Laura Fusco

Laura Fusco
University of Padova | UNIPD · Department of Biomedical Sciences - DSB

PhD

About

26
Publications
5,370
Reads
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928
Citations
Introduction
After receiving a M.Sc. in Medical Biotechnologies, in 2018 Dr. Fusco earned a Ph.D. in Chemistry from the Univ. of Trieste (Italy) with an H2020 project. She integrated her research at Karolinska Institutet and at Sidra Medicine (Qatar) in the framework of an H2020-MSCA-RISE project. She is a Postdoc at the Univ. of Padua (Italy) working on a project supported by the European Space Agency. In 2021, she was awarded a Marie Sklodowska-Curie Action “Global Individual Fellowships” (H2020-MCSA-GF).
Additional affiliations
July 2020 - present
University of Padova
Position
  • PostDoc Position
May 2019 - June 2020
Sidra Medicine
Position
  • PostDoc Position
December 2018 - present
University of Trieste
Position
  • PostDoc Position
Education
June 2017 - August 2017
Karolinska Institutet
Field of study
  • Institute of Environmental Medicine (IMM), Division of Molecular Toxicology
November 2014 - February 2018
University of Trieste
Field of study
  • "Toxicological effects of graphene family nanomaterials after cutaneous exposure"
October 2011 - July 2014
University of Trieste
Field of study
  • Medical Biotechnologies

