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Introduction
Skills and Expertise
Publications
Publications (398)
Background and purpose:
Germinal matrix hemorrhage is a frequent complication of prematurity and can be associated with adverse neurodevelopmental outcome, depending on its severity. In addition to parenchymal damage, intraventricular residues of hemorrhage and hydrocephalus MR imaging findings include superficial siderosis. The purpose of this st...
Clinical issue:
Child abuse is the physical, sexual or emotional maltreatment, or neglect of a child or children. Child maltreatment is defined as any act or series of acts of commission or omission by a parent or other caregiver that results in harm, potential for harm, or threat of harm to a child. Child abuse can occur in a child's home, or in...
Zusammenfassung
Kinder mit Down-Syndrom haben einen nicht abschließend charakterisierten humoralen und zellulären Immundefekt mit unterschiedlicher klinischer Ausprägung, der in den ersten Lebensjahren das Risiko von Atemwegsinfektionen deutlich erhöht. Einige Publikationen beschreiben das Down-Syndrom (auch ohne Frühgeburtlichkeit oder einen hämod...
Pädiatrische lebensbedrohliche Notfälle sind in der präklinischen Praxis relativ seltene Ereignisse. Dadurch bedingt kann es den behandelnden Notärzten an einer gewissen Routine im Umgang mit diesem Patientenkollektiv fehlen. Pädiatrische Notfälle erfordern andererseits ein rasches Erkennen derselben und die umgehende Einleitung spezifischer Therap...
Life-threatening pediatric emergencies are relatively rare in the prehospital setting; therefore, the treating emergency physician may not always be familiar with and well trained in these situations. However, pediatric emergencies require early recognition and initiation of specific diagnostic and therapeutic interventions to prevent further compl...
Life-threatening pediatric emergencies are relatively rare in the prehospital setting. Thus, the treating emergency physician may not always be familiar with and well trained in these situations. However, pediatric emergencies require early recognition and initiation of specific diagnostic and therapeutic interventions to prevent further damage. Th...
In this study we investigated changes of serum leptin in 74 newborn lambs and associations with environmental temperature (from - 8°C to + 25°C), body temperature, and concentrations of plasma lipids, 3-beta-hydroxybutyric acid and blood glucose. A leptin radioimmunoassay was established, using an antiserum (rabbit) produced against a partial seque...
Background
In recent publications stem cell therapy was described in preterm neonates with impending bronchopulmonary dysplasia (BPD) and in term newborns with severe hypoxic-ischemic encephalopathy (HIE).
Aim
These first descriptions formed the basis to evaluate risks and benefits of stem cell therapy and other forms of regenerative therapy in neo...
Background
Outbreaks of nosocomial infections in neonates have recently received broad media interest.
Objectives
Data on nosocomial infections in German neonatal intensive care units are presented.
Material and methods
The available epidemiological data, mostly based on the NEO-KISS (hospital infection surveillance system) surveillance system were...
Fetal intestinal volvulus is a rare but serious finding with a high risk of potential life threatening fetal complications. Delay in diagnosis or treatment can increase mortality and morbidity. We report a case of mild fetal bowel dilatation at 30 weeks of gestation and intestinal volvulus presented by the 'whirl-sign', intestinal perforation and m...
Background:
Gender differences in overall neonatal survival and in short term pulmonary outcome have been reported. Furthermore gender differences in childhood chronic lung disorders have been described all in favor of females.
Methods:
A typical survey on published data regarding gender differences in lung development has been carried out.
Res...
Introduction:
Being born small for gestational age (SGA) can be a reference to intrauterine growth retardation (IUGR) and is associated with increased neonatal morbidity and mortality. In pregnancies complicated by IUGR placental insufficiency is thought to be one of the leading underlying pathogenetic mechanisms. As cytokines appear to be implicat...
Purpose:
Very premature delivery is a major cause of infant morbidity and mortality. Obesity, diabetes and pregnancy hypertension are known risk factors for pregnancy complications. The study aimed to scrutinize differences of pregnancy complications in a cohort of very premature deliveries compared to a national group.
Methods:
In a multicenter...
Hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR) syndrome (MIM 146255) is a rare autosomal dominant disorder caused by mutations in the gene encoding GATA3, a dual zinc-finger transcription factor involved in vertebrate embryonic development.
In this clinical case study we report on a follow-up of a phenotype associated with a G...
Die bronchopulmonale Dysplasie (BPD) ist unverändert eine der wesentlichen pulmonalen Komplikationen bei sehr unreifen Frühgeborenen, d. h. Kindern eines Gestationsalters
Regenerative therapy based on stem cells is applied as standard therapy in pediatric oncology. Furthermore, they are frequently used to treat immunodeficiency disorders of infants. For severe neonatal diseases, e. g. hypoxic-ischemic encephalopathy in term neonates or bronchopulmonary dysplasia in preterm infants, animal models have been establishe...
Mid-aortic stenosis (MAS) is a rare clinical entity that is characterised by profound narrowing of the abdominal aorta. MAS usually presents with severe hypertension. Treatment modalities include antihypertensive medication, angioplasty, and surgery. If adequate treatment is initiated long-term prognosis is favourable.
