Latheef Kasala

Meril Life Sciences Pvt. Ltd. · Division of Clinical Research

BACKGROUND The present study was aimed to study the effect of Heartfulness meditation in modulation of cardiovascular response in hypertensive patients which was done by measuring heart rate (HR), blood pressure (BP) and rate pressure product (RPP) under normal and isometric stress conditions. METHODS Measurements included Pulse pressure (PP), m...

Background This study was an attempt to assess and compare the gender-wise lifestyle patterns and well-being status among the employees of a tertiary care teaching hospital. Material and Methods This is a cross-sectional, questionnaire-based study conducted at a tertiary care hospital between May and August 2019. A total of 777 employees belonging...

Background: The present study was undertaken to screen the employees of a tertiary care hospital aged ≥40 years to know their health status and to diagnose their new health problems. Methods: This cross-sectional, descriptive study was conducted with 487 employees of our hospital aged ≥40 years from November 2019 to February 2020. Study procedures...

Objective To identify the burden of rotavirus acute gastroenteritis (AGE) and the genotypes presenting in the authors’ area in the period after introduction of rotavirus vaccine in Universal Immunization Programme (UIP).Methods Children aged less than 5 y and presenting to hospital for the treatment of AGE were enrolled into the study from January...

Introduction: Coronary artery calcium score (CACS) and carotid artery intima-media thickness (CIMT) are the markers of atherosclerosis. An association between CACS and CIMT with presence of atherosclerotic coronary artery disease (CAD) is well established. However relationship between severity of CAD with CACS and CIMT is less clear. This study aim...

Introduction: Acute pulmonary thromboembolism (PTE) presents with wide spectrum and has variable prognosis. Factor V Leiden (FVL) is the most common inherited thrombophilia, with a prevalence of 3%-7% in the general US population, approximately 5% in Whites, 2.2% in Hispanics and 1.2% in Blacks. PTE most commonly originates from venous thrombosis....

Background and Aims: Individual barriers to change in lifestyle include lack of proper knowledge particularly about nutrition and physical activity, lack of acceptance to change behaviour, lack of self-motivation and lastly physical and socioeconomic limitations. Methods: This is a prospective, questionnaire based study conducted at a tertiary care...

Primary pulmonary hypertension (PPH) is a progressive disease with poor prognosis for which limited treatment options are available. This study prospective, randomized, controlled trial aimed to investigate the effect of sildenafil citrate, an orally active phosphodiesterase-5 inhibitor on clinical profile and hemodynamics of patients with PPH comp...

Statins have turned out to be widely recommended in the prevention of cardiovascular diseases (CVD) owing to their favorable effect on lipid metabolism and patient survival. Statin treatment is usually all around endured and effective in the prevention and treatment of CVD, irrespective of cholesterol levels. However, studies on statin therapy have...

Introduction: Cardiovascular disease is the leading cause of mortality and morbidity all over the world. Among these cardiovascular deaths, half result from coronary artery disease (CAD). Increased prevalence of CAD is associated with increased levels of inflammatory markers. Phenotypic variations of these markers may depend on physiological stress...

The present study was undertaken to find out the effects of tobacco smoking on innate immune mechanism of the body. A total of 60 adult consenting men in the age group of 30 to 50 years were recruited of which 30 were chronic smokers and the rest were non smoking controls. 5ml of venous blood was drawn from each of the subjects and the following pa...

Background Right ventricular infarction (RVI) is common in patients with inferior wall myocardial infarction (IWMI). Right ventricular involvement increases mortality and morbidity in IWMI patients. Clinical presentation of RVI differs, and accordingly treatment and management of patients also differs. Aim To find out the frequency of RVI among pa...

Technologies Pvt. Ltd, Surat, India) is a Sirolimus-eluting stent that comprises L605 cobalt-chromium alloy as a stent platform coated with a blend of Sirolimus drug and biodegradable polymer. Drug eluting stent is associated with certainly lower risk of restenosis and revascularization as compared to bare metal stents. The aim of this study is to...

Objective: The aim of this study is to prospectively assess the diagnostic accuracy of pulmonary embolism severity index, echocardiogram, computed tomography pulmonary angiogram (CTPA), and N-terminal pro b-type natriuretic peptide (NT-proBNP) for predicting adverse events in acute pulmonary embolism patients. Methods: Thirty consecutive acute p...

Background: Percutaneous atrial septal defect (ASD) device closure is a safe and effective means of reducing or eliminating interatrial shunting. The response of the right heart to device closure is incompletely understood. Aim: To evaluate the effects of transcatheter closure of secundum ASD on right ventricle size and function, that is, both s...

