Lara Dugas

Lara Dugas
Loyola University Chicago | LUC · Department of Public Health Sciences

Ph.D, MPH, FTOS
AXA Research Chair in Non-Communicable Disease Epidemiology

About

183
Publications
54,334
Reads
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4,497
Citations
Citations since 2016
104 Research Items
3563 Citations
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20162017201820192020202120220200400600
20162017201820192020202120220200400600
20162017201820192020202120220200400600
Introduction
Lara Dugas is an epidemiologist in the Department of Public Health Sciences, Loyola University Chicago. Her work focuses on the role of the gut microbiota and cardiometabolic disease risk in Africa-origin populations from 5 international populations from the US, the Seychelles, Jamaica, South Africa and Ghana.
Additional affiliations
July 2018 - October 2018
Loyola University Chicago
Position
  • Professor (Associate)
August 2014 - June 2018
Loyola University Chicago
Position
  • Professor (Assistant)
January 2007 - July 2014
Loyola University Chicago
Position
  • Professor (Assistant)
Education
January 2012 - May 2013
Loyola University Chicago
Field of study
  • Public Health
July 2008 - May 2010
Loyola University Chicago
Field of study
  • Epidemiology
January 1998 - July 2004
University of Cape Town
Field of study
  • Exercise Physiology

Publications

Publications (183)
Article
Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using...
Article
Full-text available
In mammals, trait variation is often reported to be greater among males than females. However, to date, mainly only morphological traits have been studied. Energy expenditure represents the metabolic costs of multiple physical, physiological, and behavioral traits. Energy expenditure could exhibit particularly high greater male variation through a...
Article
Background : Non-communicable diseases (NCDs) such as obesity, hypertension (HPT), and type II diabetes (T2D) are of increasing concern in South Africa (SA), with women being more at risk. Authors conducted a scoping review to identify and map the evidence available about the barriers of access to obesity, HPT, and T2D care among women in SA. Metho...
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Lower ambient temperature (Ta) requires greater energy expenditure to sustain body temperature. However, effects of Ta on human energetics may be buffered by environmental modification and behavioral compensation. We used the IAEA DLW database for adults in the USA (n = 3213) to determine the effect of Ta (-10 to +30°C) on TEE, basal (BEE) and acti...
Article
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The Pulvers’ silhouette showcards provide a non-invasive and easy-to-use way of assessing an individual’s body size perception using nine silhouette shapes. However, their utility across different populations has not been examined. This study aimed to assess: 1) the relationship between silhouette perception and measured anthropometrics, i.e., body...
Article
Prior studies of early antibiotic use and growth have shown mixed results, primarily on cross-sectional outcomes. This study examined the effect of oral antibiotics before age 24 months on growth trajectory at age 2–5 years. We captured oral antibiotic prescriptions and anthropometrics from electronic health records through PCORnet, for children wi...
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Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval:...
Article
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Background Cardiometabolic (CM) risk affects approximately 25% of adults globally, and is diagnosed by meeting 3 out of 5 of the following CM risk factors: elevated blood pressure, high triglycerides, elevated blood sugar, low high-density lipoprotein (HDL) level, and abdominal obesity. Adults with CM risk are approximately 22% more likely to have...
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Sleep disorders are increasingly being characterized in modern society as contributing to a host of serious medical problems, including obesity and metabolic syndrome. Changes to the microbial community in the human gut have been reportedly associated with many of these cardiometabolic outcomes. In this study, we investigated the impact of sleep le...
Article
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Background: Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass. Objectives: A study is presented of the association between FFM and physical activity in relation to age. Methods: In a cross-sectional study, FFM was analyzed in relation t...
Article
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A lifetime of change Measurements of total and basal energy in a large cohort of subjects at ages spanning from before birth to old age document distinct changes that occur during a human lifetime. Pontzer et al . report that energy expenditure (adjusted for weight) in neonates was like that of adults but increased substantially in the first year o...
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Understanding the impacts of activity on energy balance is crucial. Increasing levels of activity may bring diminishing returns in energy expenditure because of compensatory responses in non-activity energy expenditures.1, 2, 3 This suggestion has profound implications for both the evolution of metabolism and human health. It implies that a long-te...
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Long-chain omega-3 PUFAs, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are of increasing interest because of their favorable effect on cardiometabolic risk. This study explores the association between omega 6 and 3 fatty acids intake and cardiometabolic risk in four African-origin populations spanning the epidemiological...
Article