Publications

Publications (26)
Article
Cancer represents one of the main causes of death in the world; hence the development of more specific approaches for its diagnosis and treatment is urgently needed in clinical practice. Here we aim at providing a comprehensive review on the use of 2-dimensional materials (2DMs) in cancer theranostics. In particular, we focus on graphene-related ma...
Article
Full-text available
Carbon-based materials (CBMs), such as graphene, nanodiamonds, carbon fibers, and carbon dots, have attracted a great deal scientific attention due to their potential as biomedical tools. Following exposure, particularly intravenous injection, these nanomaterials can be recognized by immune cells. Such interactions could be modulated by the differe...
Article
Full-text available
Skin provides the first interface between body and environment, representing one of the most feasible exposure routes to graphene-based materials (GBMs). However, interactions of GBMs with the skin are poorly understood. In particular, low-concentration effects have not been investigated. Here we explored the ability of endotoxin-free, few-layer gr...
Article
Full-text available
Besides inhalation, skin contact may be considered one of the most relevant exposure routes to graphene-based materials (GBMs). However, very few data on the cutaneous toxicity of these materials are available, so far. This study is focused on skin irritation potential of a panel of GBMs: a few-layer graphene (FLG), exfoliated by ball milling of gr...
Article
Graphene nanoribbons (GNRs) are emerging graphene materials showing clear promising applications in the biomedical field. The evaluation of GNR biocompatibility at the immune level is a critical aspect of their clinical translation. Here, we report the ex vivo immune profiling and tracking of GNRs at the single-cell level on eight human blood immun...
Article
Due to their excellent physicochemical properties, carbon-based nanomaterials (CBNs) have attracted considerable attention for multiple applications, including electronics, optoelectronics, photonics and biomedicine. An active area of research is related to their potential exploitation at the skin level, mainly as wearable and stretchable electroni...
Article
Full-text available
Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a rapidly spreading pandemic and is severely threatening public health globally. The human-to-human transmission route of SARS-CoV-2 is now well established. The reported clinical observations and symptoms of this infection in huma...
Article
We recently found by single-cell mass cytometry that ex vivo human B cells internalize graphene oxide (GO). The functional impact of such uptake on B cells remains unexplored. Here, we disclosed the effects of GO and amino-functionalized GO (GONH2) interacting with human B cells in vitro and ex vivo at the protein and gene expression levels. Moreov...
Article
Given the wide variety of potential applications of graphene oxide (GO), its consequent release into the environment poses serious concerns on its safety. The future production and exploitation of graphene in the years to come should be guided by its specific chemical-physical characteristics. The unparalleled potential of single-cell mass cytometr...
Article
Full-text available
In article number 2101483, Kostas Kostarelos, Açelya Yilmazer, and co‐workers report that thin, biological‐grade graphene oxide (GO) nanosheets show molecular affinity toward the SARS‐CoV‐2 viral spike and the ACE2‐bound spike complex. GO nanosheets were shown to inhibit the infection of wild‐type SARS‐CoV‐2 experimentally in cell cultures. Through...
Article
Full-text available
Nanotechnology can offer a number of options against coronavirus disease 2019 (COVID‐19) acting both extracellularly and intracellularly to the host cells. Here, the aim is to explore graphene oxide (GO), the most studied 2D nanomaterial in biomedical applications, as a nanoscale platform for interaction with SARS‐CoV‐2. Molecular docking analyses...
Article
Two-dimensional transition metal carbides/carbonitrides known as MXenes are rapidly growing as multimodal nanoplatforms in biomedicine. Here, taking SARS-CoV-2 as a model, we explored the antiviral properties and immune-profile of a large panel of four highly stable and well-characterized MXenes - Ti3C2Tx, Ta4C3T x , Mo2Ti2C3T x and Nb4C3T x . T...
Article
Given the numerous potential applications of graphene oxide (GO) and its consequent release into the environment, this study was carried out to assess the toxic effects of GO on Artemia franciscana, a well-established model organism for marine ecotoxicological studies. A. franciscana stage I nauplii or adults were exposed to GO (1–100 μg mL⁻¹) up t...
Article
Full-text available
Prolonged exposure to microgravity (MG) during long-duration space flights is known to induce severe dysregulation of osteoblast functions connected to a significant bone loss, similar to the condition induced by osteoporosis. Hence, we here present MG as a promising model to challenge the effectiveness of new scaffolds designed for bone regenerati...
Article
Nanodiamonds (NDs) represent a class of carbon nanostructures widely investigated as promising biomedical nanotools. The possible immune system reactions indicate success or failure for any nanosystem bioapplication. Moreover the assessment of the role of nanomaterial functionalization on the immune system response needs to be fully elucidated. We...
Article
Full-text available
Cancer is one of the leading causes of death in the world. Therefore, the development of new advanced and targeted strategies in cancer research for early diagnosis and treatment has become essential to improve diagnosis outcomes and reduce therapy side effects. Graphene and more recently, MXene, are the main representatives of the family of two-di...
Article
Full-text available
Neutrophils are key components of the innate arm of the immune system and represent the frontline of host defense against intruding pathogens. However, neutrophils can also cause damage to the host. Nanomaterials are being developed for a multitude of different purposes and these minute materials may find their way into the body through deliberate...
Article
Full-text available
The marine algal toxin palytoxin (PLTX) and its analogues are some of the most toxic marine compounds. Their accumulation in edible marine organisms and entrance into the food chain represent their main concerns for human health. Indeed, several fatal human poisonings attributed to these compounds have been recorded in tropical and subtropical area...
Article
Full-text available
The extraordinary physicochemical properties of graphene-based nanomaterials (GBNs) make them promising tools in nanotechnology and biomedicine. Considering the skin contact as one of the most feasible exposure routes to GBNs, the mechanism of toxicity of two GBNs (few-layer-graphene, FLG, and graphene oxide, GO) towards human HaCaT skin keratinocy...
Article
Aim: To apply an innovative LC-MS/MS method to quantify thiopurine metabolites in human hepatocytes and to associate them to cytotoxicity. Methods: Immortalized human hepatocytes (IHH cells) were treated for 48 and 96 h, with 1.4 × 10(-4) M azathioprine and 1.1 × 10(-3) M mercaptopurine, concentrations corresponding to the IC50 values calculated...
Article
Full-text available
Impressive properties make graphene-based materials (GBMs) promising tools for nanoelectronics and biomedicine. However, safety concerns need to be cleared before mass production of GBMs starts. As skin, together with lungs, displays the highest exposure to GBMs, it is of fundamental importance to understand what happens when GBMs get in contact wi...
Article
Azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are antimetabolite drugs, widely used as immunosuppressants and anticancer agents. Despite their proven efficacy, high incidence of toxic effects in patients during the standard-dose therapy is recorded. The aim of this study is to explain, from a mechanistic point of view, the cl...

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Projects

Projects (3)
Project
Biocompatibility and immune modulation of nanomaterials
Project
Toward nanotechnology-enabled approaches against the COVID-19 pandemic.
Project
Toxicological effects of graphene-related materials