Lakshya GangwarUniversity of Minnesota | UMN · Department of Mechanical Engineering
Lakshya Gangwar
Doctor of Philosophy
About
19
Publications
1,485
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145
Citations
Introduction
Lakshya Gangwar currently works at the Department of Mechanical Engineering, University of Minnesota, USA. Lakshya does research in Bio-heat Transfer related problems in Cryobiology. More specifically, their current research project is related to organ cryopreservation and nanowarming technologies.
Additional affiliations
May 2016 - July 2016
Position
- Research Internship
Description
- Development and Performance testing of a flexible heat pipe for spacecraft applications
May 2017 - July 2017
Position
- Research Internship
Description
- Investigation of flow behaviour in a steam generator prototype for alcohol-water mixtures
July 2014 - present
Publications
Publications (19)
Organ banking by vitrification could revolutionize transplant medicine. However, vitrification and rewarming have never been demonstrated at the human organ scale. Using modeling and experimentation, we tested the ability to vitrify and rewarm 0.5–3 L volumes of three common cryoprotective agent (CPA) solutions: M22, VS55, and 40% EG+0.6M Sucrose....
Banking cryopreserved organs could transform transplantation into a planned procedure that more equitably reaches patients regardless of geographical and time constraints. Previous organ cryopreservation attempts have failed primarily due to ice formation, but a promising alternative is vitrification, or the rapid cooling of organs to a stable, ice...
Cryopreservation by vitrification to achieve an "ice free" glassy state is an effective technique for preserving biomaterials including cells, tissues, and potentially even whole organs. The major challenges in cooling to and rewarming from a vitrified state remain ice crystallization and cracking/fracture. Ice crystallization can be inhibited by t...
Deep-seated tumors of the liver, brain, and other organ systems often recur after initial surgical, chemotherapeutic, radiation, or focal treatments. Repeating these treatments is often invasive and traumatic. We propose an iron oxide nanoparticle (IONP)-enhanced precipitating hydrophobic injectable liquid (PHIL, MicroVention inc.) embolic as a loc...
DP6, VS55 and M22 are the most commonly used cryoprotective agent (CPA) cocktails for vitrification experiments in tissues and organs. However, complete phase diagrams for the three CPAs are often unavailable or incomplete (only available for full strength CPAs) thereby hampering optimization of vitrification and rewarming procedures. In this paper...
Vitrification can dramatically increase the storage of viable biomaterials in the cryogenic state for years. Unfortunately, vitrified systems ≥3 mL like large tissues and organs, cannot currently be rewarmed sufficiently rapidly or uniformly by convective approaches to avoid ice crystallization or cracking failures. A new volumetric rewarming techn...