Introduction: Changes to the overall diversity and relative abundance of the microbiota have been shown to alter not only the functionality of the gut system, in particular with regards to the metabolic rates and levels of pro-inflammatory cytokines, but also the development of disease states such as metabolic syndrome (METS). The purpose of this s...
Article
To sustain life, humans and other terrestrial animals must maintain a tight balance of water gain and water loss each day.1-3 However, the evolution of human water balance physiology is poorly understood due to the absence of comparative measures from other hominoids. While humans drink daily to maintain water balance, rainforest-living great apes...
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Full-text available
The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The...
Article
Background Childhood overweight and obesity (OW/OB) is increasingly centered in low- and middle-income countries (LMICs) as rural populations experience market integration and lifeway change. Most explanatory studies have relied on imprecise estimates of children's energy expenditure, restricting understanding of the relative effects of changes in...
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Transcriptome prediction methods such as PrediXcan and FUSION have become popular in complex trait mapping. Most transcriptome prediction models have been trained in European populations using methods that make parametric linear assumptions like the elastic net (EN). To potentially further optimize imputation performance of gene expression across g...
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Nearly one in five young people in the United States has obesity, putting one-fifth of America’s children at higher risk of having chronic health conditions and of having obesity into adulthood. Family-based lifestyle interventions (FBLI) have been proposed as effective mechanisms to improve the health through health education and the adoption of h...
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This study explored adipocytokine associations with acute and chronic hyperglycemia in African-American men (AAM). Fourteen adipocytokines were measured from men with normal glucose tolerance (NGT) or type 2 diabetes (T2D, drug-naïve MF(−) or using metformin MF(+)). Acute and chronic hyperglycemia were evaluated by 120 min oral glucose tolerance te...
Article
Significance The increase in obesity has been accompanied by a rise in the prevalence of peripheral neuropathy. Because there is no disease-modifying therapy, paradigm-shifting research on pain associated with obesity, metabolic syndrome, and type 2 diabetes is urgently needed. Our data suggest that fecal transplantation from lean to obese, insulin...
Article
Introduction. Evidence suggests that early-life antibiotic use can alter gut microbiome, predisposing children to obesity. The obesity epidemic has a disproportionate effect on individuals from lower socioeconomic status (SES). Thus, this study aims to explore the link between SES and antibiotic use. Design. We performed a retrospective cohort stud...
Article
Study Design Retrospective review Background Temporomandibular disorder (TMD) encompasses a spectrum of disorders associated with pain in the temporomandibular joint (TMJ) and the surrounding musculature. Current research shows conservative physical therapy (PT) is beneficial in management of the disorder. This study further explores if PT is an e...
Preprint
Full-text available
Background: Adipocytokines are important in type 2 diabetes (T2D). This study explored adipocytokine associations with acute and chronic hyperglycemia in African American Men (AAM). Methods: Fourteen adipocytokines were measured (multiplex assay) in blood samples from men with normal glucose tolerance (NGT) or T2D (drug-naïve MF(-) or using metform...
Preprint
Full-text available
Background: The Pulvers’ silhouette showcards provide a non-invasive, easy-to-use, and possibly cross-culturally acceptable way of assessing an individual’s perception of their body size. This study examined, in three different populations: 1) the relationship between silhouettes and body mass index (BMI), 2) the predictive performance of silhouett...
Article
Objectives Dietary modifications can be an effective therapeutic approach to prevent and manage metabolic syndrome. The aim of this study is to explore the association between fiber intake with metabolic syndrome and between omega 3 and 6 fatty acids with metabolic syndrome in four countries spanning the epidemiological transition. The study partic...
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Background There are no clinical longitudinal studies exploring the associations between sport specialization and intense training patterns and injuries in young athletes. Purpose To prospectively determine the relationship between young athletes’ degree of sport specialization and their risk of injuries and reinjuries. Study Design Case-control...
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Objectives To investigate associations between self-reported sleep duration and cardiometabolic (CM) risk factors in African-origin adults residing in five countries spanning the epidemiologic transition. Design Cross-sectional. Setting and participants Ghanaian (n = 491), South African (n = 503), Jamaican (n = 508), Seychellois (n = 501) and Ame...
Article
Full-text available
Background: The prevalence of obesity among infants less than 2 years of age has increased by more than 60% over the last three decades. Obese infants and toddlers are at an increased risk for staying overweight into adolescence and adulthood. Metabolic programming has been demonstrated in animal models whereby early life feeding habits result in...
Preprint
Full-text available
