Laura Smith

Laura Smith
Aneurin Bevan University Health Board · Research & Development

BSc (Hons) Psychology with Professional Placement

About

3
Publications
122
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
21
Citations

Publications

Publications (3)
Poster
Huntington’s Disease is a life-shortening neurodegenerative condition caused by a CAG repeat expansion in exon 1 of the HTT gene. The age at onset of involuntary motor symptoms is inversely correlated with CAG repeat length but there is considerable variation between patients. A recent genome-wide association study has identified DNA repair process...
Article
Background The CAG repeat expansion in the HTT gene that causes Huntington’s disease (HD) is known to vary in length, both intergenerationally and between different tissues within one patient. Repeat expansion in the striatum correlates with the neurodegeneration seen in HD, and one explanation is that repeat expansion drives pathogenesis. Recent w...
Article
Full-text available
On the basis of measurements of the perceived coherence of superimposed drifting gratings, Krauskopf and Farell (1990) proposed that motion is analysed independently in different chromatic channels. They found that two gratings appeared to slip if each modulated one of the two 'cardinal' color mechanisms S/(L+M) and L/(L+M). If the gratings were de...

Network

Cited By

Projects

Project (1)
Project
We aim to characterise the behavioural and molecular effects of SNPs associated with variance in age of onset of HD. We will do this in R6/1 mice carrying the mutations.