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Huntington’s Disease is a life-shortening neurodegenerative condition caused by a CAG repeat expansion in exon 1 of the HTT gene. The age at onset of involuntary motor symptoms is inversely correlated with CAG repeat length but there is considerable variation between patients. A recent genome-wide association study has identified DNA repair process...
Background The CAG repeat expansion in the HTT gene that causes Huntington’s disease (HD) is known to vary in length, both intergenerationally and between different tissues within one patient. Repeat expansion in the striatum correlates with the neurodegeneration seen in HD, and one explanation is that repeat expansion drives pathogenesis. Recent w...
On the basis of measurements of the perceived coherence of superimposed drifting gratings, Krauskopf and Farell (1990) proposed that motion is analysed independently in different chromatic channels. They found that two gratings appeared to slip if each modulated one of the two 'cardinal' color mechanisms S/(L+M) and L/(L+M). If the gratings were de...
We aim to characterise the behavioural and molecular effects of SNPs associated with variance in age of onset of HD. We will do this in R6/1 mice carrying the mutations.