Background: The prevalence of obesity among infants less than 2 years of age has increased by more than 60 percent over the last three decades. Obese infants and toddlers are at an increased risk for staying overweight into adolescence and adulthood. Metabolic programming has been demonstrated in animal models whereby early life feeding habits resu...
Preprint
Full-text available
Background: The prevalence of obesity among infants less than 2 years of age has increased by more than 60 percent over the last three decades. Obese infants and toddlers are at an increased risk for staying overweight into adolescence and adulthood. Metabolic programming has been demonstrated in animal models whereby early life feeding habits resu...
Preprint
Background: The prevalence of obesity among infants less than 2 years of age has increased by more than 60 percent over the last three decades. Obese infants and toddlers are at an increased risk for staying overweight into adolescence and adulthood. Metabolic programming has been demonstrated in animal models whereby early life feeding habits resu...
Preprint
Full-text available
Background: The prevalence of obesity among infants less than 2 years of age has increased by more than 60 percent over the last three decades. Obese infants and toddlers are at an increased risk for staying overweight into adolescence and adulthood. Metabolic programming has been demonstrated in animal models whereby early life feeding habits resu...
Article
Full-text available
Children’s metabolic energy expenditure is central to evolutionary and epidemiological frameworks for understanding variation in human phenotype and health. Nonetheless, the impact of a physically active lifestyle and heavy burden of infectious disease on child metabolism remains unclear. Using energetic, activity, and biomarker measures, we show t...
Article
Full-text available
Gut microbiota and their biomarkers may be associated with obesity. This study evaluated associations of body mass index (BMI) with circulating microbiota biomarkers in African American men (AAM) (n = 75). The main outcomes included fecal microbial community structure (16S rRNA), gut permeability biomarkers (ELISA), and short-chain fatty acids (SCF...
Article
Full-text available
Oral and fecal microbial biomarkers have previously been associated with cardiometabolic (CM) risk, however, no comprehensive attempt has been made to explore this association in minority populations or across different geographic regions. We characterized gut- and oral-associated microbiota and CM risk in 655 participants of African-origin, aged 2...
Article
Full-text available
Background: The prevalence of pediatric allergic diseases has increased rapidly in the United States over the past few decades. Recent studies suggest an association between the increase in allergic disease and early disturbances to the gut microbiome. The gut microbiome is a set of intestinal microorganisms that begins to form during birth and is...
Article
Objective: Abnormalities of water and sodium balance, including diabetes insipidus and the syndrome of inappropriate antidiuretic hormone (SIADH), are common complications of transsphenoidal surgery. Postoperative practice patterns vary among clinicians, and no consensus guidelines exist to direct their monitoring and management. We aimed to identi...
Article
The limits on maximum sustained energy expenditure are unclear but are of interest because they constrain reproduction, thermoregulation, and physical activity. Here, we show that sustained expenditure in humans, measured as maximum sustained metabolic scope (SusMS), is a function of event duration. We compiled measurements of total energy expendit...
Article
Full-text available
Purpose Oxytocin is a hypothalamus derived, posterior pituitary stored nonapeptide which has gained recent interest as an important neuropsychiatric and metabolic hormone beyond its classic role in lactation and parturition. Hypopituitarism is a heterogenous disorder of derangement in one or more anterior or posterior pituitary hormones. Diagnosis...
Preprint
Full-text available
Oral and fecal microbial biomarkers have previously been associated with cardiometabolic (CM) risk, however, no comprehensive attempt has been made to explore this association in minority populations or across different geographic regions. We characterized gut- and oral-associated microbiota and CM risk in 655 participants of African-origin, aged 2...
Article
Full-text available
Objectives: This study examines the prospective association between sugar-sweetened beverages (SSB) consumption and change in body weight over a 4-5-year period in a socio-economically disadvantaged South African population. Methods: This is a longitudinal study involving 800 adults (212 men, 588 women); 247 from the original METS (Modelling the...
Article
Objective To investigate physiological and performance adaptations associated with extremely high daily sustained physical activity levels, we followed six runners participating in the 2015 Race Across the USA. Participants completed over 42.2 km a day for 140 days, covering nearly 5,000 km. This analysis examines the improvement in running speed a...
Data
Table S1. Analyses of Composition of Microbiome (ANCOM) between the four strains of mice i.e. CD1, C57Bl6/J, FVB, NIH‐Swiss on normal chow (NC) diet. Table S2. Analyses of Composition of Microbiome (ANCOM) between the C57Bl6/J mice on protein deficient (PD) and Normal Chow diet (NC). Table S3. Analyses of Composition of Microbiome (ANCOM) between...
Article
Full-text available
Malnutrition remains a major health problem in low‐ and middle‐income countries. During low protein intake, <0.67 g/kg/day, there is a loss of nitrogen (N2) balance, due to the unavailability of amino acid for metabolism and unbalanced protein catabolism results. However, there are individuals, who consume the same low protein intake, and preserve...
Article
Full-text available
Abstract We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI