Laura Mählmann

Laura Mählmann
Seerave Foundation

Doctor of Public Health

About

15
Publications
2,768
Reads
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227
Citations
Introduction
Education
September 2009 - August 2014
Maastricht University
Field of study
  • Health Science Reserach

Publications

Publications (15)
Article
Full-text available
A promising new treatment approach for major depressive disorder (MDD) targets the microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions affected in MDD. This is the first randomized controlled trial to determine whether short-term, high-dose probiotic supplementation reduces depressive symptoms along with gut m...
Article
Full-text available
Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota and depression have been observed in recent years, opening novel treatment avenues. Here, we present the first two patients with major depressive disorder ever treated with fecal microbiota transplantation as add-...
Article
Full-text available
Anhedonia has been associated with abnormal reward-related striatal dopamine functioning in patients with different psychiatric disorders. Here, we tested whether anhedonia expression mapped onto striatal volume across several psychiatric diagnoses. T1-weighted images from 313 participants including 89 healthy controls (HC), 22 patients with opioid...
Article
Full-text available
Background: Evidence is growing that both short- and long-term physical exercise have the potential to positively impact on the physiological system related to inflammatory indices, though, such patterns are unknown for pediatric patients with Inflammatory Bowel Disease (IBD). The aim of the present intervention study was to investigate the influe...
Preprint
Background There is urgent need to develop novel augmentation options for improving inadequate response to antidepressants. Emerging evidence showed that the composition of the gut microbiota is altered in patients with depression and related to their symptoms, suggesting that restoring microbial composition may constitute a promising strategy in d...
Article
Digitization is considered to radically transform healthcare. As such, with seemingly unlimited opportunities to collect data, it will play an important role in the public health policy-making process. In this context, health data cooperatives (HDC) are a key component and core element for public health policy-making and for exploiting the potentia...
Article
Objective: To assess the willingness of older Swiss adults to share genetic data for research purposes and to investigate factors that might impact their willingness to share data. Methods: Semi-structured interviews were conducted among 40 participants (19 male and 21 female) aged between 67 and 92 years, between December 2013 and April 2014 at...
Article
Full-text available
Background: Children and adolescents with inflammatory bowel disease (IBD) report impairments in daily activities, social interactions and coping. Findings regarding psychological functioning are inconsistent, while limited information is available on objectively assessed physical activity (PA). The aims of the present study were therefore to compa...
Chapter
Personalised Medicine has become a reality over the last years. The emergence of ‘omics’ and big data has started revolutionizing healthcare. New ‘omics’ technologies lead to a better molecular characterization of diseases and a new understanding of the complexity of diseases. The approach of PM is already successfully applied in different healthca...
Article
Objectives: Poor sleep and higher inflammation markers are associated, and impaired sleep quality is common among patients with inflammatory bowel diseases (IBD). However, information on sleep among children and adolescents with IBD is currently lacking. The aims of the present study were to compare subjective and objective sleep of children and ad...
Article
People with Inflammatory Bowel Disease (IBD) are at risk for mental health issues, poor sleep quality and limited engagement in physical activity (PA). Standard treatment consists of immune modulating pharmaceuticals though evidence is growing that aerobic exercise training (AET) could serve as an adjuvant option to reduce disease symptoms and impr...
Article
People with Inflammatory Bowel Disease (IBD) are at risk for mental health issues, poor sleep quality and limited engagement in physical activity (PA). Standard treatment consists of immune modulating pharmaceuticals though evidence is growing that aerobic exercise training (AET) could serve as an adjuvant option to reduce disease symptoms and impr...
Article
Full-text available
The brain–gut-axis is an interdependent system affecting neural functions and controlling our eating behaviour. In recent decades, neuroimaging techniques have facilitated its investigation. We systematically looked into functional and neurochemical brain imaging studies investigating how key molecules such as ghrelin, glucagon-like peptide-1 (GLP-...
Article
Background and aims Patients with inflammatory bowel disease (IBD) report increased mental health issues, poorer sleep quality and less engagement in physical activity (PA). Standard treatment consists of immune modulating pharmaceuticals, though evidence is growing that aerobic exercise training (AET) might serve as adjuvant option to reduce disea...
Article
Full-text available
Objectives: To explore attitudes of Swiss older adults towards personal genomics (PG). Methods: Using an anonymized voluntary paper-and-pencil survey, data were collected from 151 men and women aged 60-89 years attending the Seniorenuniversität Zurich, Switzerland (Seniors' University). Analyses were conducted using descriptive and inferential s...

Questions

Questions (3)
Question
Usually te control intervention in nutritional RCTs is a “healthy local variety” of foods, but we are looking for a detailed definition, especially one that works globally.
Question
There exists an inter-individual response to dietary intervention due to which a sub population may benefit more than others. This underlying variability can be attributed to genetics, age, gender, lifestyle, environmental exposure, gut microbiome, epigenetics, metabolism nutrition derived from diet, and foods. The inter-individual variability to treatments and nutritional recommendations is largely reflected in biomarker values.
How can we screen approproately to stratify patients prior to the study?
Question
Assessment of compliance with dietary interventions is necessary to understand the observed magnitude of the health effects of the diet per se. The gold standard would be to measure metabolites in blood representing the entire meals - however that is not possible. How can we get as close a possible?

Network

Cited By

Projects

Projects (3)
Project
The Seerave Foundation aspires to broaden and enhance the Standard of Care for cancer patients. We aim to do this by augmenting current cancer therapies with novel, benign and diverse approaches.
Project
The aim of the present randomized controlled trial is to investigate the effect of short-term, high-dose probiotic supplementation on symptoms and gut microbiota-brain interactions in patients with depression