Background: India has the highest burden of coronary artery disease in the world. It also has a higher rate of STsegment elevation myocardial infarction than that in developed countries. Primary percutaneous coronary intervention is an effective treatment, yet little is known about its feasibility and outcome in India. We studied the outcomes of p...

Introduction: Percutaneous transvenous mitral commissurotomy (PTMC) is a safe and effective procedure for relief of severe mitral stenosis. PTMC is being done widely and many transseptal procedures requiring large diameter catheters, sheaths are becoming popular. The knowledge of iatrogenic atrial septal defect (iASD) is vital. This study assessed...

Transesophageal echocardiogram (TEE) is a gold standard test for diagnosis of left atrial (LA) thrombus, but it has limited sensitivity for identification of small thrombi within side lobes. Thus, the absence of visualizing a left atrial appendage (LAA) thrombus does not equate with the absence of a LAA thrombus. To assess the predictive value of m...

Background: Electrocardiogram (ECG) waveforms are influenced by physiological, pathological, and psychological factors. Acute mental stress affects the hypothalamic–pituitary–adrenal axis resulting in alterations in various physiological functions of the body particularly the cardiovascular system. Objective: To study the ECG changes during acute m...

Background: Heart failure (HF) has become a main cardiac problem. Doppler echocardiography has been used to examine left ventricular (LV) diastolic filling dynamics. Limitations of this modality suggest the need for other objective measures of diastolic HF. Aim of the Study: The hypothesis of this study is to assess the utility of N-terminal pro-B...

Background To investigate prospectively the improvement of myocardial performance index (MPI) in coronary artery disease (CAD) patients after successful percutaneous coronary intervention (PCI), to assess prognostic value of MPI in predicting acute periprocedural adverse events and to analyze influence of other correlating factors on MPI and its po...

Background: Metabolic syndrome is associated with the development of diabetes mellitus and cardiovascular disease. The impact of metabolic syndrome on the progression of atherosclerosis has been well documented. This study was designed to evaluate the impact of metabolic syndrome on global left ventricular function by using left ventricular myocar...

Context: Endothelial dysfunction is an early predictor of adverse cardiovascular events. The present study evaluated asymptomatic metabolic syndrome (MS) patients with brachial artery endothelial dysfunction to determine whether a reversal of endothelial dysfunction occurs with statin treatment. Aim: To evaluate the short term effects of statins on...

ntroduction: There are various physiological factors that affect ECG waveforms which include sex, age, ethnicity, height, weight, body mass index, and pregnancy and produce inter individual variability in ECGs. Hypothesis: The present study was done to find out the electrocardiographic changes in relation to body mass index. Approach: The study was...

BACKGROUND: Endothelial dysfunction is an early predictor of cardiovascular events. The present study is aimed at observing association of the asymptomatic metabolic syndrome (MS) patients with brachial artery endothelial dysfunction and reversal of endothelialdysfunction with statin treatment. STUDY DESIGN: This is a prospective study comprising o...

Left ventricular end diastolic pressure Early diastolic mitral inflow velocity Early diastolic mitral annulus velocity Ejection fraction a b s t r a c t Background: Diastolic dysfunction is common in cardiac diseases and contributes to the

Intima-media Ultrasound a b s t r a c t Background: Carotid arterial intima-media thickness (IMT) has been a good indicator of the

The prevalence of Coronary artery disease (CAD) in India has increased considerably over the past few years and could become the number one killer disease if interventions are not done. Factor V Leiden (FVL) mutation and FII G20210A polymorphism are two recently described genetic factors with a propensity towards venous thrombosis. This warrants th...

BACKGROUND: The prevalence of Coronary artery disease (CAD) in India has increased considerably over the past few years and could become the number one killer disease if interventions are not done. Factor V Leiden mutation (FVL) and FII G20210A polymorphism are two recently described genetic factors with a propensity towards venous thrombosis. This...

Background: C-reactive protein (CRP) is an acute-phase reactant protein synthesized by the liver in response to acute stress in a wide range of acute and chronic inflammatory conditions. In healthy subjects and patients presenting with coronary artery disease (CAD), elevated levels of CRP has repeatedly been demonstrated to predict future cardiovas...

S.aureus is a Gram positive opportunistic pathogen, causes pneumonia, endocarditis, toxic shock syndrome etc. S.aureus infections can be found in any anatomical locales in the body. Tyrosine kinase regulates the pathogenicity and antibiotic resistance in S.aureus through the phosphorylation of tyrosine residues present on the target proteins. In th...