Lankalapalli Srinivas

GITAM University | GITAM

Objective: Tazarotene is used as a topical retinoid for the treatment of acne, psoriasis and sun-damaged skin. But its topical formulation has many side effects, including itching, burning, dryness, redness, stinging, rash blistering, skin discoloration, peeling at the site of application and low bioavailability. The present study focuses on the re...

The Enteric Capsule Drug Delivery Technology (ECDDT) was designed to enable oral administration while ensuring complete enteric protection and swift release in the upper gastrointestinal (GI) tract, without the need for coatings. Current study used a 32factorial design (Stat-Ease Design Expert v12) to formulate a mini-tablet in an enteric-coated ca...

Budesonide, a corticosteroid, was used as a model drug to study the effects of independent variables like HPMC K4M as a release retarding polymer at 2-6% and Crospovidone as a super disintegrant at 2-5% on in vitro drug release to meet desired Q points of dissolution. Current study used a 32 factorial design (Stat-Ease Design Expert v12) to formula...

The aim of this study was to develop and validate one discriminatory dissolution method for evaluation of amorphous solid dispersion of Artemether in its fixed dose combination (FDC) of Artemether lumefantrine tablets. Methods: The evaluation of discriminatory power of the selected dissolution method was based on saturation solubility and sink cond...

Objective: The aim of this study was to evaluate and optimize the amorphous solid dispersion of a low-soluble BCS Class IV anti-platelet drug using factorial design in line with the Quality by Design (QbD) principle. Methods: Ticagrelor, a low-soluble anti-platelet agent, was used as the model drug for the current study. A solid dispersion techniqu...

Clinical failure remains an ongoing challenge in pharmaceutical drug product development. Solubility and permeability therefore play a very critical role in achieving desired bioavailability and pharmacological response, which in turns affects clinical safety and efficacy significantly. The situation becomes more critical when the drug candidate ex...

Breast cancer (BC) is the most common cancer in women worldwide. Letrozole (LTZ) is a third-generation selective nonsteroidal aromatase inhibitor and one of many anticancer drugs. Conventional LTZ therapies for BC are often administered orally or parenterally and frequently result in severe systemic side effects. To improve this situation, efforts...

Objective: The objective behind this study was to expose the prospective of ethanolic extract of Ochna obtusata (EEOO) for its in vitro anti-cancer anti-inflammatory and anti-arthritic activities. Methods: The fresh leaves were used to prepare the extracts using petroleum ether, chloroform, ethanol, methanol and water in increasing order of the pol...

Several efforts have been focused on targeted drug delivery systems for delivering a drug to a particular region of the body for better control of systemic as well as local action. Liposomes have proven their efficiency as a choice of carrier for targeting the drugs to the site of action. The main reason for continuous research on liposomes drug de...

Cancer refers to the division of abnormal cells at an uncontrollable rate that possesses the ability to infiltrate and destroy normal tissues. It frequently spreads to normal tissues throughout the body, a condition known as metastasis, which is a significant concern. It is the second leading cause of mortality globally and treatment therapy can as...

The present work contributes to modulate the biopharmaceutical parameters through co-crystallization of posaconazole. The cocrystals of posaconazole were fabricated with amino acids as co-formers, which are zwitterionic, GRAS status, and biological non-hazardous in nature using solvent evaporation and liquid assistant grinding. Preliminary screenin...

The study was aimed to conduct a pharmacokinetic evaluation of Raltegravir in rabbit plasma using a sensitive HPLC method. The plasma samples were assayed by Waters alliance e-2695 HPLC instrument using X-bridge phenyl hexyl column (150x4.6mm, 5 µ) under isocratic condition. Acetonitrile and Tri ethyl amine buffer (30:70 v/v) was used as mobile pha...

Multiple charged macromolecular compounds with opposite charges precipitate from aqueous solutions depending on the charge distribution and molecular weight. These complexes are composed of a macromolecular multiple-charged component of one polarity and many low molecular weight ions of the other polarity, or two macromolecular partners with differ...

Objective: The current research was aimed to formulate and evaluate raft forming gastro retentive floating drug delivery systems of Lafutidine for improving gastric residence time and sustained drug release for an extended time. Methods: Using Box-Behnken experimental design 17 formulations of lafutidine GRDDS were designed and evaluated for variou...

Objective: The current research was aimed to formulate and evaluate raft forming gastro retentive floating drug delivery systems of Lafutidine for improving gastric residence time and sustained drug release for an extended time. Methods: Using Box–Behnken experimental design 17 formulations of lafutidine GRDDS were designed and evaluated for variou...

