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16
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216
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Introduction
Additional affiliations
July 2019 - March 2023
TICEBA GmbH
Position
- Quality Control Specialist
Publications
Publications (16)
Background
Human dermal mesenchymal stromal cells (MSCs) expressing the ATP-binding cassette (ABC) efflux transporter ABCB5 represent an easily accessible MSC population that, based on preclinical and first-in-human data, holds significant promise to treat a broad spectrum of conditions associated not only with skin-related but also systemic inflam...
Background: Human dermal mesenchymal stromal cells (MSCs) expressing the ATP-binding cassette (ABC) efflux transporter ABCB5 represent an easily accessible MSC population that, based on preclinical and first-in-human data, holds significant promise to treat a broad spectrum of conditions associated not only with skin-related but also systemic infla...
Background: Human dermal mesenchymal stromal cells (MSCs) expressing the ATP-binding cassette (ABC) efflux transporter ABCB5 represent an easily accessible MSC population that, based on preclinical and first-in-human data, holds significant promise to treat a broad spectrum of conditions associated not only with skin-related but also systemic infla...
Neurotoxicity is mediated by a variety of modes-of-actions leading to disturbance of neuronal function. In order to screen larger numbers of compounds for their neurotoxic potential, in vitro functional neuronal networks (NN) might be helpful tools. We established and characterized human NN (hNN) from hiPSC-derived neural progenitor cells by compar...
The human developing central nervous system is more vulnerable to the adverse effects of chemical agents than the adult brain. At present, due to the lack of available data on human neurodevelopmental toxicants, there is an urgent need for testing and subsequently regulating chemicals for their potential to interfere with nervous system development...
In the future, novel in vitro neurotoxicological screening methods to monitor the function of neuronal networks are crucial for safety assessment of compounds, i.e. chemicals and pharmaceuticals. These tests should be of human origin, standardized, reproducible, well characterized and allowing a medium-throughput. The three-dimensional (3D) bioprin...
There is evidence that chemical exposure during development can cause irreversible impairments of the human developing nervous system (Andersen et al. 2000; Bearer 2001; Claudio 2001; Grandjean and Landrigan 2006; Grandjean and Landrigan 2014; Mendola et al. 2002; Rodier 1995; Slikker 1994). Neurological damage ranging from subtle to severe imposes...
Human brain development consists of a series of complex spatiotemporal processes that if disturbed by chemical exposure causes irreversible impairments of the nervous system. To evaluate a chemical disturbance in an alternative assay, the concept evolved that the complex procedure of brain development can be disassembled into several neurodevelopme...
Developmental neurotoxicity (DNT) testing performed in rats is resource-intensive (costs, time, animals) and bears the issue of species extrapolation. Thus, reliable alternative human-based approaches are needed for predicting neurodevelopmental toxicity. Human induced pluripotent stem cells (hiPSCs) represent a basis for an alternative method poss...
