Larysa Baraban

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• Professor
• Head of Department at Helmholtz-Zentrum Dresden-Rossendorf

The continuous advances in micro- and nanofabrication technologies have inevitably led to major improvements in field-effect transistor (FET) design and architecture, significantly reducing the component footprint and enabling highly efficient integration into many electronic devices. Combined efforts in the areas of materials science, life science...

The selection and optimization of therapies for cancer patients urgently need personalization. Portable point‐of‐care electronic biosensors emerge as a groundbreaking solution contributing to better decision‐making in precision oncology. In this study, the innovative use of extended‐gate field‐effect‐transistor (EG‐FET) biosensors is showcased for...

Progress in our knowledge of tumor mechanisms and complexity led to the understanding of the physical parameters of cancer cells and their microenvironment, including the mechanical, thermal, and electrical properties, solid stress, and liquid pressure, as critical regulators of tumor progression and potential prognostic traits associated with clin...

Progress in our knowledge of tumor mechanisms and complexity led to the understanding of the physical parameters of cancer cells and their microenvironment, including the mechanical, thermal, and electrical properties, solid stress, and liquid pressure, as critical regulators of tumor progression and potential prognostic traits associated with clin...

The efficiency of immunotherapy stays limited for solid tumors. It is mainly caused by the tumoral structural heterogeneity and its complex microenvironment, which impede the infiltration of immune cells into malignant tissues. Mimicking this environment in frames of microphysiological models remains a challenge, significantly increasing costs of t...

Selection and optimization of therapies for cancer patients urgently needs personalization. Portable point-of-care electronic biosensors emerge as a groundbreaking solution to contribute to better decision-making in precision oncology. This study showcases the innovative use of extended gate field-effect transistor (EG-FET) biosensors to monitor th...

Acoustic focusing of particle flow in microfluidics has been shown to be an efficient tool for particle separation for various chemical and biomedical applications. The mechanism behind the method is the selective effect of the acoustic radiation force on distinct particles. In this way, they can be selectively focused and separated. The technique...

With the ever‐growing requirements in the healthcare sector aimed at personalized diagnostics and treatment, continuous and real‐time monitoring of relevant parameters is gaining significant traction. In many applications, health status monitoring may be carried out by dedicated wearable or implantable sensing devices only within a defined period a...

Acoustic focusing of particle flow in microfluidics has been shown to be an efficient tool for particle separation for various chemical and biomedical applications. The mechanism behind the method is the selective effect of the acoustic radiation force on distinct particles. In this way, they can be selectively focused and separated. The technique...

The extracellular environment regulates the structures and functions of cells, from the molecular to the tissue level. However, the underlying mechanisms influencing the organization and adaptation of cancer in three‐dimensional (3D) environments are not yet fully understood. In this study, the influence of the viscosity of the environment is inves...

Introduction Bacterial strains that are resistant to antibiotics may protect not only themselves, but also sensitive bacteria nearby if resistance involves antibiotic degradation. Such cross-protection poses a challenge to effective antibiotic therapy by enhancing the long-term survival of bacterial infections, however, the current understanding is...

Extracellular environment regulates structures and functions of cells, from molecular up to the tissue level. However, underlying mechanisms that influence organization and adaptation of cancer in 3D environments are not yet fully understood. In this study, we investigate the influence of viscosity of the environment on the mechanical adaptability...

Active systems – including sperm cells, living organisms like bacteria, fish, birds, or active soft matter systems like synthetic “microswimmers” – are characterized by motility, i.e., the ability to propel...

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to millions of infections and deaths worldwide. As this virus evolves rapidly, there is a high need for treatment options that can win the race against new emerging variants of concern. Here, we describe a novel immunotherapeu...

Postoperative complications after pancreatic surgery are frequent and life-threatening. Current clinical diagnostic strategies involve time-consuming quantification of α-amylase activity in abdominal drain fluid, which is taken on the first and third postoperative day. The lack of real-time data can delay adjustment of medical treatment upon compli...

Functional interaction between cancer cells and the surrounding microenvironment is still not sufficiently understood, which motivates the tremendous interest for the development of numerous in vitro tumor models. Diverse parameters, e.g., transport of nutrients and metabolites, availability of space in the confinement, etc. make an impact on the s...