Oral mucosa offers several advantages in the delivery of therapeutic molecules. It avoids presystemic metabolism, Nanoencapsulation techniques might be applied to conquer physical, chemical challenges and enhance drug penetration, formulation performance, prolonging drug residence time, and improving sensorial feeling. The present investigation is...

Background The meager physicochemical properties like low solubility and low dissolution rate of rosuvastatin calcium remain as an obstruction for formulation development. In the present work, we explore the evolution of rosuvastatin cocrystal, which may offer the synergetic physico-chemical properties of the drug. Cocrystal crafting depends on two...

Nanotherapeutics for the cure of breast cancer remains unswervingly succeeding and being practiced to eradicate innumerable restrictions of conventional practice obtainable for the supervision of breast cancer. Nanoparticles offer an interdisciplinary extent for exploration in imaging, diagnosis and targeting of breast cancer. Through a progressive...

The aim of any research work is to find the complications associated with the drug or formulation and find the conclusion of what can be the best possible way to solve them. It has been observed that drugs with short half-life, pH-dependent solubility and having absorption window in upper part of GIT forms good drug candidate for gastro retentiv...

The poor physicochemical properties like low solubility and low dissolution rate of rosuvastatin calcium remain as an obstruction for formulation development. In the present investigation, we explore the evolution of rosuvastatin cocrystal, which may offer the synergetic physico-chemical properties of the drug. Cocrystal crafting depends on two pos...

Objectives: Rosuvastatin calcium (RSC) is a synthetic biopharmaceutical classification system class-II drug with a low solubility but high permeability. The drug is used in hyperlipidemia management. In this study, the physicochemical properties of RSC were modified via crystal engineering to produce a cocrystal form. The solvent evaporation metho...

Ochna obtusata was examined for its Hepatoprotective activity against Paracetamol induced liver damage in Rats since it has been reported to have antioxidant activity but the potential Hepatoprotective activity is still unclear and not reported. The objective of the study is to confirm the Hepatoprotective activity of ethanolic extract of Ochna obt...

The present research is an approach to develop a formulation platform that shall help in minimizing the time and effort taken to develop a drug delivery system. Taking bilayer tablet technology as a representation for drug delivery system, well accepted antihypertensive drugs, Amlodipine besylate and Metoprolol succinate were considered as model dr...

The present study is an attempt to develop bilayer matrix tablets of Nebivolol Hydrochloride and Valsartan with immediate release for Nebivolol Hydrochloride and sustained release for Valsartan. Superdisintegrants such as sodium starch glycolate and Crosscarmellose sodium were evaluated for immediate release of Nebivolol Hydrochloride and polymers...

The objective of the present work was to formulate and characterize multi-unit floating drug delivery system of Clopidogrel bisulphate to increase the bioavailability and sustain the drug release properties up to 8 h with more predictable drug release kinetics that avoids all or nothing emptying effect wherefore to improve patient compliance. Clopi...

Enhancement of the bioavailability of poorly water-soluble drugs is a challenging task in drug development. Currently 40% of new chemical entities are discovered as poorly water-soluble drugs. Solid dispersion is one of the best technology for improving solubility, dissolution rate, and bioavailability. Solid dispersion techniques are more useful f...

Objective: The objective was to improve the solubility and dissolution of ivacaftor tablets by using solid dispersion (SD) technique.Methods: Ivacaftor is practically insoluble (<0.001 mg/mL) over pH value of 3.0–7.5 due to low solubility, and it shows poor bioavailability after oral administration. Therefore, SDs of Ivacaftor were prepared by SD t...

Objective: The objective was to improve the solubility and dissolution of ivacaftor tablets by using solid dispersion (SD) technique.Methods: Ivacaftor is practically insoluble (<0.001 mg/mL) over pH value of 3.0–7.5 due to low solubility, and it shows poor bioavailability after oral administration. Therefore, SDs of Ivacaftor were prepared by SD t...

The ever-growing interest in exosomes research is mainly due to their potential applications in health and disease, especially in therapy and diagnosis. To explore the applications of exosomes in the clinical setting, we must understand their characteristics at the molecular levels. Furthermore, exosomes are cell and function specific; therefore, w...

Since the leave extracts of Ochna obtusata is reportedly used to treat ulcer, asthma and bronchitis, an attempt was made to study the Anti-Inflammatory activity of leaves of Ochna obtusata. Ethanolic extracts was prepared and used for the evaluation. The anti-inflammatory activity of EEOO was studied by reported methods to check acute and chronic a...

