Lan Li

Lan Li
University of Kentucky | UKY · Department of Chemistry

About

62
Publications
2,494
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731
Citations
Citations since 2017
28 Research Items
578 Citations
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2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250

Publications

Publications (62)
Article
Full-text available
T cells play an integral role in the generation of an effective immune response and are responsible for clearing foreign microbes that have bypassed innate immune system defenses and possess cognate antigens. The immune response can be directed toward a desired target through the selective priming and activation of T cells. Due to their ability to...
Article
Full-text available
Objective The purpose of this study was to investigate the dynamic functional network connectivity (FNC) and its relationship with cognitive function in obstructive sleep apnea (OSA) patients from normal cognition (OSA-NC) to mild cognitive impairment (OSA-MCI).Materials and methodsEighty-two male OSA patients and 48 male healthy controls (HC) were...
Article
Objective: This study aims to investigate the expression, prognostic value, and function of kinesin superfamily 4A (KIF4A) in cervical cancer. Methods: Cervical cancer cell lines (Hela and SiHa) and TCGA data were used for experimental and bioinformatic analyses. Overall survival (OS) and progression free survival (PFS) were compared between pat...
Article
Full-text available
Objective Many studies have explored the neural mechanisms of cognitive impairment in chronic obstructive pulmonary disease (COPD) patients using the functional MRI. However, the dynamic properties of brain functional networks are still unclear. The purpose of this study was to explore the changes in dynamic functional network attributes and their...
Article
e21028 Background: Advanced non-small cell lung cancer (NSCLC) patients responded differently to checkpoint inhibitors (ICIs) therapy, leading to the confuse of choosing the optimal regimens for patients. Therefore, we performed this network meta-analysis to compare different agents across clinical trials. Methods: We searched databases, including...
Article
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Background: Mainstream application of cancer immunotherapy is hampered by the low response rate of most cancer patients. A novel immunotherapeutic target or a biomarker predicting response to immunotherapy needs to be developed. Guanylate-binding protein 1 (GBP1) is an interferon (IFN)-inducible guanosine triphosphatases (GTPases) involving inflamm...
Article
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Purpose: Previous studies have demonstrated abnormal local spontaneous brain activity in the conventional frequency bands (0.01-0.08 Hz) in obstructive sleep apnea (OSA). However, it is not clear whether these abnormalities are associated with the specific frequency band of low-frequency oscillations or whether it can be improved with a continuous...
Article
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IntroductionCorticospinal tract injury caused by direct hematoma compression and secondary damage induced from blood toxic substances might influence the outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to evaluate the safety and efficacy of hematoma evacuation via image-guided para-corticospinal tract approach based on th...
Article
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Abnormal local spontaneous brain activity during the resting state has been observed in chronic obstructive pulmonary disease (COPD). However, it is still largely unclear whether the abnormalities are related to specific frequency bands. Our purpose was to explore intrinsic neural activity changes in different frequency bands by using the amplitude...
Article
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Tumor microenvironment (TME) has been reported to exhibit a crucial effect in lung cancer. Therefore, this study was aimed to investigate the genes associated with TME and develop a risk score to predict the overall survival (OS) of patients with lung adenocarcinoma (LUAD) based on these genes. The immune and stromal scores were generated by the ES...
Article
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Purpose For resectable cases of stage III-N2 non-small cell lung cancer (NSCLC), the best treatment after surgery is still uncertain. The effect of postoperative radiotherapy (PORT) is controversial. Thus, we performed this updated meta-analysis to reassess the data of PORT in stage III-N2 NSCLC patients, to figure out whether these patients can be...
Article
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Immunotherapy has moved to the forefront of modern oncologic treatment in the past few decades. Various forms of immunotherapy currently are emerging, including oncolytic viruses. In this therapy, viruses are engineered to selectively propagate in tumor cells and reduce toxicity for non-neoplastic tissues. Adenovirus is one of the most frequently e...
Article
Objectives Acute kidney injury (AKI) following intracerebral hemorrhage (ICH) is an intractable medical complication and an independent predictor of short-term mortality. However, the correlation between AKI and long-term mortality has not been fully investigated. The aim of the present study was to determine the relationship between AKI following...
Article
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The 2019 novel coronavirus has spread rapidly around the world. Cancer patients seem to be more susceptible to infection and disease deterioration, but the factors affecting the deterioration remain unclear. We aimed to develop an individualized model for prediction of COVID‐19 deterioration in cancer patients. The clinical data of 276 cancer patie...
Article
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Hydrocephalus after intracerebral hemorrhage (ICH) is a common and treatable complication. However, the long-term outcomes and factors for predicting hydrocephalus have seldom been studied. The goal of this study was to determine the long-term outcomes and analyze the risk factors of hydrocephalus after ICH. A consecutive series of 1342 patients wi...
Article
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Background: Inflammation plays an essential role in secondary brain injury after intracerebral hemorrhage (ICH). Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) have been suggested to suppress neuroinflammation after central nervous system (CNS) damage in animal models. However, the role of ACEIs and AR...
Article
Objective High grade endometrial stromal sarcoma is a rare and highly malignant tumor that lacks a prognostic model. The aim of this study was to develop a prognostic nomogram predicting the overall survival of patients with high grade endometrial stromal sarcoma. Methods Clinical data for patients were derived from the Surveillance Epidemiology,...
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The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1-8 (previously called chemokine-like factor superfamily 1-8, CKLFSF1-8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multi...
Article
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Background Low‐grade endometrial stromal sarcoma (LG‐ESS) is a rare tumor that lacks a prognostic prediction model. Our study aimed to develop a nomogram to predict overall survival of LG‐ESS patients. Methods A total of 1172 patients confirmed to have LG‐ESS between 1988 and 2015 were selected from the Surveillance, Epidemiology and End Results (...
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Background: This study aimed to explore the correlation of forkhead box Q1 (FOXQ1) with clinicopathological features and survival profiles in patients with non-small cell lung cancer (NSCLC). Methods: A total of 238 NSCLC patients with TNM stage I-III who underwent surgical resection were reviewed, and the expression of FOXQ1 in tumor and paired...
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Background: Considering the effect of smoking on tumor immunity, we attempted to investigate the impact of smoking history on the prognostic value of circulating naïve and memory CD4+ and CD8+ T cells in advanced non-small cell lung cancer (NSCLC) treated with chemo(radio)therapy. Methods: Of 196 histologically confirmed advanced NSCLC, 98 eligi...
Data
Relative expression levels of immune molecules in the peripheral blood of patients with early-stage BC and advanced BC. Note: Levels of (A) PD-1, (B) CTLA-4, (C) FOXP3, (D) TGF-β, (E) IL-10, (F) IL-2Rα, and (G) CD28. Abbreviations: BC, breast cancer; PD-1, programmed cell death 1; CTLA-4, cytotoxic T lymphocyte antigen 4; FOXP3, forkhead box P3; TG...
Article
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Introduction Programmed cell death protein 1 (PD-1), an immune checkpoint molecule, has recently been recognized as a predictive and prognostic biomarker in several malignant tumors, but its diagnostic value remains largely unknown. We aimed to investigate the differential diagnostic efficiency of PD-1 and other immune molecules and propose a panel...
Article
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Transforming growth factor-β (TGF-β), interleukin-10 (IL-10), and forkhead box P3 (Foxp3) have important roles in breast cancer development. Previous studies confirmed a correlation between these immune molecules and tumor characteristics, but their association with nutritional status in breast cancer is largely unknown. We aimed to investigate the...
Article
T lymphocytes migrate into the brain after intracerebral hemorrhage (ICH) and promote cerebral inflammation, thus exacerbating neuronal injury. However, the relationship between of T lymphocytes infiltration and blood-brain barrier (BBB) injury after ICH has not been clarified. In this study, we investigated the spatial-temporal distribution of inf...
