detect the difference...
Article
Full-text available
Currently, there is strong interest within the military to better understand the effects of long-term occupational exposure to repeated low-level blast on health and performance. To gain traction on the chronic sequelae of blast, we focused on breaching —a tactical technique for gaining entry into closed/blocked spaces by placing explosives and mai...
Article
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Adults exposed to blast and blunt impact often experience mild traumatic brain injury, affecting neural functions related to sensory, cognitive, and motor function. In this perspective article, we will review the effects of impact and blast exposure on functional performance that requires the integration of these sensory, cognitive, and motor contr...
Preprint
Full-text available
The perception of color is an important cognitive feature of the human brain. The variety of colors that impinge upon the human eye can trigger changes in brain activity which can be captured using electroencephalography (EEG). In this work, we have designed a multiclass classification model to detect the primary colors from the features of raw EEG...
Article
The present study expands previous work on eye-hand decoupling deficits in youth with concussion history. It examines whether deficits can be linked to difficulties adapting to new task constraints or meeting ongoing task demands. Data from 59 youth with concussion history (M=11 months post-concussion) and 55 no history controls were analyzed. All...
Article
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Background: With the prevalence of dementia increasing each year, pre-clinically implemented therapeutic interventions are needed. It has been suggested that cascading neural network failures may bring on behavioural deficits associated with Alzheimer's disease. Methods: Previously we have shown that cognitive-motor integration (CMI) training in...
Article
Full-text available
Aim: We examined the long-term effects of concussions in young adult females on visuomotor behavior during a visually-guided reaching task of various complexities. Materials & methods: 20 females with a history of longer than 6 months since a concussion and 20 healthy females quickly and accurately performed a delayed reach to a previously cued...
Article
Full-text available
Background: Cognitive-motor integration (CMI) involves concurrent thought and action which requires the interaction of large brain networks. Given that early-stage dementia involves neural network dysfunction, deficits in CMI may prove useful for early dementia detection. Objective: Our research objective was to investigate sex-related differenc...
Article
Objective: Does group physiotherapy methods produce different results when compared with individual physiotherapy in persons with surgically repaired rotator cuff tears? No studies to date have examined the feasibility or effectiveness of such therapy formats. Given the prevalence of rotator cuff tears, a study examining group format therapy is wa...
Article
A previous study showed prolonged cognitive–motor integration (CMI) deficits in youth with a history of concussion who were classified as asymptomatic by current return-to-play protocols, highlighting potential differences between clinical symptom recovery and skill recovery. The present study examines factors that may influence skilled performance...
Article
Full-text available
In the present study, we characterize how the ability to decouple guiding visual information from a motor action emerges during childhood and adolescence. Sixty-two participants (age range 8–15 yrs.) completed two eye-hand coordination tasks. In a direct interaction task, vision and motor action were in alignment, and participants slid their finger...
Article
Full-text available
Standard visually guided reaching begins with foveation of a target of interest followed by an arm movement to the same spatial location. However, many visually guided arm movements, as well as a majority of imaging studies examining such movements, require participants to perform non-standard visuomotor mappings where the locations of gaze and arm...
Article
Full-text available
Background Concussion is a preventable injury that can have long-term health consequences for children and youth. In Ontario, the Policy/Program Memorandum # 158 (PPM) was introduced by the Ministry of Education of Ontario in March 2014. The PPM’s main purpose is to require each school board in the province to create and implement a concussion poli...
Article
This study compared cognitive-motor integration between young individuals with a concussion history to participants with Alzheimer’s disease risk. Participants made finger movements on a touchscreen from a central to peripheral target. We observed performance impairments in both groups relative to neurologically healthy control groups, even when ag...
Conference Paper
Cognitive-motor integration (CMI) tasks require the implementation of a cognitive rule to perform the necessary motor action, e.g., when we look to the right but have to move to the left (i.e., decoupling of vision and action). We use this ability often during our daily life and in sport activities. A previous study showed CMI deficits in children...
Article
Cognitive-motor integration (CMI) tasks require the implementation of a cognitive rule to perform the necessary motor action, e.g., when we look to the right but have to move to the left (i.e., decoupling of vision and action). We use this ability often during our daily life and in sport activities. A previous study showed CMI deficits in children...
Article
Full-text available
Background Noninvasive interventions to aid healthy cognitive aging are considered an important healthcare priority. Traditional approaches typically focus on cognitive training or aerobic exercise training. In the current study, we investigate the effect of exercises that directly combine cognitive and motor functions on visuomotor skills and gene...
Article
Full-text available
Objective To investigate the use of the Sport Concussion Assessment Tool 3 (SCAT3) as an assessment tool in the varsity population, as well as the effects of sex and concussion history on both baseline and postconcussion scores. Methods A comparison between baseline and postconcussion SCAT3 scores of varsity level athletes was conducted through re...
Article
Full-text available
A history of action video game (AVG) playing is associated with improvements in several visuospatial and attention-related skills and these improvements may be transferable to unrelated tasks. These facts make video games a potential medium for skill-training and rehabilitation. However, examinations of the neural correlates underlying these observ...