Background: Drug delivery through liposomes offers several advantages, but still challenging to the researchers for the use of liposomes as carriers in drug delivery due to their poor physical stability, unpredictable drug encapsulation and systemic availability of the loaded drug. Objective: The present investigation was planned with an objecti...

Vancomycin hydrochloride is water soluble and poorly absorbable glycopeptide antibiotic act by inhibition of the synthesis of peptidoglycan a major component of bacteria cell wall. It is highly effective against the Staphylococcus aureus and other Staphylococcus species microorganisms. Structurally vancomycin hydrochloride has six peptide bonds wit...

The present investigation deals with the formulation and evaluation of sodium alginate and pectin based In situ gel of Losartan Potassium. Sodium alginate and guar gum were used as a polymer and CaCO3 was used as a crosslinking agent. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultra-vio...

Liposomes are potential carriers for targeting and controlled drug delivery by the intravenous route. Beta cyclodextrin and Hydroxy propyl beta cyclodextrin inclusion complexes with Itraconazole were prepared by kneading method and these complexes were incorporated in the aqueous phase of the liposomes to prepare Itraconazole liposomes. Factors suc...

Advanced drug delivery technologies can increase safety and efficacy, extend patent lives and provide competitive differentiation for biopharmaceuticals by helping drug manufacturers in differentiating new therapeutics from existing products that enable novel treatments. It provides improved therapy through increased efficacy and duration of drug a...

Febuxostat is a urate lowering drug, an inhibitor of xanthine oxidase used in the treatment of hyperuricemia and chronic gout. The drug shows dissolution-rate limited absorption, there by poor and variable bioavailability. It needs enhancement in bioavailability to derive maximum therapeutic efficacy. The main objective of the present research work...

Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the advantages of oral route of drug administration. In certain conditions conventional drug release pattern is not suitable like Diabetes mellitus, Asthma, cardiovascular diseases Arthritis, Peptic ulcer etc. In such conditions pulsatile d...

Citicoline sodium (citicoline) has a broad spectrum of therapeutic index, as a neuroprotectant or cerebroprotectant.Citicoline is useful in the treatment of ischemic stroke, head trauma and neurodegenerative disease. The present study was planned to develop controlled release tablets of citicoline. The effect of various hydrophilic and hydrophobic...

An isocratic RP-HPLC method was developed for the determination of Cefditoren pivoxil in pharmaceutical formulations using a C-18 column with water–acetonitrile (50:50, v/v) as mobile phase and flow rate 1.2 mL/min (UV detection at 218 nm). Linearity was observed in the concentration range 1.0–250 μg/mL (R2=0.999) with regression equation y=24194x+...

A selective, specific and sensitive stability-indicating high-performance liquid chromatographic method was developed and validated for the determination of Rufinamide in tablet dosage forms. Reversed-phase chromatography was performed on Shimadzu Model CBM-20A/20 Alite, equipped with SPD M20A prominence photodiode array detector using C18 column (...

The electrostatic interactions between oppositely charged polyelectrolytes lead to formation of insoluble polyelectrolyte complexes in aqueous medium. The polyelectrolyte complexes formed between a poly acid and poly base are little affected by the pH variation of the dissolution medium. In the present study attempts were made to prepare polyelectr...

The phenomena of polymer interactions and formation of polyelectrolyte complexes (PECs) of oppositely charged polymers have been the focus of interest in fundamental and applied research. Such PECs may possess unique properties that are different from those of individual polymers. In the present study, attempts were made to prepare PECs of negative...

The electrostatic interaction between oppositely charged polyelectrolytes leads to formation of insoluble polyelectrolyte complexes in aqueous medium. The polyelectrolyte complexes formed between a polyacid and a polybase are little affected by the pH variation of the dissolution medium. In the present study attempts were made to prepare polyelectr...

Over the past several years, great advances have been made towards novel drug delivery systems. The phenomena of interpolymer interactions and formation of polyelectrolyte complexes have been the focus of intensive fundamental and applied research. Interpolyelectrolyte complexes combine unique physicochemical properties with high biocompatibility....

Ibuprofen suspensions were formulated employing its solid dispersions in HPMC, PVP, PEG and dextrin and were evaluated for particle size, physical stability and dissolution rate. Ibuprofen suspensions formulated employing its solid dispersions exhibited good suspendability and gave higher dissolution rates of ibuprofen than those formulated with ib...

Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesive drug delivery systems prolong the residence time of the dosage form at the site of application or absorption and facilitate an intimate contact of the dosage form with the underlying absorption surface and thus contribute to improved and/or better thera...