Laura E Liao

Laura E Liao
Ryerson University · Department of Physics

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26
Publications
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479
Citations
Introduction

Publications

Publications (26)
Article
Full-text available
Inducing latency reversal to reveal infected cells to the host immune system represents a potential strategy to cure HIV infection. In separate studies, we have previously shown that CD8 ⁺ T cells may contribute to the maintenance of viral latency and identified a novel SMAC mimetic/IAP inhibitor (AZD5582) capable of reversing HIV/SIV latency in vi...
Article
Full-text available
Mathematical modelling has successfully been used to provide quantitative descriptions of many viral infections, but for the Ebola virus, which requires biosafety level 4 facilities for experimentation, modelling can play a crucial role. Ebola virus modelling efforts have primarily focused on in vivo virus kinetics, e.g., in animal models, to aid t...
Preprint
Full-text available
Mathematical modelling has successfully been used to provide quantitative descriptions of many viral infections, but for the Ebola virus, which requires biosafety level 4 facilities for experimentation, modelling can play a crucial role. Ebola modelling efforts have primarily focused on in vivo virus kinetics, e.g., in animal models, to aid the dev...
Article
Treatment of HIV infection with either antiretroviral (ARV) therapy or neutralizing monoclonal antibodies (NAbs) leads to a reduction in HIV plasma virus. Both ARVs and NAbs prevent new rounds of viral infection, but NAbs may have the additional capacity to accelerate the loss of virus-infected cells through Fc gamma receptor (FcγR)-mediated effect...
Article
Full-text available
In combating viral infections, the Fab portion of an antibody could mediate virus neutralization, whereas Fc engagement of Fc-γ receptors (FcγRs) could mediate an array of effector functions. Evidence abounds that effector functions are important in controlling infections by influenza, Ebola, or HIV-1 in animal models. However, the relative contrib...
Article
Mathematical modeling has been instrumental in enhancing our understanding of the viral dynamics of hepatitis B virus (HBV) infection. We give a primer on HBV infection in humans and a brief overview of the development of within-host mathematical models of HBV infection. In the last decade, models have advanced from considering chronic HBV infectio...
Preprint
This tutorial introduces participants to the design and implementation of an agent-based model using NetLogo through one of two different projects: modelling T cell movement within a lymph node or modelling the progress of a viral infection in an in vitro cell culture monolayer. Each project is broken into a series of incremental steps of increasin...
Article
Mathematical modelling of influenza A virus infection has seen increased use over the last several years. Models applied to both in vitro and in vivo data have provided important new understanding of the kinetics of the virus, the role of different components of the immune response, the importance of non-infectious influenza A virus particles, the...
Data
This tutorial introduces participants to the design and implementation of an agent-based model using NetLogo through one of two different projects: modelling T cell movement within a lymph node or modelling the progress of a viral infection in an in vitro cell culture monolayer. Each project is broken into a series of incremental steps of increasin...
Article
Full-text available
Mathematical models (MMs) have been used to study the kinetics of influenza A virus infections under antiviral therapy, and to characterize the efficacy of antivirals such as neuraminidase inhibitors (NAIs). NAIs prevent viral neuraminidase from cleaving sialic acid receptors that bind virus progeny to the surface of infected cells, thereby inhibit...
Data
Determination of critical release rates and parameters predicted by release MM. (PDF)
Data
The critical free virus release rate, rf, weakly depends on infection parameters. The critical free virus release rate, rf, weakly depends on the rate of loss of virion infectivity, production rate, infection rate, eclipse phase and infectious lifespan. The rf when all parameters are at their base values is indicated with a horizontal dotted line....
Data
The critical bound virus release rate, rb, depends on infection parameters. The critical bound virus release rate, rb, depends on the rate of loss of virion infectivity, production rate, infection rate, eclipse phase, and infectious lifespan. The rb when all parameters are at their base values is indicated with a black circle. (TIF)
Data
Determination of critical free and bound virus release rates, rf and rb. (Left) The sum-of-squared residuals per point (SSR/pt) is computed between each free virus curve in the release MM, as the release rate is varied, and the simulated MC data in the simple MM (black). The critical free virus release rate, rf = 3.72 h−1 (teal circle), corresponds...
Data
The simple MM does not significantly misestimate the infection rate, rate of loss of virion infectivity, or the basic reproductive number. As in Fig 4, but showing the infection rate, rate of loss of virion infectivity, and the basic reproductive number. (TIF)
Article
Full-text available
A defective interfering particle (DIP) in the context of influenza A virus is a virion with a significantly shortened RNA segment substituting one of eight full-length parent RNA segments, such that it is preferentially amplified. Hence, a cell co-infected with DIPs will produce mainly DIPs, suppressing infectious virus yields and affecting infecti...
Article
S1 Biological basis of key co-infection parameters of influenza A virus; S2 Alternative explanation for the reversal of DIP-mediated interference; S3 Sensitivity of the B&C assay to samples containing very high or very low DIP MOIs; S4 Classification of types and causes of curvature in the B&C assay; S5 Methods
Article
S1 Biological basis of key co-infection parameters of influenza A virus; S2 Alternative explanation for the reversal of DIP-mediated interference; S3 Sensitivity of the B&C assay to samples containing very high or very low DIP MOIs; S4 Classification of types and causes of curvature in the B&C assay; S5 Methods
Article
Wounded cells such as Xenopus oocytes respond to damage by assembly and closure of an array of actin filaments and myosin-2 controlled by Rho GTPases including Rho and Cdc42. Rho and Cdc42 are patterned around wounds in a characteristic manner, with active Rho concentrating in a ring-like zone inside a larger, ring-like zone of active Cdc42. How th...
Article
A series of model linear tristannanes [((1R)3Sn)2(2R)2Sn (1: 1R = 2R = n-Bu, 2: 1R = Ph, 2R = n-Bu, 3: 1R = Me, 2R = n-Bu, 4: 1R = n-Bu, 2R = Ph, 5: 1R = Me, 2R = Ph, 6: 1R = n-Bu, 2R = Me, 7: 1R = Ph, 2R = Me)] were prepared by condensation reactions of one equivalent of a dialkyl or diaryl tin diamide or dihydride and two equivalents of a trialky...
Article
Full-text available
This tutorial will introduce the participant to designing and implementing an agent-based model using NetLogo through one of two different projects: modelling T cell movement within a lymph node or modelling the progress of a viral infection through an in vitro cell culture. Each project is broken into a series of incremental steps of increasing co...
Article
Full-text available
Rapid detection of compact binary coalescence (CBC) with a network of advanced gravitational-wave detectors will offer a unique opportunity for multi-messenger astronomy. Prompt detection alerts for the astronomical community might make it possible to observe the onset of electromagnetic emission from CBC. We demonstrate a computationally practical...
Article
Experimentation in vitro is a vital part of the process by which the clinical and epidemiological characteristics of a particular influenza virus strain are determined. We detail the considerations which must be made in designing appropriate theoretical/mathematical models of these experiments and show how modeling can increase the information outp...
Article
Full-text available
In 2007, the A/Brisbane/59/2007 (H1N1) seasonal influenza virus strain acquired the oseltamivir-resistance mutation H275Y in its neuraminidase (NA) gene. Although previous studies had demonstrated that this mutation impaired the replication capacity of the influenza virus in vitro and in vivo, the A/Brisbane/59/2007 H275Y oseltamivir-resistant muta...

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