Lauren Carson

Lauren Carson
King's College London | KCL · Division of Women's Health

Doctor of Philosophy

About

22
Publications
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351
Citations

Publications

Publications (22)
Article
Full-text available
Children and young people with Autism Spectrum Disorder (ASD) have an increased risk of comorbidities, such as epilepsy and Attention-Deficit/Hyperactivity Disorder (ADHD). However, little is known about the relationship between early childhood epilepsy (below age 7) and later ADHD diagnosis (at age 7 or above) in ASD. In this historical cohort stu...
Article
Full-text available
Background Domestic violence and abuse (DVA) and mental illness during pregnancy have long-lasting and potentially serious consequences, which may have been exacerbated during the COVID-19 pandemic. Aims To investigate how the UK COVID-19 lockdown policy influenced the identification of DVA and depressive symptoms during pregnancy in health servic...
Article
Background It is unclear how best to identify and treat women with mental disorders in pregnancy and the year after birth (i.e. the perinatal period). Objectives (1) To investigate how best to identify depression at antenatal booking [work package (WP) 1]. (2) To estimate the prevalence of mental disorders in early pregnancy (WP1). (3) To develop...
Article
Full-text available
Background Psychiatric mother and baby units (MBUs) are recommended for severe perinatal mental illness, but effectiveness compared with other forms of acute care remains unknown. Aims We hypothesised that women admitted to MBUs would be less likely to be readmitted to acute care in the 12 months following discharge, compared with women admitted t...
Article
Full-text available
The response to the coronavirus outbreak and how the disease and its societal consequences pose risks to already vulnerable groups such those who are socioeconomically disadvantaged and ethnic minority groups. Researchers and community groups analysed how the COVID-19 crisis has exacerbated persisting vulnerabilities, socio-economic and structural...
Article
Full-text available
Purpose: Linked maternity, neonatal and maternal mental health records were created to support research into the early life origins of physical and mental health, in mothers and children. The Early Life Cross Linkage in Research (eLIXIR) Partnership was developed in 2018, generating a repository of real-time, pseudonymised, structured data derived...
Article
Full-text available
IntroductionThe use of linked data and non-consent methodologies is a rapidly growing area of health research due to the increasing detail, availability and scope of routinely collected electronic health records data. However, gaining the necessary legal and governance approvals to undertake data linkage is a complex process in England. Objectives...
Article
Background Prenatal stress is associated with altered fetal and infant development. Previous studies have suggested that these effects may be mediated in part via altered functioning of placental enzymes and receptors involved in the HPA-axis, including the glucocorticoid receptor (NR3C1) and HSD11B2, the enzyme which metabolises cortisol. However,...
Article
Background: Prenatal stress is associated with altered fetal and infant development. Previous studies have suggested that these effects may be mediated in part via altered functioning of placental enzymes and receptors involved in the HPA-axis, including the glucocorticoid receptor (NR3C1) and HSD11B2, the enzyme which metabolises cortisol. Howeve...
Article
Parenting begins before birth. This includes prenatal maternal and paternal bonding with the baby, and biological effects on fetal development. Recent research has confirmed how prenatal maternal stress can alter the development of the fetus and the child, and that this can persist until early adulthood. Children are affected in different ways depe...
Article
Full-text available
Background: Maternal prenatal stress during pregnancy is associated with fetal growth restriction and adverse neurodevelopmental outcomes, which may be mediated by impaired placental function. Imprinted genes control fetal growth, placental development, adult behaviour (including maternal behaviour) and placental lactogen production. This study ex...
Chapter
There is good evidence that maternal stress, anxiety, and depression during pregnancy can have long-term effects on a variety of outcomes for the child. We need to understand how an altered emotional state in the pregnant woman affects her biology in a way that in turn affects the development of her fetus. Cortisol is one probable mediating factor,...
Article
Full-text available
Maternal antenatal depression and anxiety are associated with increased risk of childhood behavioural and emotional problems in offspring; it remains unclear to what extent this is due to a maternal biological impact on foetal development. Here, we compare associations between maternal and paternal antenatal depression and anxiety with offspring an...

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Projects

Project (1)
Project
Theme Lead: Prof. Jane Sandall (Maternity) Deputy Theme Lead: Dr. Abigail Easter (Perinatal Mental Health) This project brings together the core and adopted projects associated with the Maternity and Perinatal Mental Health research being conducted at the South London National Institute for Health Research Applied Research Collaboration [NIHR ARC]. We are a cross-disciplinary group of researchers based between the Department of Women & Children's Health (School of Life Course Sciences) and the Section for Women's Mental Health (Institute of Psychiatry, Psychology & Neuroscience) at King's College London. Collectively, we have varying academic backgrounds in Midwifery, Psychiatry, Psychology, Nursing, Anthropology, Reproductive Physiology, and Statistics. Our focus is on co-morbidities and health inequalities, specifically in South East London.