Bacteria primarily live in structured environments, such as colonies and biofilms, attached to surfaces or growing within soft tissues. They are engaged in local competitive and cooperative interactions impacting our health and well-being, for example, by affecting population-level drug resistance. Our knowledge of bacterial competition and coopera...

Detection of antigens and antibodies (Abs) is of great importance in determining the infection and immunity status of the population, as they are key parameters guiding the handling of pandemics. Current point-of-care (POC) devices are a convenient option for rapid screening; however, their sensitivity requires further improvement. We present an in...

Multiphase microfluidics enables the high-throughput manipulation of droplets for multitude of applications, from the confined fabrication of nano- and micro-objects to the parallelization of chemical reactions of biomedical or biological interest. While the standard methods to follow droplets on a chip are represented by a visual observation throu...

The field of autonomous motile micro/nanomotors that can propel in the liquid environment strongly benefits from the use of magnetic materials, winning in the long-time deterministic locomotion and controllability of such microscopic objects. This chapter reviews the applications of curved magnetic micro/nanostructures to be employed for biomedical...

Ionic and molecular selectivity is considered unique for the nanoscale and not realizable in microfluidics. This is due to the scale-matching problem -- a difficulty to match the dimensions of ions and electrostatic potential screening lengths with the micron-sized confinements. Here, we demonstrate a microscale realization of the ionic transport p...

Ionic and molecular selectivity are considered unique for the nanoscale and not realizable in microfluidics. This is due to the scale-matching problem — a difficulty to match the dimensions of ions and electrostatic potential screening lengths with micron-sized confinements. Here, we demonstrate a microscale realization of ionic transport processes...

Functional interaction between cancer cells and the surrounding microenvironment is still not sufficiently understood, which motivates the tremendous interest for the development of numerous in vitro and in vivo tumor models. Diverse parameters, e.g., transport of nutrients and metabolites, availability of space in the confinement, interaction with...

Many biomarkers including neurotransmitters are found in external body fluids, such as sweat or saliva, but at lower titration levels than they are present in blood. Efficient detection of such biomarkers thus requires, on the one hand, to use techniques offering high sensitivity, and, on the other hand, to use a miniaturized format to carry out di...

The number of patients in intensive care units has increased over the past years. Critically ill patients are treated with a real time support of the instruments that offer monitoring of relevant blood parameters. These parameters include blood gases, lactate, and glucose, as well as pH and temperature. Considering the COVID-19 pandemic, continuous...

Immunotherapy using CAR-T cells is a new technological paradigm for cancer treatment. To avoid severe side effects and tumor escape variants observed for conventional CAR-T cells approach, adaptor CAR technologies are under development, where intermediate target modules redirect immune cells against cancer. In this work, silicon nanowire field-effe...

Guest editors Juliane Simmchen, Larysa Baraban, and Wei Wang introduce the topics covered in this special collection covering the synthesis, applications, and dynamics of active colloids.

Immunotherapy using CAR-T cells is a new paradigm technology for cancer treatment. To avoid severe side effects and tumor escape variants observed for conventional CAR-T cells approach, adaptor CAR technologies are under development, where intermediate target modules redirect immune cells against cancer. In this work, silicon nanowire field effect...

The real-time monitoring of physiological parameters is essential for point-of-care testing. While nowadays routine tests are done through ex vivo analysis on frequently extracted blood, placing implantable sensors monitoring key blood parameters such as lactate, glucose, ions, and oxygen would mean a giant step forward in the care of critically il...

Although showing impressive therapeutic potential, treatments of leukemias with T-cells expressing chimeric antigen receptors (CARs) is limited by their risk of several severe side effects. To overcome these problems, a switchable CAR platform has been developed termed UniCAR. Unlike conventional CAR, which is directed against tumor-associated anti...

Impedance cytometry represents a technique that allows the electronic characterization of colloids and living cells in a highly miniaturized way. In contrast with impedance spectroscopy, the measurements are performed at a fixed frequency, providing real-time monitoring of the species traveling over the sensor. By measuring the electrical propertie...

