Laura Orsolini

Laura Orsolini
University of Hertfordshire | UH · Psychopharmacology, Drug Misuse and Novel Psychoactive Substances

MB ChB (Hons), MScCrim, PGCert (Forensic PSY), psychiatrist and clinical researcher at Hertfordshire University, Hatfield, Uk and Department of Clinical Neurosciences/DIMSC, School of Medicine, Polytechnic Univ. of Marche, Ancona, Italy

About

239
Publications
113,983
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Introduction
Dr Laura Orsolini (MD psychiatrist and clinical researcher) at Department of Clinical Neurosciences/DIMSC, School of Medicine, Section of Psychiatry, Polytechnic University of Marche, Ancona, Italy and Psychopharmacology Drug Misuse and NPS Research Unit- Univ.Hertfordshire, Hatfield (UK). MSc in Forensic Psychiatry, Criminology, PGCert in Forensic Psychology, MSc in Affective Neurosciences, MSc in Health Economy and Management. ECP member of SIP, SIPS, EPA, WPA, NECPAM, ISAM-NEXT
Additional affiliations
November 2015 - January 2017
University of Hertfordshire
Position
  • M.D., Psychiatrist, Forensic Psychiatrist
January 2014 - present
University of Hertfordshire
Position
  • academic researcher visitor
January 2014 - present
University of Hertfordshire
Position
  • Research Assistant
Education
January 2014 - September 2014
University of Hertfordshire
Field of study
  • Drug misuse/Psychopharmacology; Substance-related research
September 2012 - December 2013
University of the Republic of San Marino
Field of study
  • Criminology, Forensic Psychiatry
December 2011 - December 2012
Associazione italiana di psicologia giuridica
Field of study
  • Forensic Psychology, Clinical and forensic Psydiagnosis, forensic psychopatology

Publications

Publications (239)
Chapter
Chocolate is the most desired food in the world, and it has always been considered as a pleasant food, sought after both for hedonistic reasons and for its role as a “panacea” for mood and affectivity. Multiple features of “the food of Gods” can explain how it is induced/increased to induce/increase the desire to eat it. Its unique orosensory quali...
Article
Abstract Background: The COVID-19 pandemic has impacted people with substance use disorders (SUDs) worldwide and healthcare systems have reorganized their services in response to the pandemic. Methods: One week after the announcement of the COVID-19 as a pandemic, in a global survey, 177 addiction medicine professionals described COVID-19-related h...
Article
Full-text available
Introduction Ekbom Syndrome (ES) is characterised by fixed, delusional beliefs that one’s body is infested by parasites or other vermin in absence of supporting clinical evidence. Antipsychotic (AP) treatment, including long-acting injectable (LAI) AP in subjects with poor compliance, is prescribed to manage behavioural and psychotic symptomatology...
Article
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The COVID-19 pandemic situation significantly affected the mental health of the general and clinical population. However, few studies investigated which COVID-19-related psychopathological determinants may predispose to perinatal depression. We evaluated the impact of COVID-19 related anxiety and fear on perinatal depression in Italy. We retrospect...
Article
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Climate change has become a global emergency, which mental health effects are increasingly being described and understood. Children and adolescents, especially those in low income countries and minority communities, are particularly vulnerable to experience the worst impacts of climate change now and in the coming decades. Our group of early career...
Article
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How many kinds of malevolent characters are out there? In line with Paulhus and Williams (2002) the answer is three, namely the Dark Triad of Machiavellianism, Narcissism, and Psychopathy. Dark traits (DT) are associated with emotional deficits, exploitation, immoral strategic thinking, and risky behaviors. All three traits have been largely invest...
Article
Introduction Hikikomori is a Japanese term etymologically derived from ‘ hiku’ (i.e. ‘ to pull back’) and ‘ komoru’ (i.e. ‘ seclude oneself’), which identifies those subjects who deliberately withdraw themselves by social life, remaining confined into their own home/room. The phenomenon is widely diffused in Japan, even though it is currently sprea...
Article
Acute agitation is common in youths presenting to emergency departments, and, in some cases, may escalate into aggression and violence. Therefore, acute agitation in youths should be immediately and appropriately recognized and treated to avoid the consequences of its escalation. Agitation is widespread in youths, being reported in around 7% of all...
Article
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Grief is the physical or mental suffering experienced after a major loss, usually the death of a loved one. It is a universal experience, but sociocultural factors, such as cultural or ethnic identity and religious beliefs predict and shape the expression of grief. The circumstances under which people are experiencing grief during the coronavirus o...
Article
Introduction Esketamine was approved for adults with treatment-resistant depression (TRD) in conjunction with an oral antidepressant, and for treating depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior. However, evidence of great efficacy and safety of esketamine is accompanied by a widespread con...
Article
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Introduction Adolescents and young adults represent a vulnerable population in the context of the Coronavirus disease 2019 (COVID-19) pandemic. The present retrospective study aims to investigate the pandemic’s psychological impact on adolescents and young adults by analyzing data from an outpatient mental health service dedicated to youths in Umbr...
Article
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Background and Objectives: Now more than ever, there is an obvious need to reduce the overall burden of disease and risk of premature mortality that are associated with mental health and substance use disorders among young people. However, the current state of research and evidence-based clinical care for high-risk substance use among youth is frag...
Article
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Declaration of cCompeting iInterestNone.Abstract Objectives We examined the associations of lockdown stringency and duration with Google searches for four mental health concepts (i.e., “Anxiety,” “Depression,” “Suicide,” “Mental Health”) in nine countries (i.e., Hungary, India, Iran, Italy, Paraguay, Serbia, South Africa, Spain, Turkey) during the...
Article
Clozapine-resistant schizophrenia (CRS) occurs in 40%-70% of clozapine-treated schizophrenic patients. Hereby we describe a 20-year-old CRS subject with comorbid cannabinoid use disorder, successfully treated with clozapine-brexpiprazole combination, subsequently switched to clozapine plus long-acting injectable aripiprazole.
Preprint
Full-text available
Addiction medicine is a developing field, with many young professionals opting for a career in this area. However, globally, early-career professionals often face challenges in this field, such as lack of competency-based training due to a shortage of trainers, low availability of institutions with appropriate infrastructure, and limited resources...
Article
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Background. Aripiprazole long-acting injection (LAI) is approved for the treatment of schizophrenia in adults. Recently, Europe and Canada approved the use of the two-injection start regimen: two separate injections of 400-mg long-acting aripiprazole along with a single 20-mg dose of oral aripiprazole. Aripiprazole showed efficacy in the treatment...
Article
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The COVID-19 pandemic led to the implementation of digital psychiatry (DP), resulting in the need for a new skilled healthcare workforce. The purpose of this study was to investigate the level of training, knowledge, beliefs, and experiences of young mental health professionals and medical students in DP. An ad hoc cross-sectional survey was admini...
Article
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The etiopathogenesis of depression is not entirely understood. Several studies have investigated the role of inflammation in major depressive disorder. The present work aims to review the literature on the association between C-Reactive Protein (CRP) and depression. A systematic review was performed for the topics of 'CRP' and 'depression' using th...
Article
Full-text available
COVID-19 pandemic and its related containment measures have been associated with increased levels of stress, anxiety and depression in the general population. While the use of digital media has been greatly promoted by national governments and international authorities to maintain social contacts and healthy lifestyle behaviors, its increased acces...
Preprint
Purpose . The COVID-19 pandemic situation significantly affected the mental health of the general and clinical population including that of pregnant and puerperal women due to lack of access to healthcare, social isolation, sleep loss, feelings of fear and uncertainties. However, few studies investigated which COVID-19-related psychopathological de...
Article
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Introduction: Bipolar disorder (BD) onset typically occurs between 15 to 30 years, being diagnosed under the age of 50 in 90% of cases, named ‘non-late onset BD’ (non-LOBD). However, clinical observation of late-onset BD (LOBD) raised some concern regarding a differential psychopathological pattern, outcomes and treatment, including a specific affe...
Article
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The World Health Organization (WHO) has added gaming disorder to ICD-11 as a clinical condition associated with distress or interference with personal functioning. This inclusion leads to clinical and public health benefits, such as harmonising terminology, offering clinical landmarks and improving monitoring capabilities and data comparability. Tr...
Article
There is an increasing movement toward international collaboration and global discussion in mental health. If provided with the right opportunities, early career psychiatrists (ECPs) and researchers in mental health can contribute meaningfully to this discussion. However, they often experience multiple barriers when attempting to add their voices v...
Article
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Background: Digital mental health interventions and digital psychiatry have been rapidly implemented over the past decade, particularly with the intent to offer a cost-effective solution in those circumstances in which the current mental health services and infrastructure are not able to properly accommodate the patients' needs. However, mental hea...
Article
The substantial strain that women are facing during the COVID-19 pandemic can affect their menstrual cycle and further impair their quality of life. In low- and middle-income countries, this strain is exacerbated by: cultural taboos and poor education related to menstruation; ‘period poverty’; unavailability of menstrual hygiene products; and poor...
Article
In the article, a group of early career psychiatrists presents the results of a discussion about the relationship between attention deficit and hyperactivity disorder (ADHD) and addictions. Modern views on the commonality of the occurrence of these conditions at the genetic, morphological and functional levels are considered. Possible clinical mani...
