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Publications (5)
In ischemic tissue, platelets can modulate angiogenesis. The specific factors influencing this function, however, are poorly understood. Here, we characterized the complement anaphylatoxin C5a-mediated activation of C5a receptor 1 (C5aR1) expressed on platelets as a potent regulator of ischemia-driven revascularization. We assessed the relevance of...
Platelets contribute to the regulation of tissue neovascularization, although the specific factors underlying this function are unknown. Here, we identified the complement anaphy-latoxin C5a-mediated activation of C5a receptor 1 (C5aR1) on platelets as a negative regulatory mechanism of vessel formation. We showed that platelets expressing C5aR1 ex...
Der Begriff Thrombose beschreibt die Bildung eines Thrombus infolge einer deregulierten, intravasal lokalisierten Blutgerinnung, welche insbesondere als tiefe Bein- und Beckenvenenthrombose (TVT), seltener als Thrombose der oberen Extremitäten, mit einer partiellen oder vollständigen Verlegung der Venen in Erscheinung tritt. Die Verschleppung throm...
Cardiovascular disease remains the main cause of death worldwide. For this reason, strategies for the primary prevention of atherosclerosis and atherosclerosis-related pathologies like stroke or myocardial infarction are needed.
Platelets are key players of atherosclerosis-related vascular thrombotic pathologies and their role as targets in seconda...