Article
Spinal cord injury (SCI) leads to glial scar formation by astrocytes, which severely hinders neural regeneration. Curcumin (cur) can inhibit glial scar formation, but the underlying mechanism is not fully understood. Using both in vivo and in vitro experiments, the current study investigated the phenotypic transformation of astrocytes following cur...
Article
Full-text available
Purpose Obstructive sleep apnea (OSA) has been associated with changes in brain structure and regional function in certain brain areas. However, the functional features of network organization in the whole brain remain largely uncertain. The purpose of this study was to identify the OSA-related spatial centrality distribution of the whole brain fun...
Data
Highly similar spatial distributions of the functional hubs (high degree centrality) were identified in the two groups, which were localized in the frontal lobe, precuneus, parietal lobule, posterior cingulate, occipital lobe, and temporal lobe, according to different correlation thresholds (r0 = 0.15, 0.2, 0.25, 0.3 and 0.35). (TIF)
Data
Significant differences in DC between the patients with OSA and GSs (r0 = 0.30). (DOC)
Data
Decreased regions of seed-based FC in OSA patients compared to GSs. (DOC)
Data
Altered degree centrality between the patients with OSA and good sleepers (r0 = 0.25) (including demographic and clinical data). (ZIP)
Data
Significant differences in DC between the patients with OSA and GSs (r0 = 0.15). (DOC)
Data
Significant differences in DC between the patients with OSA and GSs (r0 = 0.35). (DOC)
Data
Seed-based functional connectivity analysis. (DOC)
Data
Significantly decreased regions of seed-based FC in the patients with OSA compared to the GSs (P < 0.001, cluster > 40 voxels, AlphaSim corrected). (TIF)
Data
Significant differences in DC between the patients with OSA and GSs (r0 = 0.20). (DOC)
Article
Two new pterosin-type sesquiterpenes, nicosesquiterpenes A and B, are isolated along with four known sesquiterpene derivatives.
Article
In searching for more bioactive compounds, phytochemical investigations on the acetone extract of the leaves of Nicotiana tabacum resulted in the isolation of two new sesquiterpenes, nicosesquiterpene A and B (1 and 2), along with four known sesquiterpene derivatives (3-6). Structural elucidation of 1 and 2 was performed by spectral methods, such a...
Article
T lymphocytes contribute to inflammation, thereby exacerbating neuronal injury after cerebral ischemia. An increasing amount of evidence indicates that inflammation is a key contributor to intracerebral hemorrhage (ICH)-induced secondary brain injury. Curcumin, a low-molecular-weight curry spice that is derived from the Curcuma longa plant, suppres...
Article
A new phenolic compound, gramniphenol I (1), was isolated from the whole plant of Arundina gramnifolia. Its structure was determined by means of HRESIMS, extensive 1D and 2D NMR spectroscopic studies and chemical evidence. Compound 1 was also tested for its antitobacco mosaic virus (anti-TMV) activity and it exhibited notable antitobacco mosaic vir...
Article
Three new isoflavones, 4′,8-dihydroxy-6,7-dimethoxyisoflavone (1), 4′,6-dihydroxy-8-methoxycarbonyl-7-methoxyisoflavone (2), 4′,7-dimethoxy-8-hydroxymethyl-6-hydroxyisoflavone (3), together with three known flavones (4–6), were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extens...
Article
Four new flavones, tobaflavones E-H (1-4), together with two known flavones (5 and 6), were isolated from the leaves of Dali Tiandeng tobacco (a variety of Yunnan local air cured tobacco). Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compound 2 is the first naturally occurring flavone bea...
Article
Three new flavone derivatives, paranicflavones A–C (1–3), together with three known similar compounds (4–6), were isolated from their roots and stems of Tiandeng tobacco. Their structures were elucidated by spectroscopic methods, including extensive 1H and 13C NMR techniques. Additionally, compounds 1–6 were evaluated for their anti-tobacco mosaic...