Article
Affective Disorders are on a clinical continuum in which temperaments and other coexisting or emerging mental conditions may cover the role of risk factors or determinants of specific dimensional aspects of Bipolar Disorder. Overall, it is important to better characterize the psychopathological conditions associated to the clinical picture of an af...
Article
Digital phenotyping represents a new approach aimed at measuring the human behavior by using smartphones and personal device sensors, smartphone apps, keyboard interaction, and various features of subject’s voice and speech. Data collected by a digital phenotyping smartphone application are divided into two categories: a) active data (i.e., those u...
Article
Background and Aims: COVID-19 has infected more than 77 million people worldwide and impacted the lives of many more, with a particularly devastating impact on vulnerable populations, including people with substance use disorders (SUDs). Quarantines, travel bans, regulatory changes, social distancing, and “lockdown” measures have affected drug and...
Article
Full-text available
Background and Objectives: The Internet is widely used and disseminated amongst youngsters and many web-based applications may serve to improve mental health care access, particularly in remote and distant sites or in settings where there is a shortage of mental health practitioners. However, in recent years, specific digital psychiatry interventio...
Article
The COVID-19 pandemic and its impact on mental health has remained immense and global in all senses . Various types of induced psychiatric disorders, both new episodes and exacerbation of the preexisiting ones has been reported - starting from adjustment disorder to full psychotic illnesses . Various clinical symptoms, including systematized delusi...
Article
Every health care system requires an adequate health care workforce, service delivery, financial support, and information technology. During the COVID-19 pandemic, global health systems were ill prepared to address the rising prevalence of mental health problems, especially in low- and middle-income countries (LMICs), thereby increasing treatment g...
Article
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Background and Objectives: Over the past twenty years a large number of new psychoactive substances (NPS) have entered and modified the recreational drug scene. Their intake has been associated with health-related risks, especially so for vulnerable populations such as people with severe mental illness, who might be at higher risk of suicidality or...
Article
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Attention deficit hyperactivity disorder (ADHD) is a condition that usually has its onset in childhood. Although the disorder persists into adulthood in half of cases, adult ADHD is often not recognized due to different psychopathological characteristics, quite often overlapping with other diagnoses such as mood, anxiety and personality disorders....
Article
Introduction: Pregnant women and foetuses are more likely than ever to be exposed to antipsychotic drugs (APs) during pregnancy and post-partum period. Second-generation APs (SGA) are increasingly used among women in reproductive age. Key outcomes (i.e. congenital malformations, pregnancy and maternal outcomes, neonatal/infant risks and development...
Article
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Although believed safer compared to short-acting benzodiazepines (BZD), in the past few years a growing concern has developed relating to the abuse of Z-drugs, and specifically of zolpidem. Here we aim to review the evidence for the misuse of zolpidem and describe several related cases collected in Italy. A comprehensive overview is here carried by...
Article
Objective Psychiatric patients are at increased risk of attempting suicide. Several potential biomarkers of suicide risk have been proposed, with inconsistent findings. The present paper aimed to evaluate differences in peripheral BDNF levels between psychiatric patients with and without a history of suicide attempts. Methods We conducted a system...
Article
Background: Schizophrenia is frequently complicated by the occurrence of depressive symptoms, anhedonia, obsessions and compulsions, suicidal ideation, and substance abuse, that causes exacerbations and remissions and, in several cases, sustained morbidity and disability. Aim: The present study aimed to evaluate the effect of paliperidone palmit...
Article
Full-text available
Background: The coronavirus disease 2019 (COVID-19) pandemic has impacted people with substance use disorders (SUDs) worldwide, and healthcare systems have reorganized their services in response to the pandemic. Methods: One week after the announcement of the COVID-19 as a pandemic, in a global survey, 177 addiction medicine professionals describe...
Article
Introduction The Unit of Clinical Psychiatry of the University Hospital “Ospedali Riuniti – Ancona”, in collaboration with the Marche Region Health System, is conducting a national observational project entitled “Measures related to the prevention, diagnosis, treatment and assistance of postpartum depressive syndrome”, aiming at promoting women’s M...
Article
Introduction. Quarantine, although essential during contagious outbreaks, has been correlated with poor psychological outcomes in the general population. Such outcomes include low mood, suicide, and post-traumatic stress symptoms. Studies have mostly looked at the mental health of general citizens, healthcare workers, or infected survivors, with li...
Article
Full-text available
The COVID-19 pandemic continues to cause an immense psychosocial strain worldwide. Excessive use of the internet during these psychologically trying times, fueled by physical isolation as a result of lockdowns, has translated into dysfunctional behaviors. A growing body of evidence suggests an unprecedented increase in internet use and consumption...
