Lauren Mackenzie Reynolds

Lauren Mackenzie Reynolds
École Supérieure de Physique et de Chimie Industrielles | ESPCI · Laboratoire de Plasticité du Cerveau

PhD in Neuroscience

About

22
Publications
2,184
Reads
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386
Citations
Citations since 2016
18 Research Items
349 Citations
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Additional affiliations
May 2019 - September 2021
Sorbonne Université
Position
  • PostDoc Position
May 2015 - June 2015
The University of Queensland
Position
  • Visting Student
September 2012 - December 2018
McGill University
Position
  • PhD Student
Education
September 2012 - December 2018
McGill University
Field of study
  • Neuroscience
September 2006 - May 2010
Northeastern University
Field of study
  • Behavioral Neuroscience

Publications

Publications (22)
Article
Full-text available
Individuals differ in their traits and preferences, which shape their interactions, their prospects for survival and their susceptibility to diseases. These correlations are well documented, yet the neurophysiological mechanisms underlying the emergence of distinct personalities and their relation to vulnerability to diseases are poorly understood....
Article
Full-text available
Long-term exposure to nicotine alters brain circuits and induces profound changes in decision-making strategies, affecting behaviors both related and unrelated to drug seeking and consumption. Using an intracranial self-stimulation reward-based foraging task, we investigated in mice the impact of chronic nicotine on midbrain dopamine neuron activit...
Article
Full-text available
Mesocorticolimbic dopamine circuity undergoes a protracted maturation during adolescent life. Stable adult levels of behavioral functioning in reward, motivational, and cognitive domains are established as these pathways are refined, however, their extended developmental window also leaves them vulnerable to perturbation by environmental factors. I...
Article
Nicotine stimulates dopamine (DA) neurons of the ventral tegmental area (VTA) to establish and maintain reinforcement. Nicotine also induces anxiety through an as yet unknown circuitry. We found that nicotine injection drives opposite functional responses of two distinct populations of VTA DA neurons with anatomically segregated projections: it act...
Preprint
Full-text available
Long-term exposure to nicotine alters brain circuits and induces profound changes in decision-making strategies, affecting behaviors both related and unrelated to drug seeking and consumption. Using an intracranial self-stimulation reward-based foraging task, we investigated the impact of chronic nicotine on the trade-off between exploitation and e...
Chapter
Adolescence is a period of dynamic physical, hormonal, and behavioral changes that coincide with the transition from a juvenile state to independence. In humans, this period has historically been framed as occurring between 12 and 20 years of age, although advances in research indicate that the boundaries are more fluid than previously considered....
Article
Full-text available
The fine arrangement of neuronal connectivity during development involves the coordinated action of guidance cues and their receptors. In adolescence, the dopamine circuitry is still developing, with mesolimbic dopamine axons undergoing target-recognition events in the nucleus accumbens (NAcc), while mesocortical projections continue to grow toward...
Article
The guidance cue receptor DCC controls mesocortical dopamine development in adolescence. Repeated exposure to an amphetamine regimen of 4 mg/kg during early adolescence induces, in male mice, downregulation of DCC expression in dopamine neurons by recruiting the Dcc microRNA repressor, microRNA‐218 (miR‐218). This adolescent amphetamine regimen als...
Article
Psychiatric conditions marked by impairments in cognitive control often emerge during adolescence, when the prefrontal cortex (PFC) and its inputs undergo structural and functional maturation and are vulnerable to disruption by external events. It is not known, however, whether there exists a specific temporal window within the broad range of adole...
Article
Full-text available
The prefrontal cortex (PFC) is divided into subregions, including the medial and orbital prefrontal cortices. Dopamine connectivity in the medial PFC (mPFC) continues to be established throughout adolescence as the result of the continuous growth of axons that innervated the nucleus accumbens (NAcc) prior to adolescence. During this period, dopamin...
Poster
Full-text available
Development of a restraint system enabling awake mouse imaging using commercially-available RF coils.
Article
The development of the dopamine input to the medial prefrontal cortex occurs during adolescence and is a process that is vulnerable to disruption by stimulant drugs such as amphetamine. We have previously linked the amphetamine-induced disruption of dopamine connectivity and prefrontal cortex maturation during adolescence to the downregulation of t...
Article
Preclinical neuroimaging allows for the assessment of brain anatomy, connectivity and function in laboratory animals, such as mice and rats. Most of these studies are performed under anesthesia to avoid movement during the scanning sessions. Due to the limitations associated with anesthetized imaging, recent efforts have been made to conduct rodent...
Article
Background Dopaminergic input to the prefrontal cortex (PFC) increases throughout adolescence and, by establishing precisely localized synapses, calibrates cognitive function. However, why and how mesocortical dopamine axon density increases across adolescence remains completely unknown. Methods We used a developmental application of axon-initiate...
Conference Paper
Full-text available
On June 7–9, 2017, The Canadian College of Neuropsycho-pharmacology (CCNP) held its 40th Annual Meeting in Kingston, Ontario. At the core of the scientific program were 6 symposia, where clinical and basic neuroscientists presented their ideas and most recent discoveries in the hope of significantly advancing our understanding and treatment of ment...
Article
Full-text available
Mesocortical dopamine connectivity continues to mature during adolescence. This protracted development confers increased vulnerability for environmental and genetic factors to disrupt mesocortical wiring and subsequently influence responses to drugs of abuse in adulthood. The netrin-1 receptor, DCC, orchestrates medial prefrontal cortex dopamine in...
Article
Full-text available
Initiation of drug use during adolescence is a strong predictor of both the incidence and severity of addiction throughout the lifetime. Intriguingly, adolescence is a period of dynamic refinement in the organization of neuronal connectivity, in particular medial prefrontal cortex (mPFC) dopamine circuitry. The guidance cue receptor, DCC (deleted i...
Article
Full-text available
Despite long-standing concerns regarding the abuse liability of benzodiazepines, the mechanisms underlying properties of benzodiazepines that may be relevant to abuse are still poorly understood. Earlier studies showed that compounds selective for α1-containing GABAA receptors (α1GABAARs) are abused by humans and self-administered by animals, and t...
Article
Full-text available
Benzodiazepines such as diazepam are widely prescribed as anxiolytics and sleep aids. Continued use of benzodiazepines, however, can lead to addiction in vulnerable individuals. Here, we investigate the neural mechanisms of the behavioral effects of benzodiazepines using the intracranial self-stimulation (ICSS) test, a procedure with which the rewa...

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Projects

Projects (3)
Project
Aimed at identifying a mechanism by which drugs of abuse disrupt adolescent brain development and influence long-term vulnerability to psychopathology such as addiction