Laure Dutrieux

Laure Dutrieux
Institute of Human Genetics

Master of Science
PhD student in Epigenome modifications and genomic instability in normal and malignant B cells lab

About

9
Publications
545
Reads
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22
Citations

Publications

Publications (9)
Article
Plasma cells (PC) are highly specialized cells representing the end stage of B cell differentiation. We have shown that PC differentiation can be reproduced in vitro using elaborate culture systems. The molecular changes occurring during PC differentiation are recapitulated in this in vitro differentiation model. However, a major challenge exists t...
Article
Full-text available
Multiple myeloma (MM) is a hematological malignancy characterized by an abnormal clonal proliferation of malignant plasma cells. Despite the introduction of novel agents that have significantly improved clinical outcome, most patients relapse and develop drug resistance. MM is characterized by genomic instability and a high level of replicative str...
Article
Multiple Myeloma (MM) is a plasma cell (PC) disorder without definitive treatment and associated with multiple relapses. There is therefore an urgent need to develop innovative therapeutic strategies to overcome drug resistance. mRNA translation deregulation in involved in cancer progression by promoting aberrant proliferation or cell survival, and...
Article
Full-text available
Multiple myeloma (MM) is a hematologic cancer characterized by accumulation of malignant plasma cells in the bone marrow. To date, no definitive cure exists for MM and resistance to current treatments is one of the major challenges of this disease. The DNA helicase BLM, whose depletion or mutation causes the cancer-prone Bloom’s syndrome (BS), is a...
Article
Multiple myeloma (MM) is the second most frequent hematological malignancy, characterized by the accumulation of malignant plasma cells (PCs) within the bone marrow. To date, there is no definitive treatment for this pathology and a majority of patients will invariably relapse. Antibody secretion, the key biological function of PCs, is maintained i...
Article
Full-text available
Plasma cells (PCs) have an essential role in humoral immune response by secretion of antibodies, and represent the final stage of B lymphocytes differentiation. During this differentiation, the pre-plasmablastic stage is characterized by highly proliferative cells that start to secrete immunoglobulins (Igs). Thus, replication and transcription must...

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