Article
Full-text available
Objective There is a higher risk of re-injury for athletes with concussion history when returning to play, despite being asymptomatic and cleared for activity. One possible explanation is that current return to play assessments test thinking and moving separately, but sport activities often require their concurrent processing (cognitive-motor integ...
Article
Our brain's ability to flexibly control the communication between the eyes and the hand allows for our successful interaction with the objects located within our environment. This flexibility has been observed in the pattern of neural responses within key regions of the frontoparietal reach network. More specifically, our group has shown how single...
Article
We characterize bimanual coordination development for the first time in a large sample of children (n = 303) in relation to age, sex, and athletic experience. A further aim is to document the effect of these factors on development to indirectly gain insight into the neural processes that underlie this advanced level of eye–hand coordination. This w...
Article
Background: Many neuroimaging parameters have demonstrated utility as biomarkers in preclinical AD, including resting-state functional connectivity in the default mode network. However, neuroimaging is not a practical, cost effective screening instrument. Objective: Here we investigate the relationship between performance on a cognitive-motor in...
Article
Full-text available
Aim We investigated whether children and adolescents with concussion history show cognitive–motor integration (CMI) deficits. Method Asymptomatic children and adolescents with concussion history (n = 50; mean 12.84 years) and no history (n = 49; mean: 11.63 years) slid a cursor to targets using their finger on a dual-touch-screen laptop; target lo...
Article
Objective: To provide incidence rates and days to symptom resolution and cognitive recovery stratified by sex and sport at a Canadian institution. Study design: A retrospective chart analysis. Subjects: Seven hundred fifty-nine varsity level athletes competing in men's football, men's and women's soccer, men's and women's volleyball, men's and...
Article
"Standard" visually-guided reaching movements consist of a saccade and an arm movement to the same target location. In the current study, functional magnetic resonance imaging was used to contrast brain activity during standard visually-guided reaches with activity during a "non-standard" visuomotor mapping where the targets of the saccade and arm...
Article
Full-text available
Background: The ability to perform visually-guided motor tasks requires the transformation of visual information into programmed motor outputs. When the guiding visual information does not align spatially with the motor output, the brain processes rules to integrate the information for an appropriate motor response. Here, we look at how performanc...
Article
Guiding a reach when the spatial location of the viewed target and the hand movement are not congruent (i.e. decoupled) can rely on the use of explicit cognitive rules (strategic control) or on the implicit recalibration of gaze and the limb position (sensorimotor recalibration). We previously demonstrated, in a patient with optic ataxia (OA) havin...
Article
Often, the brain receives more sensory input than it can process simultaneously. Spatial attention helps overcome this limitation by preferentially processing input from a behaviorally-relevant location. Recent neuropsychological and psychophysical studies suggest that attention is deployed to near-hand space much like how the oculomotor system can...
Article
Alzheimer's disease (AD) is typically associated with impairments in memory and other aspects of cognition, while deficits in complex movements are commonly observed later in the course of the disease. Recent studies, however, have indicated that subtle deteriorations in visuomotor control under cognitively demanding conditions may in fact be an ea...
Article
Full-text available
Background and objective: Recent evidence suggests that visuomotor behaviors may be disrupted in the very early stages of Alzheimer's disease (AD). Here we propose that using kinematic measures under conditions that place demands on visual-spatial and cognitive-motor processing may provide an effective behavioral means to detect subtle changes ass...
Article
Full-text available
Eye-hand coordination is crucial for our ability to interact with the world around us. However, much of the visually guided reaches that we perform require a spatial decoupling between gaze direction and hand orientation. These complex decoupled reaching movements are in contrast to more standard coupled eye and hand reaching movements in which the...
Article
Full-text available
Guiding a limb often involves situations in which the spatial location of the target for gaze and limb movement are not congruent (i.e. have been decoupled). Such decoupled situations involve both the implementation of a cognitive rule (i.e. strategic control) and the online monitoring of the limb position relative to gaze and target (i.e. sensorim...
Article
Full-text available
The aim of this research was to understand how the brain controls voluntary movement when not directly interacting with the object of interest. Here we examined the role of premotor cortex in this behaviour. The goal of this study was to characterize the oscillatory activity within the caudal and rostral subdivisions of PMd (PMdc and PMdr) when goi...
Article
Full-text available
Background There is a paucity of information regarding visuospatial (VS) and visuomotor (VM) task performance in patients with chronic right fronto-parietal lobe stroke, as the majority of knowledge to date in this realm has been gleaned from acute stroke patients. The goal of this paper is to determine how VS and VM performance in chronic stroke p...
Article
Cognition allows for the use of different rule-based sensorimotor strategies, but the neural underpinnings of such strategies are poorly understood. The purpose of this study was to compare neural activity in the superior parietal lobule during a standard (direct interaction) reaching task, with two nonstandard (gaze and reach spatially incongruent...
