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March 2001 - October 2017
Publications
Publications (87)
Background: Alcohol use and hypertriglyceridemia are the second and third common causes of acute pancreatitis after choledocholithiasis. Still, few studies directly compare the severity and outcomes of these two groups, which share pathophysiology pathways. Methods: In our study, we compared the biologic profile, severity according to the Atlanta c...
Daily exposure to contaminated environments and surfaces leads to serious health issues, increasing healthcare costs. Active materials that act against pathogens can effectively prevent their proliferation and contribute to increased protection against infections. In this contribution, nanostructured thin films containing silver are investigated, u...
Non-alcoholic fatty liver disease (NAFLD) is the predominant cause of chronic liver conditions, and its progression is marked by evolution to non-alcoholic steatosis, steatohepatitis, cirrhosis related to non-alcoholic steatohepatitis, and the potential occurrence of hepatocellular carcinoma. In our systematic review, we searched two databases, Med...
Background: Acute pancreatitis is an inflammation of the pancreas with variable outcomes depending on its severity. Multiple systems of prediction have been proposed, each with variable specificity and sensitivity and with uneven clinical use. Ferritin is a versatile protein associated with various acute and chronic conditions. Aims: In our study,...
Hepatocellular adenomas are benign endothelial tumors of the liver, mostly associated with female individual users of estrogen-containing medications. However, the precise factors underlying the selective development of hepatic adenomas in certain females remain elusive. Additionally, the conventional profile of individuals prone to hepatic adenoma...
The Golgi apparatus plays a central role in protein sorting, modification and trafficking within cells; its dysregulation has been implicated in various cancers including those affecting the GI tract. This review highlights two Golgi target proteins, namely GOLPH3 and GOLGA proteins, from this apparatus as they relate to gastroenterological cancers...
Considering the increasing incidence of hyperuricemia and oxidative stress-related diseases, quantification of uric acid has become essential. Therefore, the evolution on sensing devices being favorable, these questions are more often addressed to the field of medical researchers. As for many metabolites, (bio)sensors provide a reliable method for...
Matrix metalloproteinases (MMPs) are enzymes involved in the modulation of extracellular matrix (ECM) and adipocytes and preadipocyte differentiation. The pathophysiology of obesity has characterized by many cellular and molecular processes such as inflammatory processes, macrophage infiltration of adipose tissue, and remodeling of ECM via MMP. The...
Acute pancreatitis (AP) represents an inflammatory condition,-with a wide spectrum of local and systemic complications. Early stratification of severity of pancreatitis is an important step in guiding the management of the disease and improving outcomes. Throughout the years many researchers have looked at various risk stratification parameters whi...
Background. Acute pancreatitis represents an inflammatory disease with different grades of severity, ranging from mild to severe presentation. In current practice there are a lot of biomarkers used in diagnosis and prognosis of pancreatitis.
The aim of this study was to evaluate de differences between a group with acute pancreatitis and a group of...
Inorganic elements have been associated with brain tumours for long. The blood concentration of 47 elements was assessed by ICP-MS in 26 brain tumour patients and 21 healthy subjects from Bucharest (Romania). All 47 elements were detected in the brain tumour tissue, and 22 were detected in > 80% of samples; this implies that these elements can cros...
Biomonitoring studies are important for quantifying the body burden of pollutants and their possible effects on health. Serum concentration of 42 elements was assessed by ICP-MS in 89 children (7.2 ± 3.4 years old) from Bucharest (Romania). Levels of pollutants were compared with the clinical data obtained from routine blood tests. Clinical paramet...
Background. Groove pancreatitis or paraduodenal pancreatitis represents a rare type of pancreatitis, and can be classified into cystic dystrophy of the duodenal wall in heterotopic pancreas, paraduodenal cyst or myoadenomatosis.
Case presentation. We present a case of a 58 year old man, drinker and smoker who was admitted in the Department of Gastr...
It is known that cigarette smoking is correlated with medical associated inquires. New electronic cigarettes are intensively advertised as an alternative to conventional smoking, but only a few studies demonstrate their harmful potential. A cross-sectional study was designed using 150 subjects from Brasov (Romania), divided into three groups: non-s...
The aim of this study was to examine the impact of weight loss on oxidant-antioxidant profile in obese T2D patients. The study was
carried out on 38 obese T2D males randomized in two groups, one that underwent laparoscopic sleeve gastrectomy (LSG) and the
other an intensive diet intervention (DTG) and standard diabetes treatment. Body mass index (B...
Changes in lipid metabolism from pregnancies with preeclampsia (PE) are a challenge for the obstetrician, because they contribute to the pathological chain and to some specific severe complications (severe hypertriglyceridemia of pregnancy, acute pancreatitis etc). Patients at risk for PE have higher levels of triglycerides, total and LDL cholester...
Smoking is considered an important source for inorganic elements, most of them toxic for human health. During the last years, there has been a significant increase in the use of e-cigarettes, although the role of them as source of inorganic elements has not been well established. A cross-sectional study including a total of 150 subjects from Brasov...