The vast majority of adder bites among children in Germany is caused by the common viper (vipera berus). The venom that is applicated by the viper contains several enzymes, some of them with hemorrhagic and neurotoxic activity. Adder bites among children may be without any symtoms but as well may cause severe intoxication.
Case report: We report a...
Study purpose: The electroencephalogram (EEG) is an essential diagnostic tool in children with epilepsy. The recording of a sleep EEG can increase the yield of EEG recordings in certain epileptic syndromes.
The primary aim of this study was to assess the influence of melatonin on EEG recording (quality, EEG characteristics), and to assess its effi...
Zusammenfassung
Neonatale Atemstörungen sind bei Früh- und Neugeborenen der Hauptgrund der postnatalen Hospitalisierung. Atemstörungen bei reifen Neugeborenen werden meist durch transiente Tachypnoen, beim Frühgeborenen durch ein Atemnotsyndrom (RDS) hervorgerufen. Durch die wachsende Zahl von abdominellen Schnittentbindungen ohne vorherige Wehen k...
Zusammenfassung
Steigende Frühgeburten- sowie steigende Überlebensraten sehr unreifer Frühgeborener in den letzten Dekaden haben zu einem Anstieg der Anzahl von Kindern mit einem Risiko für psychoneurologische Entwicklungsauffälligkeiten geführt, welche Auffälligkeiten in der motorischen und kognitiven Entwicklung, Seh- und Hörstörungen, Teilleistu...
Objective:
Cytokines play an important role in immune regulation and fetal lung development. The systemic inflammatory response in newborns with congenital diaphragmatic hernia (CDH) has not been characterized so far. We compared various concentrations of cytokines in serum from newborns with CDH and in healthy term neonates. We analyzed cytokine p...
Background: Preterm newborns with intrauterine growth retardation (IUGR) are at increased risk for the development of pulmonary disorders. Vitamin A and its active form, all-trans retinoic acid (ATRA), are essential for growth and development of cells and tissues. Retinoids play an important role in the lung and respiratory epithelium. The fetal lu...
Background and Aims: Nanoparticles can pass the lung tissue, reach the circulation and in case of transplacental transport may affect the unborn child. Aim of this work was to determine whether exposure to particulate matter containing nanoparticles in part resulting from diesel exhaust may influence cytokine levels in the cord blood of newborns. W...
Respiratory disorders remain a major problem in postnatal adaptation. In term neonates, an increased incidence of the risk for transient tachypnoea of the neonate has been observed during the past decade, most likely secondary to an increased usage of primary Caesarean section. The disorder is mainly caused by a delayed resorption of foetal lung fl...
Die beatmungsassoziierte Pneumonie (VAP: „ventilator-associated pneumonia“) im Kindesalter ist nach aktuellen Daten der KISS-Studie
(KISS: Krankenhausinfektionssurveillancesystem) eine in Deutschland insgesamt seltene, aber potenziell lebensbedrohliche Komplikation
der pädiatrischen Intensivtherapie, die besonders häufig bei Kindern mit schweren Gr...
Neonatal emergencies still represent a major challenge with important implications for obstetricians and perinatologists. Meconium aspiration syndrome (MAS incidence 0.5–1 per 1,000 live births in Europe) is characterized by an early onset of respiratory failure and often by pulmonary hypertension. Endotracheal inspection and suctioning of meconium...
Respiratory Distress Syndrome (RDS) is a common complication in preterm neonates. If RDS is not responding to conventional treatment modalities (surfactant therapy, ventilatory support, etc.), an underlying pathology (pulmonary lymphangiectasia, capillary alveolar dysplasia, alpha-1 antitrypsin deficiency, etc.) other then prematurity should be tak...
Mid-aortic stenosis (MAS) is a rare clinical entity that is characterised by profound narrowing of the abdominal aorta. MAS usually presents with severe hypertension. Treatment modalities include antihypertensive medication, angioplasty, and surgery. If adequate treatment is initiated long-term prognosis is favourable. Here, we report on 13-year-ol...
During a period of 12 months 7 newborns with a partially severe fetopathy caused most probably by maternal sartan-intake in pregnancy were treated in 5 German teaching hospitals. Sartans antagonize the effect of angiotensin II at the AT1-receptor and are used to treat arterial hypertension.
We presented 2 cases at the yearly GNPI meeting 2010 and w...
Background: Non-ketotic hyperhyperglycinemia with manifestation in the neonatal period constitutes a severe inborn error of metabolism with a very poor prognosis. Methods: Case report Patient: The female baby was born to a GII, PI mother (unrelated parents) after an uneventful pregnancy with normal fetal movements (birth weight: 3510 gr) at 38 week...
Left ventricular compromise in the neonate may be caused by birth asphyxia, metabolic disease, congenital heart disease, and systemic bacterial or viral infections. In rare cases, enterovirus infection may cause severe disease including cardiac, cerebral, hepatic and multi organ failure.
Case report.
A 3-week-old neonate was admitted to our NICU in...