Understanding competition and cooperation within microbiota is of high fundamental and clinical importance, helping to comprehend species' evolution and biodiversity. We co-encapsulated and cultured two isogenic Escherichia coli strains expressing blue (BFP) and yellow (YFP) fluorescent proteins into numerous emulsion droplets and quantified their...

Control over micromotors’ motion is of high relevance for lab-on-a-chip and biomedical engineering, wherein such particles encounter complex microenvironments. Here, we introduce an efficient way to influence Janus micromotors’ direction of motion and speed by modifying their surface properties and those of their immediate surroundings. We fabricat...

Small molecules with no or little charge are considered to have minimal impact on signals measured by field effect transistor (FET) sensors. This fact typically excludes steroids from the family of analytes, detected by FETs. We present a portable multiplexed platform based on an array of nanowire sensors for label-free monitoring of daytime levels...

Supporting videos

The shape of objects has a strong influence on their dynamics. Here, we present comparative studies of two different motile objects, spherical Ag/AgCl Janus particles and polystyrene Janus nanorods, that move due to an ionic self-diffusiophoretic propulsion mechanism when exposed to blue light. In this paper, we propose a method to fabricate Janus...

Crystals melt when thermal excitations or the concentration of defects in the lattice is sufficiently high. Upon melting, the crystalline long-range order vanishes, turning the solid to a fluid. In contrast to this classical scenario of solid melting, here we demonstrate a counter-intuitive behavior of the occurrence of crystalline long-range order...

In article number 2003851, Denys Makarov, Larysa Baraban, and co‐workers discuss inverse solidification driven by active colloids, which provides novel insight into the collective effects in mixed colloidal systems comprising of active and passive species. It offers versatile possibilities to study the processes of solidification in various systems...

A flexible sensor is presented for electrochemical detection of ascorbic acid in sweat based on single-step modified gold microelectrodes. The modification consists of electrodeposition of alginate membrane with trapped CuO nanoparticles. The electrodes are fabricated at a thin polyimide support and the soft nature of the membrane can withstand mec...

Crystals melt when thermal excitations or the concentration of defects in the lattice is sufficiently high. Upon melting, the crystalline long‐range order vanishes, turning the solid to a fluid. In contrast to this classical scenario of solid melting, here a counter‐intuitive behavior of the occurrence of crystalline long‐range order in an initiall...

We realize an ultra-compact nanocytometer for real-time impedimetric detection and classification of subpopulations of living cells. Nanoscopic nanowires in a microfluidic channel act as nanocapacitors and measure in real time the change of the amplitude and phase of the output voltage and, thus, the electrical properties of living cells. We perfor...

[Full text: https://rdcu.be/b4ovR] Neuromorphic architectures merge learning and memory functions within a single unit cell and in a neuron-like fashion. Research in the field has been mainly focused on the plasticity of artificial synapses. However, the intrinsic plasticity of the neuronal membrane is also important in the implementation of neurom...

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Despite the recent progress in the synthesis of crystalline boronate ester covalent organic frameworks (BECOFs) in powder and thin‐film through solvothermal method and on‐solid‐surface synthesis, respectively, their applications in electronics, remain less explored due to the challenges in thin‐film processability and device integration associated...

We demonstrate the functionalization of silicon nanowire based field effect transistors (SiNW FETs) FETs with stimuli-responsive polymer brushes of poly(N-isopropylacrylamide) (PNIPAAM) and poly(acrylic acid) (PAA). Surface functionalization was confirmed by atomic force microscopy, contact angle measurements, and verified electrically using a sili...

Despite the recent progress in the synthesis of crystalline boronate ester covalent organic frameworks (BECOFs) in powder and thin‐film through solvothermal method and on‐solid‐surface synthesis, respectively, their applications in electronics, remain less explored due to the challenges in thin‐film processability and device integration associated...

Synthetic nano- and micromotors interact with each other and their surroundings in a complex manner. Here, we report on the anisotropy of the active-passive particles interaction in a soft matter system containing an immobile yet photochemical Ag/AgCl-based Janus particle embedded in a dense matrix of passive beads in pure water. The asymmetry in t...