Despite recent advances in understanding the complex pathogenesis of pancreatitis, the management of the disease remains suboptimal. The use of phytoceuticals (plant-derived pleiotropic multitarget molecules) represents a new research trend in pancreatology. The purpose of this review is to discuss the phytoceuticals with pancreatoprotective potent...
A remarkably high number of analytical methods concerning bioactive compounds, contaminants and biomarkers of exposure in Plant Food Supplements (PFS) have been developed by different scientific groups. The work present an update of classic and new developed methods for detection of several heavy metals, pesticides and mycotoxins from different sam...
Background. Osteoporosis is a bone metabolic disease affecting a large percentage of aging population, which leads to an increased risk of fractures and has a negative impact on life quality. The available treatments for osteoporosis are effective, but are associated with several severe adverse reactions, hence the interest for alternative treatmen...
Whole cell optical biosensors, made by immobilizing whole algal, bacterial or mammalian cells on various supports have found applications in several fields, from ecology and ecotoxicity testing to biopharmaceutical production or medical diagnostics. We hereby report the deposition of functional bacterial layers of Micrococcus lysodeikticus (ML) via...
Microwave heating is a common cooking procedure.Heating can accelerate oxidative processes in oil sand oxidation products are known to have potential toxic effects on human health.Therefore it would be useful to have a method to anticipate the vegetable oils behaviour under thermal conditions. Several methods to evaluate total oxidant activity were...
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated w...
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated w...
Oxidative modified lipid products are associated with various pathological conditions like cardiovascular disease and different types of cancers. Cooking can accelerate the oxidative degradation of vegetable oils. The aim of our study was to assess lipid oxidation parameters together with antioxidant parameters in oils heated in microwave and elect...
Supraphysiological administration of anabolic androgenic steroids has been linked to increased blood pressure. The widely distributed amino acid taurine seems to be an effective depressor agent in drug-induced hypertension. The purpose of this study was to assess the impact of chronic high dose administration of nandrolone decanoate (DECA) and taur...
Clozapine, one of the atypical antipsychotics drugs used
in schizophrenia patients has several adverse effects
among them being agranulocytosis and lipid metabolism
disturbances.
Takeing into account that granulocytes are cells able to
produce freee radicals and lipid metabolism
perturbances are associated with antioxidant systems
disregulation we...
Background: Surgical treatments of obesity have demonstrated rapid improvements in insulin sensitivity and oxidative stress. The current study focuses on metabolic and oxidative stress differences between obese patients with or without type 2 diabetes mellitus (T2DM) prior and after metabolic surgery (Laparoscopic Sleeve
Gastrectomy). Objective: Th...
Flavonoids are preserving phenolic acids in vegetable oils under microwave heating - Volume 75 Issue OCE2 - L. Iosif, L.E. Gaman, M. Gilca, E. Torac, I. Crihana, M. Petran, I.M. Gheorghiu, V. Atanasiu, I. Stoian
Objective. Over the last 20 years became obvious that immune system plays a critical role in modulation of learning, memory and neural plasticity. Neuroprogression consists in cumulative restructuring of nervous system which mediates appearance and persistence of the mental illness. The present study investigates the relationship between performanc...
Estrogens role in schizophrenia patients is a subject, which has gained an increased attention from the medical community. Estrogens have been shown to inhibit dopamine actions, improve neuronal regeneration, and overall, have a protective role in the pathology of schizophrenia. The adjunctive estrogen therapy for men is currently under debate. Ant...
Alopecia areata (AA) is an inflammatory and autoimmune disease presenting with non-scarring hair loss. The aethiopathogenesis of alopecia areata is unclear and many factors including autoimmunity, genetic predisposition, emotional and environmental stress are thought to play important roles in its development. Antioxidant/ oxidant balance perturbat...
Introduction Intravenous iron administration in patients treated by haemodialysis for end stage renal disease can exacerbate oxidative stress by increasing the level of free redox active iron. A way to reduce the impact of iron on oxidative stress in haemodialysis patients may be the administration of iron through arterial extracorporeal circuit.
O...
Introduction
The atherosclerosis development and plasma antioxidant protection are strongly linked. The intima damage is reflected through the difference between the antioxidants and oxidants in patients with atheromatous plaques. A high level of oxidative stress in atherosclerotic subjects lead to an imbalance in the serum antioxidant capacity.
Th...
Chronic renal failure is associated with increased oxidative and carbonyl stress. Even if haemodialysis eliminates toxic metabolic products, the procedure per se is associated with further increased oxidative and carbonyl stress in patients with renal disease. The aim of our work was to evaluate the influence of long term haemodialysis treatment on...
Glaucoma is the second cause of blindness worldwide. This disease is a neurodegenerative disorder characterized by high intraocular pressure, loss of retinal ganglion cells (apoptosis). Even though there is much research done in this field, the results have not yet managed to stop the progression of glaucoma or to heal this pathology. Free oxygen r...
