Laura Bystrom

• PhD
• Lecturer at Bath Spa University

Key Points A-PACs target primary AML cells, sparing healthy CD34+ cord blood cells in vitro and reducing AML tumor burden with in vivo treatment. NF-κB activation plays a role in A-PAC–induced cell death.

Acute myelogenous leukemia (AML) is often a fatal disease where after strong induction therapy most patients relapse and die. A-type proanthocyanidins (A-PACs) are a unique class of compounds found in cranberries (Vaccinium macrocarpon Ait.) that we have found to be effective against several leukemia cell lines and primary AML samples in vitro. Mor...

Acute myeloid leukemia (AML) is incurable in the majority of patients. While allogeneic stem cell transplantation remains the most effective therapy for AML to date, other types of cellular therapy have not yet been successful in this disease. The success of autologous T-cells expressing chimeric antigen receptors (CARs) in patients with advanced B...

The sesquiterpene lactones dehydroleucodine (1) and leucodine (2) were isolated from Gynoxys verrucosa, a species used in traditional medicine in southern Ecuador. The activity of these compounds was determined against eight acute myeloid leukemia (AML) cell lines and compared with their activity against normal peripheral blood mononuclear cells. C...

Iron is essential for the growth and proliferation of cells, as well as for many biological processes that are important for the maintenance and survival of the human body. However, excess iron is associated with the development of cancer and other pathological conditions, due in part to the pro-oxidative nature of iron and its damaging effects on...

Cited By (since 1996):3, Export Date: 18 October 2014

Anemia of inflammation (AI) is commonly observed in chronic inflammatory states and may hinder patient recovery and survival. Induction of hepcidin, mediated by interleukin 6, leads to iron-restricted erythropoiesis and anemia. Several translational studies have been directed at neutralizing hepcidin overexpression as a therapeutic strategy against...

Anemia of inflammation (AI) is a complex condition commonly observed in chronic inflammatory states and associated with poor health outcomes and low quality of life. Increased hepcidin (Hamp) expression triggered by interleukin-6 (IL6) is a hallmark of AI and is responsible for iron-restricted erythropoiesis and anemia. Several translational studie...

Acute myelogenous leukemia (AML) is often a fatal disease where after strong induction therapy most patients relapse and die. AML originates and is maintained by leukemia stem cells (LSCs). Failure to eliminate LSCs by chemotherapy is likely to result in disease relapse. Therefore, it is a priority to identify new therapies that eliminate blasts wh...

American Botanic Council / HerbClip™ P.O. Box 144345 Austin, TX 78714-4345  512.926.4900  Fax: 512.926.2345  www.herbalgram.org Bertoglio JC, Folatre I, Bombardelli E, et al. Management of gastrointestinal mucositis due to cancer therapies in pediatric patients: results of a case series with SAMITAL®. Future Oncol. November 2012;8(11):1481-1486...

Significance: In this review, the dual nature of both iron and reactive oxygen species (ROS) will be explored in normal and cancer cell metabolism. Although iron and ROS play important roles in cellular homeostasis, they may also contribute to carcinogenesis. On the other hand, many studies have indicated that abrogation of iron metabolism, elevat...

2986 Acute myelogenous leukemia (AML) is a fatal disease in which the majority of patients relapse and die even after attaining initial complete remission. AML is thought to be initiated and maintained by chemoresistant leukemia stem cells (AML-SCs). Therefore, identifying therapies that can eliminate AML-SCs is a priority. Iron is crucial to norma...

Some of the health effects of cranberries are associated with a unique class of compounds known as A-type proanthocyanidins (A-PACs). Preliminary studies of the biological effects of A-PACs indicated these activities may be associated with their ability to function as iron chelators. Several studies indicated that iron chelators have anti-tumor act...

Most natural product research is market-driven and thus many plant species are overlooked for their health value due to lack of financial incentives. This may explain the limited information available about the health effects of the edible fruit species Melicoccus bijugatus, a member of the Sapindaceae family that grows mostly in the Caribbean and...

3165 Anemia of inflammation (AI) is associated with the immune response that occurs when inflammatory diseases interfere with the body's ability to absorb and use iron. Cancer and other chronic illnesses produce inflammatory cytokines, some of which can diminish the production of red blood cells by affecting erythropoietin levels. Cancer cells migh...

Edible fruits of the native South American tree Melicoccus bijugatus Jacq. are consumed fresh or in traditional food, drink and medicinal preparations. Some therapeutic effects of these fruits may be due to phenolics and sugars. Aqueous acetone, methanol or ethanol tissue extracts of different cultivars or collections of M. bijugatus fruits from th...

Fruits of the native South American tree Melicoccus bijugatus Jacq. (Sapindaceae) are consumed for both dietary and medicinal purposes, but limited information is available about the phytochemistry and health value of M. bijugatus fruits. Fruit tissues of the Florida Montgomery cultivar were assessed for sugars, using gas chromatography, and for to...