Lara H. Sattgast

National Institutes of Health | NIH

Objective: The aim was to evaluate differences in nutritional intake of calcium, vitamin D, and phosphorus; serologic indices of these nutrients; and bone health among adults with and without probable, undiagnosed celiac disease (CD). Method: Cross-sectional data from What We Eat in America and the National Health and Nutrition Examination Survey...

Chronic heavy alcohol use is often associated with reduced bone mineral density and altered bone turnover. However, the dose response effects of ethanol on bone turnover have not been established. This study examined the effects of graded increases of ethanol consumption on biochemical markers of bone turnover in young adult male cynomolgus macaque...

Alcohol consumption is often reported to influence bone health in a dose-dependent manner where moderate alcohol intake is deemed beneficial and heavy drinking detrimental. However, this relationship may not be valid for individual alcohol consumers, as small quantities of alcohol can have detrimental skeletal effects and not all studies report cli...

Development of optimal bone mass during early adulthood is determined by the balance between bone formation and resorption. The utility of minimally invasive biomarkers for monitoring bone turnover balance in maturing non-human primates has received limited attention. This study evaluated the biological variation of osteocalcin (a marker of bone fo...

Mechanical loading of the skeleton during normal weight bearing plays an important role in bone accrual and turnover balance. We recently evaluated bone microarchitecture in the femoral head in 5.6-week-old male Sprague Dawley rats subjected to a 4-day spaceflight aboard STS-41. Compared to weight bearing ground controls, cancellous bone volume fra...

Mice are typically housed at temperatures well below their thermoneutral zone. When individually housed at room temperature (~22 °C) mice experience cold stress which results in cancellous bone loss and has the potential to alter the skeletal response to treatment. It is not clear if there is a threshold temperature for cold stress-induced bone los...

Insulin-like growth factor 1 (IGF-1) influences bone turnover. Transient decreases in IGF-I levels and/or bioavailability may contribute to the detrimental effects of alcohol on bone. The goals of this non-human primate study were to (1) evaluate the 20-hour response of bone turnover markers to ethanol consumption, and (2) assess how ethanol consum...

Objective: Mice are facultative daily heterotherms with a thermoneutral point of ~32°C and when housed at standard room temperature (~22°C) experience cold stress and premature cancellous bone loss. It is unclear whether housing mice at the maximum recommended temperature of 26°C or group housing affects bone. The objectives of this study were to...

Scope: We performed a dose-ranging study using young estrogen-depleted rats to determine whether dietary isoliquiritigenin (ILQ) alters bone metabolism and if the effects are associated with estrogen receptor signaling. Methods and results: Six-week-old rats (ovariectomized at 4 weeks of age) were fed diets containing 0, 100, 250 or 750 ppm ILQ...

Objectives Weight gain during middle age is associated with several chronic diseases. Dieting is a common but often ineffective long-term strategy for stabilizing body weight at optimal levels for health. Similar to humans, middle-aged rats exhibit progressive weight gain and are a useful model for evaluating strategies for controlling weight. The...

Objectives Isoliquiritigenin (ILQ) is a phenolic compound found in licorice and is a popular dietary supplement. ILQ exhibits model-specific antioxidant, anti-inflammatory, anti-tumor, and estrogenic activities. Limited data suggest the potential of ILQ to prevent or treat osteoporosis. Therefore, this study evaluated the effects of short-duration...