Article
Three new isocoumarin derivatives, tabaisocoumarins A-C (1-3), together with three known phenolic compounds (4-6), were isolated from the roots and stems of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1-6 were evaluated for their anti-tobacco mosaic virus (an...
Article
A new chromone 8-methoxy-2,2-dimethyl-7-(2-oxopropyl)-2,3-dihydrochromen-4-one (1) was isolated from the stems of Cassia fistula. Its structures was elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compound 1 was evaluated for its anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 1 ex...
Data
Full-text available
Acyl-acyl carrier protein thioesterases are intraplastidial enzymes that determine the types and amounts of fatty acids found in plants and then release them into the cytosol to be incorporated into glycerolipids. To better understand the role of the FatB class of acyl-acyl carrier protein thioesterase, a 1.2 kb cDNA fragment of AhFatB1 was amplifi...
Article
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The existence of all components of the renin-angiotensin system (RAS) and the iron metabolism system, and the recent findings on the functions of angiotensin II (ANGII) in peripheral iron metabolism imply that ANG II might play a role in iron homeostasis by regulating expression of iron transport proteins in the brain. Here, we investigated effects...
Article
Based on the studies on the role of complement C3, C1q and factor B, we hypothesized that complement C5a is detrimental to locomotor recovery at the early stage of secondary injury after spinal cord injury (SCI). To test this hypothesis, we investigated effect of inhibition of complement C5a receptor (C5aR) by using C5aR antagonist PMX53 (C5aRA) an...
Article
Full-text available
Diacylglycerol acyltransferase (DGAT) is the rate-limiting enzyme in triacylglycerol biosynthesis in eukaryotic organisms. Triacylglycerols are important energy-storage oils in plants such as peanuts, soybeans and rape. In this study, Arachis hypogaea type 2 DGAT (AhDGAT2) genes were cloned from the peanut cultivar 'Luhua 14' using a homologous gen...
Data
Comparison of the nucleotide sequences of AhDGAT2a and AhDGAT2b. The 14 nucleotide differences are shaded in gray. The red underlines show the initiation and termination codons. (TIF)
Data
Original data and data analysis. (XLS)
Article
Full-text available
In this study, a full-length cDNA of the acyl-ACP thioesterase, AhFatA, was cloned from developing seeds of Arachis hypogaea L. by 3'-RACE. Sequence analysis showed that the open reading frame encodes a peptide of 372 amino acids and has 50-70% identity with FatA from other plants. Real-time quantitative PCR analysis revealed that AhFatA was expres...
Data
Supplementary Figure 1: Sequence analysis of AhFatA and any other plants. (A) Amino acid sequence alignment of AhFatA and the FatA sequences of other plants. The identical amino acids were showed in white with black background and the conserved amino acids were showed in white and gray background. The three conserved residues are indicated by arrow...
Article
Spinal cord injury results in loss of neurons, degeneration of axons, formation of glial scar, and severe functional impairment. Human umbilical cord mesenchymal stem cells can be induced to form neural cells in vitro. Thus, these cells have a potential therapeutic role for treating spinal cord injury. Rats were randomly divided into three groups:...
Article
Bovine serum albumin (BSA) is generally used in biomedical experiments. In the solution of some reagents, BSA is necessary to maintain the stability and concentration of the effective component. Therefore, the potential impact of BSA on experimental results should not be neglected when BSA is used. In this study, we observed that BSA induced signif...
Article
The formation of glial scar and cystic cavities restricts axon regeneration after spinal cord injury. Chondroitin sulphate proteoglycans (CSPGs) are regarded as the prominent inhibitory molecules in the glial scar, and their inhibitory effects may be abolished in part by chondroitinase ABC (ChABC), which can digest CSPGs. CSPGs are secreted mostly...

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