Here, we present a miniaturized lab-on-a-chip detecting system for an all-electric and label-free analysis of the emulsion droplets incorporating the nanoscopic silicon nanowires-based field-effect transistors (FETs). We specifically focus on the analysis of β-galactosidase e.g., activity, which is an important enzyme of the glycolysis metabolic pa...

We demonstrate a flexible sensor for ascorbic acid detection in sweat based on single-step modified gold microelectrodes. The modification consists on the electrodeposition of alginate membrane with trapped CuO nanoparticles on top of the electrodes. The electrodes are fabricated at a thin polyimide support and the soft nature of the membrane can w...

We demonstrate a flexible sensor for ascorbic acid detection in sweat based on single-step modified gold microelectrodes. The modification consists on the electrodeposition of alginate membrane with trapped CuO nanoparticles on top of the electrodes. The electrodes are fabricated at a thin polyimide support and the soft nature of the membrane can w...

We propose a hybrid device substituting the software synapse in artificial neural networks with an individual hardware transistor unit. The unit merges a silicon nanowire semiconductor channel with a metal-ion doped solgel film as hybrid gate of the transistor. The film, amorphous and transparent, shows a memristive property due to ion redistributi...

Here we present a miniaturized lab-on-a-chip detecting system for all-electric and label-free analysis of the emulsion droplets incorporating the nanoscopic silicon nanowires based field-effect transistors for real-time monitoring of the enzymatic reaction of β-galactosidase and ortho-nitrophenol-galactose (ONPG).

In the pool of nanostructured materials, silicon nanostructures are known as conventionally used building blocks of commercially available electronic devices. Their application areas span from miniaturized elements of devices and circuits to ultrasensitive biosensors for diagnostics. In this Review, the current trends in the developments of silicon...

2D molybdenum disulfide (MoS2) gives a new inspiration for the field of nanoelectronics, photovoltaics, and sensorics. However, the most common processing technology, e.g., liquid‐phase based scalable exfoliation used for device fabrication, leads to the number of shortcomings that impede their large area production and integration. Major challenge...

In article number 1803613, Larysa Baraban, Denys Makarov, and co‐workers present an experimental and theoretical study of visible light‐driven Ag/AgCl Janus micromotors revealing high motility in pure H2O. The propulsion efficiency is dependent on the intensity of visible light and contributed by the coupled effect of the plasmonic light absorption...

Visible light‐driven nano/micromotors are promising candidates for biomedical and environmental applications. This study demonstrates blue light‐driven Ag/AgCl‐based spherical Janus micromotors, which couple plasmonic light absorption with the photochemical decomposition of AgCl. These micromotors reveal high motility in pure water, i.e., mean squa...

Insight is provided into the collective behavior of visible‐light photochemically driven plasmonic Ag/AgCl Janus particles surrounded by passive polystyrene (PS) beads. The active diffusion of single Janus particles and their clusters (small: consisting of two or three Janus particles and large: consisting of more than ten Janus particles), and the...

Implementing large arrays of gold nanowires as functional elements of a plasmonic biosensor is an important task for future medical diagnostic applications. Here we present a microfluidic-channel-integrated sensor for the label-free detec-tion of biomolecules, relaying on localized surface plasmon resonances. Large arrays (~ 1 cm2) of vertically al...

We present a biosensor chip with integrated large area silicon nanowire-based field effect transistors (FET) for human α-thrombin detection and propose to implement the hysteresis width of the FET transfer curve as a reliable parameter to quantify the concentration of biomolecules in the solution. We further compare our results to conventional surf...

Miniaturized and cost-efficient methods aiming at high throughput analysis of microbes is of

Fabrication and comparative analysis of the gas sensing devices based on individualized single-walled carbon nanotubes of four different types (pristine, boron doped, nitrogen doped and semi-conducting ones) for detection of low-concentrations of ammonia, is presented. The comparison of the detection performance of different devices, in terms of re...

The intriguing properties of self-assembled microtubular architectures open new possibilities to develop three-dimensional functional devices for molecule and cell analysis. [...]

Parallel arrays of silicon nanowire transistors are novel types of transducers under study for chemical and biochemical sensing that exploit the high surface to volume ratio of nanowires for sampling of low analyte concentrations and yet provide high output conductance. To investigate the applicability and practical sensitivity of parallel nanowire...