Article
Objectives The global crisis of COVID-19 and its consequential strict public health measures placed around the world have impacted mental health. New scales and tools have been developed to measure these mental health effects. This narrative review assesses the psychometric properties of these scales and tools and methodological aspects of their de...
Chapter
La comorbilità tra ADHD e DCA è un fenomeno clinicamente significativo, soprattutto per i soggetti che mostrano comportamenti alimentari di tipo binge eating. • Alcuni aspetti neurobiologici appaiono essere condivisi tra ADHD, DCA e disturbi metabolici. • I soggetti con ADHD dovrebbero essere sempre sottoposti a una valutazione specifica per la pr...
Article
Every health care system requires an adequate health care workforce, service delivery, financial support, and information technology. During the COVID-19 pandemic, global health systems were ill prepared to address the rising prevalence of mental health problems, especially in low-and middle-income countries (LMICs), thereby increasing treatment ga...
Article
Full-text available
The goal of this study was to evaluate the potential relationships between religiosity and suicide ideation in drug-naïve outpatients with Major Depression (MDD). Filthy-four adult outpatients with MDD were assessed through the Hamilton Depression Rating Scale (HAM-D), the Duke University Religion Index (DUREL), and the Scale of Suicide Ideation (S...
Article
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Background. Although psychoactive substance use disorders are a domain of mental health, addiction psychiatry is only formally recognized as a subspecialty in few European countries, and there is no standardized training curriculum. Methods. A 76-item questionnaire was developed and disseminated through an online anonymous data-collecting system a...
Presentation
Full-text available
Introduction: Workplace Violence (WPV) in hospital settings appears to be a public concern worldwide. The National Institute of Occupational Safety and Health defines WPV as "any type of physical aggressiveness , verbal threatening or abuse which occur in the workplace". Objectives: a) analysing the main determinants of hetero-aggressiveness (physi...
Article
Full-text available
Bipolar disorder (BD) is a complex neurobiological disorder characterized by a pathologic mood swing. Digital phenotyping, defined as the 'moment-by-moment quantification of the individual-level human phenotype in its own environment', represents a new approach aimed at measuring the human behavior and may theoretically enhance clinicians' capabili...
Preprint
Full-text available
Background: The COVID-19 pandemic has impacted people with substance use disorders (SUDs) worldwide, and healthcare systems have reorganized their services in response to the pandemic. Methods: One week after the announcement of the COVID-19 as a pandemic, in a global survey, 177 addiction medicine professionals described COVID-19-related health re...
Article
Full-text available
The collaborative effort of an international research team from the Early Career Psychiatrist section of the World Psychiatry Association has brought about an easy-to-use, quick and stepwise mental health care toolkit for the identification and appropriate referral of those in need of mental health care during the pandemic. This simple guide can be...
Article
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Background The rapid spread of the Coronavirus disease 2019 (COVID-19) has forced most countries to take drastic public health measures, including the closure of most mental health outpatient services and some inpatient units. This has suddenly created the need to adapt and expand telepsychiatry care across the world. However, not all health care s...
Article
Introduction Adverse events (AEs) monitoring of mood stabilizers (MS) is essential during the treatment of mood disorders as safety and tolerability profiles of MS may greatly influence treatment adherence, patient’s compliance and discontinuation rate. Therefore, clinicians should be aware of their AEs profile and tapering a variety of strategies...
Article
Full-text available
Well-tuned emotional regulation is fundamental for human life and psychological well-being. Negative physiological emotions are counterbalanced by positive ones, and this equilibrium is the mainstay of human physiological affective states. However, this mechanism may sometimes become dysfunctional when negative emotions are not correctly counterbal...
Article
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Alexithymia (from the greek αλεξιθυμία: α-(a)=absence, λέξις (lexis)= word, θυμός (thymos)= emotion) represents the difficulty in identifying, describing and communicating emotions and in discriminating own emotional experiences from the underpinning physiological activation. The incapability in modulating emotions, due to a cognitive elaboration,...
Article
Eating disorders have been reported to be characterized by a specific profile of psychological defenses. Defense mechanisms refer to involuntary psychological processes, relatively stable cognitive response patterns that may serve to distort reality whenever individual resources, skills or motivations do not ensure functional adaptation to internal...
Preprint
Full-text available
Background and aims: COVID-19 has infected more than 13 million people worldwide and impacted the lives of many more, with a particularly devastating impact on vulnerable populations, including people with substance use disorders (SUDs). Quarantines, travel bans, regulatory changes, social distancing and ′lockdown′ measures have affected drug and a...
Article
Introduction. There are several new and emerging antipsychotic medication strategies recently marketed or under clinical development for the treatment of several mental disorders. There is the need to provide an up-to-date overview on the safety of this new generation of antipsychotic medications, which includes also the third-generation antipsycho...