Atherosclerosis, one of the main causes of cardiovascular diseases, is a complex process that involves manifold factors. Besides the vascular lipids accumulation, inflammatory factors could be considered as a proatherogenic factor – RCAN1. RCAN1 is a regulator of calcineurin, both of them being calcium dependent proteins. Recent studies have shown...
Introduction
Atypical antipsychotics have significantly improved the quality of life for schizophrenic patients. Despite their beneficial effects, these antipsychotics induce weight gain, diabetes, and dyslipidemia. The aims of this study were to investigate the antioxidative activity of paraoxonase and assess lipid profile as a cardiovascular risk...
To investigate paraoxonase-1 (PON1) lactonase activity, myeloperoxidase (MPO) activity (as a marker of inflammation) and antioxidant status in plasma of patients with type 1 diabetes mellitus.
Whole blood and plasma samples were collected from patients with diabetes and healthy control subjects. PON1 lactonase and MPO activities and total antioxida...
The brain and erythrocytes have similar susceptibility toward free radicals. Therefore, erythrocyte abnormalities might indicate the progression of the oxidative damage in Alzheimer disease (AD). The aim of this study was to investigate erythrocyte membrane stability and plasma antioxidant status in AD. Fasting blood samples (from 17 patients with...
One of the biggest obstacles to progress in traditional Chinese medicine (TCM) development in Western countries is the difficulty of applying the traditional concepts to the Western medicinal plants, which are not traditionally described in ancient literature. During recent years, new advances in the field of understanding Yin/Yang aspects from a m...
Objective. The present study investigates the relationship between performance in an emotional Stroop task with fearful faces and plasma level of interleukin 6 (IL6) and interleukin 4 (IL4). Method. Participants were 27 healthy adults, mean age 29.9 years. They completed an emotional variant of Stroop task and their performance was correlated with...
Abstract During recent years, new advances in the field of estrogen signaling (e.g., the discovery of the second estrogen receptor named ERβ) have led to the conclusion that all the major human tissues are estrogen-responsive. The impact of estrogen on human health is far more complex and stronger than scientists had previously thought. Several sci...
Oxidative stress is implicated in the pathophysiology of diabetes mellitus and its chronic complications. The aim of this study was to evaluate plasma antioxidant status in patients with uncomplicated type 2 diabetes, in order to understand the interactions between its components and the diabetic milieu.
Plasma samples were collected from 15 patien...
Intracerebral hemorrhage (ICH) represents the most lethal form of stroke and has deleterious conequences. Primary injuries are generated by the blood collection itself and consist in local tissue destruction. They are prolonged and amplified by a combination of secondary injuries involving the toxic effects of blood, oxidative stress, recruitment o...
Redox metabolism has long been considered to play important roles in aging and the
development of age-related diseases. Both dietary and pharmacological manipulations of
redox metabolism have been associated with the extension of lifespan. Increasing new
evidence s also suggests that the process of aging may derive from imperfect clearance of
oxida...
Redox metabolism has long been considered to play important roles in aging and the development of age-related diseases. Both dietary and pharmacological manipulations of redox metabolism have been associated with the extension of lifespan. Increasing new evidence s also suggests that the process of aging may derive from imperfect clearance of oxida...
The brain has a particular predisposition to oxidative stress which makes it vulnerable to free radicals. They trigger lipid peroxidation of the cellular membranes, oxidation of proteins and DNA leading to changes in chromosome structure, genetic mutation, and/or modulation of cell growth. It was shown that oxygen-derived free radicals play an impo...
Impaired glucose metabolism, dyslipidemia and chronic inflammation are present in diabetes mellitus. Ulceration of the foot in diabetes is common and disabling and frequently leads to amputation of the leg. The aim of this study was to assess the relationship between fasting plasma glucose (FPG), postprandial plasma glucose (PPG), plasma lipids and...
Full text available on request
Chelidonium majus L. (family Papaveraceae), or greater celandine, is an important plant in western phytotherapy and in traditional Chinese medicine. Crude extracts of C. majus as well as purified compounds derived from it exhibit a broad spectrum of biological activities (antiinflammatory, antimicrobial, antitumoral, analgesic, hepatoprotective) th...
Poster available upon request
Poster available upon request
Poster available on request
Poster available on request
The influence of Geriforte, an Ayurvedic natural supplement, on the antioxidant defense systems in human erythrocytes and plasma was investigated in an open human clinical study. The ability of Geriforte to inhibit the azo-bis 2-amidinopropane dihydrochloride (AAPH) dependent lysis of erythrocytes was also evaluated. Geriforte supplementation incre...
The first aim of this study was to evaluate some plasma oxidative stress markers in diabetic patients (type2 diabetes mellitus) with peripheral arteriopathy. Secondly, these patients were divided into two groups considering the presence or absence of retinopathy. The differences in the levels of the oxidative stress parameters could be important to...
Oxidative stress and inflammation are involved in the initiation and progression of obesity and diabetes mellitus. The aim of our study was to find out some markers of oxidative stress in twenty obese patients with type 2 diabetes mellitus (group D) and twenty age-matched obese subjects (group O) and compare the results with the control values from...