Miniaturized and cost-efficient methods aiming at high throughput analysis of microbes is of great importance for the surveillance and control of infectious diseases and the related issue of antimicrobial resistance. Here we demonstrate a miniature nanosensor chip based on a honeycomb-patterned silicon nanowire field effect transistor (FET) capable...

We report the first observation of negative photoconductance (NPC) in n- and p-doped Si nanowire field-effect transistors (FETs) and demonstrate the strong influence of doping concentrations on the nonconventional optical switching of the devices. Furthermore, we show that the NPC of Si nanowire FETs is dependent on the wavelength of visible light...

We demonstrate the direct biosensing of the Ebola VP40 matrix protein, using a memristor mode of a liquid-integrated nanodevice, based on a large array of honeycomb-shaped silicon nanowires. To shed more light on the principle of biodetection using memristors, we engineered the opening of the current-minima voltage gap VGAP by involving the third g...

We developed chemiresistor-type biosensors based on carbon nanotubes for highly efficient and fast detection of avian influenza virus (AIV) subtype H5N1 DNA sequences. Semiconducting single-walled carbon nanotube (sc-SWCNTs) or nitrogen-doped multi-walled carbon nanotubes (N-MWCNTs) were used as two alternative active sensing elements, and their se...

Combining catalytic Janus swimmers and passive beads in narrow channels, L. Baraban and co-workers observe many dynamic properties, ranging from distinct bulk and boundary-free diffusivity at low densities, whereby a Janus swimmer transports large clusters of passive particles. This research (on page 5882) is an important milestone towards understa...

The society is aging and therefore there is a need for new mobile and reliable health monitoring systems. An idea of such wireless, stretchable and mobile health monitoring platform has been developed. It consists of a wireless stretchable, biocompatible sensor tag placed on the skin and an RFID reader collecting and evaluating all the data, which...

Self-propelled Janus particles, acting as microscopic vehicles, have the potential to perform complex tasks on a microscopic scale, suitable, e.g., for environmental applications, on-chip chemical information processing, or in vivo drug delivery. Development of these smart nanodevices requires a better understanding of how synthetic swimmers move i...

Antimicrobial activity of surfactant-modified multi-walled carbon nanotubes (MWCNTs) was investigated by analyzing the growth curves of an Escherichia coli (E. coli) population in ionic and non-ionic surfactant-modified MWCNTs in Luria Bertani (LB) broth. The ionic surfactants (sodium dodecylbenzenesulfonate (SDBS), sodium cholate (SC), dodecyltrim...

Conjunction of miniature nanosensors and droplet-based microfluidic systems conceptually opens a new route towards sensitive, optics-less analysis of biochemical processes with high throughput, where single device can be employed for probing of thousands independent reactors. Here we combine droplet microfluidics with the compact silicon nanowire b...

Carbon nanotubes (CNTs) show great potential for biosensing, because of their quasi-one-dimensional structure offering high sensitivity, high electron mobility and their effective and facile integration into electrode network. In this study, we fabricated two types of chemiresistor arrays: based on nitrogen doped multi-walled CNTs (N-MWCNTs) and se...

We report an ultrasensitive label-free DNA biosensor with fully on-chip integrated rolled-up nanomembrane electrodes in which the hybridization of complementary DNA strands (Avian Influenza Virus subtype H1N1) is selectively detected down to attomolar concentrations - an unprecedented level for miniaturized sensors without amplification. Impedimetr...

This is a commentary on the Special Issue continuation involving “Single File Dynamics and Generalizations in Interdisciplinary Sciences”.

In this paper, we present a novel technology of printable bottom-up grown Si nanowire parallel arrays for low-dissipation power electronics. Parallel aligned layers of monocrystalline Si nanowires can be deposited on arbitrary substrates over large areas by the printing process. The presented transistors consist of parallel arrays of longitudinal N...

Precise analysis of the aquatic cells and their responses to the toxic chemicals, i.e., water disinfective agents, is of crucial importance due to their role in the ecosystem. We demonstrate the application of the droplets based millifluidic tool for isolating and longtime monitoring of single Paramecium tetraurelia cells using a large number of wa...