Article
Full-text available
Patients with optic ataxia (OA), who are missing the caudal portion of their superior parietal lobule (SPL), have difficulty performing visually-guided reaches towards extra-foveal targets. Such gaze and hand decoupling also occurs in commonly performed non-standard visuomotor transformations such as the use of a computer mouse. In this study, we t...
Article
Identifying the multitude of deficits associated with dementia-related illnesses such as Alzheimer's disease (AD) presents a significant challenge for many health care facilities, particularly as current screening procedures may lack the sensitivity to highlight all the relative functional deficits within these populations. Although quick assessmen...
Article
Background: There is a paucity of information regarding visuospatial (VS) and visuomotor (VM) task performance in patients with chronic right fronto-parietal lobe stroke, as the majority of knowledge to date in this realm has been gleaned from acute stroke patients. Aim: To determine how VS and VM performance in chronic stroke patients compare to t...
Article
Full-text available
This study examined cognitive-motor integration in adults with mild cognitive impairment (MCI). Previously, we showed that the performance of early-stage Alzheimer's disease patients declined significantly as a visually-guided movement went from having a standard mapping (vision and action spatially aligned) to having a non-standard mapping (vision...
Article
Using event-related functional magnetic resonance imaging (fMRI), we examined the effect of video-game experience on the neural control of increasingly complex visuomotor tasks. Previously, skilled individuals have demonstrated the use of a more efficient movement control brain network, including the prefrontal, premotor, primary sensorimotor and p...
Article
Full-text available
Single-unit recordings in macaque monkeys have identified effector-specific regions in posterior parietal cortex (PPC), but functional neuroimaging in the human has yielded controversial results. Here we used on-line repetitive transcranial magnetic stimulation (rTMS) to determine saccade and reach specificity in human PPC. A short train of three T...
Article
Primate neurophysiology and human brain imaging studies have identified effector-related regions in the posterior parietal cortex (PPC). However, this specialization is less clear in human fMRI studies. Here we used fMRI-derived regions of interest to navigate transcranial magnetic stimulation (TMS) and causally determine saccade and reach specific...
Article
Many of our daily movements use visual information to guide our arms toward objects of interest. Typically, these visually guided movements involve first focusing our gaze on the intended target and then reaching toward the direction of our gaze. The literature on eye-hand coordination provides a great deal of evidence that circuitry in the brain e...
Article
Full-text available
Optic ataxia (OA) is one of the symptoms pertaining to Bálint's Syndrome. It has been described clinically for nearly 80 years before it became a cornerstone of the most popular dual stream theory of the visual brain. Over the last 10 years a regain of interest for this neurological condition lead to a number of precise analyses of the deficits fou...
Article
Full-text available
Posterior parietal cortex (PPC) has been implicated in the integration of visual and proprioceptive information for the planning of action. We previously reported that single-pulse transcranial magnetic stimulation (TMS) over dorsal-lateral PPC perturbs the early stages of spatial processing for memory-guided reaching. However, our data did not dis...
Article
Full-text available
An increasing number of projects in neuroscience require statistical analysis of high-dimensional data, as, for instance, in the prediction of behavior from neural firing or in the operation of artificial devices from brain recordings in brain-machine interfaces. Although prevalent, classical linear analysis techniques are often numerically fragile...
Article
Do neurons in primary motor cortex encode the generative details of motor behavior, such as individual muscle activities, or do they encode high-level movement attributes? Resolving this question has proven difficult, in large part because of the sizeable uncertainty inherent in estimating or measuring the joint torques and muscle forces that under...
Article
In the past it has often been assumed that the cortical networks for visually guided movement are the same for males and females. Here we use functional magnetic resonance imaging (fMRI) to show significant sex-related differences in human brain activity during visual-to-motor transformation tasks. Although the behavioural performance of the male a...
Article
Full-text available
This study examined the ability of neurologically healthy individuals and individuals with Alzheimer's disease (AD) to successfully complete procedures involving short-term spatial visuomotor memory tasks, and tasks involving increasingly complex visuomotor transformations. Participants made sliding finger movements over a clear touch-sensitive scr...
Article
Full-text available
Dorsal posterior parietal cortex (PPC) has been implicated through single-unit recordings, neuroimaging data, and studies of brain-damaged humans in the spatial guidance of reaching and pointing movements. The present study examines the causal effect of single-pulse transcranial magnetic stimulation (TMS) over the left and right dorsal posterior pa...
Article
Full-text available
The saccade generator updates memorized target representations for saccades during eye and head movements. Here, we tested if proprioceptive feedback from the arm can also update handheld object locations for saccades, and what intrinsic coordinate system(s) is used in this transformation. We measured radial saccades beginning from a central light-...
Article
When the sensory information guiding a reach movement is dissociated from the required motor output, humans must integrate rule-based information in order to reach accurately. Here, we examine the accuracy of movements requiring a visuomotor transformation in neurologically healthy elderly subjects and patients diagnosed with probable Alzheimer's d...